Robert Adams

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. ncbi request reprint TCD in sickle cell disease: an important and useful test
    Robert J Adams
    Medical College of Georgia, 1429 Harper St, HF 1154, Augusta, GA 30912 3235, USA
    Pediatr Radiol 35:229-34. 2005
  2. ncbi request reprint Regular transfusion lowers plasma free hemoglobin in children with sickle-cell disease at risk for stroke
    Nelson E Lezcano
    Department of Neurology, School of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    Stroke 37:1424-6. 2006
  3. pmc Access to Expert Stroke Care with Telemedicine: REACH MUSC
    Abby Swanson Kazley
    Department of Health Care Leadership and Management, Medical University of South Carolina Charleston, SC, USA
    Front Neurol 3:44. 2012
  4. pmc REACH MUSC: A Telemedicine Facilitated Network for Stroke: Initial Operational Experience
    Robert J Adams
    Department of Neurosciences, Medical University of South Carolina Charleston, SC, USA
    Front Neurol 3:33. 2012
  5. ncbi request reprint Big strokes in small persons
    Robert J Adams
    Department of Neurology, Medical College of Georgia, Augusta, USA
    Arch Neurol 64:1567-74. 2007
  6. doi request reprint Risk of recurrent stroke, myocardial infarction, or death in hospitalized stroke patients
    Wuwei Feng
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Neurology 74:588-93. 2010
  7. ncbi request reprint Influence of age on racial disparities in stroke admission rates, hospital charges, and outcomes in South Carolina
    Wuwei Feng
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Stroke 40:3096-101. 2009
  8. ncbi request reprint Declining stroke rates in Californian children with sickle cell disease
    Heather J Fullerton
    University of California, San Francisco, Department of Neurology, 505 Parnassus Ave, Box 0114, San Francisco, CA 94143, USA
    Blood 104:336-9. 2004
  9. ncbi request reprint Stroke and conversion to high risk in children screened with transcranial Doppler ultrasound during the STOP study
    Robert J Adams
    Department of Neurology, Medical College of Georgia, Augusta, GA 30912 3200, USA
    Blood 103:3689-94. 2004
  10. pmc Genetic risk factors for cerebrovascular disease in children with sickle cell disease: design of a case-control association study and genomewide screen
    Gaye T Adams
    Sickle Cell Center, Department of Medicine, Medical College of Georgia, Augusta, GA, USA
    BMC Med Genet 4:6. 2003

