Erhard Bieberich

Summary

Affiliation: Medical College of Georgia
Country: USA

Publications

  1. ncbi Probing quantum coherence in a biological system by means of DNA amplification
    E Bieberich
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street CB 2803, Augusta, GA 30912, USA
    Biosystems 57:109-24. 2000
  2. ncbi Integration of glycosphingolipid metabolism and cell-fate decisions in cancer and stem cells: review and hypothesis
    Erhard Bieberich
    Institute of Molecular Medicine and Genetics, School of Medicine, Medical College of Georgia, 1120 15th Street Room CB 2803, Augusta, GA 30912, USA
    Glycoconj J 21:315-27. 2004
  3. ncbi Replacement of insulin by LongR3-IGF-1 allows for the differentiation of ES cells into neuroprogenitors and insulin-secreting cells
    Erhard Bieberich
    Institute of Molecular Medicine and Genetics, School of Medicine, Medical College of Georgia, 1120 15th Street Room CB 2803, Augusta, GA 30912, USA
    Anal Biochem 346:185-7. 2005
  4. pmc Regulation of cell death in mitotic neural progenitor cells by asymmetric distribution of prostate apoptosis response 4 (PAR-4) and simultaneous elevation of endogenous ceramide
    Erhard Bieberich
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street, Room CB 2803, Augusta, GA 30912, USA
    J Cell Biol 162:469-79. 2003
  5. pmc Selective apoptosis of pluripotent mouse and human stem cells by novel ceramide analogues prevents teratoma formation and enriches for neural precursors in ES cell-derived neural transplants
    Erhard Bieberich
    Institute of Molecular Medicine and Genetics, School of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    J Cell Biol 167:723-34. 2004
  6. ncbi Synthesis and characterization of novel ceramide analogs for induction of apoptosis in human cancer cells
    Erhard Bieberich
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street, Room CB 2803, Augusta, GA 30912, USA
    Cancer Lett 181:55-64. 2002
  7. ncbi Regulation of ganglioside biosynthesis by enzyme complex formation of glycosyltransferases
    Erhard Bieberich
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    Biochemistry 41:11479-87. 2002
  8. ncbi Regulation of apoptosis during neuronal differentiation by ceramide and b-series complex gangliosides
    E Bieberich
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Biol Chem 276:44396-404. 2001
  9. pmc Regulation of neural progenitor cell motility by ceramide and potential implications for mouse brain development
    Guanghu Wang
    Program in Developmental Neurobiology, Institute of Molecular Medicine and Genetics, School of Medicine, Medical College of Georgia, Augusta, Georgia, USA
    J Neurochem 106:718-33. 2008
  10. ncbi Direct binding to ceramide activates protein kinase Czeta before the formation of a pro-apoptotic complex with PAR-4 in differentiating stem cells
    Guanghu Wang
    Institute of Molecular Medicine and Genetics, School of Medicine, Medical College of Georgia, Augusta 30912, USA
    J Biol Chem 280:26415-24. 2005

Research Grants

  1. Regulation of neuronal stem cell death
    Erhard Bieberich; Fiscal Year: 2003
  2. Regulation of neuronal stem cell death
    Erhard Bieberich; Fiscal Year: 2004
  3. Regulation of neuronal stem cell death
    Erhard Bieberich; Fiscal Year: 2005
  4. Regulation of neuronal stem cell death
    Erhard Bieberich; Fiscal Year: 2006
  5. Ceramide-induced cell death in neurodegeneration
    Erhard Bieberich; Fiscal Year: 2010

