Phillip D Bell
Affiliation: Medical University of South Carolina
- TRPP2 and TRPV4 form an EGF-activated calcium permeable channel at the apical membrane of renal collecting duct cellsZhi Ren Zhang
Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America
PLoS ONE 8:e73424. 2013..However, the molecular identity and the regulators of the transporter/channel, which is responsible for apical calcium entry and what factors regulate the calcium conduction remain unclear...
- Deletion of airway cilia results in noninflammatory bronchiectasis and hyperreactive airwaysSandra K Gilley
70 President St, DDB520, MUSC, Charleston, SC 29425
Am J Physiol Lung Cell Mol Physiol 306:L162-9. 2014..This monocilium is a prerequisite for these progenitor cells to transition into respiratory epithelial cells. In conclusion, motile cilia may play an important role in controlling airway structure and function. ..
- An inducible CiliaGFP mouse model for in vivo visualization and analysis of cilia in live tissueAmber K O'Connor
1Department of Cell, Development, and Integrative Biology, University of Alabama at Birmingham Medical School, Birmingham, AL 35294, USA
Cilia 2:8. 2013..Much of what we know about the formation and maintenance of cilia comes from model systems like C. elegans and Chalmydomonas. Studies of mammalian cilia in live tissues have been hampered by difficulty visualizing them...
- Collecting duct cells that lack normal cilia have mislocalized vasopressin-2 receptorsTakamitsu Saigusa
Dept of Medicine, Division of Nephrology, Medical University of South Carolina, 173 Ashley Ave, Charleston, SC 29425, USA
Am J Physiol Renal Physiol 302:F801-8. 2012..Whether such apical localization contributes to enhanced fluid retention and hypertension in PKD remains to be determined...
- Loss of primary cilia upregulates renal hypertrophic signaling and promotes cystogenesisP Darwin Bell
Ralph H Johnson Veterans Administration Medical Center, Charleston, South Carolina 29425, USA
J Am Soc Nephrol 22:839-48. 2011..These data suggest that events initiating hypertrophic signaling, such as structural or functional loss of renal mass, may accelerate progression of adult polycystic kidney disease toward end-stage renal disease...
- ATP as a mediator of macula densa cell signallingP Darwin Bell
Department of Medicine, Division of Nephrology, Children s Research Institute, Medical University of South Carolina, Charleston, SC, USA
Purinergic Signal 5:461-71. 2009..However, the critical step in signalling would appear to be the regulated release of ATP across the basolateral membrane of macula densa cells...
- Telomerase immortalization of principal cells from mouse collecting ductStacy L Steele
Ralph H Johnson Veterans Affairs Medical Center, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29403, USA
Am J Physiol Renal Physiol 299:F1507-14. 2010..This technique should be valuable in generating cell lines from genetically engineered mouse models...
- Tubuloglomerular feedback mechanisms in nephron segments beyond the macula densaPeter Komlosi
Division of Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
Curr Opin Nephrol Hypertens 18:57-62. 2009..To summarize recent evidence regarding the role of distal nephron segments other than the macula densa in sensing the tubular environment and transmitting this signal to the adjacent vasculature...
- N-methyl-D-aspartate receptor subunit NR3a expression and function in principal cells of the collecting ductAdrian Sproul
Department of Medicine, Medical University of South Carolina, Charleston, SC 29403, USA
Am J Physiol Renal Physiol 301:F44-54. 2011....
- Cilia movement regulates expression of the Raf-1 kinase inhibitor proteinKelli M Sas
Ralph H Johnson Veterans Affairs Medical Center, Medical University of South Carolina, Charleston, 29425, USA
Am J Physiol Renal Physiol 300:F1163-70. 2011..In terms of polycystic kidney disease, loss of cilia and therefore sensitivity to flow may lead to reduced RKIP levels, activation of the MAPK pathway, and contribute to the formation of cysts...
- SODIUM-CALCUIM EXCHANGE IN THE RENAL MICROCIRCULATIONPhillip Bell; Fiscal Year: 2003....
- Cellular Mechanisms for Tubuloglomerular FeedbackPhillip Bell; Fiscal Year: 2009..Overall these studies should provide important new information regarding the role of ATP in macula densa signaling, activation of the tubuloglomerular feedback mechanism, and control of glomerular hemodynamics. ..