P Yang

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study
    Nifang Niu
    Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    BMC Cancer 12:422. 2012
  2. pmc Meta-analysis of 8q24 for seven cancers reveals a locus between NOV and ENPP2 associated with cancer development
    Abra G Brisbin
    Department of Health Sciences Research, Mayo Clinic, Rochester, USA
    BMC Med Genet 12:156. 2011
  3. pmc Genetic variants associated with the risk of chronic obstructive pulmonary disease with and without lung cancer
    Mariza de Andrade
    Division of Epidemiology, Mayo Clinic, Rochester, MN 55905, USA
    Cancer Prev Res (Phila) 5:365-73. 2012
  4. pmc Can gene expression profiling predict survival for patients with squamous cell carcinoma of the lung?
    Zhifu Sun
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    Mol Cancer 3:35. 2004
  5. pmc Impact of sample acquisition and linear amplification on gene expression profiling of lung adenocarcinoma: laser capture micro-dissection cell-sampling versus bulk tissue-sampling
    Eric W Klee
    Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA
    BMC Med Genomics 2:13. 2009
  6. ncbi request reprint Glutathione pathway genes and lung cancer risk in young and old populations
    P Yang
    Division of Epidemiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Carcinogenesis 25:1935-44. 2004
  7. pmc A rigorous and comprehensive validation: common genetic variations and lung cancer
    Ping Yang
    Department of 1Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, 55905, USA
    Cancer Epidemiol Biomarkers Prev 19:240-4. 2010
  8. ncbi request reprint Role of the glutathione metabolic pathway in lung cancer treatment and prognosis: a review
    Ping Yang
    Division of Epidemiology and Cancer Center, Nicotine Dependence Center, and Department of Molecular Pharmacology and Experimental Therapeutics, Rochester, MN 55905, USA
    J Clin Oncol 24:1761-9. 2006
  9. pmc Alpha1-antitrypsin deficiency carriers, tobacco smoke, chronic obstructive pulmonary disease, and lung cancer risk
    Ping Yang
    Division of Epidemiology and Cancer Center, Mayo Clinic, Rochester, Minnesota 55905, USA
    Arch Intern Med 168:1097-103. 2008
  10. ncbi request reprint Clinical features of 5,628 primary lung cancer patients: experience at Mayo Clinic from 1997 to 2003
    Ping Yang
    Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Chest 128:452-62. 2005

Collaborators

Detail Information

Publications98

  1. pmc Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study
    Nifang Niu
    Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    BMC Cancer 12:422. 2012
    ....
  2. pmc Meta-analysis of 8q24 for seven cancers reveals a locus between NOV and ENPP2 associated with cancer development
    Abra G Brisbin
    Department of Health Sciences Research, Mayo Clinic, Rochester, USA
    BMC Med Genet 12:156. 2011
    ..However, the abundance of associations around 128 Mb on chromosome 8 could mask the appearance of a weaker, but important, association elsewhere on 8q24...
  3. pmc Genetic variants associated with the risk of chronic obstructive pulmonary disease with and without lung cancer
    Mariza de Andrade
    Division of Epidemiology, Mayo Clinic, Rochester, MN 55905, USA
    Cancer Prev Res (Phila) 5:365-73. 2012
    ..Functional studies are needed to elucidate the mechanisms of these genes in the development of COPD, lung cancer, or both...
  4. pmc Can gene expression profiling predict survival for patients with squamous cell carcinoma of the lung?
    Zhifu Sun
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    Mol Cancer 3:35. 2004
    ..We also evaluated the gene markers' accuracy in segregating samples to their respective group. Functional gene networks for the significant genes were retrieved, and their association with survival was tested...
  5. pmc Impact of sample acquisition and linear amplification on gene expression profiling of lung adenocarcinoma: laser capture micro-dissection cell-sampling versus bulk tissue-sampling
    Eric W Klee
    Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA
    BMC Med Genomics 2:13. 2009
    ..Consequently, LCM may enable investigators to obtain additional information in microarray studies not easily found using bulk tissue samples, but it is of critical importance that potential amplification biases are controlled for...
  6. ncbi request reprint Glutathione pathway genes and lung cancer risk in young and old populations
    P Yang
    Division of Epidemiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Carcinogenesis 25:1935-44. 2004
    ..Carefully evaluating multiple levels of gene-environment and gene-gene interactions is critical in assessing lung cancer risk...
  7. pmc A rigorous and comprehensive validation: common genetic variations and lung cancer
    Ping Yang
    Department of 1Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, 55905, USA
    Cancer Epidemiol Biomarkers Prev 19:240-4. 2010
    ..We evaluated five of the top candidate SNPs (rs402710, rs2736100, rs4324798, rs16969968, and rs8034191) for their effects on lung cancer risk and overall survival...
  8. ncbi request reprint Role of the glutathione metabolic pathway in lung cancer treatment and prognosis: a review
    Ping Yang
    Division of Epidemiology and Cancer Center, Nicotine Dependence Center, and Department of Molecular Pharmacology and Experimental Therapeutics, Rochester, MN 55905, USA
    J Clin Oncol 24:1761-9. 2006
    ..The potential application of glutathione system polymorphic genetic markers in identifying patients who may respond favorably, selecting effective antitumor drugs, and balancing drug efficacy and toxicity are discussed...
