J L Whitwell

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi request reprint A longitudinal study of brain volume changes in normal aging using serial registered magnetic resonance imaging
    Rachael I Scahill
    Dementia Research Group, Department of Clinical Neurology, Institute of Neurology, University College London, England
    Arch Neurol 60:989-94. 2003
  2. ncbi request reprint Neuroimaging in dementia
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Neurol Clin 25:843-57, viii. 2007
  3. pmc Microbleeds in the logopenic variant of primary progressive aphasia
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN, USA Electronic address
    Alzheimers Dement 10:62-6. 2014
  4. pmc Neuroimaging comparison of primary progressive apraxia of speech and progressive supranuclear palsy
    J L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Eur J Neurol 20:629-37. 2013
  5. pmc Distinct regional anatomic and functional correlates of neurodegenerative apraxia of speech and aphasia: an MRI and FDG-PET study
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Brain Lang 125:245-52. 2013
  6. doi request reprint Imaging measures predict progression in progressive supranuclear palsy
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Mov Disord 27:1801-4. 2012
  7. pmc Frontal asymmetry in behavioral variant frontotemporal dementia: clinicoimaging and pathogenetic correlates
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Neurobiol Aging 34:636-9. 2013
  8. pmc Comparison of imaging biomarkers in the Alzheimer Disease Neuroimaging Initiative and the Mayo Clinic Study of Aging
    Jennifer L Whitwell
    Department of Radiology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Arch Neurol 69:614-22. 2012
  9. pmc Recent advances in the imaging of frontotemporal dementia
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
    Curr Neurol Neurosci Rep 12:715-23. 2012
  10. pmc Neuroimaging correlates of pathologically defined subtypes of Alzheimer's disease: a case-control study
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Lancet Neurol 11:868-77. 2012

Detail Information

Publications83

  1. ncbi request reprint A longitudinal study of brain volume changes in normal aging using serial registered magnetic resonance imaging
    Rachael I Scahill
    Dementia Research Group, Department of Clinical Neurology, Institute of Neurology, University College London, England
    Arch Neurol 60:989-94. 2003
    ..To investigate the effect of age on global and regional brain volumes and rates of atrophy, and to compare directly results based on cross-sectional and longitudinal data...
  2. ncbi request reprint Neuroimaging in dementia
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Neurol Clin 25:843-57, viii. 2007
    ..The most important development in the field over the past decade is the ability to image amyloid in the brain. This technique will revolutionize patient management and care...
  3. pmc Microbleeds in the logopenic variant of primary progressive aphasia
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN, USA Electronic address
    Alzheimers Dement 10:62-6. 2014
    ..We aimed to assess the presence and clinical correlates of microbleeds in lvPPA...
  4. pmc Neuroimaging comparison of primary progressive apraxia of speech and progressive supranuclear palsy
    J L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Eur J Neurol 20:629-37. 2013
    ..We aimed to compare, for the first time, atrophy patterns, as well as white matter tract degeneration, between these two syndromes...
  5. pmc Distinct regional anatomic and functional correlates of neurodegenerative apraxia of speech and aphasia: an MRI and FDG-PET study
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Brain Lang 125:245-52. 2013
    ..Progressive agrammatic aphasia and AOS have non-overlapping regional correlations, suggesting that these are dissociable clinical features that have different neuroanatomical underpinnings...
  6. doi request reprint Imaging measures predict progression in progressive supranuclear palsy
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Mov Disord 27:1801-4. 2012
    ..The aim of this work was to determine whether the progressive supranuclear palsy rating scale, a measure of disease severity, is associated with neuroanatomical changes in progressive supranuclear palsy...
  7. pmc Frontal asymmetry in behavioral variant frontotemporal dementia: clinicoimaging and pathogenetic correlates
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Neurobiol Aging 34:636-9. 2013
    ..These findings therefore suggest that neuroanatomical patterns of frontal lobe atrophy in bvFTD are influenced by specific gene mutations...
  8. pmc Comparison of imaging biomarkers in the Alzheimer Disease Neuroimaging Initiative and the Mayo Clinic Study of Aging
    Jennifer L Whitwell
    Department of Radiology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Arch Neurol 69:614-22. 2012
    ..To determine whether magnetic resonance imaging measurements observed in the Alzheimer Disease Neuroimaging Initiative (ADNI) convenience sample differ from those observed in the Mayo Clinic Study of Aging (MCSA) population-based sample...
