ANTHONY JOHN WINDEBANK

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi request reprint Cell death in the peripheral nervous system: potential rescue strategies
    Anthony J Windebank
    Department of Neurology, Mayo Medical School, Rochester, Minnesota 55905, USA
    Neuroscientist 8:62-72. 2002
  2. pmc Transient Receptor Potential Vanilloid 1 is essential for cisplatin-induced heat hyperalgesia in mice
    Lauren E Ta
    Program in Molecular Neuroscience, Mayo Graduate School, Mayo Clinic, College of Medicine, Rochester, MN 55905, USA
    Mol Pain 6:15. 2010
  3. pmc Mice with cisplatin and oxaliplatin-induced painful neuropathy develop distinct early responses to thermal stimuli
    Lauren E Ta
    Program in Molecular Neuroscience, Mayo Graduate School and Cellular Neurobiology Laboratory, Department of Neurology, Mayo Clinic, College of Medicine, Rochester, MN 55905, USA
    Mol Pain 5:9. 2009
  4. ncbi request reprint Chemotherapeutic neuropathy
    A J Windebank
    Mayo Medical Center, Rochester, MN 55905, USA
    Curr Opin Neurol 12:565-71. 1999
  5. ncbi request reprint Role of insulin-like growth factor-I in the treatment of painful small fiber predominant neuropathy
    Anthony J Windebank
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Peripher Nerv Syst 9:183-9. 2004
  6. doi request reprint Chemotherapy-induced neuropathy
    Anthony J Windebank
    Division of Neuroscience, Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Peripher Nerv Syst 13:27-46. 2008
  7. doi request reprint Electrophysiologic findings and grip strength after nerve injuries in the rat forelimb
    Huan Wang
    Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA
    Muscle Nerve 38:1254-65. 2008
  8. ncbi request reprint A 15-year follow-up of neuromuscular function in patients with prior poliomyelitis
    Eric J Sorenson
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 64:1070-2. 2005
  9. ncbi request reprint History of standard scoring, notation, and summation of neuromuscular signs. A current survey and recommendation
    Peter J Dyck
    Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    J Peripher Nerv Syst 10:158-73. 2005
  10. ncbi request reprint Incidence of adaptive equipment use in subjects with a remote history of paralytic poliomyelitis
    Eric J Sorenson
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 65:963. 2005

Research Grants

  1. MECHANISMS OF NEURONAL DEATH AND NEUROPROTECTION
    Anthony Windebank; Fiscal Year: 2007
  2. Biodegradable Polymer Implants for Spinal Cord Repair
    Anthony Windebank; Fiscal Year: 2006
  3. MECHANISMS OF NEURONAL DEATH AND NEUROPROTECTION
    Anthony Windebank; Fiscal Year: 2004
  4. MECHANISMS OF NEURONAL DEATH AND NEUROPROTECTION
    ANTHONY JOHN WINDEBANK; Fiscal Year: 2010

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Cell death in the peripheral nervous system: potential rescue strategies
    Anthony J Windebank
    Department of Neurology, Mayo Medical School, Rochester, Minnesota 55905, USA
    Neuroscientist 8:62-72. 2002
    ..It leads to orderly disassembly of the cell. Advances in understanding of the pathways from specific disease to neuronal death are leading to new strategies designed to prevent death and treat diseases of the nervous system...
  2. pmc Transient Receptor Potential Vanilloid 1 is essential for cisplatin-induced heat hyperalgesia in mice
    Lauren E Ta
    Program in Molecular Neuroscience, Mayo Graduate School, Mayo Clinic, College of Medicine, Rochester, MN 55905, USA
    Mol Pain 6:15. 2010
    ..The mechanisms underlying painful platinum-induced neuropathy remain poorly understood. Previous studies have demonstrated important roles for TRPV1, TRPM8, and TRPA1 in inflammation and nerve injury induced pain...
  3. pmc Mice with cisplatin and oxaliplatin-induced painful neuropathy develop distinct early responses to thermal stimuli
    Lauren E Ta
    Program in Molecular Neuroscience, Mayo Graduate School and Cellular Neurobiology Laboratory, Department of Neurology, Mayo Clinic, College of Medicine, Rochester, MN 55905, USA
    Mol Pain 5:9. 2009
    ..Thirty to forty percent of cancer patients receiving these agents develop pain and sensory loss. Oxaliplatin induces distinctive cold-associated dysesthesias in up to 80% of patients...