  9. pmc Alpha1-antitrypsin deficiency carriers, tobacco smoke, chronic obstructive pulmonary disease, and lung cancer risk
    Ping Yang
    Division of Epidemiology and Cancer Center, Mayo Clinic, Rochester, Minnesota 55905, USA
    Arch Intern Med 168:1097-103. 2008
    ..Genetic susceptibility in lung cancer risk has long been recognized but remains ill defined, as does the role of tobacco smoke exposure and chronic obstructive pulmonary disease (COPD)...
  10. ncbi request reprint Clinical features of 5,628 primary lung cancer patients: experience at Mayo Clinic from 1997 to 2003
    Ping Yang
    Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Chest 128:452-62. 2005
    ..In this report, we present the clinical features and survival rates up to 5 years of a patient cohort...
  11. pmc Evaluation of glutathione metabolic genes on outcomes in advanced non-small cell lung cancer patients after initial treatment with platinum-based chemotherapy: an NCCTG-97-24-51 based study
    Ping Yang
    College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Thorac Oncol 4:479-85. 2009
    ....
  12. pmc Lung cancer in never smokers
    Ping Yang
    Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Semin Respir Crit Care Med 32:10-21. 2011
    ....
  13. ncbi request reprint Alpha1-antitrypsin and neutrophil elastase imbalance and lung cancer risk
    Ping Yang
    Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Chest 128:445-52. 2005
    ..We conducted a case-control study to investigate whether genetic variations indicative of alpha(1)-antitrypsin deficiency (A1ATD) or an excess of neutrophil elastase modify lung cancer risk..
  14. ncbi request reprint Study design considerations in clinical outcome research of lung cancer using microarray analysis
    P Yang
    Division of Epidemiology, Mayo Clinic, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Lung Cancer 46:215-26. 2004
    ..The focus of this report is on the methodology used in the identification of potential genes as prognostic factors...
  15. ncbi request reprint Adenocarcinoma of the lung is strongly associated with cigarette smoking: further evidence from a prospective study of women
    P Yang
    Mayo Clinic Cancer Center, Rochester, MN 55905, USA
    Am J Epidemiol 156:1114-22. 2002
    ..Adenocarcinoma of the lung is more strongly associated with tobacco smoke exposure than previously recognized...
  16. ncbi request reprint Alpha1-antitrypsin deficiency allele carriers among lung cancer patients
    P Yang
    Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Cancer Epidemiol Biomarkers Prev 8:461-5. 1999
    ..9% and 23.8%, P < or = 0.01, respectively). Our preliminary findings suggest that individuals who carry an alpha1AD allele may have an increased risk for developing LC, specifically squamous cell or bronchoalveolar carcinoma...
  17. ncbi request reprint Lung cancer risk in families of nonsmoking probands: heterogeneity by age at diagnosis
    P Yang
    Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Genet Epidemiol 17:253-73. 1999
    ..Our results suggest the presence of a high-risk gene contributing to early-onset lung cancer in a population where the probands are nonsmokers...
  18. pmc Quality of life and symptom burden among long-term lung cancer survivors
    Ping Yang
    Mayo Clinic, College of Medicine, Rochester, Minnesota 55905, USA
    J Thorac Oncol 7:64-70. 2012
    ..The primary aim of this study was to conduct a 7-year longitudinal study in survivors of primary lung cancer which identified factors associated with either decline or improvement in QOL over time...
  19. ncbi request reprint Worse disease-free survival in never-smokers with ALK+ lung adenocarcinoma
    Ping Yang
    Division of Epidemiology, Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Thorac Oncol 7:90-7. 2012
    ....
  20. ncbi request reprint Higher risk of mismatch repair-deficient colorectal cancer in alpha(1)-antitrypsin deficiency carriers and cigarette smokers
    P Yang
    Department of Health Sciences Research, Department of Laboratory Medicine and Pathology, Department of Medical Genetics, Mayo Clinic and Foundation, 200 First Street SW, Rochester, Minnesota 55905, USA
    Mol Genet Metab 71:639-45. 2000
    ..Our findings suggest an etiologic link between alpha(1)ATD alleles and development of CRC with defective MMR, and a synergistic effect between smoking and alpha(1)ATD allele in the development of MSI-H CRC...
  21. ncbi request reprint Genetic determinants of lung cancer short-term survival: the role of glutathione-related genes
    Ping Yang
    Department of Health Sciences Research, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Lung Cancer 35:221-9. 2002
    ..We tested the hypothesis that genes encoding glutathione enzymes may predict lung cancer short-term survival...
  22. ncbi request reprint Polymorphisms in GLTSCR1 and ERCC2 are associated with the development of oligodendrogliomas
    Ping Yang
    Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Cancer 103:2363-72. 2005
    ..The authors have previously described a 150-kilobase minimal deletion region in gliomas that maps to 19q13.33 and contains 3 novel candidate genes (GLTSCR1, EHD2, and GLTSCR2)...