Collaborators

Detail Information

Publications38

  1. ncbi Probing quantum coherence in a biological system by means of DNA amplification
    E Bieberich
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street CB 2803, Augusta, GA 30912, USA
    Biosystems 57:109-24. 2000
    ..g. during folding or association of macromolecules. The experimental model described in this paper provides a low-cost tool for simulating and probing quantum coherence in a biological system...
  2. ncbi Integration of glycosphingolipid metabolism and cell-fate decisions in cancer and stem cells: review and hypothesis
    Erhard Bieberich
    Institute of Molecular Medicine and Genetics, School of Medicine, Medical College of Georgia, 1120 15th Street Room CB 2803, Augusta, GA 30912, USA
    Glycoconj J 21:315-27. 2004
    ....
  3. ncbi Replacement of insulin by LongR3-IGF-1 allows for the differentiation of ES cells into neuroprogenitors and insulin-secreting cells
    Erhard Bieberich
    Institute of Molecular Medicine and Genetics, School of Medicine, Medical College of Georgia, 1120 15th Street Room CB 2803, Augusta, GA 30912, USA
    Anal Biochem 346:185-7. 2005
  4. pmc Regulation of cell death in mitotic neural progenitor cells by asymmetric distribution of prostate apoptosis response 4 (PAR-4) and simultaneous elevation of endogenous ceramide
    Erhard Bieberich
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street, Room CB 2803, Augusta, GA 30912, USA
    J Cell Biol 162:469-79. 2003
    ..Asymmetric distribution of PAR-4 and simultaneous elevation of endogenous ceramide provides a possible mechanism underlying asymmetric differentiation and apoptosis of neuronal stem cells in the developing brain...
  5. pmc Selective apoptosis of pluripotent mouse and human stem cells by novel ceramide analogues prevents teratoma formation and enriches for neural precursors in ES cell-derived neural transplants
    Erhard Bieberich
    Institute of Molecular Medicine and Genetics, School of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    J Cell Biol 167:723-34. 2004
    ..Our results show for the first time that ceramide-induced apoptosis eliminates residual, pluripotent EBCs, prevents teratoma formation, and enriches the EBCs for cells that undergo neural differentiation after transplantation...
  6. ncbi Synthesis and characterization of novel ceramide analogs for induction of apoptosis in human cancer cells
    Erhard Bieberich
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street, Room CB 2803, Augusta, GA 30912, USA
    Cancer Lett 181:55-64. 2002
    ..The target specificity of novel ceramide analogs for tumor cells, their water solubility, and fast pro-apoptotic mechanism indicates a high therapeutic potential for cancer treatment...
  7. ncbi Regulation of ganglioside biosynthesis by enzyme complex formation of glycosyltransferases
    Erhard Bieberich
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    Biochemistry 41:11479-87. 2002
    ..Taken together, our results support the concept that ganglioside biosynthesis is tightly regulated by the formation of glycosyltransferase complexes in the ER and/or Golgi...
  8. ncbi Regulation of apoptosis during neuronal differentiation by ceramide and b-series complex gangliosides
    E Bieberich
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Biol Chem 276:44396-404. 2001
    ....
  9. pmc Regulation of neural progenitor cell motility by ceramide and potential implications for mouse brain development
    Guanghu Wang
    Program in Developmental Neurobiology, Institute of Molecular Medicine and Genetics, School of Medicine, Medical College of Georgia, Augusta, Georgia, USA
    J Neurochem 106:718-33. 2008
    ..In summary, our study provides novel evidence that ceramide is critical for NP motility and polarity in vitro and in vivo...
  10. ncbi Direct binding to ceramide activates protein kinase Czeta before the formation of a pro-apoptotic complex with PAR-4 in differentiating stem cells
    Guanghu Wang
    Institute of Molecular Medicine and Genetics, School of Medicine, Medical College of Georgia, Augusta 30912, USA
    J Biol Chem 280:26415-24. 2005
    ..Taken together, our results show that direct physical association with ceramide and PAR-4 regulates the activity of PKCzeta. They also indicate that this interaction regulates the activity of glycogen synthase kinase-3beta and NF-kappaB...
  11. pmc Characterization of an apical ceramide-enriched compartment regulating ciliogenesis
    Qian He
    Program in Developmental Neurobiology, Institute of Molecular Medicine and Genetics, School of Medicine, Georgia Health Sciences University, Augusta, GA 30912, USA
    Mol Biol Cell 23:3156-66. 2012
    ..Taken together, our results suggest that the ACEC is a novel compartment in which SM-derived ceramide induces formation of a ciliogenic lipid-protein complex that sustains primary cilia by preventing deacetylation of microtubules...
  12. ncbi Lipids isolated from bone induce the migration of human breast cancer cells
    Jeane Silva
    Institute of Molecular Medicine and Genetics, School of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    J Lipid Res 47:724-33. 2006
    ..Our results suggest a novel mechanism by which DC-induced increase of uPA and binding to the uPA receptor of the same breast cancer cell self-propel its migration and metastasis to the bone...
  13. pmc The carboxyl-terminal domain of atypical protein kinase Czeta binds to ceramide and regulates junction formation in epithelial cells
    Guanghu Wang
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    J Biol Chem 284:14469-75. 2009
