Wendy B Bollag

Summary

Affiliation: Medical College of Georgia
Country: USA

Publications

  1. pmc Ultraviolet B irradiation and activation of protein kinase D in primary mouse epidermal keratinocytes
    S N Arun
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA, USA
    Oncogene 30:1586-96. 2011
  2. pmc A hypothesis concerning a potential involvement of ceramide in apoptosis and acantholysis induced by pemphigus autoantibodies
    Wendy B Bollag
    Charlie Norwood VA Medical Center, Research Service, One Freedom Way, Augusta, GA 30904, USA
    Dermatol Res Pract 2010:702409. 2010
  3. ncbi request reprint Differentiation of human keratinocytes requires the vitamin d receptor and its coactivators
    Wendy B Bollag
    Institute of Molecular Medicine and Genetics, Department of Medicine Dermatology, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Invest Dermatol 127:748-50. 2007
  4. ncbi request reprint Characterization and phospholipase D mediation of the angiotensin II priming response in adrenal glomerulosa cells
    Wendy B Bollag
    Program in Regenerative Medicine, Department of Medicine, Institute of Molecular Medicine and Genetics, 1120 15th Street, Medical College of Georgia, Augusta, Georgia 30912 2630, USA
    Endocrinology 148:585-93. 2007
  5. ncbi request reprint A potential role for the phospholipase D2-aquaporin-3 signaling module in early keratinocyte differentiation: production of a phosphatidylglycerol signaling lipid
    Wendy B Bollag
    Department of Medicine Dermatology, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Invest Dermatol 127:2823-31. 2007
  6. doi request reprint Wherefore art thou, YY1?
    Wendy B Bollag
    Charlie Norwood VA Medical Center, Augusta, Georgia, USA
    J Invest Dermatol 131:11-2. 2011
  7. pmc Phorbol ester increases mitochondrial cholesterol content in NCI H295R cells
    Wendy B Bollag
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Mol Cell Endocrinol 296:53-7. 2008
  8. doi request reprint Protein kinase Calpha puts the hand cuffs on epidermal keratinocyte proliferation
    Wendy B Bollag
    Charlie Norwood VA Medical Center, Augusta, Georgia, USA
    J Invest Dermatol 129:2330-2. 2009
  9. ncbi request reprint Green tea polyphenol induces caspase 14 in epidermal keratinocytes via MAPK pathways and reduces psoriasiform lesions in the flaky skin mouse model
    Stephen Hsu
    Department of Oral Biology and Maxillofacial Pathology, School of Dentistry, Medical College of Georgia, Augusta, GA 30912, USA
    Exp Dermatol 16:678-84. 2007
  10. pmc The potential use of protein kinase D inhibitors for prevention/treatment of epidermal tumors
    Senthil Nathan Arun
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    J Dermatol Sci 60:29-39. 2010

Collaborators

Detail Information

Publications74

  1. pmc Ultraviolet B irradiation and activation of protein kinase D in primary mouse epidermal keratinocytes
    S N Arun
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA, USA
    Oncogene 30:1586-96. 2011
    ..Thus, our data indicate that UVB irradiation of keratinocytes induces Src-mediated activation of PKD, which protects cells from UVB-stimulated apoptosis, providing a possible explanation for the observed upregulation of PKD in BCC...
  2. pmc A hypothesis concerning a potential involvement of ceramide in apoptosis and acantholysis induced by pemphigus autoantibodies
    Wendy B Bollag
    Charlie Norwood VA Medical Center, Research Service, One Freedom Way, Augusta, GA 30904, USA
    Dermatol Res Pract 2010:702409. 2010
    ....
  3. ncbi request reprint Differentiation of human keratinocytes requires the vitamin d receptor and its coactivators
    Wendy B Bollag
    Institute of Molecular Medicine and Genetics, Department of Medicine Dermatology, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Invest Dermatol 127:748-50. 2007
    ....
  4. ncbi request reprint Characterization and phospholipase D mediation of the angiotensin II priming response in adrenal glomerulosa cells
    Wendy B Bollag
    Program in Regenerative Medicine, Department of Medicine, Institute of Molecular Medicine and Genetics, 1120 15th Street, Medical College of Georgia, Augusta, Georgia 30912 2630, USA
    Endocrinology 148:585-93. 2007
    ..Thus, our results suggest that persistent DAG resulting from PLD signaling mediates the priming response to AngII or PDBu...
