Phillip D Bell

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. ncbi Collecting duct cells that lack normal cilia have mislocalized vasopressin-2 receptors
    Takamitsu Saigusa
    Dept of Medicine, Division of Nephrology, Medical University of South Carolina, 173 Ashley Ave, Charleston, SC 29425, USA
    Am J Physiol Renal Physiol 302:F801-8. 2012
  2. ncbi ATP as a mediator of macula densa cell signalling
    P Darwin Bell
    Department of Medicine, Division of Nephrology, Children s Research Institute, Medical University of South Carolina, Charleston, SC, USA
    Purinergic Signal 5:461-71. 2009
  3. ncbi Loss of primary cilia upregulates renal hypertrophic signaling and promotes cystogenesis
    P Darwin Bell
    Ralph H Johnson Veterans Administration Medical Center, Charleston, South Carolina 29425, USA
    J Am Soc Nephrol 22:839-48. 2011
  4. ncbi Telomerase immortalization of principal cells from mouse collecting duct
    Stacy L Steele
    Ralph H Johnson Veterans Affairs Medical Center, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29403, USA
    Am J Physiol Renal Physiol 299:F1507-14. 2010
  5. ncbi Tubuloglomerular feedback mechanisms in nephron segments beyond the macula densa
    Peter Komlosi
    Division of Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
    Curr Opin Nephrol Hypertens 18:57-62. 2009
  6. ncbi N-methyl-D-aspartate receptor subunit NR3a expression and function in principal cells of the collecting duct
    Adrian Sproul
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29403, USA
    Am J Physiol Renal Physiol 301:F44-54. 2011
  7. ncbi Cilia movement regulates expression of the Raf-1 kinase inhibitor protein
    Kelli M Sas
    Ralph H Johnson Veterans Affairs Medical Center, Medical University of South Carolina, Charleston, 29425, USA
    Am J Physiol Renal Physiol 300:F1163-70. 2011

Research Grants

  1. CELLULAR MECHANISMS FOR TUBULOGLOMERULAR FEEDBACK SYSTEM
    Phillip Bell; Fiscal Year: 2000
  2. SODIUM-CALCUIM EXCHANGE IN THE RENAL MICROCIRCULATION
    Phillip Bell; Fiscal Year: 2003
  3. CELLULAR MECHANISMS FOR TUBULOGLOMERULAR FEEDBACK SYSTEM
    Phillip Bell; Fiscal Year: 2004
  4. Cellular Mechanisms for Tubuloglomerular Feedback
    Phillip Bell; Fiscal Year: 2007
  5. CALCIUM ENTRY REGULATED BY CILIA IN POLYCYSTIC DISEASE
    Phillip Bell; Fiscal Year: 2006
  6. CELLULAR MECHANISM FOR TUBULOGLOMERULAR FEEDBACK SYSTEM
    Phillip Bell; Fiscal Year: 1993
  7. Cellular Mechanisms for Tubuloglomerular Feedback
    Phillip Bell; Fiscal Year: 2009

Collaborators

  • Peter Komlosi
  • Robert A Fenton
  • John Bissler
  • Stacy L Steele
  • Takamitsu Saigusa
  • Robert J Kolb
  • Monika Gooz
  • Kelli M Sas
  • Adrian Sproul
  • Ryan Reichert
  • Brian J Siroky
  • Jennifer Guare
  • Stacy Steele
  • Janet D Klein
  • Jeff M Sands
  • Shanping Yu
  • Elizabeth Favre
  • John M Arthur
  • Tiffany L Thai
  • Michael G Janech
  • Hai Yao
  • Courtney J Haycraft
  • Kent T Keyser
  • Yongren Wu
  • Lisa Guay-Woodford

