Research Topics
Species | David A BakerSummaryAffiliation: Medical University of South Carolina Country: USA Publications
| Collaborators
|
Detail Information
Publications
Cystine/glutamate exchange serves as the source for extracellular glutamate: modifications by repeated cocaine administrationD A Baker
Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston South Carolina 29425, USA
Amino Acids 23:161-2. 2002..The studies presented reveal that this long-term neuroadaptation elicited by repeated cocaine results from a decrease in the activity of cystine/glutamate exchange...- The origin and neuronal function of in vivo nonsynaptic glutamateDavid A Baker
Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Neurosci 22:9134-41. 2002..These results suggest that nonvesicular release from the cystine-glutamate antiporter is the primary source of in vivo extracellular glutamate and that this glutamate can modulate both glutamate and dopamine transmission... - Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbensZheng Xiong Xi
Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Pharmacol Exp Ther 300:162-71. 2002.... - N-acetyl cysteine-induced blockade of cocaine-induced reinstatementDavid A Baker
Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Ann N Y Acad Sci 1003:349-51. 2003 - Inhibition of non-vesicular glutamate release by group III metabotropic glutamate receptors in the nucleus accumbensZheng Xiong Xi
Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, SC, USA
J Neurochem 87:1204-12. 2003..Together, these data indicate that group III mGluRs regulate in vivo extracellular glutamate in the nucleus accumbens by inhibiting non-vesicular glutamate release... - Neuroadaptations in cystine-glutamate exchange underlie cocaine relapseDavid A Baker
Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Nat Neurosci 6:743-9. 2003..Thus, withdrawal from repeated cocaine increases susceptibility to relapse in part by reducing cystine/glutamate exchange, and restoring exchanger activity prevents cocaine-primed drug seeking... - Modulation of group II metabotropic glutamate receptor signaling by chronic cocaineZheng-Xiong Xi
Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Avenue, BSB 403, Charleston, SC 29464, USA
J Pharmacol Exp Ther 303:608-15. 2002..Together, these data demonstrate that repeated cocaine produces an enduring reduction in mGluR2/3 function in the nucleus accumbens... - The temporal sequence of changes in gene expression by drugs of abusePeter W Kalivas
Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, SC, USA
Methods Mol Med 79:3-11. 2003 
Repeated N-acetylcysteine administration alters plasticity-dependent effects of cocaineAric Madayag
Department of Biomedical Sciences, Marquette University, Milwaukee, Wisconsin 53233, USA
J Neurosci 27:13968-76. 2007....- Stressor- and corticotropin releasing factor-induced reinstatement and active stress-related behavioral responses are augmented following long-access cocaine self-administration by ratsJohn R Mantsch
Department of Biomedical Sciences, Marquette University, Schroeder Health Complex, P O Box 1881, Milwaukee, WI 53201 1881, USA
Psychopharmacology (Berl) 195:591-603. 2008..Excessive cocaine use may increase susceptibility to stressor-induced relapse through alterations in brain corticotropin-releasing factor (CRF) responsiveness... - Contribution of cystine-glutamate antiporters to the psychotomimetic effects of phencyclidineDavid A Baker
Department of Biomedical Sciences, Marquette University, Milwaukee, WI 53233, USA
Neuropsychopharmacology 33:1760-72. 2008..These data advance cystine-glutamate antiporters as novel targets capable of reversing the psychotomimetic effects of PCP... - Daily cocaine self-administration under long-access conditions augments restraint-induced increases in plasma corticosterone and impairs glucocorticoid receptor-mediated negative feedback in ratsJohn R Mantsch
Department of Biomedical Sciences, Box 1881, Marquette University, Milwaukee, WI 53201 1881, USA
Brain Res 1167:101-11. 2007..The findings suggest that cocaine use produces persistent changes in individual responsiveness to stressors that may contribute to the addiction process... - Surgical adrenalectomy with diurnal corticosterone replacement slows escalation and prevents the augmentation of cocaine-induced reinstatement in rats self-administering cocaine under long-access conditionsJohn R Mantsch
Department of Biomedical Sciences, Marquette University, Milwaukee, WI 53201, USA
Neuropsychopharmacology 33:814-26. 2008.... - Levo-tetrahydropalmatine attenuates cocaine self-administration and cocaine-induced reinstatement in ratsJohn R Mantsch
Department of Biomedical Sciences, Marquette University, Schroeder Health Complex, P O Box 1881, Milwaukee, WI 53201 1881, USA
Psychopharmacology (Berl) 192:581-91. 2007..Accordingly, l-THP has been reported to reduce heroin craving and relapse in recovering addicts... - Adenylyl and guanylyl cyclases from the malaria parasite Plasmodium falciparumDavid A Baker
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
IUBMB Life 56:535-40. 2004..Study of these enzymes could therefore lead to novel strategies for anti-malarial intervention in addition to providing unique insights into the intriguing biology of the parasite... - Structure, function and evolution of microbial adenylyl and guanylyl cyclasesDavid A Baker
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Mol Microbiol 52:1229-42. 2004..A review is timely because the explosion of data from the various genome projects is providing new and exciting insights into protein function and evolution... - Purine nucleotide cyclases in the malaria parasiteDavid A Baker
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Trends Parasitol 20:227-32. 2004 - Multiple splice variants encode a novel adenylyl cyclase of possible plastid origin expressed in the sexual stage of the malaria parasite Plasmodium falciparumDavid K Muhia
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, United Kingdom
J Biol Chem 278:22014-22. 2003.... - Gametogenesis in malaria parasites is mediated by the cGMP-dependent protein kinaseLouisa McRobert
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
PLoS Biol 6:e139. 2008..falciparum, and demonstrates the feasibility of selective inhibition of a crucial regulator of the malaria parasite life cycle...