  4. ncbi request reprint Chemotherapeutic neuropathy
    A J Windebank
    Mayo Medical Center, Rochester, MN 55905, USA
    Curr Opin Neurol 12:565-71. 1999
    ..A better understanding of cellular mechanisms will lead to novel treatment strategies that will protect neurons without decreasing therapeutic efficacy...
  5. ncbi request reprint Role of insulin-like growth factor-I in the treatment of painful small fiber predominant neuropathy
    Anthony J Windebank
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Peripher Nerv Syst 9:183-9. 2004
    ..Analysis of secondary endpoints and a global impression of improvement by patients and physicians did not show consistent differences between the groups. IGF-I was safe, but did not improve symptoms in this 6-month trial...
  6. doi request reprint Chemotherapy-induced neuropathy
    Anthony J Windebank
    Division of Neuroscience, Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Peripher Nerv Syst 13:27-46. 2008
    ..In patients with neuropathy, restorative approaches have not been well established. Symptomatic and other management are necessary to maintain and improve quality of life...
  7. doi request reprint Electrophysiologic findings and grip strength after nerve injuries in the rat forelimb
    Huan Wang
    Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA
    Muscle Nerve 38:1254-65. 2008
    ..We conclude that it is possible to conduct minimally invasive electrophysiologic testing in rat forelimbs. The CMAP is a valid parameter that shows the typical time course of nerve regeneration and reinnervation...
  8. ncbi request reprint A 15-year follow-up of neuromuscular function in patients with prior poliomyelitis
    Eric J Sorenson
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 64:1070-2. 2005
    ..There was no association between symptoms of late deterioration and magnitude of decline. Rather, the presence of these symptoms was associated with the magnitude of the residual deficits...
  9. ncbi request reprint History of standard scoring, notation, and summation of neuromuscular signs. A current survey and recommendation
    Peter J Dyck
    Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    J Peripher Nerv Syst 10:158-73. 2005
    ..representing increasing impairment based on the judgment of percentage abnormality with corrections made for age, sex, physical fitness, and physical characteristics...
  10. ncbi request reprint Incidence of adaptive equipment use in subjects with a remote history of paralytic poliomyelitis
    Eric J Sorenson
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 65:963. 2005
  11. ncbi request reprint Cisplatin preferentially binds to DNA in dorsal root ganglion neurons in vitro and in vivo: a potential mechanism for neurotoxicity
    Elizabeth S McDonald
    Molecular Neuroscience Program, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Neurobiol Dis 18:305-13. 2005
    ..In addition, disproportionate platinum accumulation may explain why a drug aimed at killing rapidly dividing cells causes sensory neurotoxicity...
  12. ncbi request reprint Electrophysiological findings in a cohort of old polio survivors
    Eric J Sorenson
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    J Peripher Nerv Syst 11:241-6. 2006
    ..Of these two models of neuron loss, the proportional loss of motor neurons was a better fit of the data than a linear loss...
  13. ncbi request reprint Motor unit number estimates correlate with strength in polio survivors
    Eric J Sorenson
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Muscle Nerve 34:608-13. 2006
    ..These findings confirm the clinical relevance of MUNE as an outcome measure in the motor neuron diseases and provide further validation for its use in clinical trial research...
  14. pmc SEPT9 mutations and a conserved 17q25 sequence in sporadic and hereditary brachial plexus neuropathy
    Christopher J Klein
    Peripheral Neuropathy Research Laboratory, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Arch Neurol 66:238-43. 2009
    ..These mutations were not found in North American kindreds with H-BPN with a conserved 500-kilobase sequence of DNA at the 17q25 chromosomal region (where SEPT9 localizes) where a founder mutation has been suggested...
