Research Topics
Genomes and GenesSpecies | Raymond AntonSummaryAffiliation: Medical University of South Carolina Country: USA Publications
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Publications
Recessive genetic mode of an ADH4 variant in substance dependence in African-Americans: A model of utility of the HWD testXingguang Luo
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Behav Brain Funct 4:42. 2008..abstract:..
Comparison of Bio-Rad %CDT TIA and CDTect as laboratory markers of heavy alcohol use and their relationships with gamma-glutamyltransferaseR F Anton
Clinical Neurobiology Laboratories and Alcohol Research Center, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
Clin Chem 47:1769-75. 2001..Carbohydrate-deficient transferrin (CDT) is used as a serum marker for heavy drinking. We compared a new Bio-Rad %CDT TIA assay with the CDTect assay; we also compared both to gamma-glutamyltransferase (GGT) as markers of heavy drinking...- Current pharmacotherapies of alcoholism: a U.S. perspectiveRaymond F Anton
Department of Psychiatry and the Alcohol Research Center, Medical University of South Carolina, Charleston, SC 29425, USA
Am J Addict 12:S53-68. 2003..The serotonin type-3 antagonist, ondansetron, has shown promise in early-onset alcoholics but needs more extensive study... - A multi-site dose ranging study of nalmefene in the treatment of alcohol dependenceRaymond F Anton
Medical University of South Carolina, Charleston, SC 29425, USA
J Clin Psychopharmacol 24:421-8. 2004..However, possibly because of variation among the sites or the comparatively small sample size, there was no evidence of superior efficacy outcomes with nalmefene treatment... - Naltrexone for the management of alcohol dependenceRaymond F Anton
Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston 29425, USA
N Engl J Med 359:715-21. 2008 - Naltrexone combined with either cognitive behavioral or motivational enhancement therapy for alcohol dependenceRaymond F Anton
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
J Clin Psychopharmacol 25:349-57. 2005..Because CBT and naltrexone share common mechanisms of action, such as craving reduction and relapse prevention, these therapies are likely to be well suited to use in combination... - An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) studyRaymond F Anton
Center for Drug and Alcohol Programs, Medical University of South Carolina, 67 President St, PO Box 250861, Charleston, SC 29425, USA
Arch Gen Psychiatry 65:135-44. 2008..Naltrexone hydrochloride treatment for alcohol dependence works for some individuals but not for everyone. Asn40Asp, a functional polymorphism of the mu-opioid receptor gene (OPRM1), might predict naltrexone response... 
A randomized, multicenter, double-blind, placebo-controlled study of the efficacy and safety of aripiprazole for the treatment of alcohol dependenceRaymond F Anton
Medical University of South Carolina, Charleston, SC 29425, USA
J Clin Psychopharmacol 28:5-12. 2008....- Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trialRaymond F Anton
Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston 29425, USA
JAMA 295:2003-17. 2006..Alcohol dependence treatment may include medications, behavioral therapies, or both. It is unknown how combining these treatments may impact their effectiveness, especially in the context of primary care and other nonspecialty settings... - Naltrexone effects on alcohol consumption in a clinical laboratory paradigm: temporal effects of drinkingRaymond F Anton
Charleston Alcohol Research Center, Medical University of South Carolina, 67 President Street, PO Box 250861, Charleston, SC 29425, USA
Psychopharmacology (Berl) 173:32-40. 2004..This clinical laboratory study evaluated how the timing of drinking and subjective responses to alcohol are effected by the opioid antagonist naltrexone... - Factors affecting %CDT status at entry into a multisite clinical treatment trial: experience from the COMBINE StudyRaymond F Anton
Medical University of South Carolina, and Center for Drug and Alcohol Problems, 67 President Street, Charleston, SC 29425, USA
Alcohol Clin Exp Res 30:1878-83. 2006..These parameters might include level of drinking, days of abstinence before testing, and severity of alcohol dependence before evaluation... - Carbohydrate-deficient transferrin for detection and monitoring of sustained heavy drinking. What have we learned? Where do we go from here?R F Anton
Medical University of South Carolina, 67 President Street, P O Box 250861, Charleston, SC 29425, USA
Alcohol 25:185-8. 2001..How to combine CDT with both verbal tools of alcohol assessment and newer biological markers will also need more extensive evaluation... - Carbohydrate-deficient transferrin and gamma-glutamyltransferase for the detection and monitoring of alcohol use: results from a multisite studyRaymond F Anton