  5. ncbi request reprint A potential role for the phospholipase D2-aquaporin-3 signaling module in early keratinocyte differentiation: production of a phosphatidylglycerol signaling lipid
    Wendy B Bollag
    Department of Medicine Dermatology, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Invest Dermatol 127:2823-31. 2007
    ..Thus, our results support the idea that AQP3 supplies PLD2 with glycerol for synthesizing PG, a lipid signal that promotes early keratinocyte differentiation...
  6. doi request reprint Wherefore art thou, YY1?
    Wendy B Bollag
    Charlie Norwood VA Medical Center, Augusta, Georgia, USA
    J Invest Dermatol 131:11-2. 2011
    ..In primary keratinocytes, overexpressed YY1 also inhibits differentiation marker expression induced by calcium, supporting the idea that YY1 is important in regulating epidermal structure and function...
  7. pmc Phorbol ester increases mitochondrial cholesterol content in NCI H295R cells
    Wendy B Bollag
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Mol Cell Endocrinol 296:53-7. 2008
    ..These findings suggest that the ability of ANP to inhibit steroidogenesis induced by multiple agents may be related to its capacity to reduce cholesterol mobilization...
  8. doi request reprint Protein kinase Calpha puts the hand cuffs on epidermal keratinocyte proliferation
    Wendy B Bollag
    Charlie Norwood VA Medical Center, Augusta, Georgia, USA
    J Invest Dermatol 129:2330-2. 2009
    ..In this issue, Jerome-Morais et al. describe their use of multiple in vitro, in situ, overexpression, and knockdown approaches to demonstrate that PKCalpha induces keratinocyte growth arrest...
  9. ncbi request reprint Green tea polyphenol induces caspase 14 in epidermal keratinocytes via MAPK pathways and reduces psoriasiform lesions in the flaky skin mouse model
    Stephen Hsu
    Department of Oral Biology and Maxillofacial Pathology, School of Dentistry, Medical College of Georgia, Augusta, GA 30912, USA
    Exp Dermatol 16:678-84. 2007
    ..This suggests that GTP-activated pathways may be potential targets for novel therapeutic approaches to the treatment of some psoriasiform skin disorders...
  10. pmc The potential use of protein kinase D inhibitors for prevention/treatment of epidermal tumors
    Senthil Nathan Arun
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    J Dermatol Sci 60:29-39. 2010
    ....
  11. ncbi request reprint Glucose-dependent insulinotropic peptide-overexpressing transgenic mice have increased bone mass
    Ding Xie
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, CB 2803, 1120 15th Street, Augusta, GA 30912, USA
    Bone 40:1352-60. 2007
    ..In view of GIP's role in nutrient absorption, our data suggest that this hormone may serve an important role in linking nutrient ingestion to bone formation...
  12. pmc A role for phospholipase D in angiotensin II-induced protein kinase D activation in adrenal glomerulosa cell models
    Lawrence O Olala
    Department of Physiology, Georgia Health Sciences University Formerly the Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, United States
    Mol Cell Endocrinol 366:31-7. 2013
    ..These results indicate that PKD is downstream of PLD and suggest that PKD is one of the mechanisms through which PLD promotes aldosterone production in response to AngII in adrenal glomerulosa cells...
  13. ncbi request reprint Mechanism of angiotensin II-induced phospholipase D activation in bovine adrenal glomerulosa cells
    Wendy B Bollag
    Program in Cell Signaling, Department of Medicine, Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street, 30912 2630, Augusta, GA, USA
    Mol Cell Endocrinol 192:7-16. 2002
    ..Thus, our results suggest a role for PKC, independent of calcium influx, in mediating AngII-induced PLD activation in glomerulosa cells...
  14. ncbi request reprint Phospholipase d signaling and extracellular signal-regulated kinase-1 and -2 phosphorylation (activation) are required for maximal phorbol ester-induced transglutaminase activity, a marker of keratinocyte differentiation
    Wendy B Bollag
    Institute of Molecular Medicine and Genetics CB 2803, Medical College of Georgia, 1120 15th St, Augusta, GA 30912 2630, USA
    J Pharmacol Exp Ther 312:1223-31. 2005
    ..Thus, our results suggest the independent involvement of the PLD and ERK-1/2 pathways in mediating transglutaminase activity and keratinocyte differentiation...
  15. ncbi request reprint Regulation of protein kinase D during differentiation and proliferation of primary mouse keratinocytes
    M Ernest Dodd
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Invest Dermatol 125:294-306. 2005
    ..This work describes the inverse regulation of PKD during keratinocyte differentiation and proliferation and the pro-proliferative/anti-differentiative effects of PKD co-expression on keratinocyte maturation...