Detail Information

Publications7

  1. ncbi Collecting duct cells that lack normal cilia have mislocalized vasopressin-2 receptors
    Takamitsu Saigusa
    Dept of Medicine, Division of Nephrology, Medical University of South Carolina, 173 Ashley Ave, Charleston, SC 29425, USA
    Am J Physiol Renal Physiol 302:F801-8. 2012
    ..Whether such apical localization contributes to enhanced fluid retention and hypertension in PKD remains to be determined...
  2. ncbi ATP as a mediator of macula densa cell signalling
    P Darwin Bell
    Department of Medicine, Division of Nephrology, Children s Research Institute, Medical University of South Carolina, Charleston, SC, USA
    Purinergic Signal 5:461-71. 2009
    ..However, the critical step in signalling would appear to be the regulated release of ATP across the basolateral membrane of macula densa cells...
  3. ncbi Loss of primary cilia upregulates renal hypertrophic signaling and promotes cystogenesis
    P Darwin Bell
    Ralph H Johnson Veterans Administration Medical Center, Charleston, South Carolina 29425, USA
    J Am Soc Nephrol 22:839-48. 2011
    ..These data suggest that events initiating hypertrophic signaling, such as structural or functional loss of renal mass, may accelerate progression of adult polycystic kidney disease toward end-stage renal disease...
  4. ncbi Telomerase immortalization of principal cells from mouse collecting duct
    Stacy L Steele
    Ralph H Johnson Veterans Affairs Medical Center, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29403, USA
    Am J Physiol Renal Physiol 299:F1507-14. 2010
    ..This technique should be valuable in generating cell lines from genetically engineered mouse models...
  5. ncbi Tubuloglomerular feedback mechanisms in nephron segments beyond the macula densa
    Peter Komlosi
    Division of Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
    Curr Opin Nephrol Hypertens 18:57-62. 2009
    ..To summarize recent evidence regarding the role of distal nephron segments other than the macula densa in sensing the tubular environment and transmitting this signal to the adjacent vasculature...
  6. ncbi N-methyl-D-aspartate receptor subunit NR3a expression and function in principal cells of the collecting duct
    Adrian Sproul
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29403, USA
    Am J Physiol Renal Physiol 301:F44-54. 2011
    ....
  7. ncbi Cilia movement regulates expression of the Raf-1 kinase inhibitor protein
    Kelli M Sas
    Ralph H Johnson Veterans Affairs Medical Center, Medical University of South Carolina, Charleston, 29425, USA
    Am J Physiol Renal Physiol 300:F1163-70. 2011
    ..In terms of polycystic kidney disease, loss of cilia and therefore sensitivity to flow may lead to reduced RKIP levels, activation of the MAPK pathway, and contribute to the formation of cysts...

Research Grants31

  1. CELLULAR MECHANISMS FOR TUBULOGLOMERULAR FEEDBACK SYSTEM
    Phillip Bell; Fiscal Year: 2000
    ..These studies should provide important new insights into the generation and transmission of tubuloglomerular feedback signals from macula densa cells to arteriolar contractile elements. ..
  2. SODIUM-CALCUIM EXCHANGE IN THE RENAL MICROCIRCULATION
    Phillip Bell; Fiscal Year: 2003
    ....
  3. CELLULAR MECHANISMS FOR TUBULOGLOMERULAR FEEDBACK SYSTEM
    Phillip Bell; Fiscal Year: 2004
    ..These studies will provide important new insights into this macula densa cell-to-cell TGF signaling pathway which serves a vital role in the regulation of renal hemodynamics. ..
  4. Cellular Mechanisms for Tubuloglomerular Feedback
    Phillip Bell; Fiscal Year: 2007
    ..Overall these studies should provide important new information regarding the role of ATP in macula densa signaling, activation of the tubuloglomerular feedback mechanism, and control of glomerular hemodynamics. ..
  5. CALCIUM ENTRY REGULATED BY CILIA IN POLYCYSTIC DISEASE
    Phillip Bell; Fiscal Year: 2006
    ..The third aim is to define the role of cilia in the spatial organization of TRP channels at the apical membrane. The role of cilia cytoskeletal interactions in the regulating TRP location and activity will also be addressed. ..
  6. CELLULAR MECHANISM FOR TUBULOGLOMERULAR FEEDBACK SYSTEM
    Phillip Bell; Fiscal Year: 1993
    ....
  7. Cellular Mechanisms for Tubuloglomerular Feedback
    Phillip Bell; Fiscal Year: 2009
    ..Overall these studies should provide important new information regarding the role of ATP in macula densa signaling, activation of the tubuloglomerular feedback mechanism, and control of glomerular hemodynamics. ..