  23. ncbi request reprint DNA mismatch repair genes hMLH1, hMSH2, and hMSH6 are not inactivated in bronchioloalveolar carcinomas of the lung
    M C Aubry
    Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Cancer 92:2898-901. 2001
    ..Inactivation of hMLH1, hMSH2, and hMSH6 is observed as a loss of expression of these proteins by immunohistochemistry. Bronchioloalveolar carcinoma is a subtype of adenocarcinoma with distinctive clinical and pathologic features...
  24. ncbi request reprint Lung cancer risk reduction after smoking cessation: observations from a prospective cohort of women
    J O Ebbert
    Nicotine Research Center, Division of Community Internal Medicine, Mayo Clinic Cancer Center, Rochester, Minneapolis, MN, USA
    J Clin Oncol 21:921-6. 2003
    ....
  25. ncbi request reprint Environmental tobacco smoke exposure in women with lung cancer
    M de Andrade
    Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Lung Cancer 43:127-34. 2004
    ..We report the patterns of ETS exposure history in a clinical cohort of women with newly diagnosed lung cancer...
  26. ncbi request reprint Duration of smoking abstinence as a predictor for non-small-cell lung cancer survival in women
    J O Ebbert
    Division of Primary Care Internal Medicine, Department of Internal Medicine, Nicotine Research Program, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Lung Cancer 47:165-72. 2005
    ..Previous studies have attempted to investigate the impact of smoking cessation on lung cancer survival but have been limited by small numbers of former smokers and incomplete data...
  27. ncbi request reprint Quality of life in 650 lung cancer survivors 6 months to 4 years after diagnosis
    Adam Svobodnik
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 79:1024-30. 2004
    ..To present the results of a quality-of-life (QOL) assessment performed with the current version of the Lung Cancer Symptom Scale (LCSS) questionnaire in a large single-institutional data set of 650 patients with lung cancer...
  28. ncbi request reprint Differential association of body mass index and fat distribution with three major histologic types of lung cancer: evidence from a cohort of older women
    J E Olson
    Health Sciences Research, Mayo Foundation, Rochester, MN55905, USA
    Am J Epidemiol 156:606-15. 2002
    ..Results suggest that waist circumference may be differentially associated with histologic subtypes of lung cancer...
  29. ncbi request reprint Gender differences in non-small-cell lung cancer survival: an analysis of 4,618 patients diagnosed between 1997 and 2002
    Antonio L Visbal
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Thorac Surg 78:209-15; discussion 215. 2004
    ..Most of the reports are limited to selected groups of patients. The magnitude of gender effect on NSCLC survival across disease stage, tumor histology, and therapies needs to be further characterized...
  30. ncbi request reprint Myeloperoxidase -463 (G-->A) polymorphism associated with lower risk of lung cancer
    Orhun H Kantarci
    Department of Neurology, Mayo Clinic, Rochester, Minn 55905, USA
    Mayo Clin Proc 77:17-22. 2002
    ..To study the association of the myeloperoxidase (MPO) -463 (G-->A) polymorphism with lung cancer risk...
  31. pmc Genetic variation in glutathione metabolism and DNA repair genes predicts survival of small-cell lung cancer patients
    Z Sun
    Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Ann Oncol 21:2011-6. 2010
    ..Genes in the glutathione metabolism and DNA repair pathways were tested through tag single-nucleotide polymorphisms (SNPs) to assess their association with survival in SCLC...
  32. ncbi request reprint Is voluntary vitamin and mineral supplementation associated with better outcome in non-small cell lung cancer patients? Results from the Mayo Clinic lung cancer cohort
    Aminah Jatoi
    Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA
    Lung Cancer 49:77-84. 2005
    ..The goal of this study was to determine whether vitamin/mineral supplementation is associated with improved survival and quality of life in a cohort of NSCLC patients...
  33. pmc The role of desmoglein-3 in the diagnosis of squamous cell carcinoma of the lung
    Cemile Dilara Savci-Heijink
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Pathol 174:1629-37. 2009
    ..9. Using immunohistochemistry, sensitivity and specificity of DSG3 for lung cancers were 98% and 99%, respectively. Therefore, DSG3 can be a useful ancillary marker to separate SQCC from other subtypes of lung cancer...
  34. doi request reprint Anaplastic lymphoma kinase immunoreactivity correlates with ALK gene rearrangement and transcriptional up-regulation in non-small cell lung carcinomas
    Jennifer M Boland
    Department of Laboratory Medicine and Pathology, Mayo Medical School, Rochester, MN 55905, USA
    Hum Pathol 40:1152-8. 2009
    ..Anaplastic lymphoma kinase immunohistochemistry may have utility as a screening tool or as a surrogate marker for the molecular techniques to detect the EML4-ALK fusion gene in these tumors...
  35. pmc Clinical features of bronchioloalveolar carcinoma with new histologic and staging definitions
    Jon O Ebbert
    Division of Primary Care Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
    J Thorac Oncol 5:1213-20. 2010
    ....
  36. pmc Genetic variants and risk of lung cancer in never smokers: a genome-wide association study
    Yafei Li
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Lancet Oncol 11:321-30. 2010
    ..Lung cancer in individuals who have never smoked tobacco products is an increasing medical and public-health issue. We aimed to unravel the genetic basis of lung cancer in never smokers...