  9. pmc Recent advances in the imaging of frontotemporal dementia
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
    Curr Neurol Neurosci Rep 12:715-23. 2012
    ..Importantly, neuroimaging signatures have been identified that will improve the clinician's ability to predict underlying genetic and pathological features, and hence ultimately improve patient diagnosis...
  10. pmc Neuroimaging correlates of pathologically defined subtypes of Alzheimer's disease: a case-control study
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Lancet Neurol 11:868-77. 2012
    ..We aimed to determine whether MRI patterns of atrophy differ between these subtypes and whether structural neuroimaging could be a useful predictor of pathological subtype at autopsy...
  11. pmc Rates of brain atrophy and clinical decline over 6 and 12-month intervals in PSP: determining sample size for treatment trials
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Parkinsonism Relat Disord 18:252-6. 2012
    ..Sample size estimates suggest that treatment trials could be performed over this interval, with rate of midbrain atrophy providing the best outcome measure...
  12. pmc Neuroimaging signatures of frontotemporal dementia genetics: C9ORF72, tau, progranulin and sporadics
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Brain 135:794-806. 2012
    ..Our analysis suggested that imaging has the potential to be useful to help differentiate C9ORF72 from these other groups at the single-subject level...
  13. ncbi request reprint The protective role of brain size in Alzheimer's disease
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA
    Expert Rev Neurother 10:1799-801. 2010
    ..Therefore, these findings support the brain reserve hypothesis. This article will discuss the brain reserve concept and potential limitations and significance of this study...
  14. pmc Gray and white matter water diffusion in the syndromic variants of frontotemporal dementia
    J L Whitwell
    Department of Radiology, Mayo Clinic, Rochester MN 55905, USA
    Neurology 74:1279-87. 2010
    ..To use diffusion tensor imaging (DTI) to assess gray matter and white matter tract diffusion in behavioral variant frontotemporal dementia (bvFTD), semantic dementia (SMD), and progressive nonfluent aphasia (PNFA)...
  15. doi request reprint Progression of atrophy in Alzheimer's disease and related disorders
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
    Neurotox Res 18:339-46. 2010
    ..Hence, longitudinal MRI shows promise as a biomarker of disease progression in neurodegenerative disease...
  16. pmc Distinct anatomical subtypes of the behavioural variant of frontotemporal dementia: a cluster analysis study
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Brain 132:2932-46. 2009
    ..Our findings suggest behavioural variant of frontotemporal dementia can therefore be subdivided into four different anatomical subtypes...
  17. doi request reprint Longitudinal imaging: change and causality
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Curr Opin Neurol 21:410-6. 2008
    ..Longitudinal studies that use MRI scans performed over multiple time-points have been increasingly employed in the study of different neurological disorders, including degenerative dementia, multiple sclerosis, and epilepsy...
  18. pmc Imaging correlates of pathology in corticobasal syndrome
    J L Whitwell
    Department of Radiology, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA
    Neurology 75:1879-87. 2010
    ..The aim of this study was to determine whether patterns of atrophy on imaging could be useful to help predict underlying pathology in CBS...
  19. ncbi request reprint Comparisons between Alzheimer disease, frontotemporal lobar degeneration, and normal aging with brain mapping
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Top Magn Reson Imaging 16:409-25. 2005
    ..This article will review the findings of these studies and discuss the role of VBM in these neurodegenerative diseases...
  20. doi request reprint Assessing subtle structural changes in Alzheimer's disease patients
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN, USA
    Methods Mol Biol 711:535-50. 2011
    ....
  21. pmc Disrupted thalamocortical connectivity in PSP: a resting-state fMRI, DTI, and VBM study
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA
    Parkinsonism Relat Disord 17:599-605. 2011
    ..PSP is therefore associated with disrupted thalamocortical connectivity that is associated with degeneration of the dentatorubrothalamic tract and the presence of cortical atrophy...
  22. pmc Trajectories of brain and hippocampal atrophy in FTD with mutations in MAPT or GRN
    J L Whitwell
    Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Neurology 77:393-8. 2011
    ..To use multiple serial MRI to assess rates and trajectories of brain and hippocampal atrophy in subjects with frontotemporal dementia (FTD) with progranulin (GRN) or microtubule-associated protein tau (MAPT) gene mutations...