  16. ncbi request reprint Effects of glucose-dependent insulinotropic peptide on osteoclast function
    Qing Zhong
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Am J Physiol Endocrinol Metab 292:E543-8. 2007
    ..These data are consistent with the hypothesis that GIP inhibits bone breakdown through a direct effect on osteoclast-resorptive activity and suggest one mechanism for the postprandial reduction in markers of bone breakdown...
  17. pmc Angiotensin II-activated protein kinase D mediates acute aldosterone secretion
    Brian A Shapiro
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA
    Mol Cell Endocrinol 317:99-105. 2010
    ..Thus, we demonstrate for the first time that PKD mediates acute AngII-induced aldosterone secretion...
  18. pmc The role of calcium influx pathways in phospholipase D activation in bovine adrenal glomerulosa cells
    Haixia Qin
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Endocrinol 202:77-86. 2009
    ..In summary, our results indicate that Ca(2+) entry only through certain Ca(2+) influx pathways is linked to PLD activation...
  19. ncbi request reprint Modulation of phospholipase D-mediated phosphatidylglycerol formation by differentiating agents in primary mouse epidermal keratinocytes
    Xiangjian Zheng
    Program in Cell Signaling, Institute of Molecular Medicine and Genetics, Department of Medicine Dermatology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912 2630, USA
    Biochim Biophys Acta 1643:25-36. 2003
    ..Our results also suggest that PLD-mediated PG synthesis may be regulated at the level of both PLD activity and alcohol substrate availability via changes in glycerol uptake...
  20. pmc The caveolin-1 scaffolding domain peptide decreases phosphatidylglycerol levels and inhibits calcium-induced differentiation in mouse keratinocytes
    Haixia Qin
    Department of Physiology, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, United States of America
    PLoS ONE 8:e80946. 2013
    ....
  21. doi request reprint Aquaporin-3 re-expression induces differentiation in a phospholipase D2-dependent manner in aquaporin-3-knockout mouse keratinocytes
    Vivek Choudhary
    1 Charlie Norwood VA Medical Center, Augusta, Georgia, USA 2 Department of Physiology, Georgia Regents University, Augusta, Georgia, USA 3 Section of Dermatology, Department of Medicine, Georgia Regents University, Augusta, Georgia, USA
    J Invest Dermatol 135:499-507. 2015
    ..Thus, our results indicate that AQP3 has a pro-differentiative role in epidermal keratinocytes and that PLD2 activity is necessary for this effect...
  22. ncbi request reprint A sensitive and restricted enzyme-linked immunosorbent assay for detecting a heterogeneous antibody population in serum from people suffering from a new variant of endemic pemphigus
    Ana Maria Abreu-Velez
    Institute for Molecular Medicine and Genetics, Medical College of Georgia, CB 2803, 1120 15th Street, GA 30912 2630, Augusta, USA
    Arch Dermatol Res 295:434-41. 2004
    ..Finally, autoantibody serum levels obtained with this ELISA correlated well with the clinical activity and extent of disease in patients with El Bagre EPF...
  23. ncbi request reprint Inhibition of autoantigen expression by (-)-epigallocatechin-3-gallate (the major constituent of green tea) in normal human cells
    Stephen Hsu
    Department of Oral Biology and Maxillofacial Pathology, School of Dentistry, Medical College of Georgia, Augusta, 30912 1126, USA
    J Pharmacol Exp Ther 315:805-11. 2005
    ..These findings, taken together with green tea's anti-inflammatory and antiapoptotic effects, suggest that green tea polyphenols could serve as an important component in novel approaches to combat autoimmune disorders in humans...
  24. pmc Cell wounding activates phospholipase D in primary mouse keratinocytes
    Senthil N Arun
    Charlie Norwood VA Medical Center, Augusta, GA 30904, USA
    J Lipid Res 54:581-91. 2013
    ..In an in vivo full-thickness mouse skin wound model, PG accelerated wound healing. These results suggest that PLD and the PLD2/AQP3 signaling module may be involved in membrane repair and wound healing...
  25. pmc Impact of glucose-dependent insulinotropic peptide on age-induced bone loss
    Ke Hong Ding
    Institute of Molecular Medicine and Genetics, Program in Regenerative Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Bone Miner Res 23:536-43. 2008
    ..We show for the first time that BMSCs express functional GIP receptors, that expression decreases with aging, and that elevations in GIP can prevent age-associated bone loss...