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, PO Box 250861, Charleston, SC 29425, USA
Alcohol Clin Exp Res 26:1215-22. 2002.... - The Alcohol Clinical Trials Initiative (ACTIVE): purpose and goals for assessing important and salient issues for medications development in alcohol use disordersRaymond F Anton
Center for Drug and Alcohol Programs, Medical University of South Carolina, Institute of Psychiatry, Charleston, SC 29425, USA
Neuropsychopharmacology 37:402-11. 2012..Future papers will focus on knowledge gained from the re-analysis of completed trials and provide consensus opinions regarding the performance of clinical trials that might be undertaken in the future... - Gabapentin combined with naltrexone for the treatment of alcohol dependenceRaymond F Anton
Medical University of South Carolina, Institute of Psychiatry, SC 29425, USA
Am J Psychiatry 168:709-17. 2011..This clinical trial evaluated whether the combination of naltrexone and gabapentin was better than naltrexone alone and/or placebo during the early drinking cessation phase (first 6 weeks), and if so, whether this effect persisted... - Efficacy of a combination of flumazenil and gabapentin in the treatment of alcohol dependence: relationship to alcohol withdrawal symptomsRaymond F Anton
Medical University of South Carolina, Charleston, SC, USA
J Clin Psychopharmacol 29:334-42. 2009..These results suggest a differential response to FMZ/GBP treatment, depending on pretreatment AW status that should be taken into account during future treatment trials... - A double-blind evaluation of gabapentin on alcohol effects and drinking in a clinical laboratory paradigmHugh Myrick
Ralph H Johnson Department of Veterans Affairs Medical Center, Research and Development Service, Charleston, South Carolina, USA
Alcohol Clin Exp Res 31:221-7. 2007..In addition, the ability of gabapentin to reduce alcohol craving and consumption was evaluated... - Aripiprazole effects on alcohol consumption and subjective reports in a clinical laboratory paradigm--possible influence of self-controlKonstantin Voronin
Alcohol Research Center, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Alcohol Clin Exp Res 32:1954-61. 2008..The current clinical laboratory study was conducted to evaluate the safety and efficacy of aripiprazole as a potential agent to alter drinking and objective effects of alcohol... - Recent advances in the pharmacotherapy of alcoholismHugh Myrick
Alcohol Research Center, Medical University of South Carolina Department of Psychiatry and Behavioral Sciences, 67 President Street, Charleston, SC 29425, USA
Curr Psychiatry Rep 6:332-8. 2004..Data on naltrexone, acamprosate, and topiramate will be highlighted. In addition, data concerning the use of serotonin reuptake inhibitors in subtypes of alcoholism and the use of combination pharmacotherapy will be reviewed... - The differential effects of medication on mood, sleep disturbance, and work ability in outpatient alcohol detoxificationRobert Malcolm
Alcohol Research Center, Medical University of South Carolina, Charleston 29425, USA
Am J Addict 11:141-50. 2002..025). In this study of outpatients with mild to moderate alcohol withdrawal, carbamazepine was superior to lorazepam in reducing anxiety and improving sleep... - Impact of lifetime alcohol quit attempts and medicated detoxifications on time to relapse during an index alcohol detoxificationTara M Wright
From the Center for Drug and Alcohol Program TMW, hm, RM, PR, EB, SH, RA, Medical University of South Carolina, Department of Psychiatry and Behavioral Sciences, Charleston, SC and Ralph H Johnson Department of Veteran Affairs Medical Center HM, Research and Development Service, Charleston, SC
J Addict Med 1:15-20. 2007.... - Does comorbid anxiety or depression affect clinical outcomes in patients with post-traumatic stress disorder and alcohol use disorders?Lawrence A Labbate
Mental Health Service, VA Medical Center, and Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, USA
Compr Psychiatry 45:304-10. 2004..Hence, contrary to our hypothesis, having additional anxiety or mood disorder comorbidity did not decrease treatment response in individuals with comorbid PTSD and an alcohol use disorder... - What role does measuring medication compliance play in evaluating the efficacy of naltrexone?Alicia M Baros
Charleston Alcohol Research Center, MUSC, Charleston, South Carolina 29425, USA
Alcohol Clin Exp Res 31:596-603. 2007.... - The effect of aripiprazole on cue-induced brain activation and drinking parameters in alcoholicsHugh Myrick
Ralph H Johnson Department of Veterans Affairs Medical Center, Research and Development Service, Medical University of South Carolina, Charleston, SC 29425, USA
