Phillip D Bell

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. pmc TRPP2 and TRPV4 form an EGF-activated calcium permeable channel at the apical membrane of renal collecting duct cells
    Zhi Ren Zhang
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America
    PLoS ONE 8:e73424. 2013
  2. ncbi request reprint Deletion of airway cilia results in noninflammatory bronchiectasis and hyperreactive airways
    Sandra K Gilley
    70 President St, DDB520, MUSC, Charleston, SC 29425
    Am J Physiol Lung Cell Mol Physiol 306:L162-9. 2014
  3. pmc An inducible CiliaGFP mouse model for in vivo visualization and analysis of cilia in live tissue
    Amber K O'Connor
    1Department of Cell, Development, and Integrative Biology, University of Alabama at Birmingham Medical School, Birmingham, AL 35294, USA
    Cilia 2:8. 2013
  4. pmc Collecting duct cells that lack normal cilia have mislocalized vasopressin-2 receptors
    Takamitsu Saigusa
    Dept of Medicine, Division of Nephrology, Medical University of South Carolina, 173 Ashley Ave, Charleston, SC 29425, USA
    Am J Physiol Renal Physiol 302:F801-8. 2012
  5. pmc Loss of primary cilia upregulates renal hypertrophic signaling and promotes cystogenesis
    P Darwin Bell
    Ralph H Johnson Veterans Administration Medical Center, Charleston, South Carolina 29425, USA
    J Am Soc Nephrol 22:839-48. 2011
  6. pmc ATP as a mediator of macula densa cell signalling
    P Darwin Bell
    Department of Medicine, Division of Nephrology, Children s Research Institute, Medical University of South Carolina, Charleston, SC, USA
    Purinergic Signal 5:461-71. 2009
  7. pmc Telomerase immortalization of principal cells from mouse collecting duct
    Stacy L Steele
    Ralph H Johnson Veterans Affairs Medical Center, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29403, USA
    Am J Physiol Renal Physiol 299:F1507-14. 2010
  8. doi request reprint Tubuloglomerular feedback mechanisms in nephron segments beyond the macula densa
    Peter Komlosi
    Division of Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
    Curr Opin Nephrol Hypertens 18:57-62. 2009
  9. pmc N-methyl-D-aspartate receptor subunit NR3a expression and function in principal cells of the collecting duct
    Adrian Sproul
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29403, USA
    Am J Physiol Renal Physiol 301:F44-54. 2011
  10. pmc Cilia movement regulates expression of the Raf-1 kinase inhibitor protein
    Kelli M Sas
    Ralph H Johnson Veterans Affairs Medical Center, Medical University of South Carolina, Charleston, 29425, USA
    Am J Physiol Renal Physiol 300:F1163-70. 2011

Collaborators

  • Peter Komlosi
  • Robert A Fenton
  • John Bissler
  • Monika Gooz
  • Stacy L Steele
  • Courtney J Haycraft
  • Kelli M Sas
  • Sandra K Gilley
  • Bradley K Yoder
  • Amber K O'Connor
  • Zhi Ren Zhang
  • Stacy Steele
  • Takamitsu Saigusa
  • Adrian Sproul
  • Robert J Kolb
  • Joseph H Sisson
  • Antine E Stenbit
  • Patrick Flume
  • Marlene A Bunni
  • Raymond C Pasek
  • Jacqueline A Pavlik
  • Caroline Miller
  • May Amria
  • Kimberly P Estell
  • Lisa M Schwiebert
  • Grant A Turner
  • Grzegorz Owsianik
  • Mandy J Croyle
  • Pal Gooz
  • Nicolas F Berbari
  • Binlin Song
  • Peter Hohenstein
  • Aleksander Baldys
  • Jia Ning Zhang
  • Robert A Kesterson
  • Bernd Nilius
  • Wen Feng Chu
  • Chang Jiang Yu
  • Shuai Jiang
  • Erik B Malarkey
  • Jennifer Guare
  • Ryan Reichert
  • Brian J Siroky
  • Jeff M Sands
  • Shanping Yu
  • John M Arthur
  • Janet D Klein
  • Elizabeth Favre
  • Tiffany L Thai
  • Michael G Janech
  • Kent T Keyser
  • Yongren Wu
  • Hai Yao
  • Lisa Guay-Woodford