  26. pmc Phospholipase D2 mediates acute aldosterone secretion in response to angiotensin II in adrenal glomerulosa cells
    Haixia Qin
    Department of Physiology, Medical College of Georgia, Augusta, Georgia 30912 2630, USA
    Endocrinology 151:2162-70. 2010
    ..In both cases, the lipase-inactive PLD mutants showed essentially no effect on PLD activity or aldosterone secretion. Our results suggest that PLD2 is the isoform that mediates aldosterone secretion and likely priming...
  27. pmc Aquaporin-3 in keratinocytes and skin: its role and interaction with phospholipase D2
    Haixia Qin
    Institute of Molecular Medicine and Genetics, Georgia Health Sciences University formerly Medical College of Georgia, Augusta, GA 30912, USA
    Arch Biochem Biophys 508:138-43. 2011
    ..AQP3 levels have also been found to be altered in human skin diseases. In this article the evidence supporting a role for AQP3 in the epidermis will be discussed...
  28. pmc Lasp1 gene disruption is linked to enhanced cell migration and tumor formation
    Han Zhang
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia, USA
    Physiol Genomics 38:372-85. 2009
    ..The striking contrast in the functional effects of loss of Lasp1 in innate cells compared with cell lines reveals distinct differences in mechanisms of motility and attachment in these models...
  29. ncbi request reprint AngII induces transient phospholipase D activity in the H295R glomerulosa cell model
    Xiangjian Zheng
    Institute of Molecular Medicine and Genetics CB 2803, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912 2630, USA
    Mol Cell Endocrinol 206:113-22. 2003
    ..These results suggested that in H295R adrenocortical carcinoma cells, AngII-induced PLD activation was promoted by PKC and inhibited by the constitutively active PI3K pathway...
  30. ncbi request reprint Green tea polyphenols reduce autoimmune symptoms in a murine model for human Sjogren's syndrome and protect human salivary acinar cells from TNF-alpha-induced cytotoxicity
    Stephen D Hsu
    Department of Oral Biology and Maxillofacial Pathology, School of Dentistry, Medical College of Georgia, Augusta, GA, USA
    Autoimmunity 40:138-47. 2007
    ..In conclusion, GTPs may provide a degree of protection against autoimmune-induced tissue damage in SS, mediated in part through activation of MAPK elements...
  31. ncbi request reprint Analyses of autoantigens in a new form of endemic pemphigus foliaceus in Colombia
    Ana Maria Abreu-Velez
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, GA 30912, USA
    J Am Acad Dermatol 49:609-14. 2003
    ..We previously described a new focus of endemic pemphigus foliaceus in rural areas of El Bagre, Colombia, with clinical and direct immunofluorescence characteristics of pemphigus erythematosus...
  32. doi request reprint Diltiazem enhances the apoptotic effects of proteasome inhibitors to induce prostate cancer cell death
    Ismail Kaddour-Djebbar
    Charlie Norwood VA Medical Center, One Freedom Way, Augusta, GA 30904, USA
    J Pharmacol Exp Ther 341:646-55. 2012
    ..Thus, our results demonstrate a potential therapeutic advantage of combining a frequently used calcium channel blocker with proteasome inhibitors in the treatment of prostate cancer...
  33. pmc Abnormal aquaporin-3 protein expression in hyperproliferative skin disorders
    Kristen E Voss
    Institute of Molecular Medicine and Genetics, Georgia Health Sciences University formerly Medical College of Georgia, Augusta, GA 30912, USA
    Arch Dermatol Res 303:591-600. 2011
    ..These results suggest that abnormalities in the AQP3/PLD2 signaling module correlate with hyperproliferation in psoriasis and the NMSCs...
  34. ncbi request reprint Expression of caspase-14 reduces tumorigenicity of skin cancer cells
    Stephen Hsu
    Department of Oral Biology and Maxillofacial Pathology, School of Dentistry, Medical College of Georgia, Augusta, USA
    In Vivo 21:279-83. 2007
    ..Caspase-14, a member of the caspase family associated with epithelial cell differentiation, planned cell death, and barrier formation, is induced by EGCG in normal human epidermal keratinocytes but not in cancer cells...
  35. pmc 8-Cl-Adenosine enhances 1,25-dihydroxyvitamin D3-induced growth inhibition without affecting 1,25-dihydroxyvitamin D3-stimulated differentiation of primary mouse epidermal keratinocytes
    Wendy B Bollag
    Department of Medicine Dermatology, Medical College of Georgia, Augusta, GA 30912 USA
    BMC Pharmacol 4:13. 2004
    ..We previously demonstrated that 8-Cl-adenosine (8-Cl-Ado) can induce keratinocyte growth arrest without inducing differentiation...