  15. ncbi request reprint Cisplatin-induced apoptosis of DRG neurons involves bax redistribution and cytochrome c release but not fas receptor signaling
    Elizabeth S McDonald
    Molecular Neuroscience Program, Mayo Graduate School, Rochester, Minnesota 55905, USA
    Neurobiol Dis 9:220-33. 2002
    ..This demonstrates for the first time that cisplatin does not signal for death via the fas pathway, but it does initiate the mitochondrial stress pathway in neurons and that NGF blocks death upstream of bax redistribution...
  16. ncbi request reprint Diabetic and nondiabetic lumbosacral radiculoplexus neuropathies: new insights into pathophysiology and treatment
    P James B Dyck
    Peripheral Neuropathy Research Laboratory, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Muscle Nerve 25:477-91. 2002
    ..It is likely that DLRPN and LRPN are immune-mediated neuropathies that should be separated from chronic inflammatory demyelinating polyneuropathy and from systemic necrotizing vasculitis...
  17. ncbi request reprint Prospective 15-year study of neuromuscular function in a cohort of patients with prior poliomyelitis
    Jasper R Daube
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Suppl Clin Neurophysiol 60:197-201. 2009
    ..There was an association with reported weakness and initial deficits. There was a slow decline in MUNE values over time in both groups...
  18. ncbi request reprint Neurotoxicity of oxaliplatin and cisplatin for dorsal root ganglion neurons correlates with platinum-DNA binding
    Lauren E Ta
    Molecular Neuroscience Program and Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurotoxicology 27:992-1002. 2006
    ..Our results demonstrate that both compounds cause apoptosis of DRG neurons but compared to cisplatin, oxaliplatin forms fewer Pt-DNA adducts and is less neurotoxic to DRG neurons in vitro...
  19. ncbi request reprint Biodegradable polymer grafts for surgical repair of the injured spinal cord
    Jonathan A Friedman
    Department of Neurologic Surgery, Mayo Clinic, and Mayo Medical School and Mayo Foundation, Rochester, Minnesota, USA
    Neurosurgery 51:742-51; discussion 751-2. 2002
    ....
  20. ncbi request reprint Acute glucose deprivation leads to apoptosis in a cell model of acute diabetic neuropathy
    Hiroyuki Honma
    Molecular Neuroscience PhD Program, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Peripher Nerv Syst 8:65-74. 2003
    ..Our aims were to better understand the mechanisms underlying peripheral neuropathy with diabetes mellitus and to test the hypothesis that acute lowering of glucose levels induces apoptosis in hypoxic neurons...
  21. ncbi request reprint Phase I and pharmacokinetic study of two different schedules of oxaliplatin, irinotecan, Fluorouracil, and leucovorin in patients with solid tumors
    Matthew P Goetz
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    J Clin Oncol 21:3761-9. 2003
    ..Additionally, we investigated the effect of CPT-11 on oxaliplatin pharmacokinetics...
  22. doi request reprint Cisplatin and dimethyl sulfoxide react to form an adducted compound with reduced cytotoxicity and neurotoxicity
    Stephanie J Fischer
    Molecular Neuroscience Program, Mayo Graduate School, Mayo Clinic, Rochester, MN 55905, USA
    Neurotoxicology 29:444-52. 2008
    ..We present work that demonstrates that cisplatin reacts rapidly with dimethyl sulfoxide (DMSO) in solution and identify the structure and reactivity of the resulting compound...
  23. ncbi request reprint Multiple-channel scaffolds to promote spinal cord axon regeneration
    Michael J Moore
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Biomaterials 27:419-29. 2006
    ..Axon regeneration was demonstrated by three-dimensional reconstruction of serial histological sections...
  24. pmc Neural stem cell- and Schwann cell-loaded biodegradable polymer scaffolds support axonal regeneration in the transected spinal cord
    Heather E Olson
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Tissue Eng Part A 15:1797-805. 2009
    ..Further, these multichannel biodegradable polymer scaffolds effectively serve as platforms for quantitative analysis of axonal regeneration...
  25. pmc Relationship between scaffold channel diameter and number of regenerating axons in the transected rat spinal cord
    Aaron J Krych
    Department of Orthopedic Surgery, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Acta Biomater 5:2551-9. 2009
    ..Optimization of this scaffold environment establishes a platform for future studies of the effects of cell types, trophic factors or pharmacological agents on the regenerative capacity of the injured spinal cord...