Detail Information

Publications10

  1. pmc TRPP2 and TRPV4 form an EGF-activated calcium permeable channel at the apical membrane of renal collecting duct cells
    Zhi Ren Zhang
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America
    PLoS ONE 8:e73424. 2013
    ..However, the molecular identity and the regulators of the transporter/channel, which is responsible for apical calcium entry and what factors regulate the calcium conduction remain unclear...
  2. ncbi request reprint Deletion of airway cilia results in noninflammatory bronchiectasis and hyperreactive airways
    Sandra K Gilley
    70 President St, DDB520, MUSC, Charleston, SC 29425
    Am J Physiol Lung Cell Mol Physiol 306:L162-9. 2014
    ..This monocilium is a prerequisite for these progenitor cells to transition into respiratory epithelial cells. In conclusion, motile cilia may play an important role in controlling airway structure and function. ..
  3. pmc An inducible CiliaGFP mouse model for in vivo visualization and analysis of cilia in live tissue
    Amber K O'Connor
    1Department of Cell, Development, and Integrative Biology, University of Alabama at Birmingham Medical School, Birmingham, AL 35294, USA
    Cilia 2:8. 2013
    ..Much of what we know about the formation and maintenance of cilia comes from model systems like C. elegans and Chalmydomonas. Studies of mammalian cilia in live tissues have been hampered by difficulty visualizing them...
  4. pmc Collecting duct cells that lack normal cilia have mislocalized vasopressin-2 receptors
    Takamitsu Saigusa
    Dept of Medicine, Division of Nephrology, Medical University of South Carolina, 173 Ashley Ave, Charleston, SC 29425, USA
    Am J Physiol Renal Physiol 302:F801-8. 2012
    ..Whether such apical localization contributes to enhanced fluid retention and hypertension in PKD remains to be determined...
  5. pmc Loss of primary cilia upregulates renal hypertrophic signaling and promotes cystogenesis
    P Darwin Bell
    Ralph H Johnson Veterans Administration Medical Center, Charleston, South Carolina 29425, USA
    J Am Soc Nephrol 22:839-48. 2011
    ..These data suggest that events initiating hypertrophic signaling, such as structural or functional loss of renal mass, may accelerate progression of adult polycystic kidney disease toward end-stage renal disease...
  6. pmc ATP as a mediator of macula densa cell signalling
    P Darwin Bell
    Department of Medicine, Division of Nephrology, Children s Research Institute, Medical University of South Carolina, Charleston, SC, USA
    Purinergic Signal 5:461-71. 2009
    ..However, the critical step in signalling would appear to be the regulated release of ATP across the basolateral membrane of macula densa cells...
  7. pmc Telomerase immortalization of principal cells from mouse collecting duct
    Stacy L Steele
    Ralph H Johnson Veterans Affairs Medical Center, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29403, USA
    Am J Physiol Renal Physiol 299:F1507-14. 2010
    ..This technique should be valuable in generating cell lines from genetically engineered mouse models...
  8. doi request reprint Tubuloglomerular feedback mechanisms in nephron segments beyond the macula densa
    Peter Komlosi
    Division of Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
    Curr Opin Nephrol Hypertens 18:57-62. 2009
    ..To summarize recent evidence regarding the role of distal nephron segments other than the macula densa in sensing the tubular environment and transmitting this signal to the adjacent vasculature...
  9. pmc N-methyl-D-aspartate receptor subunit NR3a expression and function in principal cells of the collecting duct
    Adrian Sproul
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29403, USA
    Am J Physiol Renal Physiol 301:F44-54. 2011
    ....
  10. pmc Cilia movement regulates expression of the Raf-1 kinase inhibitor protein
    Kelli M Sas
    Ralph H Johnson Veterans Affairs Medical Center, Medical University of South Carolina, Charleston, 29425, USA
    Am J Physiol Renal Physiol 300:F1163-70. 2011
    ..In terms of polycystic kidney disease, loss of cilia and therefore sensitivity to flow may lead to reduced RKIP levels, activation of the MAPK pathway, and contribute to the formation of cysts...

