Galina S Bogatkevich

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. ncbi request reprint Contractile activity and smooth muscle alpha-actin organization in thrombin-induced human lung myofibroblasts
    Galina S Bogatkevich
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Physiol Lung Cell Mol Physiol 285:L334-43. 2003
  2. ncbi request reprint Distinct PKC isoforms mediate cell survival and DNA synthesis in thrombin-induced myofibroblasts
    Galina S Bogatkevich
    Division of Rheumatology and Immunology, Dept of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Physiol Lung Cell Mol Physiol 288:L190-201. 2005
  3. ncbi request reprint Impairment of the antifibrotic effect of hepatocyte growth factor in lung fibroblasts from African Americans: possible role in systemic sclerosis
    Galina S Bogatkevich
    Medical University of South Carolina, Charleston 29425, USA
    Arthritis Rheum 56:2432-42. 2007
  4. ncbi request reprint Down-regulation of collagen and connective tissue growth factor expression with hepatocyte growth factor in lung fibroblasts from white scleroderma patients via two signaling pathways
    Galina S Bogatkevich
    Medical University of South Carolina, Charleston, SC 29425, USA
    Arthritis Rheum 56:3468-77. 2007
  5. pmc Proteomic analysis of CTGF-activated lung fibroblasts: identification of IQGAP1 as a key player in lung fibroblast migration
    Galina S Bogatkevich
    Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Physiol Lung Cell Mol Physiol 295:L603-11. 2008
  6. pmc Dabigatran, a direct thrombin inhibitor, demonstrates antifibrotic effects on lung fibroblasts
    Galina S Bogatkevich
    Medical University of South Carolina, Charleston, SC 29425, USA
    Arthritis Rheum 60:3455-64. 2009
  7. pmc Antiinflammatory and antifibrotic effects of the oral direct thrombin inhibitor dabigatran etexilate in a murine model of interstitial lung disease
    Galina S Bogatkevich
    Medical University of South Carolina, Charleston, SC, USA
    Arthritis Rheum 63:1416-25. 2011
  8. pmc The PPARĪ³ Agonist Rosiglitazone Is Antifibrotic for Scleroderma Lung Fibroblasts: Mechanisms of Action and Differential Racial Effects
    Galina S Bogatkevich
    Division of Rheumatology and Immunology, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 912, Charleston, SC 29425 6370, USA
    Pulm Med 2012:545172. 2012
  9. pmc Coagulation and autoimmunity in scleroderma interstitial lung disease
    Anna Ludwicka-Bradley
    Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Semin Arthritis Rheum 41:212-22. 2011

Research Grants

  1. CTGF-interacting proteins in scleroderma lung fibrosis
    GALINA BOGATKEVICH; Fiscal Year: 2007

Detail Information

Publications9

  1. ncbi request reprint Contractile activity and smooth muscle alpha-actin organization in thrombin-induced human lung myofibroblasts
    Galina S Bogatkevich
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Physiol Lung Cell Mol Physiol 285:L334-43. 2003
    ....
  2. ncbi request reprint Distinct PKC isoforms mediate cell survival and DNA synthesis in thrombin-induced myofibroblasts
    Galina S Bogatkevich
    Division of Rheumatology and Immunology, Dept of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Physiol Lung Cell Mol Physiol 288:L190-201. 2005
    ..These data demonstrate that two distinct PKC isoforms mediate thrombin-induced resistance to apoptosis and proliferation and suggest that p21Cip1/WAF1 promotes both phenomena...
  3. ncbi request reprint Impairment of the antifibrotic effect of hepatocyte growth factor in lung fibroblasts from African Americans: possible role in systemic sclerosis
    Galina S Bogatkevich
    Medical University of South Carolina, Charleston 29425, USA
    Arthritis Rheum 56:2432-42. 2007
    ..To compare the composition of cytokines in African American and Caucasian patients with systemic sclerosis (SSc; scleroderma) and in healthy individuals, particularly the expression and function of hepatocyte growth factor (HGF)...
  4. ncbi request reprint Down-regulation of collagen and connective tissue growth factor expression with hepatocyte growth factor in lung fibroblasts from white scleroderma patients via two signaling pathways
    Galina S Bogatkevich
    Medical University of South Carolina, Charleston, SC 29425, USA
    Arthritis Rheum 56:3468-77. 2007
    ..To study the mechanisms by which hepatocyte growth factor (HGF) down-regulates collagen and connective tissue growth factor (CTGF) in scleroderma (systemic sclerosis [SSc]) lung fibroblasts...
  5. pmc Proteomic analysis of CTGF-activated lung fibroblasts: identification of IQGAP1 as a key player in lung fibroblast migration
    Galina S Bogatkevich
    Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Physiol Lung Cell Mol Physiol 295:L603-11. 2008
    ..These findings further implicate the importance of CTGF in lung tissue repair and fibrosis and propose that CTGF-induced migration of lung fibroblasts to the damaged tissue is mediated via IQGAP1 and MAPK signaling pathways...
  6. pmc Dabigatran, a direct thrombin inhibitor, demonstrates antifibrotic effects on lung fibroblasts
    Galina S Bogatkevich
    Medical University of South Carolina, Charleston, SC 29425, USA
    Arthritis Rheum 60:3455-64. 2009
    ..We undertook this study to investigate whether a selective direct thrombin inhibitor, dabigatran, interferes with signal transduction in human lung fibroblasts induced by thrombin and mediated via PAR-1...
  7. pmc Antiinflammatory and antifibrotic effects of the oral direct thrombin inhibitor dabigatran etexilate in a murine model of interstitial lung disease
    Galina S Bogatkevich
    Medical University of South Carolina, Charleston, SC, USA
    Arthritis Rheum 63:1416-25. 2011
    ..This study was undertaken to test whether dabigatran etexilate attenuates lung injury in a murine model of interstitial lung disease...
  8. pmc The PPARĪ³ Agonist Rosiglitazone Is Antifibrotic for Scleroderma Lung Fibroblasts: Mechanisms of Action and Differential Racial Effects
    Galina S Bogatkevich
    Division of Rheumatology and Immunology, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 912, Charleston, SC 29425 6370, USA
    Pulm Med 2012:545172. 2012
    ..Differential therapeutic effects might be anticipated especially relative to racial differences and the functional expression of the c-Met receptor...
  9. pmc Coagulation and autoimmunity in scleroderma interstitial lung disease
    Anna Ludwicka-Bradley
    Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Semin Arthritis Rheum 41:212-22. 2011
    ..In this review we present our current understanding of the role played by coagulation and particularly by thrombin in autoimmune-mediated tissue injury and fibrosis, mainly as it relates to SSc-ILD...

Research Grants2

  1. CTGF-interacting proteins in scleroderma lung fibrosis
    GALINA BOGATKEVICH; Fiscal Year: 2007
    ..The identified protein(s) might serve then as potential target(s) in the treatment of scleroderma pulmonary fibrosis for which no proven, effective therapy currently exists. ..