J Clin Psychopharmacol 30:365-72. 2010..The study provides both novel and valuable information regarding the effect of aripiprazole on cue-induced brain activation and voluntary drinking during treatment... - Liver disease and HPLC quantification of disialotransferrin for heavy alcohol use: a case seriesScott H Stewart
Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Alcohol Clin Exp Res 34:1956-60. 2010..The goal of this case series was to evaluate the prevalence of liver disease among individuals with poor resolution of transferrin glycoforms by high performance liquid chromatography... - Effect of naltrexone and ondansetron on alcohol cue-induced activation of the ventral striatum in alcohol-dependent peopleHugh Myrick
Research and Development Service, Ralph H Johnson Department of Veterans Affairs Medical Center, Charleston, SC, USA
Arch Gen Psychiatry 65:466-75. 2008..Medication for the treatment of alcoholism is currently not particularly robust. Neuroimaging techniques might predict which medications could be useful in the treatment of alcohol dependence... - Following alcohol consumption, nontreatment-seeking alcoholics report greater stimulation but similar sedation compared with social drinkersSuzanne E Thomas
Institute of Psychiatry, Charleston Alcohol Research Center, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Stud Alcohol 65:330-5. 2004..The present study was conducted to determine whether alcoholics and social drinkers differ in response following a challenge dose of alcohol in a clinical laboratory procedure... - A double-blind trial of gabapentin versus lorazepam in the treatment of alcohol withdrawalHugh Myrick
Ralph H Johnson Department of Veterans Affairs Medical Center, Research and Development Service, Charleston, SC, USA
Alcohol Clin Exp Res 33:1582-8. 2009..The aim of this study was to evaluate alcohol use and symptom reduction of gabapentin when compared with lorazepam in the treatment of alcohol withdrawal in a double-blinded randomized clinical trial... - Blood pressure reduction during treatment for alcohol dependence: results from the Combining Medications and Behavioral Interventions for Alcoholism (COMBINE) studyScott H Stewart
Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA
Addiction 103:1622-8. 2008..Heavy drinking is associated with hypertension. This study evaluated blood pressure changes occurring during treatment for alcohol dependence... - COMT genotype influences the effect of alcohol on blood pressure: results from the COMBINE studyScott H Stewart
Department of Psychiatry and Behavioral Sciences, Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, South Carolina, USA
Am J Hypertens 22:87-91. 2009..Catechol- O-methyltransferase (COMT) inactivates catecholamines, and a G to A substitution in codon 108 in the soluble COMT mRNA (or codon 158 in the membrane-bound form) substitutes methionine for valine and alters enzyme activity... - OPRM1 Asn40Asp predicts response to naltrexone treatment: a haplotype-based approachGabor Oroszi
Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Alcohol Clin Exp Res 33:383-93. 2009..Therefore we used a haplotype-based approach to capture information of other genetic variants that might predict treatment response to naltrexone in the COMBINE Study... - Aripiprazole: a drug with a novel mechanism of action and possible efficacy for alcohol dependenceDerick E Vergne
Center for Drugs and Alcohol Programs, Department of Psychiatry, Medical University of South Carolina, USA
CNS Neurol Disord Drug Targets 9:50-4. 2010..g., those with impulsive disorders), or non-responsive to available treatments. Early results with aripiprazole are promising and warrant further exploration... - The impact of alcohol dependence and posttraumatic stress disorder on cold pressor task responseKathleen T Brady
Division of Clinical Neuroscience, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Box 250861, Charleston, South Carolina 29425, USA
J Stud Alcohol 67:700-6. 2006..The objective of this study was to investigate HPA axis reactivity to the cold pressor task (CPT) among individuals with alcohol dependence, PTSD, and comorbid alcohol dependence and PTSD... - Confirmatory analysis of the adolescent obsessive compulsive drinking scale (A-OCDS): a measure of 'craving' and problem drinking in adolescents/young adultsDeborah Deas
Charleston Alcohol Research Center, Medical University of South Carolina, Department of Psychiatry, 29425, USA
J Natl Med Assoc 94:879-87. 2002..This scale may be useful as a screening tool, as well as monitoring change over time... - Sertraline and cognitive behavioral therapy for depressed alcoholics: results of a placebo-controlled trialDarlene H Moak
Alcohol Research Center, Center for Drug and Alcohol Programs, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
J Clin Psychopharmacol 23:553-62. 2003.... - Differential brain activity in alcoholics and social drinkers to alcohol cues: relationship to cravingHugh Myrick