  23. pmc Altered functional connectivity in asymptomatic MAPT subjects: a comparison to bvFTD
    J L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 77:866-74. 2011
    ....
  24. pmc Abnormal TDP-43 immunoreactivity in AD modifies clinicopathologic and radiologic phenotype
    K A Josephs
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 70:1850-7. 2008
    ....
  25. pmc Two distinct subtypes of right temporal variant frontotemporal dementia
    K A Josephs
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 73:1443-50. 2009
    ..We aimed to determine whether right temporal FTD is a homogeneous clinical, imaging, and pathologic/genetic entity...
  26. pmc Atrophy patterns in IVS10+16, IVS10+3, N279K, S305N, P301L, and V337M MAPT mutations
    J L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 73:1058-65. 2009
    ..To use a case-control study to assess and compare patterns of gray matter loss across groups of subjects with different mutations in the microtubule-associated protein tau (MAPT) gene...
  27. pmc Risk of dementia in MCI: combined effect of cerebrovascular disease, volumetric MRI, and 1H MRS
    K Kantarci
    Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Neurology 72:1519-25. 2009
    ..To investigate the combined ability of hippocampal volumes, 1H magnetic resonance spectroscopy (MRS) metabolites, and cerebrovascular disease to predict the risk of progression to dementia in mild cognitive impairment (MCI)...
  28. pmc Voxel-based morphometry patterns of atrophy in FTLD with mutations in MAPT or PGRN
    J L Whitwell
    Department of Radiology Research, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 72:813-20. 2009
    ..To compare patterns of gray matter loss in subjects with mutations in the progranulin (PGRN) gene to subjects with mutations in the microtubule-associated protein tau (MAPT) gene...
  29. pmc MRS in presymptomatic MAPT mutation carriers: a potential biomarker for tau-mediated pathology
    K Kantarci
    Departmentsof Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 75:771-8. 2010
    ..To determine the proton magnetic resonance spectroscopy ((1)H MRS) changes in carriers of microtubule-associated protein (MAPT) mutations in a case-control study...
  30. pmc Caudate atrophy on MRI is a characteristic feature of FTLD-FUS
    K A Josephs
    Department of Neurology Behavioral Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Eur J Neurol 17:969-75. 2010
    ..We have observed severe caudate atrophy at autopsy in FTLD-FUS, and hence, we aimed to determine whether caudate atrophy on MRI is a feature that can distinguish FTLD-FUS from FTLD-TDP and FTLD-TAU...
  31. ncbi request reprint Clinicopathologic analysis of frontotemporal and corticobasal degenerations and PSP
    K A Josephs
    Division of Movement Disorders, Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 66:41-8. 2006
    ..To examine the relationship between early clinical features, pathologies, and biochemistry of the frontotemporal lobar degenerations (FTLDs), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD)...
  32. pmc The anatomic correlate of prosopagnosia in semantic dementia
    K A Josephs
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Neurology 71:1628-33. 2008
    ..To determine the anatomic correlate of prosopagnosia in subjects with semantic dementia...
  33. pmc MRI patterns of atrophy associated with progression to AD in amnestic mild cognitive impairment
    J L Whitwell
    Department of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
    Neurology 70:512-20. 2008
    ..To compare the patterns of gray matter loss in subjects with amnestic mild cognitive impairment (aMCI) who progress to Alzheimer disease (AD) within a fixed clinical follow-up time vs those who remain stable...
  34. pmc Does TDP-43 type confer a distinct pattern of atrophy in frontotemporal lobar degeneration?
    J L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 75:2212-20. 2010
    ..To determine whether TDP-43 type is associated with distinct patterns of brain atrophy on MRI in subjects with pathologically confirmed frontotemporal lobar degeneration (FTLD)...
  35. pmc MRI correlates of neurofibrillary tangle pathology at autopsy: a voxel-based morphometry study
    J L Whitwell
    Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Neurology 71:743-9. 2008
    ..We aimed to determine whether patterns of gray matter atrophy from antemortem MRI correlate with Braak staging of NFT pathology...
  36. pmc Progressive aphasia secondary to Alzheimer disease vs FTLD pathology
    K A Josephs
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 70:25-34. 2008
    ..The pathology causing progressive aphasia is typically a variant of frontotemporal lobar degeneration, especially with ubiquitin-positive inclusions (FTLD-U). Less commonly the underlying pathology is Alzheimer disease (AD)...