  37. ncbi request reprint Familial pulmonary carcinoid tumors
    A M Oliveira
    Department of Laboratory Medicine and Pathology, Division of Anatomic Pathology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
    Cancer 91:2104-9. 2001
    ..CONCLUSIONS: The occurrence of familial pulmonary carcinoid tumors in the absence of MEN1 suggests a novel, rare germline mutation specific to the development of pulmonary carcinoids...
  38. pmc Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy
    Ann M Moyer
    Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 19:811-21. 2010
    ..We set out to test the hypotheses that single nucleotide polymorphisms (SNPs) or copy number polymorphisms for genes within the glutathione pathway might influence survival in lung cancer patients treated with these drugs...
  39. ncbi request reprint Gene expression profiling on lung cancer outcome prediction: present clinical value and future premise
    Zhifu Sun
    Department of Health Sciences Research, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 15:2063-8. 2006
    ..A strategy for establishing independent or more accurate signatures is commented...
  40. pmc A pessimistic explanatory style is prognostic for poor lung cancer survival
    Paul Novotny
    Cancer Center Statistics, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    J Thorac Oncol 5:326-32. 2010
    ..Having a pessimistic outlook has been related to negative health behaviors and higher mortality. However, the construct has not been well explored in cancer populations...
  41. ncbi request reprint Analysis of age of onset data from case-control family studies
    H Li
    Section of Biostatistics, Mayo Clinic, Rochester, Minnesota 55905, USA
    Biometrics 54:1030-9. 1998
    ....
  42. pmc Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship
    Julian R Molina
    Department of Oncology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 83:584-94. 2008
    ....
  43. ncbi request reprint Survival after recurrent nonsmall-cell lung cancer after complete pulmonary resection
    Hiroshi Sugimura
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Ann Thorac Surg 83:409-17; discussioin 417-8. 2007
    ..Survival characteristics of patients who have recurrent nonsmall-cell lung cancer after surgical resection are not well understood. Little objective evidence exists to justify treatment for these patients...
  44. pmc Motivational readiness for physical activity and quality of life in long-term lung cancer survivors
    Matthew M Clark
    Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, United States
    Lung Cancer 61:117-22. 2008
    ..Physical activity level may have important QOL and symptom management benefits for long-term lung cancer survivors...
  45. doi request reprint Does marital status impact survival and quality of life in patients with non-small cell lung cancer? Observations from the mayo clinic lung cancer cohort
    Aminah Jatoi
    Division of Medical Oncology, Mayo Clinic, Rochester, MN 55905, USA
    Oncologist 12:1456-63. 2007
    ..Previous studies have found that marriage is associated with longer survival and better quality of life among lung cancer patients. The present study used the Mayo Clinic Lung Cancer Cohort to re-examine this issue...
  46. ncbi request reprint Primary adenoid cystic carcinoma of the lung: absence of KIT mutations
    Marie Christine Aubry
    Division of Anatomic Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Cancer 110:2507-10. 2007
    ..Adjuvant therapy is often ineffective and identification of a targeted novel therapy would be useful. The objective of the current study was to evaluate KIT expression and KIT-activating mutations...
  47. ncbi request reprint Risk of cancer among relatives of patients with glioma
    Brian P O'Neill
    Department of Neurology, and the Mayo Clinic Cancer Center, Rochester Minnesota 55905, USA
    Cancer Epidemiol Biomarkers Prev 11:921-4. 2002
    ..Our results do not support the hypothesis of a familial aggregation of glioma indicative of a glioma susceptibility gene...
  48. doi request reprint Non-overlapping and non-cell-type-specific gene expression signatures predict lung cancer survival
    Zhifu Sun
    Department of Health Sciences Research, College of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Clin Oncol 26:877-83. 2008
    ..This study applied multivariate approaches to identify and evaluate value-added gene expression signatures in two types of NSCLC. MATERIALS and..
  49. ncbi request reprint Primary salivary gland-type lung cancer: spectrum of clinical presentation, histopathologic and prognostic factors
    Julian R Molina
    Division of Medical Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Cancer 110:2253-9. 2007
    ..The clinicopathologic profiles, symptoms on presentation, and long-term outcomes of patients with ACC and MEC as an overall group have not been defined recently...
  50. ncbi request reprint Exploring vitamin and mineral supplementation and purported clinical effects in patients with small cell lung cancer: results from the Mayo Clinic lung cancer cohort
    Aminah Jatoi
    Department of Oncology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Nutr Cancer 51:7-12. 2005
    ..These data suggest an association between vitamin/mineral supplementation and improved survival and point to a need for future studies on vitamin and mineral supplementation in small cell lung cancer patients...
  51. ncbi request reprint The relationship between cigarette smoking and quality of life after lung cancer diagnosis
    Yolanda I Garces
    Mayo Clinic, Charlton 6, 200 First Street SW, Rochester, MN 55905, USA
    Chest 126:1733-41. 2004
    ..To describe the relationship between cigarette smoking and quality of life (QOL) among lung cancer survivors as measured by the lung cancer symptom scale (LCSS)...
  52. ncbi request reprint Role of imbalance between neutrophil elastase and alpha 1-antitrypsin in cancer development and progression
    Zhifu Sun
    Department of Health Sciences Research, Mayo Clinic Rochester, Rochester, MN 55905, USA
    Lancet Oncol 5:182-90. 2004
    ....