  26. ncbi request reprint NGF rescues DRG neurons in vitro from oxidative damage produced by hemodialyzers
    Jewel L Podratz
    Program in Molecular Neuroscience, Mayo Graduate School, Rochester, MN, USA
    Neurotoxicology 26:343-50. 2005
    ..NGF protects DRG from this toxin by upregulating antioxidants such as catalase, GPx and GSH...
  27. pmc Misdirection of regenerating motor axons after nerve injury and repair in the rat sciatic nerve model
    Godard C W de Ruiter
    Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA
    Exp Neurol 211:339-50. 2008
    ..The results of this study can be used as basis for developing new nerve repair techniques that may improve the accuracy of regeneration...
  28. ncbi request reprint Guidelines for the diagnosis and treatment of chronic inflammatory demyelinating polyneuropathy
    Alan R Berger
    Department of Neurology, University of Florida, USA
    J Peripher Nerv Syst 8:282-4. 2003
  29. ncbi request reprint Hypoxia-induced apoptosis of dorsal root ganglion neurons is associated with DNA damage recognition and cell cycle disruption in rats
    Hiroyuki Honma
    Department of Neurology, Cellular Neurobiology Laboratory, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Neurosci Lett 354:95-8. 2004
    ..Cell cycle disruption was examined by cyclin D1 expression. Neuronal death was associated with up-regulation of markers associated with DNA damage and aberrant entry into G1 of the cell cycle...
  30. ncbi request reprint Controlled release of NFkappaB decoy oligonucleotides from biodegradable polymer microparticles
    Xun Zhu
    Department of Orthopedic Surgery and Bioengineering, Mayo Clinic, Rochester, MN 55905, USA
    Biomaterials 23:2683-92. 2002
    ..These results suggest that PLGA/PEG microparticles are useful as delivery vehicles for controlled release of ODNs and merit further investigation in cell culture and animal models of glioblastoma...
  31. pmc Importance of the vasculature in cyst formation after spinal cord injury
    Gemma E Rooney
    Department of Neurology and Molecular Neuroscience, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Neurosurg Spine 11:432-7. 2009
    ..The objective of this study was to examine the surgical methods that may be used to assess the factors that influence the level of scar and cystic formation in SCI...
  32. pmc Current tissue engineering and novel therapeutic approaches to axonal regeneration following spinal cord injury using polymer scaffolds
    Nicolas N Madigan
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    Respir Physiol Neurobiol 169:183-99. 2009
    ..Structural support of axonal regeneration is combined with integrated polymeric and cellular delivery systems for therapeutic drugs and for neurotrophic molecules to regionalize growth of specific nerve populations...
  33. pmc Lessons from the Salk polio vaccine: methods for and risks of rapid translation
    Justin E Juskewitch
    Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Clin Transl Sci 3:182-5. 2010
    ..Moreover, we look at the Cutter and Wyeth incidents after the vaccine's approval and the errors that led to them...
  34. pmc Axon regeneration through scaffold into distal spinal cord after transection
    Bing Kun Chen
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Neurotrauma 26:1759-71. 2009
    ..The pattern of myelination, with extracellular collagen and basal lamina, was characteristic of SC myelination. Our results show that FB labeling is an effective way to measure the origin of regenerating axons...
  35. pmc Microtubule destabilization and nuclear entry are sequential steps leading to toxicity in Huntington's disease
    Eugenia Trushina
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic and Foundation, Second Street SW, Rochester, MN 55905, USA
    Proc Natl Acad Sci U S A 100:12171-6. 2003
    ..Primary and reversible toxic events involve destabilization of microtubules mediated by full-length mhtt before cleavage. Restoration of microtubule structure by taxol inhibits nuclear entry and increases cell survival...
  36. ncbi request reprint Antioxidants are necessary for myelination of dorsal root ganglion neurons, in vitro
    Jewel L Podratz
    Molecular Neuroscience Program, Mayo Graduate School and Mayo Medical School, Rochester, Minnesota 55905, USA
    Glia 45:54-8. 2004
    ..Vitamin E may play an important role. Use of a serum-free medium may be beneficial for in vitro myelination studies because serum has unknown inhibitory effects...
