D P Basile

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Renal ischemic injury results in permanent damage to peritubular capillaries and influences long-term function
    D P Basile
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Renal Physiol 281:F887-99. 2001
  2. ncbi request reprint Chronic renal hypoxia after acute ischemic injury: effects of L-arginine on hypoxia and secondary damage
    David P Basile
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Renal Physiol 284:F338-48. 2003
  3. ncbi request reprint Angiostatin and matrix metalloprotease expression following ischemic acute renal failure
    David P Basile
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Renal Physiol 286:F893-902. 2004
  4. ncbi request reprint Rarefaction of peritubular capillaries following ischemic acute renal failure: a potential factor predisposing to progressive nephropathy
    David P Basile
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Curr Opin Nephrol Hypertens 13:1-7. 2004
  5. ncbi request reprint Resistance to ischemic acute renal failure in the Brown Norway rat: a new model to study cytoprotection
    David P Basile
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Kidney Int 65:2201-11. 2004
  6. ncbi request reprint Recovery from acute renal failure predisposes hypertension and secondary renal disease in response to elevated sodium
    Kimberly R Spurgeon-Pechman
    Dept of Physiology, Medical College of Wisconsin, Milwaukee, USA
    Am J Physiol Renal Physiol 293:F269-78. 2007
  7. doi request reprint Immune suppression blocks sodium-sensitive hypertension following recovery from ischemic acute renal failure
    Kimberly R Pechman
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1234-9. 2008
  8. pmc Recovery from renal ischemia-reperfusion injury is associated with altered renal hemodynamics, blunted pressure natriuresis, and sodium-sensitive hypertension
    Kimberly R Pechman
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Regul Integr Comp Physiol 297:R1358-63. 2009
  9. ncbi request reprint Identification of persistently altered gene expression in the kidney after functional recovery from ischemic acute renal failure
    David P Basile
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Am J Physiol Renal Physiol 288:F953-63. 2005
  10. ncbi request reprint Transcriptome analysis and kidney research: toward systems biology
    Mingyu Liang
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Kidney Int 67:2114-22. 2005

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Renal ischemic injury results in permanent damage to peritubular capillaries and influences long-term function
    D P Basile
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Renal Physiol 281:F887-99. 2001
    ..We hypothesize that severe ischemic injury results in a permanent alteration of renal capillary density, contributing to a urinary concentrating defect and the predisposition toward the development of renal fibrosis...
  2. ncbi request reprint Chronic renal hypoxia after acute ischemic injury: effects of L-arginine on hypoxia and secondary damage
    David P Basile
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Renal Physiol 284:F338-48. 2003
    ..These data suggest that a reduction in the peritubular capillary density after ARF results in a persistent reduction in renal Po(2) and that hypoxia may play an important role in progression of chronic renal disease after ARF...
  3. ncbi request reprint Angiostatin and matrix metalloprotease expression following ischemic acute renal failure
    David P Basile
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Renal Physiol 286:F893-902. 2004
    ..Renal angiostatin generation following ARF may modulate renal capillary density postischemia and thereby influence chronic renal function...
  4. ncbi request reprint Rarefaction of peritubular capillaries following ischemic acute renal failure: a potential factor predisposing to progressive nephropathy
    David P Basile
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Curr Opin Nephrol Hypertens 13:1-7. 2004
    ..The nature of the susceptibility that is conveyed to grafts following ischemic injury is not well understood...
  5. ncbi request reprint Resistance to ischemic acute renal failure in the Brown Norway rat: a new model to study cytoprotection
    David P Basile
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Kidney Int 65:2201-11. 2004
    ....
  6. ncbi request reprint Recovery from acute renal failure predisposes hypertension and secondary renal disease in response to elevated sodium
    Kimberly R Spurgeon-Pechman
    Dept of Physiology, Medical College of Wisconsin, Milwaukee, USA
    Am J Physiol Renal Physiol 293:F269-78. 2007
    ..These data suggest that the recovery from acute I/R injury is not complete, compromises Na homeostasis, and predisposes hypertension and secondary renal disease...
