Galina S Bogatkevich

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. pmc The PPARγ Agonist Rosiglitazone Is Antifibrotic for Scleroderma Lung Fibroblasts: Mechanisms of Action and Differential Racial Effects
    Galina S Bogatkevich
    Division of Rheumatology and Immunology, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 912, Charleston, SC 29425 6370, USA
    Pulm Med 2012:545172. 2012
  2. ncbi request reprint Contractile activity and smooth muscle alpha-actin organization in thrombin-induced human lung myofibroblasts
    Galina S Bogatkevich
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Physiol Lung Cell Mol Physiol 285:L334-43. 2003
  3. pmc Antiinflammatory and antifibrotic effects of the oral direct thrombin inhibitor dabigatran etexilate in a murine model of interstitial lung disease
    Galina S Bogatkevich
    Medical University of South Carolina, Charleston, SC, USA
    Arthritis Rheum 63:1416-25. 2011
  4. pmc Dabigatran, a direct thrombin inhibitor, demonstrates antifibrotic effects on lung fibroblasts
    Galina S Bogatkevich
    Medical University of South Carolina, Charleston, SC 29425, USA
    Arthritis Rheum 60:3455-64. 2009
  5. pmc Proteomic analysis of CTGF-activated lung fibroblasts: identification of IQGAP1 as a key player in lung fibroblast migration
    Galina S Bogatkevich
    Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Physiol Lung Cell Mol Physiol 295:L603-11. 2008
  6. ncbi request reprint Down-regulation of collagen and connective tissue growth factor expression with hepatocyte growth factor in lung fibroblasts from white scleroderma patients via two signaling pathways
    Galina S Bogatkevich
    Medical University of South Carolina, Charleston, SC 29425, USA
    Arthritis Rheum 56:3468-77. 2007
  7. ncbi request reprint Impairment of the antifibrotic effect of hepatocyte growth factor in lung fibroblasts from African Americans: possible role in systemic sclerosis
    Galina S Bogatkevich
    Medical University of South Carolina, Charleston 29425, USA
    Arthritis Rheum 56:2432-42. 2007
  8. ncbi request reprint Distinct PKC isoforms mediate cell survival and DNA synthesis in thrombin-induced myofibroblasts
    Galina S Bogatkevich
    Division of Rheumatology and Immunology, Dept of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Physiol Lung Cell Mol Physiol 288:L190-201. 2005
  9. pmc M10, a caspase cleavage product of the hepatocyte growth factor receptor, interacts with Smad2 and demonstrates antifibrotic properties in vitro and in vivo
    Ilia Atanelishvili
    Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA
    Transl Res 170:99-111. 2016
  10. doi request reprint Recent advances in understanding the pathogenesis of scleroderma-interstitial lung disease
    Tanjina Akter
    Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, 114 Doughty Street, Charleston, SC, 29425, USA
    Curr Rheumatol Rep 16:411. 2014

Collaborators

Detail Information

Publications11

  1. pmc The PPARγ Agonist Rosiglitazone Is Antifibrotic for Scleroderma Lung Fibroblasts: Mechanisms of Action and Differential Racial Effects
    Galina S Bogatkevich
    Division of Rheumatology and Immunology, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 912, Charleston, SC 29425 6370, USA
    Pulm Med 2012:545172. 2012
    ..Differential therapeutic effects might be anticipated especially relative to racial differences and the functional expression of the c-Met receptor...
  2. ncbi request reprint Contractile activity and smooth muscle alpha-actin organization in thrombin-induced human lung myofibroblasts
    Galina S Bogatkevich
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Physiol Lung Cell Mol Physiol 285:L334-43. 2003
    ....
  3. pmc Antiinflammatory and antifibrotic effects of the oral direct thrombin inhibitor dabigatran etexilate in a murine model of interstitial lung disease
    Galina S Bogatkevich
    Medical University of South Carolina, Charleston, SC, USA
    Arthritis Rheum 63:1416-25. 2011
    ..This study was undertaken to test whether dabigatran etexilate attenuates lung injury in a murine model of interstitial lung disease...
  4. pmc Dabigatran, a direct thrombin inhibitor, demonstrates antifibrotic effects on lung fibroblasts
    Galina S Bogatkevich
    Medical University of South Carolina, Charleston, SC 29425, USA
    Arthritis Rheum 60:3455-64. 2009
    ..We undertook this study to investigate whether a selective direct thrombin inhibitor, dabigatran, interferes with signal transduction in human lung fibroblasts induced by thrombin and mediated via PAR-1...
  5. pmc Proteomic analysis of CTGF-activated lung fibroblasts: identification of IQGAP1 as a key player in lung fibroblast migration
    Galina S Bogatkevich
    Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Physiol Lung Cell Mol Physiol 295:L603-11. 2008
    ..These findings further implicate the importance of CTGF in lung tissue repair and fibrosis and propose that CTGF-induced migration of lung fibroblasts to the damaged tissue is mediated via IQGAP1 and MAPK signaling pathways...
  6. ncbi request reprint Down-regulation of collagen and connective tissue growth factor expression with hepatocyte growth factor in lung fibroblasts from white scleroderma patients via two signaling pathways
    Galina S Bogatkevich
    Medical University of South Carolina, Charleston, SC 29425, USA
    Arthritis Rheum 56:3468-77. 2007
    ..To study the mechanisms by which hepatocyte growth factor (HGF) down-regulates collagen and connective tissue growth factor (CTGF) in scleroderma (systemic sclerosis [SSc]) lung fibroblasts...
  7. ncbi request reprint Impairment of the antifibrotic effect of hepatocyte growth factor in lung fibroblasts from African Americans: possible role in systemic sclerosis
    Galina S Bogatkevich
    Medical University of South Carolina, Charleston 29425, USA
    Arthritis Rheum 56:2432-42. 2007
    ..To compare the composition of cytokines in African American and Caucasian patients with systemic sclerosis (SSc; scleroderma) and in healthy individuals, particularly the expression and function of hepatocyte growth factor (HGF)...
  8. ncbi request reprint Distinct PKC isoforms mediate cell survival and DNA synthesis in thrombin-induced myofibroblasts
    Galina S Bogatkevich
    Division of Rheumatology and Immunology, Dept of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Physiol Lung Cell Mol Physiol 288:L190-201. 2005
    ..These data demonstrate that two distinct PKC isoforms mediate thrombin-induced resistance to apoptosis and proliferation and suggest that p21Cip1/WAF1 promotes both phenomena...
  9. pmc M10, a caspase cleavage product of the hepatocyte growth factor receptor, interacts with Smad2 and demonstrates antifibrotic properties in vitro and in vivo
    Ilia Atanelishvili
    Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA
    Transl Res 170:99-111. 2016
    ....
  10. doi request reprint Recent advances in understanding the pathogenesis of scleroderma-interstitial lung disease
    Tanjina Akter
    Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, 114 Doughty Street, Charleston, SC, 29425, USA
    Curr Rheumatol Rep 16:411. 2014
    ..Here we present our view on recent advances regarding the pathogenesis of SSc-ILD...
  11. pmc Coagulation and autoimmunity in scleroderma interstitial lung disease
    Anna Ludwicka-Bradley
    Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Semin Arthritis Rheum 41:212-22. 2011
    ..In this review we present our current understanding of the role played by coagulation and particularly by thrombin in autoimmune-mediated tissue injury and fibrosis, mainly as it relates to SSc-ILD...