Research Topics
| Jean W LeeSummaryAffiliation: MDS Pharma Services Country: USA Publications
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Detail Information
Publications
Fit-for-purpose method development and validation for successful biomarker measurementJean W Lee
Formerly MDS Pharma Services, Lincoln, Nebraska, USA
Pharm Res 23:312-28. 2006..Sample analysis within this context of fit-for-purpose method development and validation are well suited for successful biomarker implementation, allowing increased use of biomarkers in drug development...- Biomarker assay translation from discovery to clinical studies in cancer drug development: quantification of emerging protein biomarkersJean W Lee
Amgen Inc, Thousand Oaks, California 91320, USA
Adv Cancer Res 96:269-98. 2007..Specific references to protein biomarkers for cancer drug development are also discussed... - Method validation and measurement of biomarkers in nonclinical and clinical samples in drug development: a conference reportJean W Lee
MDS Pharma Services, Lincoln, Nebraska, USA
Pharm Res 22:499-511. 2005.... - Supercritical fluid chromatography-tandem mass spectrometry for fast bioanalysis of R/S-warfarin in human plasmaRoger A Coe
MDS Pharma Services, 621 Rose Street, Lincoln, NE 68502, USA
J Pharm Biomed Anal 42:573-80. 2006..0% C.V. for S-warfarin; and the bias was 3.7 and 3.2% R.E., respectively. The method is sensitive, accurate, selective and robust, and was applied to a drug-interaction clinical study with rapid turnaround of sample analysis... - Biomarkers, validation and pharmacokinetic-pharmacodynamic modellingWayne A Colburn
MDS Pharma Services, Phoenix, Arizona, USA
Clin Pharmacokinet 42:997-1022. 2003.... - Quantification of uric acid, xanthine and hypoxanthine in human serum by HPLC for pharmacodynamic studiesNancy Cooper
MDS Pharma Services, Lincoln, NE 68501, USA
J Chromatogr B Analyt Technol Biomed Life Sci 837:1-10. 2006..The method was simple and robust with good accuracy and precision for the measurement of serum UA, X, and HX concentrations... - Quantification of recombinant human parathyroid hormone (rhPTH(1-84)) in human plasma by immunoassay: commercial kit evaluation and validation to support pharmacokinetic studiesRichard L Sukovaty
MDS Pharma Services, Lincoln, NE, USA
J Pharm Biomed Anal 42:261-71. 2006.... - A general approach for the quantitative analysis of bisphosphonates in human serum and urine by high-performance liquid chromatography/tandem mass spectrometryLee S Zhu
MDS Pharma Services, 621 Rose Street, Lincoln, NE 68502, USA
Rapid Commun Mass Spectrom 20:3421-6. 2006..The general applicability of the approach was demonstrated by validation of bioanalytical methods for risedronate and alendronate in human serum and urine. Sensitivity was achieved at the pg/mL level with merely 100-200 microL of sample...