Robert AdamsSummaryAffiliation: Medical University of South Carolina Country: USA Publications
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Publications
TCD in sickle cell disease: an important and useful testRobert J Adams
Medical College of Georgia, 1429 Harper St, HF 1154, Augusta, GA 30912 3235, USA
Pediatr Radiol 35:229-34. 2005..Although TCD cannot predict all strokes, TCD and TCDI offer an opportunity to apply an effective therapy for patients in this risk group and reduce many first-time strokes...- Regular transfusion lowers plasma free hemoglobin in children with sickle-cell disease at risk for strokeNelson E Lezcano
Department of Neurology, School of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
Stroke 37:1424-6. 2006..CONCLUSIONS: Regular transfusion which lowers stroke risk is associated with a significant reduction in PFH. A role for PFH in promoting stroke in SCD should be investigated... - Big strokes in small personsRobert J Adams
Department of Neurology, Medical College of Georgia, Augusta, USA
Arch Neurol 64:1567-74. 2007.... 
Risk of recurrent stroke, myocardial infarction, or death in hospitalized stroke patientsWuwei Feng
Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
Neurology 74:588-93. 2010..This study examines the risk of recurrent stroke, myocardial infarction (MI), vascular death, or all-cause death after hospitalized stroke in South Carolina...- Influence of age on racial disparities in stroke admission rates, hospital charges, and outcomes in South CarolinaWuwei Feng
Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
Stroke 40:3096-101. 2009.... - Declining stroke rates in Californian children with sickle cell diseaseHeather J Fullerton
University of California, San Francisco, Department of Neurology, 505 Parnassus Ave, Box 0114, San Francisco, CA 94143, USA
Blood 104:336-9. 2004..88/100 person-years compared to 0.50 in 1999 and 0.17 in 2000 (P <.005 for trend). Since the publication of the STOP study in 1998, annual rates of admissions for first stroke for Californian children with SCD have declined... - Stroke and conversion to high risk in children screened with transcranial Doppler ultrasound during the STOP studyRobert J Adams
Department of Neurology, Medical College of Georgia, Augusta, GA 30912 3200, USA
Blood 103:3689-94. 2004..Substantial differences in the probability of conversion to abnormal TCD were observed, with younger children and those with higher velocity more likely to have an abnormal TCD with rescreening... 
Genetic risk factors for cerebrovascular disease in children with sickle cell disease: design of a case-control association study and genomewide screenGaye T Adams
Sickle Cell Center, Department of Medicine, Medical College of Georgia, Augusta, GA, USA
BMC Med Genet 4:6. 2003..The genetic factors leading to the development of a high TCD velocity (i.e. cerebrovascular disease) and ultimately to stroke are not well characterized...- Can peak systolic velocities be used for prediction of stroke in sickle cell anemia?Anne Jones
Medical College of Georgia, 1429 Harper St, HF 1154, Augusta, GA 30912, USA
Pediatr Radiol 35:66-72. 2005..The clinical application of the STOP results could be enhanced if criteria for treatment could be found that are based on peak systolic velocity (PSV), the measure more commonly used in vascular ultrasound practice... - Sickle cell disease: primary stroke preventionMehari Gebreyohanns
Department of Neurology, Medical College of Georgia, Augusta, 30912, USA
CNS Spectr 9:445-9. 2004.... - Unusual encephalopathy after acute chest syndrome in sickle cell disease: acute necrotizing encephalitisKi Hyeong Lee
Department of Neurology, Medical College of Georgia, Augusta 30912, USA
J Pediatr Hematol Oncol 24:585-8. 2002..Patients with acute neurologic deterioration in conjunction with ACS should be evaluated thoroughly for other causes of central nervous system disease including infectious/parainfectious processes as well as stroke... - Pathophysiology and treatment of stroke in sickle-cell disease: present and futureJeffrey A Switzer
Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
Lancet Neurol 5:501-12. 2006..Here we review the epidemiology, clinical spectrum, and pathophysiology of stroke in sickle-cell disease to identify potential therapeutic targets... - Intra-individual variation in blood flow velocities in cerebral arteries of children with sickle cell diseaseDonald J Brambilla
New England Research Institutes, Watertown, Massachusetts 02472, USA
Pediatr Blood Cancer 49:318-22. 2007..Interpretation of TCD results should be based on knowledge of intra-individual variation in blood flow velocity, information not currently available for sickle cell patients... - MRI abnormalities of the brain in one-year-old children with sickle cell anemiaWinfred C Wang
