Lewis T, Kundinger S, Link B, Insinna C, Besharse J. Kif17 phosphorylation regulates photoreceptor outer segment turnover. BMC Cell Biol. 2018;19:25 pubmed publisher
Besharse J, McMahon D. The Retina and Other Light-sensitive Ocular Clocks. J Biol Rhythms. 2016;31:223-43 pubmed publisher
..Circadian clocks in the eye are critical for optimum visual function where they play a role fine tuning visual sensitivity, and their disruption can affect diseases such as glaucoma or retinal degeneration syndromes. ..
Lewis T, Kundinger S, Pavlovich A, Bostrom J, Link B, Besharse J. Cos2/Kif7 and Osm-3/Kif17 regulate onset of outer segment development in zebrafish photoreceptors through distinct mechanisms. Dev Biol. 2017;425:176-190 pubmed publisher
..In conclusion, we show that both osm-3/kif17 and cos2/kif7 have comparable outer segment developmental delays, although through independent mechanisms. ..
Lewis T, Zareba M, Link B, Besharse J. Cone myoid elongation involves unidirectional microtubule movement mediated by dynein-1. Mol Biol Cell. 2018;29:180-190 pubmed publisher
..We propose a novel model by which stationary complexes of cytoplasmic dynein-1 are responsible for the shuttling of microtubules between the ellipsoid and myoid is the underlying force for the morphological change of myoid elongation. ..