  36. pmc The effect of pioglitazone on aldosterone and cortisol production in HAC15 human adrenocortical carcinoma cells
    Zhi qiang Pan
    Department of Physiology, Georgia Regents University Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA School of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    Mol Cell Endocrinol 394:119-28. 2014
    ..In turn, the ability of pioglitazone to stimulate cortisol production could potentially underlie the effects of this drug on fluid retention...
  37. ncbi request reprint Rare clinical form in two patients affected by a new variant of endemic pemphigus in northern Colombia
    Ana Maria Abreu Velez
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA
    Skinmed 3:317-21. 2004
    ..Recently, the authors described a new variant of endemic pemphigus foliaceus in rural areas surrounding El Bagre, Colombia, but without association with malignant tumors...
  38. ncbi request reprint A unique form of endemic pemphigus in northern Colombia
    Ana Maria Abreu-Velez
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, GA 30912, USA
    J Am Acad Dermatol 49:599-608. 2003
    ..The restriction to relatively well-defined regions of South and Central America and perhaps Africa characterizes these diseases...
  39. pmc Oxidation of the aromatic amino acids tryptophan and tyrosine disrupts their anabolic effects on bone marrow mesenchymal stem cells
    Mona El Refaey
    Institute for Regenerative and Reparative Medicine, Georgia Regents University, Augusta, GA, United States Department of Neuroscience and Regenerative Medicine, Georgia Regents University, Augusta, GA, United States
    Mol Cell Endocrinol 410:87-96. 2015
    ..Taken together, our data are consistent with a potential pathogenic role for oxidized amino acids in age-induced bone loss. ..
  40. pmc Impact of dietary aromatic amino acids on osteoclastic activity
    Mona El Refaey
    Institute for Regenerative and Reparative Medicine, Medical College of Georgia, Georgia Regents University, Augusta, GA, 30912, USA
    Calcif Tissue Int 95:174-82. 2014
    ..Our data are consistent with aromatic amino acids down-regulating osteoclastic differentiation by suppressing remodeling gene expression thus contributing initially to the net increase in bone mass seen in vivo. ..
  41. pmc Lessons from the gene expression pattern of the rat zona glomerulosa
    Koshiro Nishimoto
    Department of Physiology, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912, USA Department of Urology, Tachikawa Hospital, Tokyo 190 8531, Japan
    Mol Cell Endocrinol 371:107-13. 2013
    ..The list of genes we present in the current report may become an important tool for researchers working on primary aldosteronism and aldosterone-related cardiovascular diseases...
  42. pmc Adrenal cell aldosterone production is stimulated by very-low-density lipoprotein (VLDL)
    Yewei Xing
    Department of Physiology, Georgia Health Sciences University, 1120 15th Street, Augusta, Georgia 30912, USA
    Endocrinology 153:721-31. 2012
    ..In conclusion, we have shown that VLDL can stimulate aldosterone synthesis in adrenocortical cells by increasing StAR and CYP11B2 expression, an event likely mediated by a calcium-initiated signaling cascade...
  43. ncbi request reprint Protein kinase D and keratinocyte proliferation
    Wendy B Bollag
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    Drug News Perspect 17:117-26. 2004
    ..Thus, PKD/PKC micro may represent a novel target for the development of new and more efficacious drug treatments for hyperproliferative skin disorders...
  44. ncbi request reprint Carboxy-terminal PTH fragments stimulate [3H]thymidine incorporation in vascular endothelial cells
    Ke Hong Ding
    Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, CB 2803, 1120, 15th Street, Augusta, GA 30912, USA
    Peptides 26:853-62. 2005
    ..Taken together, these data suggest that the carboxy-terminal PTH is (or contains) the bioactive fragment responsible for the changes in intracellular calcium and thymidine incorporation in HUVEC stimulated with the intact PTH molecule...
  45. pmc Angiotensin II regulation of adrenocortical gene transcription
    Edson F Nogueira
    Department of Physiology, Medical College of Georgia, Augusta, GA 30912, USA
    Mol Cell Endocrinol 302:230-6. 2009
    ..Herein we discuss the Ang II-induced genes in adrenocortical cells and review the progress in defining the role of these genes in zona glomerulosa function...
  46. ncbi request reprint Green tea polyphenol-induced epidermal keratinocyte differentiation is associated with coordinated expression of p57/KIP2 and caspase 14
    Stephen Hsu
    Department of Oral Biology and Maxillofacial Pathology, School of Dentistry, AD1443, Medical College of Georgia, Augusta, GA 30912 1126, USA
    J Pharmacol Exp Ther 312:884-90. 2005
    ..Further understanding of how EGCG modulates cellular differentiation may be useful in developing green tea preparations for selected clinical applications...