  53. ncbi request reprint Predicting postrecurrence survival among completely resected nonsmall-cell lung cancer patients
    Brent A Williams
    Division of Biostatistics, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Ann Thorac Surg 81:1021-7. 2006
    ..This study sought to quantify the prognostic effects of these characteristics on postrecurrence survival...
  54. pmc The cancer anorexia/weight loss syndrome: exploring associations with single nucleotide polymorphisms (SNPs) of inflammatory cytokines in patients with non-small cell lung cancer
    Aminah Jatoi
    Division of Medical Oncology, Mayo Clinic, Rochester, MN 55905, USA
    Support Care Cancer 18:1299-304. 2010
    ....
  55. pmc Alpha-1-antitrypsin deficiency and smoking as risk factors for mismatch repair deficient colorectal cancer: a study from the colon cancer family registry
    Noralane M Lindor
    Department of Medical Genetics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Mol Genet Metab 99:157-9. 2010
    ..No difference in frequency of A1AT deficiency alleles was found between cases and controls, irrespective of the MSI subtype...
  56. pmc Perceptions of lung cancer risk and beliefs in screening accuracy of spiral computed tomography among high-risk lung cancer family members
    Pamela S Sinicrope
    Department of Psychiatry and Psychology, Mayo Clinic Rochester, Rochester, MN 55905, USA
    Acad Radiol 17:1012-25. 2010
    ..Our objective was to describe the effect of participation in SCT screening on participants' risk perceptions, worry, and expectations regarding the accuracy of the screening result...
  57. doi request reprint Correlation of IHC and FISH for ALK gene rearrangement in non-small cell lung carcinoma: IHC score algorithm for FISH
    Eunhee S Yi
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA
    J Thorac Oncol 6:459-65. 2011
    ..Fluorescent in situ hybridization (FISH) is used to detect ALK+, but it is expensive and not routinely available. We explored the potential of an immunohistochemistry (IHC) scoring system as an affordable, accessible approach...
  58. pmc Effect of disrupting seven-in-absentia homolog 2 function on lung cancer cell growth
    Atique U Ahmed
    Departments of Surgery and Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Natl Cancer Inst 100:1606-29. 2008
    ..We examined whether inhibiting SIAH-2 function blocks lung cancer growth...
  59. pmc Cystic fibrosis transmembrane conductance regulator gene mutation and lung cancer risk
    Yafei Li
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Lung Cancer 70:14-21. 2010
    ..32; 95% CI=0.15-0.68; p=0.01). Genetic variations in the CFTR gene might modulate the risk of lung cancer. This study, for the first time, provides evidence of a protective role of the CFTR deletion carrier in the etiology of lung cancer...
  60. ncbi request reprint Long-term survivorship in lung cancer: a review
    Hiroshi Sugimura
    Department of Health Sciences Research, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Chest 129:1088-97. 2006
    ..Multidisciplinary research in epidemiologic, clinical, and basic science approaches is warranted to further our knowledge base for optimal long-term management and to develop the necessary intervention strategies among LTLC survivors...
  61. ncbi request reprint Completely resected N1 non-small cell lung cancer: factors affecting recurrence and long-term survival
    Toshio Fujimoto
    Division of General Thoracic Surgery, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    J Thorac Cardiovasc Surg 132:499-506. 2006
    ..Few reports have evaluated the correlation between N1 disease and tumor recurrence or which subgroup of patients would most benefit from adjuvant chemotherapy...
  62. ncbi request reprint Histologic grade is an independent prognostic factor for survival in non-small cell lung cancer: an analysis of 5018 hospital- and 712 population-based cases
    Zhifu Sun
    Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    J Thorac Cardiovasc Surg 131:1014-20. 2006
    ..Our objective was to determine whether histologic grade independently contributes to the prognosis of non-small cell lung cancer...
  63. pmc Methylation markers for small cell lung cancer in peripheral blood leukocyte DNA
    Liang Wang
    Department of Laboratory Medicine and Pathology, Mayo Clinic, College of Medicine, Rochester, Minnesota 55905, USA
    J Thorac Oncol 5:778-85. 2010
    ..Small cell lung cancer (SCLC) is the most aggressive form of lung malignancy...
  64. ncbi request reprint Risk of cancer after the diagnosis of Parkinson's disease: a historical cohort study
    Alexis Elbaz
    Departments of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Mov Disord 20:719-25. 2005
    ..Among PD patients, there was no relation between the risk of cancer and the cumulative dose of levodopa received or the use of other PD medications...
  65. ncbi request reprint Cigarette smoking and colorectal cancer: long-term, subsite-specific risks in a cohort study of postmenopausal women
    Paul J Limburg
    Divisions of Gastroenterology and Hepatology and Epidemiology, Mayo Clinic Cancer Center, Rochester, Minnesota, USA
    Clin Gastroenterol Hepatol 1:202-10. 2003
    ..However, long-term CRC risk estimates among female smokers remain limited and inconsistent. The goal of this prospective study was to assess cigarette smoking and CRC risk, overall and by anatomic subsite, among postmenopausal women...