  37. pmc Midbrain atrophy is not a biomarker of progressive supranuclear palsy pathology
    J L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN, USA
    Eur J Neurol 20:1417-22. 2013
    ..The aim of the present study was to determine whether midbrain atrophy is a useful biomarker of PSP pathology, or whether it is only associated with typical PSPS...
  38. ncbi request reprint Survival in two variants of tau-negative frontotemporal lobar degeneration: FTLD-U vs FTLD-MND
    K A Josephs
    Department of Neurology, Mayo Clinic, 200 First St S W, Rochester, MN 55905, USA
    Neurology 65:645-7. 2005
    ..An analysis of patient outcomes in these cases reveals that FTLD-MND has significantly shorter survival than FTLD-U, suggesting that FTLD-MND is a more aggressive disease process...
  39. pmc Voxel-based morphometry in patients with obsessive-compulsive behaviors in behavioral variant frontotemporal dementia
    D C Perry
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    Eur J Neurol 19:911-7. 2012
    ..Obsessions and compulsive (OC) behaviors are a frequent feature of behavioral variant frontotemporal dementia (bvFTD), but their structural correlates have not been definitively established...
  40. pmc Rates of cerebral atrophy differ in different degenerative pathologies
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic Rochester, Rochester, MN 55905, USA
    Brain 130:1148-58. 2007
    ....
  41. pmc 3D maps from multiple MRI illustrate changing atrophy patterns as subjects progress from mild cognitive impairment to Alzheimer's disease
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
    Brain 130:1777-86. 2007
    ..These results also suggest that 3D patterns of grey matter atrophy may help to predict the time to the first diagnosis of AD in subjects with aMCI...
  42. doi request reprint Neuroanatomical correlates of the progressive supranuclear palsy corticobasal syndrome hybrid
    K A Josephs
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Eur J Neurol 19:1440-6. 2012
    ..We refer to subjects with this presentation as Hybrids. The hybrid presentation is not rare, yet there are no studies that have assessed the neuroanatomical correlates of the hybrid syndrome to explain its occurrence...
  43. pmc Focal atrophy in dementia with Lewy bodies on MRI: a distinct pattern from Alzheimer's disease
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Brain 130:708-19. 2007
    ..Damage to this network of structures in DLB may affect a number of different neurotransmitter systems which in turn may contribute to a number of the core clinical features of DLB...
  44. pmc Patterns of atrophy differ among specific subtypes of mild cognitive impairment
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Arch Neurol 64:1130-8. 2007
    ..It follows, however, that subjects with MCI who have impairment in nonmemory domains may progress to non-AD degenerative dementias...
  45. pmc Rates of brain atrophy over time in autopsy-proven frontotemporal dementia and Alzheimer disease
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Neuroimage 39:1034-40. 2008
    ..The trajectories of brain and ventricular changes were similar in AD and FTLD-U suggesting that it is independent of pathology, although subjects with FTLD-U show a more rapidly progressive decline...
  46. doi request reprint Clinical and imaging characterization of progressive spastic dysarthria
    H M Clark
    Division of Speech Pathology, Department of Neurology, Mayo Clinic, Rochester, MN, USA
    Eur J Neurol 21:368-76. 2014
    ..To describe speech, neurological and imaging characteristics of a series of patients presenting with progressive spastic dysarthria as the first and predominant sign of a presumed neurodegenerative disease...
  47. pmc Clinicopathological and imaging correlates of progressive aphasia and apraxia of speech
    Keith A Josephs
    Department of Neurology, Division of Movement Disorders and Behavioral Neurology, Mayo Clinic, Rochester, MN 55905
    Brain 129:1385-98. 2006
    ..Refining the classification of the degenerative aphasias and AOS may be necessary to improve our understanding of the relationships among behavioural, pathological and imaging correlations...
  48. ncbi request reprint Frontotemporal lobar degeneration without lobar atrophy
    Keith A Josephs
    Department of Neurology, Division of Behavioral Neurology and Movement Disorders, Mayo Clinic, Rochester, MN 55905, USA
    Arch Neurol 63:1632-8. 2006
    ..Neuronal loss and gliosis in cornu ammonis 1 and the subiculum of the hippocampus are features of hippocampal sclerosis (HpScl), which occurs in many cases of FTLD-U...