Research Grants31

  1. CELLULAR MECHANISMS FOR TUBULOGLOMERULAR FEEDBACK SYSTEM
    Phillip Bell; Fiscal Year: 2000
    ..These studies should provide important new insights into the generation and transmission of tubuloglomerular feedback signals from macula densa cells to arteriolar contractile elements. ..
  2. CELLULAR MECHANISMS FOR TUBULOGLOMERULAR FEEDBACK SYSTEM
    Phillip Bell; Fiscal Year: 2001
    ..These studies will provide important new insights into this macula densa cell-to-cell TGF signaling pathway which serves a vital role in the regulation of renal hemodynamics. ..
  3. SODIUM-CALCUIM EXCHANGE IN THE RENAL MICROCIRCULATION
    Phillip Bell; Fiscal Year: 2001
    ....
  4. CELLULAR MECHANISMS FOR TUBULOGLOMERULAR FEEDBACK SYSTEM
    Phillip Bell; Fiscal Year: 2002
    ..These studies will provide important new insights into this macula densa cell-to-cell TGF signaling pathway which serves a vital role in the regulation of renal hemodynamics. ..
  5. SODIUM-CALCUIM EXCHANGE IN THE RENAL MICROCIRCULATION
    Phillip Bell; Fiscal Year: 2002
    ....
  6. CELLULAR MECHANISMS FOR TUBULOGLOMERULAR FEEDBACK SYSTEM
    Phillip Bell; Fiscal Year: 2003
    ..These studies will provide important new insights into this macula densa cell-to-cell TGF signaling pathway which serves a vital role in the regulation of renal hemodynamics. ..
  7. SODIUM-CALCUIM EXCHANGE IN THE RENAL MICROCIRCULATION
    Phillip Bell; Fiscal Year: 2003
    ....
  8. CELLULAR MECHANISMS FOR TUBULOGLOMERULAR FEEDBACK SYSTEM
    Phillip Bell; Fiscal Year: 2004
    ..These studies will provide important new insights into this macula densa cell-to-cell TGF signaling pathway which serves a vital role in the regulation of renal hemodynamics. ..
  9. Cellular Mechanisms for Tubuloglomerular Feedback
    Phillip Bell; Fiscal Year: 2006
    ..Overall these studies should provide important new information regarding the role of ATP in macula densa signaling, activation of the tubuloglomerular feedback mechanism, and control of glomerular hemodynamics. ..
  10. Cellular Mechanisms for Tubuloglomerular Feedback
    Phillip Bell; Fiscal Year: 2007
    ..Overall these studies should provide important new information regarding the role of ATP in macula densa signaling, activation of the tubuloglomerular feedback mechanism, and control of glomerular hemodynamics. ..
  11. Cellular Mechanisms for Tubuloglomerular Feedback
    Phillip Bell; Fiscal Year: 2006
    ..Overall these studies should provide important new information regarding the role of ATP in macula densa signaling, activation of the tubuloglomerular feedback mechanism, and control of glomerular hemodynamics. ..
  12. CALCIUM ENTRY REGULATED BY CILIA IN POLYCYSTIC DISEASE
    Phillip Bell; Fiscal Year: 2006
    ..The third aim is to define the role of cilia in the spatial organization of TRP channels at the apical membrane. The role of cilia cytoskeletal interactions in the regulating TRP location and activity will also be addressed. ..
  13. SODIUM-CALCIUM EXCHANGE IN THE RENAL MICROCIRCULATION
    Phillip Bell; Fiscal Year: 2000
    ....
  14. CELLULAR MECHANISMS--TUBULOGLOMERULAR FEEDBACK SYSTEM
    Phillip Bell; Fiscal Year: 1999
    ..These studies should provide important new insights into the generation and transmission of tubuloglomerular feedback signals from macula densa cells to arteriolar contractile elements. ..
  15. CELLULAR MECHANISM FOR TUBULOGLOMERULAR FEEDBACK SYSTEM
    Phillip Bell; Fiscal Year: 1993
    ....
  16. CELLULAR MECHANISMS FOR TUBULOGLOMERULAR FEEDBACK SYSTEM
    Phillip Bell; Fiscal Year: 1999
    ..These studies should provide important new insights into the generation and transmission of tubuloglomerular feedback signals from macula densa cells to arteriolar contractile elements. ..
  17. CELLULAR MECHANISM FOR TUBULOGLOMERULAR FEEDBACK SYSTEM
    Phillip Bell; Fiscal Year: 1991
    ....
  18. CELLULAR MECHANISM FOR TUBULOGLOMERULAR FEEDBACK SYSTEM
    Phillip Bell; Fiscal Year: 1992
    ....
  19. Cellular Mechanisms for Tubuloglomerular Feedback
    Phillip Bell; Fiscal Year: 2009
    ..Overall these studies should provide important new information regarding the role of ATP in macula densa signaling, activation of the tubuloglomerular feedback mechanism, and control of glomerular hemodynamics. ..