  66. ncbi request reprint Polymorphisms in the promoter region of the neutrophil elastase gene are associated with lung cancer development
    Ken Taniguchi
    Division of Experimental Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Clin Cancer Res 8:1115-20. 2002
    ..In conclusion, our findings support an etiological role of NE in lung cancer development...
  67. ncbi request reprint Nonfatal cancer preceding Parkinson's disease: a case-control study
    Alexis Elbaz
    Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Epidemiology 13:157-64. 2002
    ..We conducted a population-based case-control study to investigate the association of Parkinson's disease (PD) with preceding nonfatal cancer...
  68. ncbi request reprint Diagnosis of alpha-1-antitrypsin deficiency: An algorithm of quantification, genotyping, and phenotyping
    Melissa R Snyder
    Division of Clinical Biochemistry and Immunology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Clin Chem 52:2236-42. 2006
    ..The purpose of this study was to define and evaluate a strategy that provides reliable laboratory evaluation of A1AT deficiency...
  69. pmc Epidemiology of lung cancer prognosis: quantity and quality of life
    Ping Yang
    Mayo Clinic, College of Medicine, Rochester, MN, USA
    Methods Mol Biol 471:469-86. 2009
    ..New knowledge to be gained should help lung cancer survivors, their healthcare providers, and their caregivers by providing evidence for establishing clinical recommendations to enhance their long-term survival and health-related QOL...
  70. pmc Inherited variation in immune genes and pathways and glioblastoma risk
    Judith A Schwartzbaum
    Division of Epidemiology, College of Public Health, Ohio State University, Columbus, OH 43210, USA
    Carcinogenesis 31:1770-7. 2010
    ..Our findings represent the first systematic description of immune genes and pathways that characterize glioblastoma risk...
  71. pmc Effect of emphysema on lung cancer risk in smokers: a computed tomography-based assessment
    Yan Li
    Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing, PR China
    Cancer Prev Res (Phila) 4:43-50. 2011
    ..These results imply that an accurate evaluation of emphysema could help reliably identify individuals at greater risk of lung cancer among smokers...
  72. ncbi request reprint Refining prognosis in non-small-cell lung cancer
    Zhifu Sun
    N Engl J Med 356:189-90; author reply 190-1. 2007
  73. pmc Inactivation of LLC1 gene in nonsmall cell lung cancer
    Kyeong Man Hong
    Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Cancer 120:2353-8. 2007
    ..These results suggest that inactivation of LLC1 by means of promoter methylation is a frequent event in nonsmall cell lung cancer and may play a role in lung tumorigenesis...
  74. ncbi request reprint GLIOGENE an International Consortium to Understand Familial Glioma
    Beatrice Malmer
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Unit 1340, P O Box 301439, Houston, TX 77230 1439, USA
    Cancer Epidemiol Biomarkers Prev 16:1730-4. 2007
    ..Here, we review the rationale for studying familial glioma and our proposed strategy for the GLIOGENE study...
  75. ncbi request reprint A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes
    Dehuang Guo
    Center for Biotechnology and Genomic Medicine, Medical College of Georgia, 1120 15th Street, CA4098, Augusta, Georgia 30912, USA
    Nat Genet 36:837-41. 2004
    ..5 times greater NF kappa B transcriptional activity and approximately 2 times greater expression of IL12B, an NF kappa B-dependent gene. These findings suggest a new pathway that may be implicated in the pathogenesis of T1D...
  76. pmc A gene expression signature predicts survival of patients with stage I non-small cell lung cancer
    Yan Lu
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Med 3:e467. 2006
    ..As a consequence, it is not possible to select those high-risk patients for more aggressive therapies and assign less aggressive treatments to patients at low risk for recurrence...
  77. pmc EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity
    Haris Vikis
    Washington University, St Louis, Missouri, USA
    Cancer Res 67:4665-70. 2007
    ..Our observations show that EGFR-T790M provides a proliferative advantage with respect to WT EGFR and suggest that the enhanced kinase activity of this mutant is the basis for rare cases of inherited susceptibility to lung cancer...
  78. ncbi request reprint DNA microarray analysis of gene expression in human optic nerve head astrocytes in response to hydrostatic pressure
    Ping Yang
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Physiol Genomics 17:157-69. 2004
    ..These HP-responsive genes may be important in the establishment and maintenance of the ONH astrocyte phenotype under conditions of elevated IOP in glaucoma...
  79. ncbi request reprint Gene expression profiles define a key checkpoint for type 1 diabetes in NOD mice
    Sarah E Eckenrode
    Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, Georgia, USA
    Diabetes 53:366-75. 2004
    ....
  80. ncbi request reprint Allelic variants in long-QT disease genes in patients with drug-associated torsades de pointes
    Ping Yang
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn 37232, USA
    Circulation 105:1943-8. 2002
    ..We have previously identified functionally important DNA variants in genes encoding K+ channel ancillary subunits in 11% of an aLQTS cohort...
  81. ncbi request reprint Mutations in the tyrosine kinase domain of the epidermal growth factor receptor in non-small cell lung cancer
    Sei Hoon Yang
    Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute NIH, 41 Library Drive, Bethesda, MD 20892, USA
    Clin Cancer Res 11:2106-10. 2005
    ..Screening subjects with EGFR mutations may identify patients whose tumors could respond to targeted therapy using tyrosine kinase inhibitors...
