R Michael McClain

Summary

Country: USA

Publications

  1. ncbi request reprint Neonatal mouse model: review of methods and results
    R M McClain
    National Center for Toxicological Research, Food and Drug Administration, USA
    Toxicol Pathol 29:128-37. 2001
  2. ncbi request reprint Summary of safety studies conducted with synthetic lycopene
    R Michael McClain
    McClain Associates, 10 Powder Horn Terr, Randolph, NJ 07869, USA
    Regul Toxicol Pharmacol 37:274-85. 2003
  3. ncbi request reprint Subchronic and chronic safety studies with genistein in dogs
    R Michael McClain
    McClain Associates, 10 Powder Horn Terr, Randolph, NJ 07869, USA
    Food Chem Toxicol 43:1461-82. 2005
  4. ncbi request reprint Genetic toxicity studies with genistein
    R Michael McClain
    McClain Associates, Randolph, NJ 07869, USA
    Food Chem Toxicol 44:42-55. 2006
  5. ncbi request reprint Acute, subchronic and chronic safety studies with genistein in rats
    R Michael McClain
    McClain Associates, Randolph, NJ 07869, USA
    Food Chem Toxicol 44:56-80. 2006
  6. ncbi request reprint Reproductive safety studies with genistein in rats
    R Michael McClain
    McClain Associates, Toxicology Department, 10 Powder Horn Terr, Randolph, NJ 07869, USA
    Food Chem Toxicol 45:1319-32. 2007

Collaborators

  • R Michael McClain
  • Jochen Bausch
  • Alberto Davidovich
  • Erich Wolz
  • James A Edwards
  • Friedlieb Pfannkuch

Detail Information

Publications6

  1. ncbi request reprint Neonatal mouse model: review of methods and results
    R M McClain
    National Center for Toxicological Research, Food and Drug Administration, USA
    Toxicol Pathol 29:128-37. 2001
    ..The model responds to chemicals that act via a genotoxic mode of action that represent a greater concern for human cancer risk...
  2. ncbi request reprint Summary of safety studies conducted with synthetic lycopene
    R Michael McClain
    McClain Associates, 10 Powder Horn Terr, Randolph, NJ 07869, USA
    Regul Toxicol Pharmacol 37:274-85. 2003
    ..In humans, there is a very long history of use with respect to dietary exposure, and even in the case of very high exposures from dietary sources, there is no indication of any significant adverse effects...
  3. ncbi request reprint Subchronic and chronic safety studies with genistein in dogs
    R Michael McClain
    McClain Associates, 10 Powder Horn Terr, Randolph, NJ 07869, USA
    Food Chem Toxicol 43:1461-82. 2005
    ..For the 52-week study, the NOAEL is considered to be >500 mg/kg/day and the NOEL is considered to be 50 mg/kg/day...
  4. ncbi request reprint Genetic toxicity studies with genistein
    R Michael McClain
    McClain Associates, Randolph, NJ 07869, USA
    Food Chem Toxicol 44:42-55. 2006
    ..This observation is in agreement with published data on the inhibitory action of genistein on topoisomerase II, which is known to lead to chromosomal damage with a threshold dose response...
  5. ncbi request reprint Acute, subchronic and chronic safety studies with genistein in rats
    R Michael McClain
    McClain Associates, Randolph, NJ 07869, USA
    Food Chem Toxicol 44:56-80. 2006
    ..The no observed effect level (NOEL) is considered to be 5 mg/kg/day based on the hormonally induced functional changes at higher doses...
  6. ncbi request reprint Reproductive safety studies with genistein in rats
    R Michael McClain
    McClain Associates, Toxicology Department, 10 Powder Horn Terr, Randolph, NJ 07869, USA
    Food Chem Toxicol 45:1319-32. 2007
    ..On the basis of the definitive Prenatal development study, the NOAEL for maternal toxicity and adverse effects on embryonic development was considered to be 100 mg/kg/day when administered orally by dietary admix...