    ..Therefore, ceramide interaction with the C20zeta binding domain is a potential mechanism by which ceramide and aPKC regulate the formation of junctional complexes in epithelial cells...
  14. ncbi Ceramide regulates atypical PKCzeta/lambda-mediated cell polarity in primitive ectoderm cells. A novel function of sphingolipids in morphogenesis
    Kannan Krishnamurthy
    Institute of Molecular Medicine and Genetics, School of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Biol Chem 282:3379-90. 2007
    ..Our data suggest a novel mechanism by which a ceramide-induced, apicolateral polarity complex with PKCzeta/lambda regulates primitive ectoderm cell polarity and morphogenesis...
  15. pmc Functional pre- mRNA trans-splicing of coactivator CoAA and corepressor RBM4 during stem/progenitor cell differentiation
    Yang S Brooks
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Biol Chem 284:18033-46. 2009
    ..The alternative splicing imbalance of CoAA and RBM4, because of loss of their common enhancer in cancer, may deregulate stem/progenitor cell differentiation...
  16. pmc Deoxycholate promotes survival of breast cancer cells by reducing the level of pro-apoptotic ceramide
    Kannan Krishnamurthy
    Institute of Molecular Medicine and Genetics, School of Medicine, Medical College of Georgia, 15th Street, Augusta, GA 30912, USA
    Breast Cancer Res 10:R106. 2008
    ..Here we provide evidence of a novel mechanism by which DC reduces apoptosis that is induced by the sphingolipid ceramide in breast cancer cells...
  17. pmc It's a lipid's world: bioactive lipid metabolism and signaling in neural stem cell differentiation
    Erhard Bieberich
    Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, 1120 15th Street Room CA4012, Augusta, GA 30912, USA
    Neurochem Res 37:1208-29. 2012
    ..The biological function of these lipids as regulators of NSC differentiation will be reviewed and their application in stem cell therapy discussed...
  18. pmc There is more to a lipid than just being a fat: sphingolipid-guided differentiation of oligodendroglial lineage from embryonic stem cells
    Erhard Bieberich
    Program in Developmental Neurobiology, Institute of Molecular Medicine and Genetics, School of Medicine, Medical College of Georgia Georgia Health Sciences University, 1120 15th Street Room CA4012, Augusta, GA 30912, USA
    Neurochem Res 36:1601-11. 2011
    ..In addition, we show that this combination promoted differentiation of ES cell-derived NPCs toward oligodendroglial lineage in vivo after transplantation into mouse brain...
  19. doi Long-chain ceramide is elevated in presenilin 1 (PS1M146V) mouse brain and induces apoptosis in PS1 astrocytes
    Guanghu Wang
    Program in Developmental Neurobiology, Institute of Molecular Medicine and Genetics, School of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    Glia 56:449-56. 2008
    ..Our results suggest that astroglial death due to ceramide/PAR-4-induced apoptosis may critically contribute to the etiology of AD...
  20. doi Breast cancer cell-derived fibroblast growth factor 2 and vascular endothelial growth factor are chemoattractants for bone marrow stromal stem cells
    Edmond Ritter
    Department of Surgery, School of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
    Ann Surg 247:310-4. 2008
    ....
  21. pmc Astrocytes secrete exosomes enriched with proapoptotic ceramide and prostate apoptosis response 4 (PAR-4): potential mechanism of apoptosis induction in Alzheimer disease (AD)
    Guanghu Wang
    Program in Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Georgia Health Sciences University, Augusta, Georgia 30912, USA
    J Biol Chem 287:21384-95. 2012
    ..Taken together, we report a novel mechanism of apoptosis induction by PAR-4/ceramide-enriched exosomes, which may critically contribute to Alzheimer disease...
  22. ncbi Osteoblast-derived oxysterol is a migration-inducing factor for human breast cancer cells
    Jeane Silva
    Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, Augusta, Georgia 30909, USA
    J Biol Chem 278:25376-85. 2003
    ..Osteoblast-derived OS may, thus, be a yet unrecognized lipid mediator for bone metastasis of breast cancer and a new target for anti-metastasis chemotherapy with statins...
  23. doi Smart drugs for smarter stem cells: making SENSe (sphingolipid-enhanced neural stem cells) of ceramide
    Erhard Bieberich
    Program in Developmental Neurobiology, Institute of Molecular Medicine and Genetics, School of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    Neurosignals 16:124-39. 2008
    ..We will also discuss results from ongoing studies in our laboratory on the use of sphingolipids in stem cell therapy...
  24. pmc Regulation of primary cilia formation by ceramide
    Guanghu Wang
    Program in Developmental Neurobiology, Institute of Molecular Medicine and Genetics, School of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    J Lipid Res 50:2103-10. 2009
    ..Consistently, inhibition of aPKC with a pseudosubstrate inhibitor prevented restoration of ciliogenesis by C2 ceramide or S18. Our data show for the first time that ceramide is required for primary cilium formation...
  25. ncbi Transcriptional regulation of the human UDP-galactose:ceramide galactosyltransferase (hCGT) gene expression: functional role of GC-box and CRE
    Tewin Tencomnao
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912 2697, USA
    Glycoconj J 20:339-51. 2004
    ..Thus, our data suggest that the GC-box and CRE function cooperatively, and that the CRE regulates the cell-specific expression of the hCGT gene...