Department of Hematology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
Pediatr Blood Cancer 51:643-6. 2008..We performed MRI examinations of the brain in infants with SCA, who were evaluated as part of the multicenter randomized double-blinded Pediatric Hydroxyurea Phase III Clinical Trial (BABY HUG)... - Sickle cell disease: the neurological complicationsMara Prengler
Neurosciences Unit, Institute of Child Health, University College and Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
Ann Neurol 51:543-52. 2002..This complex disease underscores the potential intellectual and practical distance between the determination of molecular genetics and effective clinical application and therapeutics... - Stroke Prevention Trial in Sickle Cell Anemia (STOP): extended follow-up and final resultsMargaret T Lee
Division of Pediatric Hematology and Blood and Marrow Transplantation, Columbia University, 180 Fort Washington Ave, Harkness Pavilion 5, New York, NY 10032, USA
Blood 108:847-52. 2006..Persistent TCD elevation signals ongoing stroke risk. Reduction in TCD results over time without transfusion is observed in some patients and requires further study... - Elevated blood flow velocity in the anterior cerebral artery and stroke risk in sickle cell disease: extended analysis from the STOP trialJanet L Kwiatkowski
Division of Hematology, The Children s Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Br J Haematol 134:333-9. 2006.... - Trials in sickle cell diseaseFenella J Kirkham
Institute of Child Health University of London, London, England
Pediatr Neurol 34:450-8. 2006..Pilot safety and feasibility trials of low-dose aspirin and overnight respiratory support are also beginning. The collaboration provides an infrastructure for future clinical trials in this vulnerable group of children... - Coronary risk evaluation in patients with transient ischemic attack and ischemic stroke: a scientific statement for healthcare professionals from the Stroke Council and the Council on Clinical Cardiology of the American Heart Association/American Stroke ARobert J Adams
Circulation 108:1278-90. 2003 - Organized stroke careBo Norrving
Department of Neurology, Lund University Hospital, S-221 95 Lund, Sweden
Stroke 37:326-8. 2006 - Discontinuing prophylactic transfusions used to prevent stroke in sickle cell diseaseRobert J Adams
N Engl J Med 353:2769-78. 2005..ClinicalTrials.gov number, NCT00006182.).. - Alpha Thalassemia is associated with decreased risk of abnormal transcranial Doppler ultrasonography in children with sickle cell anemiaLewis L Hsu
Emory University School of Medicine and Georgia Comprehensive Sickle Cell Center, Atlanta, Georgia 30303, USA
J Pediatr Hematol Oncol 25:622-8. 2003..The association of alpha thalassemia-2 and normal TCD adds to the evidence on the protective effects of alpha thalassemia-2 in SCD and highlights the contribution of epistatic factors... - Coronary risk evaluation in patients with transient ischemic attack and ischemic stroke: a scientific statement for healthcare professionals from the Stroke Council and the Council on Clinical Cardiology of the American Heart Association/American Stroke ARobert J Adams
Stroke 34:2310-22. 2003 - Magnetic resonance angiography in children with sickle cell disease and abnormal transcranial Doppler ultrasonography findings enrolled in the STOP studyMiguel R Abboud
Department of Pediatrics, Medical University of South Carolina, Charleston, USA
Blood 103:2822-6. 2004..Furthermore, patients with abnormal MRA findings and higher TCD velocities are at higher risk for stroke, and their cerebral TAMVs are unlikely to decrease without transfusion... - Sickle cell disease and stroke: primary prevention and transcranial DopplerRobert J Adams
Ann Neurol 54:559-63. 2003 - Longitudinal changes in ferritin during chronic transfusion: a report from the Stroke Prevention Trial in Sickle Cell Anemia (STOP)Beatrice Files
Children s Healthcare of Atlanta Scottish Rite, Atlanta, Georgia 30342, USA
J Pediatr Hematol Oncol 24:284-90. 2002..Iron overload, the inevitable result of chronic transfusion, is commonly monitored with serum ferritin concentration...
Research Grants
- TCD Ultrasound of Subjects Enrolled in Baby HUGRobert Adams; Fiscal Year: 2004..Although the sample size is purposely small as designed by the parent study, large differences in the prevalence of high-risk patients at the end of treatment could be detected by Baby TCD. ..
- Prevention of Stroke after STOP, A Retrospective Chart ReviewRobert Adams; Fiscal Year: 2009....
- Prevention of Stroke after STOP, A Retrospective Chart ReviewRobert J Adams; Fiscal Year: 2010....