  82. pmc Identification of a novel tumor suppressor gene p34 on human chromosome 6q25.1
    Min Wang
    School of Medicine, Washington University, 660 Euclid Avenue, St Louis, MO, USA
    Cancer Res 67:93-9. 2007
    ..Our results suggest that p34 may be a novel tumor suppressor gene involved in sporadic lung cancer but it seems not to be the candidate familial lung cancer susceptibility gene linked to chromosomal region 6q23-25...
  83. ncbi request reprint Intergeneration CAG expansion and contraction in a Chinese HD family
    Yanping Tang
    Department of Cell Biology and Genetics, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China
    Am J Med Genet B Neuropsychiatr Genet 141:242-4. 2006
    ..Our results are consistent with previous observations in Western Caucasians that juvenile-onset HD is more likely inherited through the male germline...
  84. ncbi request reprint Myeloperoxidase G-463A polymorphism and lung cancer: a HuGE genetic susceptibility to environmental carcinogens pooled analysis
    Emanuela Taioli
    University of Pittsburgh, Cancer Institute, Pittsburgh, Pensylvania 15232, USA
    Genet Med 9:67-73. 2007
    ..The myeloperoxidase G-463A polymorphism was significantly protective in "ever" smokers but not in "never" smokers. Myeloperoxidase is a key enzyme in tobacco-induced carcinogenesis...
  85. pmc Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival
    Maria Teresa Landi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, Maryland, USA
    PLoS ONE 3:e1651. 2008
    ..Tobacco smoking is responsible for over 90% of lung cancer cases, and yet the precise molecular alterations induced by smoking in lung that develop into cancer and impact survival have remained obscure...
  86. pmc Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer
    Pengyuan Liu
    Washington University, St Louis, MO 63110, USA
    J Natl Cancer Inst 100:1326-30. 2008
    ..67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects. Thus, further research to elucidate causal variants in the 15q24-25.1 locus that are associated with lung cancer is warranted...
  87. pmc Salivary gland-type lung carcinomas: an EGFR immunohistochemical, molecular genetic, and mutational analysis study
    Ricardo S Macarenco
    CIPAX, Medicina Diagnostica, Sao Jose dos Campos, Sao Paulo, Brazil
    Mod Pathol 21:1168-75. 2008
    ..Immunoexpression of epidermal growth factor receptor in salivary gland-type lung carcinomas is not related to epidermal growth factor receptor gene copy number or mutational status...
  88. pmc Distinguishing lung tumours from normal lung based on a small set of genes
    Tatiana Dracheva
    Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Lung Cancer 55:157-64. 2007
    ....
  89. ncbi request reprint Gene-expression profiling in lung cancer: still early days
    Ping Yang
    Pharmacogenomics 8:129-32. 2007
  90. ncbi request reprint The orphan nuclear receptor DHR38 influences transcription of the DOPA decarboxylase gene in epidermal and neural tissues of Drosophila melanogaster
    Monica M Davis
    Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada
    Genome 50:1049-60. 2007
    ..Ectopic expression of DHR38 throughout the CNS induced as much as a 20-fold increase in Ddc transcripts in the set of neurons in which DDC normally appears...
  91. ncbi request reprint Multivariate analysis in clinical monitoring: detection of intraoperative hemorrhage and light anesthesia
    Ping Yang
    Department of Electrical and Computer Engineering, University of British Columbia, Vancouver BC, Canada
    Conf Proc IEEE Eng Med Biol Soc 2007:6216-9. 2007
    ..The results show that although the detection schemes based on PCA and FA both reduce dimensionality and detect changes in the variance, the FA-based method performs better in detecting subtle changes in the correlation structure...
  92. ncbi request reprint Tissue differential microarray analysis of dexamethasone induction reveals potential mechanisms of steroid glaucoma
    Wayne R Lo
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA
    Invest Ophthalmol Vis Sci 44:473-85. 2003
    ..To search for genes highly expressed in dexamethasone (DEX)-induced HTM cells that are barely expressed or absent in DEX-induced cells from other tissues...
  93. ncbi request reprint Clinical, genetic, and biophysical characterization of a homozygous HERG mutation causing severe neonatal long QT syndrome
    Walter H Johnson
    Department of Pediatrics, L M Bargeron Division of Pediatric Cardiology, University of Alabama at Birmingham, USA
    Pediatr Res 53:744-8. 2003
    ..The homozygous mutation results in absence of functional IKr, causing a profound loss of HERG channel function, creating the equivalent of a "HERG knockout" and leading to a severe phenotype...
  94. ncbi request reprint Re: chronic disease mortality in a cohort of smokeless tobacco users
    Jon O Ebbert
    Am J Epidemiol 158:1021; author reply 1021-2. 2003
  95. ncbi request reprint Common sodium channel promoter haplotype in asian subjects underlies variability in cardiac conduction
    Connie R Bezzina
    Experimental and Molecular Cardiology Group, Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circulation 113:338-44. 2006
    ..In this study, we tested the hypothesis that an SCN5A promoter polymorphism common in Asians modulates variability in cardiac conduction...