  47. pmc Protein kinase D1 deficiency promotes differentiation in epidermal keratinocytes
    Vivek Choudhary
    Charlie Norwood VA Medical Center, Augusta, GA 30904, USA Department of Physiology, Medical College of Georgia at Georgia Regents University, Augusta, GA 30912, USA Section of Dermatology, Department of Medicine, Medical College of Georgia at Georgia Regents University, Augusta, GA 30912, USA
    J Dermatol Sci 76:186-95. 2014
    ..The balance between proliferation and differentiation processes in the predominant cells of the epidermis, the keratinocytes, is essential for normal skin function...
  48. doi request reprint Phospholipase D activity underlies very-low-density lipoprotein (VLDL)-induced aldosterone production in adrenal glomerulosa cells
    Ying Ying Tsai
    Charlie Norwood VA Medical Center V C, W B B, Augusta, Georgia 30904 Department of Physiology Y Y T, W E R, Z P, V C, W B B, Medical College of Georgia at Georgia Regents University, Augusta, Georgia 30912 and Department of Pharmacology and Center for Developmental Genetics M A F, Stony Brook University, Stony Brook, New York 11794
    Endocrinology 155:3550-60. 2014
    ..Finally, by using selective PLD inhibitors, our studies suggest that both PLD1 and PLD2 isoforms play an important role in VLDL-induced aldosterone production. ..
  49. pmc Aromatic amino acid activation of signaling pathways in bone marrow mesenchymal stem cells depends on oxygen tension
    Mona El Refaey
    Institute for Regenerative and Reparative Medicine, Georgia Regents University, Augusta, Georgia, United States of America
    PLoS ONE 9:e91108. 2014
    ..The effects of aromatic amino acids on BMMSC function in the 21% O2 environment is consistent with a potential role for these amino acids in an aging environment as functional anti oxidants. ..
  50. pmc Acute and chronic regulation of aldosterone production
    Namita G Hattangady
    Department of Physiology, Georgia Health Sciences University formerly Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA
    Mol Cell Endocrinol 350:151-62. 2012
    ..Imbalance in any of these processes may lead to several disorders of aldosterone excess. In this review we attempt to summarize the key molecular events involved in the acute and chronic phases of aldosterone secretion...
  51. ncbi request reprint Angiotensin-II acute regulation of rapid response genes in human, bovine, and rat adrenocortical cells
    Edson F Nogueira
    Department of Physiology and Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Mol Endocrinol 39:365-74. 2007
    ..The presence of adrenal cell common genes in such distinct cell models strengthens the hypothesis that these genes are regulators of aldosterone production...
  52. ncbi request reprint Effects of glucose-dependent insulinotropic peptide on behavior
    Ke Hong Ding
    Medical College of Georgia, Institute of Molecular Medicine and Genetics, Department of Medicine, CB 2803, 1120 15th Street, Augusta, GA 30912, USA
    Peptides 27:2750-5. 2006
    ..These data suggest that the GIP receptor plays a role in the regulation of locomotor activity and exploration. To our knowledge, this is the first report of effects of GIP on behavior...
  53. ncbi request reprint Green tea polyphenols induce differentiation and proliferation in epidermal keratinocytes
    Stephen Hsu
    Department of Oral Biology and Maxillofacial Pathology, School of Dentistry, AD1443 Medical College of Georgia, Augusta, GA 30912 1126, USA
    J Pharmacol Exp Ther 306:29-34. 2003
    ..These results suggest that tea polyphenols may be used for treatment of wounds or certain skin conditions characterized by altered cellular activities or metabolism...
  54. pmc VLDL-activated cell signaling pathways that stimulate adrenal cell aldosterone production
    Ying Ying Tsai
    Department of Physiology, Medical College of Georgia at Augusta University, 1120 15th Street, Augusta, GA, 30912, United States
    Mol Cell Endocrinol 433:138-46. 2016
    ..An understanding of the mechanisms mediating VLDL-induced aldosterone production may provide insights into therapies to treat obesity-associated hypertension. ..
  55. pmc Angiotensin II-induced protein kinase D activates the ATF/CREB family of transcription factors and promotes StAR mRNA expression
    Lawrence O Olala
    Charlie Norwood Veterans Administration Medical Center L O O, V C, W B B, Augusta, Georgia 30904 and Departments of Physiology L O O, V C, W B B, Biostatistics and Epidemiology M H J, and Cell Biology and Anatomy and Medicine and Orthopaedic Surgery W B B, Medical College of Georgia at Georgia Regents University, Augusta, Georgia 30912
    Endocrinology 155:2524-33. 2014
    ..Thus, these data provide insight into the previously reported role of PKD in AngII-induced acute aldosterone production, providing a mechanism by which PKD may be mediating steroidogenesis in primary bovine adrenal glomerulosa cells. ..