  37. pmc Rigid fixation of the spinal column improves scaffold alignment and prevents scoliosis in the transected rat spinal cord
    Gemma E Rooney
    Departments of Neurology and Molecular Neuroscience, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Spine (Phila Pa 1976) 33:E914-9. 2008
    ..A controlled study to evaluate a new technique for spinal rod fixation after spinal cord injury in rats. Alignment of implanted tissue-engineered scaffolds was assessed radiographically and by magnetic resonance imaging...
  38. pmc Stimulation of neurite outgrowth using positively charged hydrogels
    Mahrokh Dadsetan
    Department of Orthopedic Surgery, Mayo Clinic College of Medicine, 200 First Street SW, MS 3 69, Rochester, MN 55905, USA
    Biomaterials 30:3874-81. 2009
    ..These findings suggest that charged OPF hydrogels are capable of sustaining both primary nerve cells and the neural support cells that are critical for regeneration...
  39. pmc Synthesis, material properties, and biocompatibility of a novel self-cross-linkable poly(caprolactone fumarate) as an injectable tissue engineering scaffold
    Esmaiel Jabbari
    Department of Orthopedic Surgery and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, Minnesota 55905, USA
    Biomacromolecules 6:2503-11. 2005
    ..Our results suggest that this novel copolymer, PCLF, is an injectable, self-cross-linkable, and biocompatible macromer that may be potentially used as a scaffold for tissue engineering applications...
  40. ncbi request reprint Suppression of neurite outgrowth by high-dose nerve growth factor is independent of functional p75NTR receptors
    Anna M Conti
    Department of Neurology, Mayo Clinic, College of Medicine, Rochester, MN 55905, USA
    Neurobiol Dis 15:106-14. 2004
    ..Downstream signaling showed sustained hyperphosphorylation of MAPK (Erk(1-2)) but not of SNT or Akt. High-dose NGF may induce cytoplasmic relocation of the receptor TrkA and axonal growth arrest independently of p75NTR...
  41. ncbi request reprint Methods for in vitro characterization of multichannel nerve tubes
    Godard C de Ruiter
    Cellular Neurobiology Laboratory, Mayo Clinic, Rochester, Minnesota, USA
    J Biomed Mater Res A 84:643-51. 2008
    ..The methods presented in this study can be used as a basis for optimizing these properties for future, possibly clinical, application...
  42. pmc The development of electrically conductive polycaprolactone fumarate-polypyrrole composite materials for nerve regeneration
    M Brett Runge
    Department of Orthopedic Surgery, Mayo Clinic College of Medicine, Rochester MN 55905, USA
    Biomaterials 31:5916-26. 2010
    ..In vitro studies using PC12 cells and DRG show PCLF-PPy materials synthesized with NSA or DBSA support cell attachment, proliferation, neurite extension, and are promising materials for future studies involving electrical stimulation...
  43. ncbi request reprint Effects of NFkappaB decoy oligonucleotides released from biodegradable polymer microparticles on a glioblastoma cell line
    Jagjit S Gill
    Molecular Neuroscience Program, Mayo Clinic, Rochester, MN 55905, USA
    Biomaterials 23:2773-81. 2002
    ..These findings offer a potential therapeutic strategy in the control of human GBM cell line growth in vitro and suggest that PLGA microparticles may be appropriate as delivery vehicles for the "decoy" ODN strategy...
  44. ncbi request reprint Two-dimensional digital video ankle motion analysis for assessment of function in the rat sciatic nerve model
    Godard C de Ruiter
    Department of Neurologic Surgery, Mayo Clinic, Rochester, MN 55905, USA
    J Peripher Nerv Syst 12:216-22. 2007
    ..2D digital video ankle motion analysis is a practical and sensitive method to assess function in the rat sciatic nerve model...
  45. pmc Accuracy of motor axon regeneration across autograft, single-lumen, and multichannel poly(lactic-co-glycolic acid) nerve tubes
    Godard C de Ruiter
    Cellular Neurobiology Laboratory and Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Neurosurgery 63:144-53; discussion 153-5. 2008
    ..We also present the concept of the multichannel nerve tube that may limit dispersion by separately guiding groups of regenerating axons...