  96. pmc Recombination as a mechanism for sporadic mutation in the surfactant protein-C gene
    Amy D McBee
    Division of Newborn Medicine, Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA
    Pediatr Pulmonol 43:443-50. 2008
    ..To determine haplotype background of common mutations in the genes encoding surfactant proteins B and C (SFTPB and SFTPC) and to assess recombination in SFTPC...
  97. ncbi request reprint A quinone isolated from the nest of Vespa simillima and its growth-inhibitory effect on rat liver cancer cells
    Yumiko Fujiwara
    Graduate School of Agriculture, Iwate University, 3 18 8 Ueda, Morioka, Iwate 020 8550, Japan
    Biol Pharm Bull 31:722-5. 2008
    ..9 microM). Morphological analyses of dRLh84 cells using the synthetic compound were tested. Chromatin coagulation was induced by the synthetic compound at 31.6 muM...
  98. ncbi request reprint Molecular pathways altered by insulin b9-23 immunization
    Sarah E Eckenrode
    CBGM, Medical College of Georgia, 1120 15th Street, CA 4124, Augusta, GA 30912, USA
    Ann N Y Acad Sci 1037:175-85. 2004
    ..Furthermore, our studies discovered two genes (Irf4 and Tra1) with increased expression in B9-23-treated mice that promote the Th2 response, providing a molecular basis for the B9-23-protective therapy...

Research Grants23

  1. Genetic Determinants of Lung Cancer Survival
    Ping Yang; Fiscal Year: 2009
    ..Our ultimate goal is to build comprehensive and clinically useful models in designing patient-specific treatment plans and in predicting patients' treatment response and survival. ..
  2. ALPHA 1 AD CARRIERS AND LUNG CANCER RISK
    Ping Yang; Fiscal Year: 2001
    ....
  3. Health and QOL among Long-Term Lung Cancer Survivors
    Ping Yang; Fiscal Year: 2007
    ....
  4. Alpha-1 AD Carriers and Lung Cancer Risk
    Ping Yang; Fiscal Year: 2009
    ..abstract_text> ..
  5. Health and QOL among Long-Term Lung Cancer Survivors
    Ping Yang; Fiscal Year: 2009
    ....
  6. Genetic Determinants of Lung Cancer Survival
    Ping Yang; Fiscal Year: 2010
    ..Our ultimate goal is to build comprehensive and clinically useful models in designing patient-specific treatment plans and in predicting patients'treatment response and survival. ..
  7. Health and QOL among Long-Term Lung Cancer Survivors
    Ping Yang; Fiscal Year: 2010
    ....
  8. Alpha-1 AD Carriers and Lung Cancer Risk
    Ping Yang; Fiscal Year: 2007
    ..abstract_text> ..
  9. Genetic Determinants of Lung Cancer Survival
    Ping Yang; Fiscal Year: 2007
    ..Our ultimate goal is to build comprehensive and clinically useful models in designing patient-specific treatment plans and in predicting patients' treatment response and survival. ..
  10. Alpha-1 AD Carriers and Lung Cancer Risk
    Ping Yang; Fiscal Year: 2006
    ..abstract_text> ..
  11. Genetic Determinants of Lung Cancer Survival
    Ping Yang; Fiscal Year: 2001
    ..Through this project, we will establish a valuable data resource and an infrastructure to study promising biological markers for short- and long-term prognosis of lung cancer patients. ..
  12. ALPHA 1 AD CARRIERS AND LUNG CANCER RISK
    Ping Yang; Fiscal Year: 2002
    ....
  13. Genetic Determinants of Lung Cancer Survival
    Ping Yang; Fiscal Year: 2002
    ..Through this project, we will establish a valuable data resource and an infrastructure to study promising biological markers for short- and long-term prognosis of lung cancer patients. ..
  14. ALPHA 1 AD CARRIERS AND LUNG CANCER RISK
    Ping Yang; Fiscal Year: 2003
    ....
  15. Genetic Determinants of Lung Cancer Survival
    Ping Yang; Fiscal Year: 2003
    ..Through this project, we will establish a valuable data resource and an infrastructure to study promising biological markers for short- and long-term prognosis of lung cancer patients. ..
  16. Genetic Determinants of Lung Cancer Survival
    Ping Yang; Fiscal Year: 2004
    ..Through this project, we will establish a valuable data resource and an infrastructure to study promising biological markers for short- and long-term prognosis of lung cancer patients. ..
  17. Genetic Determinants of Lung Cancer Survival
    Ping Yang; Fiscal Year: 2005
    ..Through this project, we will establish a valuable data resource and an infrastructure to study promising biological markers for short- and long-term prognosis of lung cancer patients. ..
  18. Alpha-1 AD Carriers and Lung Cancer Risk
    Ping Yang; Fiscal Year: 2005
    ..abstract_text> ..
  19. Health and QOL among Long-Term Lung Cancer Survivors
    Ping Yang; Fiscal Year: 2006
    ....
  20. Alpha-1 AD Carriers and Lung Cancer Risk
    Ping Yang; Fiscal Year: 2009
    ..abstract_text> ..