Department of Psychiatry and Behavioral Sciences, Alcohol Research Center, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
Neuropsychopharmacology 29:393-402. 2004..This study suggests, as did our earlier study, that alcoholics and not social drinkers, when exposed to alcohol cues, have increased brain activity in areas that reportedly subserve craving for other addictive substances... - Self-report and biomarker alcohol screening by primary care physicians: the need to translate research into guidelines and practicePeter M Miller
Center for Drug and Alcohol Programs, Medical University of South Carolina, 67 President Street, P O Box 250861, Charleston 29425, USA
Alcohol Alcohol 39:325-8. 2004..To assess knowledge and use of alcohol self-report and biomarker screening by physicians... - Biochemical alcohol screening in primary health carePeter M Miller
Medical University of South Carolina, 67 President Street, P O Box 250861, Charleston, SC 29425, USA
Addict Behav 29:1427-37. 2004..Translational studies are needed on methods to facilitate knowledge and use of alcohol biomarkers by general practitioners... - Effects of naltrexone and nalmefene on subjective response to alcohol among non-treatment-seeking alcoholics and social drinkersDavid J Drobes
Charleston Alcohol Research Center, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA
Alcohol Clin Exp Res 28:1362-70. 2004..The present study evaluated the impact of naltrexone and nalmefene on craving and subjective effects after a moderate alcohol dose among non-treatment-seeking alcoholics (n = 125) and social drinkers (n = 90)... - Effectiveness of naltrexone in a community treatment programTherese K Killeen
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
Alcohol Clin Exp Res 28:1710-7. 2004..Whether this efficacy can be generalized to individuals who have alcohol use disorders and present for treatment at front-line community treatment programs has not been well established... - Sertraline in the treatment of co-occurring alcohol dependence and posttraumatic stress disorderKathleen T Brady
The Medical University of South Carolina, Department of Psychiatry, Charleston, SC 29425, USA
Alcohol Clin Exp Res 29:395-401. 2005..Posttraumatic stress disorder (PTSD) frequently co-occurs with alcohol use disorders. This study investigated the use of sertraline, a serotonin reuptake inhibitor, in treating co-occurring symptoms of alcohol dependence and PTSD... - Cold pressor task reactivity: predictors of alcohol use among alcohol-dependent individuals with and without comorbid posttraumatic stress disorderKathleen T Brady
Medical University of South Carolina, Charleston, South Carolina 29425, USA
Alcohol Clin Exp Res 30:938-46. 2006..This study investigated the relationship between subjective and neuroendocrine stress reactivity to the cold pressor task (CPT) and prospective alcohol use among individuals with alcohol dependence, with and without comorbid PTSD... - Excessive alcohol consumption and hypertension: clinical implications of current researchPeter M Miller
Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 25086, USA
J Clin Hypertens (Greenwich) 7:346-51. 2005..A routine search for excessive use of alcohol, along with brief interventions and monitoring, can have a major impact on reducing the prevalence of hypertension in the general population... - Alcohol biomarker screening in medical and surgical settingsPeter M Miller
Center for Drug and Alcohol Programs, Charleston, South Carolina 29425, USA
Alcohol Clin Exp Res 30:185-93. 2006..Presentations were discussed by Raymond Anton. - Naltrexone treatment of adolescent alcoholics: an open-label pilot studyDeborah Deas
Medical University of South Carolina, Institute of Psychiatry, Alcohol Research Center, Charleston, South Carolina 29425, USA
J Child Adolesc Psychopharmacol 15:723-8. 2005..This 6-week open-label trial of naltrexone was conducted in a preliminary fashion to determine whether naltrexone would be safe, well tolerated, and lead to a reduction in alcohol consumption in adolescents with alcohol dependence... - A clinical laboratory paradigm for evaluating medication effects on alcohol consumption: naltrexone and nalmefeneDavid J Drobes
Charleston Alcohol Research Center, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, USA
Neuropsychopharmacology 28:755-64. 2003..Similar laboratory paradigms may offer substantial advantages for observing these effects during evaluation of other medications as well... - Substance abuse is a disease of the human brain: focus on alcoholRaymond Anton
Medical University of South Carolina, USA
J Law Med Ethics 38:735-44. 2010.... - Carbohydrate-deficient transferrin levels reflect heavy drinking in alcohol-dependent women seeking treatmentMargaret R Rukstalis
Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania, and Philadelphia Medical Center for Veteran Affairs, Philadelphia Pennsylvania 19104, USA
Alcohol Clin Exp Res 26:1539-44. 2002..The study also examined the extent that E2 levels mediated the relationship between CDT levels and heavy drinking in the alcohol-dependent women... - Alleles of a functional serotonin transporter promoter polymorphism are associated with major depression in alcoholicsMaggie Nellissery
Department of Psychiatry, University of Connecticut School of Medicine, Farmington 06030 2103, USA
Alcohol Clin Exp Res 27:1402-8. 2003..Because the convergence of these disorders may provide a refined phenotype, we examined the association of serotonin (5-HT) transporter linked polymorphic region (5-HTTLPR) alleles to comorbid alcohol dependence and major depression... - Topiramate for treating alcohol dependence: a randomized controlled trialBankole A Johnson
Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22908, USA
JAMA 298:1641-51. 2007.... - Genetic basis for predicting response to naltrexone in the treatment of alcohol dependenceRaymond F Anton
Pharmacogenomics 9:655-8. 2008 - Combined pharmacotherapies and behavioral interventions for alcohol dependence (The COMBINE Study): examination of posttreatment drinking outcomesDennis M Donovan
Alcohol and Drug Abuse Institute, 1107 NE 45th Street, Suite 120, Seattle, Washington 98105 4631, USA
J Stud Alcohol Drugs 69:5-13. 2008..The aim of this study was to examine the efficacy of pharmacological and behavioral interventions across 1 year posttreatment in the COMBINE (Combining Medications and Behavioral Interventions) Study... - Depression and coronary artery atherosclerosis and reactivity in female cynomolgus monkeysCarol A Shively
Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
Psychosom Med 64:699-706. 2002..Here we report the results of a comparison of physiological characteristics, coronary artery reactivity, and atherosclerosis in 16 depressed and 26 nondepressed female cynomolgus monkeys... - Treatment of patients with substance use disorders, second edition. American Psychiatric AssociationHerbert D Kleber
Am J Psychiatry 164:5-123. 2007 - Toward standardization of carbohydrate-deficient transferrin (CDT) measurements: I. Analyte definition and proposal of a candidate reference methodJan Olof Jeppsson
Malmo University Hospital, Malmo, Sweden
Clin Chem Lab Med 45:558-62. 2007..In clinical use, CDT should be expressed in a relative amount (% CDT), to compensate for variations in the total transferrin concentration... - A review of genetic, biological, pharmacological, and clinical factors that affect carbohydrate-deficient transferrin levelsMichael F Fleming
UW Medical School, Madison, Wisconsin, USA
Alcohol Clin Exp Res 28:1347-55. 2004..The goal of this study is to review the genetic, biological, pharmacological, and clinical factors that may affect CDT levels... - New constructs and assessments for relapse and continued use potential in the ASAM Patient Placement CriteriaDavid R Gastfriend
Addiction Research Program, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02115, USA
J Addict Dis 22:95-111. 2003.... - Improvement of physical health and quality of life of alcohol-dependent individuals with topiramate treatment: US multisite randomized controlled trialBankole A Johnson
Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22908 0623, USA
Arch Intern Med 168:1188-99. 2008..We sought to determine whether topiramate's antidrinking effects are bolstered by improvements in physical and psychosocial well-being...
Research Grants
- Gabapentin as an Adjunct to Naltrexone for AlcoholismRaymond Anton; Fiscal Year: 2006..This evaluation of a novel treatment will allow us to better understand combined pharmacotherapy and develop a new paradigm for medications development for alcoholism. ..
- Naltrexonel/Acamprosate and CBT/MET Light for AlcoholismRaymond Anton; Fiscal Year: 2004..However, each study site has provided site-specific information on the budget, budget justifications, listing of key personnel, consultant/consortium agreements, and human subjects sections of their respective proposals. ..
- COMPARISON OF CBT AND MET PLUS NALTREXONE FOR ALCOHOLISMRaymond Anton; Fiscal Year: 2001..As such, these results will provide data regarding the types of treatment likely to benefit outpatient alcoholics when applied in other health care settings where issues of clinical acceptability and cost might be consideration. ..
- NALTREXONE AND COGNITIVE BEHAVIOR THERAPY OF ALCOHOLISMRaymond Anton; Fiscal Year: 1993....
- Genetic and brain mechanisms of naltrexone's treatment efficacy for alcoholismRaymond F Anton; Fiscal Year: 2010..Results will assist treatment providers in deciding who might better respond to naltrexone and, as such, improvement in the treatment of individuals with alcohol dependence could be greatly enhanced. ..