- Deficiency in core circadian protein Bmal1 is associated with a prothrombotic and vascular phenotypePayaningal R Somanath
Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, HM 1200 Medical College of Georgia, Augusta, Georgia 30912, USA
J Cell Physiol 226:132-40. 2011..Here we report a direct regulation of vWF expression in endothelial cells by biological clock gene Bmal1. This study establishes a mechanistic connection between Bmal1 and cardiovascular phenotype...
- Anticancer efficacy of simvastatin on prostate cancer cells and tumor xenografts is associated with inhibition of Akt and reduced prostate-specific antigen expressionSamith T Kochuparambil
Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, Georgia 30912, USA
J Pharmacol Exp Ther 336:496-505. 2011..Our findings demonstrate the therapeutic benefits of simvastatin for prostate cancer and suggest a link between simvastatin, regulation of Akt activity, and PSA expression in prostate tumors...