Collaborators

Detail Information

Publications28

  1. ncbi request reprint TCD in sickle cell disease: an important and useful test
    Robert J Adams
    Medical College of Georgia, 1429 Harper St, HF 1154, Augusta, GA 30912 3235, USA
    Pediatr Radiol 35:229-34. 2005
    ..Although TCD cannot predict all strokes, TCD and TCDI offer an opportunity to apply an effective therapy for patients in this risk group and reduce many first-time strokes...
  2. ncbi request reprint Regular transfusion lowers plasma free hemoglobin in children with sickle-cell disease at risk for stroke
    Nelson E Lezcano
    Department of Neurology, School of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    Stroke 37:1424-6. 2006
    ..PFH has been associated with harmful endothelial actions including scavenging nitric oxide (NO). Whether PFH plays a role in stroke in SCD has not been examined...
  3. pmc Access to Expert Stroke Care with Telemedicine: REACH MUSC
    Abby Swanson Kazley
    Department of Health Care Leadership and Management, Medical University of South Carolina Charleston, SC, USA
    Front Neurol 3:44. 2012
    ..These increases in access are especially significant for groups that have faced disparities in care and high rates of AIS. The use of telemedicine can greatly increase access to care for residents throughout South Carolina...
  4. pmc REACH MUSC: A Telemedicine Facilitated Network for Stroke: Initial Operational Experience
    Robert J Adams
    Department of Neurosciences, Medical University of South Carolina Charleston, SC, USA
    Front Neurol 3:33. 2012
    ..Despite these challenges, this robust system delivered tPA safely and in a high fraction of patients evaluated using the REACH MUSC system...
  5. ncbi request reprint Big strokes in small persons
    Robert J Adams
    Department of Neurology, Medical College of Georgia, Augusta, USA
    Arch Neurol 64:1567-74. 2007
    ....
  6. doi request reprint Risk of recurrent stroke, myocardial infarction, or death in hospitalized stroke patients
    Wuwei Feng
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Neurology 74:588-93. 2010
    ..This study examines the risk of recurrent stroke, myocardial infarction (MI), vascular death, or all-cause death after hospitalized stroke in South Carolina...
  7. ncbi request reprint Influence of age on racial disparities in stroke admission rates, hospital charges, and outcomes in South Carolina
    Wuwei Feng
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Stroke 40:3096-101. 2009
    ....
  8. ncbi request reprint Declining stroke rates in Californian children with sickle cell disease
    Heather J Fullerton
    University of California, San Francisco, Department of Neurology, 505 Parnassus Ave, Box 0114, San Francisco, CA 94143, USA
    Blood 104:336-9. 2004
    ..88/100 person-years compared to 0.50 in 1999 and 0.17 in 2000 (P <.005 for trend). Since the publication of the STOP study in 1998, annual rates of admissions for first stroke for Californian children with SCD have declined...
  9. ncbi request reprint Stroke and conversion to high risk in children screened with transcranial Doppler ultrasound during the STOP study
    Robert J Adams
    Department of Neurology, Medical College of Georgia, Augusta, GA 30912 3200, USA
    Blood 103:3689-94. 2004
    ..Substantial differences in the probability of conversion to abnormal TCD were observed, with younger children and those with higher velocity more likely to have an abnormal TCD with rescreening...
  10. pmc Genetic risk factors for cerebrovascular disease in children with sickle cell disease: design of a case-control association study and genomewide screen
    Gaye T Adams
    Sickle Cell Center, Department of Medicine, Medical College of Georgia, Augusta, GA, USA
    BMC Med Genet 4:6. 2003
    ..The genetic factors leading to the development of a high TCD velocity (i.e. cerebrovascular disease) and ultimately to stroke are not well characterized...
  11. ncbi request reprint Pathophysiology and treatment of stroke in sickle-cell disease: present and future
    Jeffrey A Switzer
    Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Lancet Neurol 5:501-12. 2006
    ..Here we review the epidemiology, clinical spectrum, and pathophysiology of stroke in sickle-cell disease to identify potential therapeutic targets...
  12. ncbi request reprint Unusual encephalopathy after acute chest syndrome in sickle cell disease: acute necrotizing encephalitis
    Ki Hyeong Lee
    Department of Neurology, Medical College of Georgia, Augusta 30912, USA
    J Pediatr Hematol Oncol 24:585-8. 2002
    ..Patients with acute neurologic deterioration in conjunction with ACS should be evaluated thoroughly for other causes of central nervous system disease including infectious/parainfectious processes as well as stroke...
  13. ncbi request reprint Can peak systolic velocities be used for prediction of stroke in sickle cell anemia?
    Anne Jones
    Medical College of Georgia, 1429 Harper St, HF 1154, Augusta, GA 30912, USA
    Pediatr Radiol 35:66-72. 2005
    ..The clinical application of the STOP results could be enhanced if criteria for treatment could be found that are based on peak systolic velocity (PSV), the measure more commonly used in vascular ultrasound practice...
  14. ncbi request reprint Sickle cell disease: primary stroke prevention
    Mehari Gebreyohanns
    Department of Neurology, Medical College of Georgia, Augusta, 30912, USA
    CNS Spectr 9:445-9. 2004
    ....
  15. pmc Stroke Prevention Trial in Sickle Cell Anemia (STOP): extended follow-up and final results
    Margaret T Lee
    Division of Pediatric Hematology and Blood and Marrow Transplantation, Columbia University, 180 Fort Washington Ave, Harkness Pavilion 5, New York, NY 10032, USA
    Blood 108:847-52. 2006
    ..Persistent TCD elevation signals ongoing stroke risk. Reduction in TCD results over time without transfusion is observed in some patients and requires further study...
  16. ncbi request reprint Elevated blood flow velocity in the anterior cerebral artery and stroke risk in sickle cell disease: extended analysis from the STOP trial
    Janet L Kwiatkowski
    Division of Hematology, The Children s Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Br J Haematol 134:333-9. 2006
    ....
  17. doi request reprint MRI abnormalities of the brain in one-year-old children with sickle cell anemia
    Winfred C Wang
    Department of Hematology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Pediatr Blood Cancer 51:643-6. 2008
    ..We performed MRI examinations of the brain in infants with SCA, who were evaluated as part of the multicenter randomized double-blinded Pediatric Hydroxyurea Phase III Clinical Trial (BABY HUG)...
  18. pmc Intra-individual variation in blood flow velocities in cerebral arteries of children with sickle cell disease
    Donald J Brambilla
    New England Research Institutes, Watertown, Massachusetts 02472, USA
    Pediatr Blood Cancer 49:318-22. 2007
    ..Interpretation of TCD results should be based on knowledge of intra-individual variation in blood flow velocity, information not currently available for sickle cell patients...
  19. ncbi request reprint Trials in sickle cell disease
    Fenella J Kirkham
    Institute of Child Health University of London, London, England
    Pediatr Neurol 34:450-8. 2006
    ..Pilot safety and feasibility trials of low-dose aspirin and overnight respiratory support are also beginning. The collaboration provides an infrastructure for future clinical trials in this vulnerable group of children...
  20. ncbi request reprint Organized stroke care
    Bo Norrving
    Department of Neurology, Lund University Hospital, S 221 95 Lund, Sweden
    Stroke 37:326-8. 2006
  21. ncbi request reprint Discontinuing prophylactic transfusions used to prevent stroke in sickle cell disease
    Robert J Adams
    N Engl J Med 353:2769-78. 2005
    ..Prophylactic transfusion prevents strokes in children with sickle cell anemia who have abnormalities on transcranial Doppler ultrasonographic examination. However, it is not known how long transfusion should be continued in these children...
  22. ncbi request reprint Magnetic resonance angiography in children with sickle cell disease and abnormal transcranial Doppler ultrasonography findings enrolled in the STOP study
    Miguel R Abboud
    Department of Pediatrics, Medical University of South Carolina, Charleston, USA
    Blood 103:2822-6. 2004
    ..Furthermore, patients with abnormal MRA findings and higher TCD velocities are at higher risk for stroke, and their cerebral TAMVs are unlikely to decrease without transfusion...
  23. ncbi request reprint Sickle cell disease and stroke: primary prevention and transcranial Doppler
    Robert J Adams
    Ann Neurol 54:559-63. 2003
  24. ncbi request reprint Coronary risk evaluation in patients with transient ischemic attack and ischemic stroke: a scientific statement for healthcare professionals from the Stroke Council and the Council on Clinical Cardiology of the American Heart Association/American Stroke A
    Robert J Adams
    Circulation 108:1278-90. 2003
  25. ncbi request reprint Coronary risk evaluation in patients with transient ischemic attack and ischemic stroke: a scientific statement for healthcare professionals from the Stroke Council and the Council on Clinical Cardiology of the American Heart Association/American Stroke A
    Robert J Adams
    Stroke 34:2310-22. 2003
  26. ncbi request reprint Alpha Thalassemia is associated with decreased risk of abnormal transcranial Doppler ultrasonography in children with sickle cell anemia
    Lewis L Hsu
    Emory University School of Medicine and Georgia Comprehensive Sickle Cell Center, Atlanta, Georgia 30303, USA
    J Pediatr Hematol Oncol 25:622-8. 2003
    ..The authors hypothesized that children with abnormal TCD are less likely to have alpha thalassemia-2, and an increased hemoglobin level accounts for this protective effect...
  27. ncbi request reprint Sickle cell disease: the neurological complications
    Mara Prengler
    Neurosciences Unit, Institute of Child Health, University College and Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
    Ann Neurol 51:543-52. 2002
    ..This complex disease underscores the potential intellectual and practical distance between the determination of molecular genetics and effective clinical application and therapeutics...
  28. ncbi request reprint Longitudinal changes in ferritin during chronic transfusion: a report from the Stroke Prevention Trial in Sickle Cell Anemia (STOP)
    Beatrice Files
    Children s Healthcare of Atlanta Scottish Rite, Atlanta, Georgia 30342, USA
    J Pediatr Hematol Oncol 24:284-90. 2002
    ..Iron overload, the inevitable result of chronic transfusion, is commonly monitored with serum ferritin concentration...