  7. doi request reprint Immune suppression blocks sodium-sensitive hypertension following recovery from ischemic acute renal failure
    Kimberly R Pechman
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1234-9. 2008
    ..The present data indicate that infiltrating immune cells mediate or participate in the development of sodium-sensitive hypertension and renal damage in rats apparently recovered from renal I/R injury...
  8. pmc Recovery from renal ischemia-reperfusion injury is associated with altered renal hemodynamics, blunted pressure natriuresis, and sodium-sensitive hypertension
    Kimberly R Pechman
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Regul Integr Comp Physiol 297:R1358-63. 2009
    ..The present data indicate that the pressure-natriuretic-diuretic response in I/R rats is blunted because of a decrease in GFR and RBF and the depressed pressure-dependent increase in medullary blood flow and interstitial pressure...
  9. ncbi request reprint Identification of persistently altered gene expression in the kidney after functional recovery from ischemic acute renal failure
    David P Basile
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Am J Physiol Renal Physiol 288:F953-63. 2005
    ..In summary, genes with known inflammatory, remodeling, and vasoactive activities were identified in rat kidneys after recovery from ARF, some of which may play a role in altering long-term renal function after recovery from ARF...
  10. ncbi request reprint Transcriptome analysis and kidney research: toward systems biology
    Mingyu Liang
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Kidney Int 67:2114-22. 2005
    ....
  11. ncbi request reprint Transforming growth factor-beta in acute renal failure: receptor expression, effects on proliferation, cellularity, and vascularization after recovery from injury
    Kimberly R Spurgeon
    Dept of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Renal Physiol 288:F568-77. 2005
    ..In contrast, the activation of this system may play an important role in the long-term structure of the postischemic kidney by influencing microvascular structure and interstitial cellularity...
  12. ncbi request reprint Novel approaches in the investigation of acute kidney injury
    David P Basile
    J Am Soc Nephrol 18:7-9. 2007
  13. doi request reprint Challenges of targeting vascular stability in acute kidney injury
    David P Basile
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Kidney Int 74:257-8. 2008
    ....
  14. doi request reprint Renal ischemia reperfusion inhibits VEGF expression and induces ADAMTS-1, a novel VEGF inhibitor
    David P Basile
    Dept of Cellular and Integrative Physiology, Indiana Univ School of Medicine, 635 Barnhill Drive MS 334, Indianapolis, IN 46202, USA
    Am J Physiol Renal Physiol 294:F928-36. 2008
    ..However, the studies do suggest an overall inhibition of the VEGF pathway during the early injury and repair phase of renal ischemia that may contribute to an overall reduction in renal microvascular density...
  15. doi request reprint An expanding role of Toll-like receptors in sepsis-induced acute kidney injury
    Pierre C Dagher
    Am J Physiol Renal Physiol 294:F1048-9. 2008
  16. ncbi request reprint Enhanced skeletal muscle arteriolar reactivity to ANG II after recovery from ischemic acute renal failure
    David P Basile
    Dept of Cellular and Integrative Physiology, Indiana Univ School of Medicine, 635 Barnhill Drive MS 334, Indianapolis, IN 46202, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1770-6. 2005
    ..Although the mechanisms of this altered responsiveness are unclear, such changes may relate, in part, to cardiovascular complications in patients with ARF and/or after renal transplant...
  17. ncbi request reprint Leptin regulates gallbladder genes related to absorption and secretion
    Deborah A Swartz-Basile
    Department of Surgery, Indiana University School of Medicine, 535 Barnhill Drive, RT 130D, Indianapolis, IN 46202, USA
    Am J Physiol Gastrointest Liver Physiol 293:G84-90. 2007
    ....
  18. ncbi request reprint Angiostatin does not contribute to skeletal muscle microvascular rarefaction with low nitric oxide bioavailability
    Jefferson C Frisbee
    Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University School of Medicine, Morgantown, WV 26505, USA
    Microcirculation 14:145-53. 2007
    ....
  19. ncbi request reprint Involvement of the ubiquitin pathway in decreasing Ku70 levels in response to drug-induced apoptosis
    Vivian Gama
    Case Comprehensive Cancer Center, Department of Pharmacology and Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Exp Cell Res 312:488-99. 2006
    ..We propose that the ubiquitin-dependent modification of Ku70 plays an important role in the control of cellular levels of Ku70...