H C Becker


Affiliation: Medical University of South Carolina
Country: USA


  1. request reprint
    Becker H, Veatch L. Effects of lorazepam treatment for multiple ethanol withdrawals in mice. Alcohol Clin Exp Res. 2002;26:371-80 pubmed
  2. Solomon M, Griffin W, Lopez M, Becker H. Brain Regional and Temporal Changes in BDNF mRNA and microRNA-206 Expression in Mice Exposed to Repeated Cycles of Chronic Intermittent Ethanol and Forced Swim Stress. Neuroscience. 2019;: pubmed publisher
    ..These results have important implications for the potential link between BDNF signaling in the brain and ethanol consumption related to stress interactions with chronic ethanol experience. ..
  3. King C, Becker H. Oxytocin attenuates stress-induced reinstatement of alcohol seeking behavior in male and female mice. Psychopharmacology (Berl). 2019;: pubmed publisher
    ..Systemic oxytocin administration attenuates stress-induced reinstatement of alcohol seeking in male and female mice. ..
  4. Anderson R, Lopez M, Griffin W, Haun H, Bloodgood D, Pati D, et al. Dynorphin-kappa opioid receptor activity in the central amygdala modulates binge-like alcohol drinking in mice. Neuropsychopharmacology. 2019;44:1084-1092 pubmed publisher
    ..Collectively, these results demonstrate that DYN/KOR signaling in the CeA contributes to excessive alcohol consumption in a binge-drinking model. ..
  5. Becker H, Mulholland P. Neurochemical mechanisms of alcohol withdrawal. Handb Clin Neurol. 2014;125:133-56 pubmed publisher
  6. Haun H, Griffin W, Lopez M, Solomon M, Mulholland P, Woodward J, et al. Increasing Brain-Derived Neurotrophic Factor (BDNF) in medial prefrontal cortex selectively reduces excessive drinking in ethanol dependent mice. Neuropharmacology. 2018;140:35-42 pubmed publisher
    ..Collectively, these results provide evidence that adaptations in cortical (mPFC) BDNF activity resulting from chronic ethanol exposure play a role in mediating excessive ethanol drinking associated with dependence. ..
  7. Becker H. Animal models of excessive alcohol consumption in rodents. Curr Top Behav Neurosci. 2013;13:355-77 pubmed publisher
  8. Samantaray S, Knaryan V, Patel K, Mulholland P, Becker H, Banik N. Chronic intermittent ethanol induced axon and myelin degeneration is attenuated by calpain inhibition. Brain Res. 2015;1622:7-21 pubmed publisher
  9. Anderson R, Moorman D, Becker H. Contribution of Dynorphin and Orexin Neuropeptide Systems to the Motivational Effects of Alcohol. Handb Exp Pharmacol. 2018;248:473-503 pubmed publisher
    ..Consideration is also given to evidence indicating that these neuropeptide systems may be viable targets for the development of potential treatments for alcohol use disorders. ..

More Information


  1. Becker H. Influence of stress associated with chronic alcohol exposure on drinking. Neuropharmacology. 2017;122:115-126 pubmed publisher
    ..This, in turn, is crucial for developing new and more effective therapeutics for treating excessive, harmful drinking, particularly stress-enhanced alcohol consumption. This article is part of the Special Issue entitled "Alcoholism". ..
  2. request reprint
    Becker H, Myrick H, Veatch L. Pregabalin is effective against behavioral and electrographic seizures during alcohol withdrawal. Alcohol Alcohol. 2006;41:399-406 pubmed
    ..Collectively, these results suggest that pregabalin may be an effective therapeutic agent for medical management of alcohol detoxification. ..
  3. Becker H, Lopez M. An Animal Model of Alcohol Dependence to Screen Medications for Treating Alcoholism. Int Rev Neurobiol. 2016;126:157-77 pubmed publisher
    ..Additionally, this preclinical approach is useful in evaluating the effects of medications on escalated drinking associated with dependence vs more stable levels displayed by nondependent animals. ..