Research Grants6

  1. TCD Ultrasound of Subjects Enrolled in Baby HUG
    Robert Adams; Fiscal Year: 2002
    ..Although the sample size is purposely small as designed by the parent study, large differences in the prevalence of high-risk patients at the end of treatment could be detected by Baby TCD. ..
  2. TCD Ultrasound of Subjects Enrolled in Baby HUG
    Robert Adams; Fiscal Year: 2003
    ..Although the sample size is purposely small as designed by the parent study, large differences in the prevalence of high-risk patients at the end of treatment could be detected by Baby TCD. ..
  3. TCD Ultrasound of Subjects Enrolled in Baby HUG
    Robert Adams; Fiscal Year: 2004
    ..Although the sample size is purposely small as designed by the parent study, large differences in the prevalence of high-risk patients at the end of treatment could be detected by Baby TCD. ..
  4. TCD Ultrasound of Subjects Enrolled in Baby HUG
    Robert Adams; Fiscal Year: 2004
    ..Although the sample size is purposely small as designed by the parent study, large differences in the prevalence of high-risk patients at the end of treatment could be detected by Baby TCD. ..
  5. Prevention of Stroke after STOP, A Retrospective Chart Review
    Robert Adams; Fiscal Year: 2009
    ....
  6. Prevention of Stroke after STOP, A Retrospective Chart Review
    Robert J Adams; Fiscal Year: 2010
    ....