  56. pmc Protein kinase C and Src family kinases mediate angiotensin II-induced protein kinase D activation and acute aldosterone production
    Lawrence O Olala
    Charlie Norwood VA Medical Center, Augusta, GA 30904, United States Department of Physiology, Medical College of Georgia at Georgia Regents University, Augusta, GA 30912, United States
    Mol Cell Endocrinol 392:173-81. 2014
    ..Taken together, our results demonstrate that AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production...
  57. ncbi request reprint Putative conventional protein kinase C inhibitor Gödecke 6976 [12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole] stimulates transglutaminase activity in primary mouse epidermal keratinocytes
    Brian A Shapiro
    Program in Cell Signaling, Department of Medicine, andDepartment of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Georgia
    J Pharmacol Exp Ther 302:352-8. 2002
    ..Therefore, our results suggest a proproliferative, antidifferentiative role for PKD in epidermal maturation...
  58. doi request reprint Mitofusin 1 degradation is induced by a disruptor of mitochondrial calcium homeostasis, CGP37157: a role in apoptosis in prostate cancer cells
    Vivek Choudhary
    Charlie Norwood VA Medical Center, Augusta, GA, USA
    Int J Oncol 44:1767-73. 2014
    ..Our results suggest that manipulation of mitofusins may provide a novel therapeutic advantage in treating prostate cancer...
  59. pmc GRowing an epidermal tumor
    Wendy B Bollag
    1 Charlie Norwood VA Medical Center, One Freedom Way, Augusta, Georgia, USA 2 Department of Physiology, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA 3 Department of Medicine Dermatology, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA 4 Department of Cellular Biology and Anatomy, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA 5 Department of Orthopaedic Surgery, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA 6 Institute of Regenerative and Reparative Medicine, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA
    J Invest Dermatol 133:2659-62. 2013
    ..demonstrate that mice lacking GR in the epidermis exhibit increased vulnerability to chemical carcinogenesis. Evidence supporting an involvement of GR signaling in physiological and pathophysiological processes in skin is discussed. ..
  60. doi request reprint COUP-TF-interacting protein-2 (Ctip2): driving the coupé of sphingolipid biosynthesis in the epidermis
    Wendy B Bollag
    Charlie Norwood VA Medical Center, and Department of Physiology, Georgia Health Sciences University, Augusta, Georgia 30912, USA
    J Invest Dermatol 133:593-4. 2013
    ..Abnormalities in Ctip2 could therefore underlie skin disorders characterized by an aberrant epidermal permeability barrier...
  61. doi request reprint Mediator1: an important intermediary of vitamin D receptor-regulated epidermal function and hair follicle biology
    Wendy B Bollag
    Charlie Norwood VA Medical Center, Georgia Health Sciences University, Augusta, Georgia 30912, USA
    J Invest Dermatol 132:1068-70. 2012
    ..The report by Oda et al. in this issue also indicates an important role of the VDR coactivator mediator 1 in these processes...
  62. doi request reprint Very low-density lipoprotein (VLDL)-induced signals mediating aldosterone production
    Ying Ying Tsai
    Department of PhysiologyMedical College of Georgia at Augusta University formerly Georgia Regents University, Augusta, Georgia, USA
    J Endocrinol 232:R115-R129. 2017
    ....
  63. pmc Distinct effects of different phosphatidylglycerol species on mouse keratinocyte proliferation
    Ding Xie
    Department of Physiology, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, United States of America
    PLoS ONE 9:e107119. 2014
    ..Thus, different PG species may be useful for treating skin diseases characterized by excessive or insufficient proliferation. ..
  64. pmc The antipsoriatic agent monomethylfumarate has antiproliferative, prodifferentiative, and anti-inflammatory effects on keratinocytes
    Inas Helwa
    Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia I H, I K D, V C, W B B Department of Oral Biology, College of Dental Medicine, I H, W B B, and Departments of Physiology I H, R P, P K, I K D, V C, W B B and Medicine Dermatology V C, W B B, Medical College of Georgia at Georgia Regents University, Augusta, Georgia
    J Pharmacol Exp Ther 352:90-7. 2015
    ..Our results support the notion that MMF has direct antiproliferative, prodifferentiative, and anti-inflammatory effects on keratinocytes, highlighting its potential use as a multifactorial antipsoriatic agent. ..