  46. doi request reprint Measurement of forelimb function by digital video motion analysis in rat nerve transection models
    Huan Wang
    Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA
    J Peripher Nerv Syst 13:92-102. 2008
    ..2D digital video motion analysis can be used to quantify movement of the wrist and the MP joint in rats. It is a valid method to evaluate functional deficit and recovery after nerve injury and repair in the forelimb...
  47. ncbi request reprint Amyotrophic lateral sclerosis in Olmsted County, Minnesota, 1925 to 1998
    Eric J Sorenson
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 59:280-2. 2002
    ..02). Mean time from symptom onset to diagnosis was 13 months. Neither survival nor time to diagnosis changed significantly over time...
  48. pmc CD8+ T cells cause disability and axon loss in a mouse model of multiple sclerosis
    Chandra Deb
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
    PLoS ONE 5:e12478. 2010
    ..We have previously observed that genetic deletion of the CD8+ T cell effector molecule perforin leads to preservation of motor function and preservation of spinal axons in chronically demyelinated mice...
  49. ncbi request reprint Synthes Award for Resident Research in Spinal Cord & Spinal Column Injury: Surgical repair of the injured spinal cord using biodegradable polymer implants to facilitate axon regeneration
    Jonathan A Friedman
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
    Clin Neurosurg 51:314-9. 2004
  50. pmc Photo-cross-linked hybrid polymer networks consisting of poly(propylene fumarate) and poly(caprolactone fumarate): controlled physical properties and regulated bone and nerve cell responses
    Shanfeng Wang
    Department of Materials Science and Engineering, The University of Tennessee, Knoxville, Tennessee 37996, USA
    Biomacromolecules 9:1229-41. 2008
    ..In addition, the role of mechanical properties such as surface stiffness in modulating cell responses has been emphasized using this model blend system...
  51. ncbi request reprint Methylmercury induces apoptosis in cultured rat dorsal root ganglion neurons
    Russell A Wilke
    Personalized Medicine Center, Marshfield Medical Research Foundation, Marshfield Clinic, Marshfield, WI, USA
    Neurotoxicology 24:369-78. 2003
    ..After 24h, 1 microM methylmercury increased both DNA end-labeling (P<0.01) and nuclear fragmentation (P<0.02). The latter effect appeared to be dose-dependent...
  52. doi request reprint Gene-modified mesenchymal stem cells express functionally active nerve growth factor on an engineered poly lactic glycolic acid (PLGA) substrate
    Gemma E Rooney
    Regenerative Medicine Institute, National University of Ireland, Galway, Ireland
    Tissue Eng Part A 14:681-90. 2008
    ..They are autologous, may be genetically modified to express neurotrophins, and are compatible with polymer surfaces that may be used as a potential delivery system...
  53. ncbi request reprint Paclitaxel toxicity in post-mitotic dorsal root ganglion (DRG) cells
    Arianna Scuteri
    Dipartimento di Neuroscienze e Tecnologie Biomediche, Universita degli Studi di Milano Bicocca, Milano, Italy
    Anticancer Res 26:1065-70. 2006
    ....

Research Grants17

  1. MECHANISMS OF NEURONAL DEATH AND NEUROPROTECTION
    Anthony Windebank; Fiscal Year: 2007
    ..The goal is to develop a mechanism-based therapy that will prevent the major dose-limiting side effect of the platinum compounds. ..
  2. Biodegradable Polymer Implants for Spinal Cord Repair
    Anthony Windebank; Fiscal Year: 2006
    ..Imaging with Micro-CT and MR microscopy will be combined with histological and functional assessments to measure success in promoting regeneration. ..
  3. MECHANISMS OF NEURONAL DEATH AND NEUROPROTECTION
    Anthony Windebank; Fiscal Year: 2004
    ..We will also determine whether the effects of NGF are shared by the other DRG growth factors, brain derived neurotrophic factor (BDNF), and neurotrophin-3 (NT3). ..
  4. MECHANISMS OF NEURONAL DEATH AND NEUROPROTECTION
    ANTHONY JOHN WINDEBANK; Fiscal Year: 2010
    ..The goal is to develop a mechanism-based therapy that will prevent the major dose-limiting side effect of the platinum compounds. ..