  26. pmc Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide
    Qian He
    Program in Developmental Neurobiology, Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912
    Mol Biol Cell 25:1715-29. 2014
    ..This is the first report on the critical role of ceramide generated by nSMase2 in stem cell ciliogenesis and differentiation. ..
  27. pmc Ceramide and sphingosine-1-phosphate signaling in embryonic stem cell differentiation
    Erhard Bieberich
    Program in Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA, USA
    Methods Mol Biol 874:177-92. 2012
    ..We show here simple methods to analyze sphingolipids in differentiating ES cells and to use ceramide and S1P analogs for the guided differentiation of mouse ES cells toward neuronal and glial lineage...
  28. ncbi Development and characterization of a novel anti-ceramide antibody
    Kannan Krishnamurthy
    School of Medicine, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    J Lipid Res 48:968-75. 2007
    ..These results indicate that the rabbit IgG is a suitable antibody to determine the localization of ceramide and its interaction with proteins by immunocytochemistry...
  29. ncbi Recurrent fractal neural networks: a strategy for the exchange of local and global information processing in the brain
    Erhard Bieberich
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street Room CB 2803, Augusta, GA 30912, USA
    Biosystems 66:145-64. 2002
    ....
  30. ncbi Regulation of glycosyltransferases in ganglioside biosynthesis by phosphorylation and dephosphorylation
    R K Yu
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA
    Mol Cell Endocrinol 177:19-24. 2001
    ..Thus, modulation of glycosyltransferases by phosphorylation and dephosphorylation should represent an important regulatory mechanism for ganglioside biosynthesis...
  31. pmc Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease
    Michael B Dinkins
    Institute of Molecular Medicine and Genetics, Georgia Regents University, Augusta, GA, USA
    Neurobiol Aging 35:1792-800. 2014
    ..Our results suggest that GW4869 reduces amyloid plaque formation in vivo by preventing exosome secretion and identifies nSMase2 as a potential drug target in AD by interfering with exosome secretion. ..
  32. pmc Regulation of embryonic stem cell pluripotency by heat shock protein 90
    ERIC BRADLEY
    Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, Augusta, Georgia 30912, USA
    Stem Cells 30:1624-33. 2012
    ..These findings support a new role for Hsp90 in maintaining ESC pluripotency by sustaining the level of multiple pluripotency factors, particularly Oct4 and Nanog...
  33. ncbi Neuronal differentiation and synapse formation of PC12 and embryonic stem cells on interdigitated microelectrode arrays: contact structures for neuron-to-electrode signal transmission (NEST)
    Erhard Bieberich
    Center for Bioelectronics, Biosensors and Biochips C3B, Virginia Commonwealth University, P O Box 843038, 601 West Main Street, Richmond, VA 23284 3038, USA
    Biosens Bioelectron 19:923-31. 2004
    ....
  34. ncbi Regulation of ganglioside biosynthesis in the nervous system
    Robert K Yu
    Institute of Molecular Medicine and Genetics, School of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    J Lipid Res 45:783-93. 2004
    ..We also review the results of analyses of the 5' regulatory sequences of several glycosyltransferases in ganglioside biosynthesis and provide insights into how their synthesis can be regulated at the level of transcription...
  35. ncbi A novel isoform of prostate apoptosis response 4 (PAR-4) that co-distributes with F-actin and prevents apoptosis in neural stem cells
    G Wang
    Institute of Molecular Medicine and Genetics, School of Medicine, Medical College of Georgia, 1120 15th Street Room CB 2803, Augusta, GA 30912, USA
    Apoptosis 11:315-25. 2006
    ..PAR-4/p33 forms a complex with PAR-4/p38, which inhibits its nuclear translocation and the induction of apoptosis. PAR-4/p33 is suggested to be a dominant negative isoform of PAR-4/p38 and may regulate PAR-4-dependent apoptosis...
  36. pmc Phytoceramide in vertebrate tissues: one step chromatography separation for molecular characterization of ceramide species
    Somsankar Dasgupta
    Program in Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Georgia Regents University, Augusta, Georgia, United States of America
    PLoS ONE 8:e80841. 2013
    ..While its function is still elusive, this is the first report of phytoceramide characterization in glial cells and vertebrate brain, heart, and liver. ..
  37. ncbi Improving neuron-to-electrode surface attachment via alkanethiol self-assembly: an alternating current impedance study
    Gymama E Slaughter
    Center for Bioelectronics, Biosensors and Biochips, School of Engineering, Virginia Commonwealth University, P O Box 843038, 601 West Main Street, Richmond, Virginia 23284 3038, USA
    Langmuir 20:7189-200. 2004
    ..Laminin performed best when compared to collagen and fibronectin. Covalent immobilization of the adhesion-promoting proteins results in enhanced NESA by tightly anchoring cells to the electrode...
  38. ncbi Metabolic studies of glycosphingolipid accumulation in mucopolysaccharidosis IIID
    S S Liour
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    Mol Genet Metab 72:239-47. 2001
    ..In addition, the consistency of observations in the cell culture and caprine models supports the cell culture system as a means of evaluating GSL metabolic perturbations...