  65. pmc Novel role of androgens in mitochondrial fission and apoptosis
    Vivek Choudhary
    Charlie Norwood VA Medical Center, Georgia Health Sciences University, Augusta, Georgia, USA
    Mol Cancer Res 9:1067-77. 2011
    ..The present study shows a novel role for androgens in the regulation of mitochondrial morphology that could potentially be utilized in prostate cancer therapy...
  66. ncbi request reprint Detection of mercury and other undetermined materials in skin biopsies of endemic pemphigus foliaceus
    Ana Maria Abreu Velez
    Institute of Molecular Medicine and Genetic, Medical College of Georgia, Augusta, GA 30912 2630, USA
    Am J Dermatopathol 25:384-91. 2003
    ..This is the first study reporting mercuric sulfides/selenides in skin biopsies from people living in a focus of EPF, and these compounds may play a role in the pathogenesis of autoimmunity...
  67. doi request reprint Preparation of primary cultures of mouse epidermal keratinocytes and the measurement of phospholipase D activity
    Lakiea J Bailey
    Department of Physiology, Georgia Regents University, 1120 15th Street, Augusta, GA, 30912, USA
    Methods Mol Biol 1195:111-31. 2014
    ....
  68. pmc CXCR4 in epidermal keratinocytes: crosstalk within the skin
    Wendy B Bollag
    1 Charlie Norwood VA Medical Center, One Freedom Way, Augusta, Georgia, USA 2 Department of Physiology, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA 3 Department of Medicine Dermatology, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA 4 Department of Cellular Biology and Anatomy, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA 5 Department of Orthopaedic Surgery, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA 6 Institute of Regenerative and Reparative Medicine, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA
    J Invest Dermatol 133:2505-8. 2013
    ..Nevertheless, CXCR4 and its ligand SDF-1 have been implicated in skin wound healing, systemic lupus erythematosus, and basal cell carcinoma tumor angiogenesis. Further study is merited. ..
  69. ncbi request reprint Enrichment of regulatory CD4(+)CD25(+) T cells by inhibition of phospholipase D signaling
    Nagendra Singh
    Immunotherapy Center, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, 1120 15th Street, Augusta, Georgia 30912, USA
    Nat Methods 3:629-36. 2006
    ..Consequently, cells expanded in vitro for one week by antigen receptor stimulation with PLD signal inhibition were markedly enriched for regulatory T cells...
  70. ncbi request reprint The tryptic cleavage product of the mature form of the bovine desmoglein 1 ectodomain is one of the antigen moieties immunoprecipitated by all sera from symptomatic patients affected by a new variant of endemic pemphigus
    Ana Maria Abreu-Velez
    Institute for Molecular Medicine and Genetics, Medical College of Georgia, CB 2803, 1120, 15th Street, Augusta, GA 30912 2630, USA
    Eur J Dermatol 13:359-66. 2003
    ..This study confirms the biological importance of the ectodomain of Dsg1 as well as the relevance of conformational epitopes in various types of pemphigus...
  71. ncbi request reprint Age-related loss of muscle mass and bone strength in mice is associated with a decline in physical activity and serum leptin
    Mark W Hamrick
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA 30912, USA
    Bone 39:845-53. 2006
    ..Our data show that mice lose a significant amount of muscle and bone tissue with age, and this loss of musculoskeletal tissue is accompanied by a drop in serum leptin and preceded by a significant decrease in physical activity...
  72. ncbi request reprint Paradoxical effects of sphingosine-1-phosphate
    Wendy B Bollag
    Department of Medicine Dermatology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, USA
    J Invest Dermatol 120:xiii-xiv. 2003
  73. ncbi request reprint Green tea polyphenol causes differential oxidative environments in tumor versus normal epithelial cells
    Tetsuya Yamamoto
    Kochi Medical School, Japan
    J Pharmacol Exp Ther 307:230-6. 2003
    ..This finding may lead to applications of naturally occurring polyphenols to enhance the effectiveness of chemo/radiation therapy to promote cancer cell death while protecting normal cells...
  74. ncbi request reprint Roles of catalase and hydrogen peroxide in green tea polyphenol-induced chemopreventive effects
    Tetsuya Yamamoto
    Kochi Medical School, Japan
    J Pharmacol Exp Ther 308:317-23. 2004
    ..In conclusion, although endogenous catalase may play a role in response to H2O2-induced cytotoxicity, the EGCG-induced cytotoxic effects on tumor cells mainly result from sources other than H2O2...