Research Grants6

  1. Regulation of neuronal stem cell death
    Erhard Bieberich; Fiscal Year: 2003
    ..In conclusion, this study will identify mechanisms for regulation of apoptosis by ceramide that are critical for normal brain development and/or the etiology of subsequent, pathological disorders in adulthood. ..
  2. Regulation of neuronal stem cell death
    Erhard Bieberich; Fiscal Year: 2004
    ..In conclusion, this study will identify mechanisms for regulation of apoptosis by ceramide that are critical for normal brain development and/or the etiology of subsequent, pathological disorders in adulthood. ..
  3. Regulation of neuronal stem cell death
    Erhard Bieberich; Fiscal Year: 2005
    ..In conclusion, this study will identify mechanisms for regulation of apoptosis by ceramide that are critical for normal brain development and/or the etiology of subsequent, pathological disorders in adulthood. ..
  4. Regulation of neuronal stem cell death
    Erhard Bieberich; Fiscal Year: 2006
    ..In conclusion, this study will identify mechanisms for regulation of apoptosis by ceramide that are critical for normal brain development and/or the etiology of subsequent, pathological disorders in adulthood. ..
  5. Ceramide-induced cell death in neurodegeneration
    Erhard Bieberich; Fiscal Year: 2010
    ..Our data strongly suggest that blocking the accumulation of ceramide will be instrumental in preventing loss of neurons in AD. ..