  49. pmc Anatomic correlates of stereotypies in frontotemporal lobar degeneration
    Keith A Josephs
    Department of Neurology, Behavioral Neurology and Movement Disorders, Mayo Clinic, Rochester, MN 55905, United States
    Neurobiol Aging 29:1859-63. 2008
    ..Stereotypies in FTLD are therefore associated with a greater proportion of striatal to cortical volume loss than those without stereotypies...
  50. pmc Voxel-based morphometry in autopsy proven PSP and CBD
    Keith A Josephs
    Department of Neurology Movement Disorders, Mayo Clinic, Rochester, MN 55905, USA
    Neurobiol Aging 29:280-9. 2008
    ..These results show regional differences between PSP and CBD that are useful in predicting the underlying pathology, and help to shed light on the in vivo distribution of regional atrophy in PSP and CBD...
  51. pmc Predicting functional decline in behavioural variant frontotemporal dementia
    Keith A Josephs
    Department of Neurology Behavioural Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Brain 134:432-48. 2011
    ....
  52. ncbi request reprint Rates of cerebral atrophy in autopsy-confirmed progressive supranuclear palsy
    Keith A Josephs
    Department of Neurology, Mayo Clinic, 200 First Street NW, Rochester, MN 55905, USA
    Ann Neurol 59:200-3. 2006
    ..To determine the rates of cerebral atrophy and ventricular expansion in six patients with autopsy confirmed progressive supranuclear palsy (PSP) and multiple antemortem volumetric head MRI scans...
  53. pmc Visual hallucinations in posterior cortical atrophy
    Keith A Josephs
    Divisions of Movement Disorders and Behavioral Neurology, Department of Neurology, Mayo Clinic, Rochester, Minn, USA
    Arch Neurol 63:1427-32. 2006
    ..It is not known, however, whether patients who meet the criteria for PCA and have hallucinations are different from those who meet the criteria and do not have hallucinations...
  54. doi request reprint Gray matter correlates of behavioral severity in progressive supranuclear palsy
    Keith A Josephs
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Mov Disord 26:493-8. 2011
    ..Behavioral changes occur in progressive supranuclear palsy. This study aimed to identify the anatomic correlate of behavioral severity in progressive supranuclear palsy...
  55. pmc Imaging correlates of posterior cortical atrophy
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Neurobiol Aging 28:1051-61. 2007
    ..1)H MRS suggested loss of neuronal integrity and glial activation in subjects with PCA and typical AD. The differing patterns of atrophy on MRI suggest that PCA should be considered a distinct entity from typical AD...
  56. pmc Anatomical differences between CBS-corticobasal degeneration and CBS-Alzheimer's disease
    Keith A Josephs
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Mov Disord 25:1246-52. 2010
    ..In subjects presenting with CBS, prominent temporoparietal, especially posterior temporal and inferior parietal, atrophy may be a clue to the presence of underlying AD pathology...
  57. doi request reprint Fluorodeoxyglucose F18 positron emission tomography in progressive apraxia of speech and primary progressive aphasia variants
    Keith A Josephs
    Department of Neurology, Division of Behavioral Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Arch Neurol 67:596-605. 2010
    ....
  58. pmc Hippocampal volumes, proton magnetic resonance spectroscopy metabolites, and cerebrovascular disease in mild cognitive impairment subtypes
    Kejal Kantarci
    Department of Diagnostic Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Arch Neurol 65:1621-8. 2008
    ..Noninvasive imaging surrogates for underlying pathological findings in MCI would be clinically useful for identifying patients who may benefit from disease-specific treatments at the prodromal stage of dementia...
  59. pmc Voxel-based morphometry in frontotemporal lobar degeneration with ubiquitin-positive inclusions with and without progranulin mutations
    Jennifer L Whitwell
    Division of Behavioral Neurology, Department of Neurology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Arch Neurol 64:371-6. 2007
    ..Mutations in the progranulin gene (PGRN) have recently been identified as a cause of frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) in some families...
  60. pmc Symmetric corticobasal degeneration (S-CBD)
    Anhar Hassan
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    Parkinsonism Relat Disord 16:208-14. 2010
    ..Asymmetry is also emphasized on neuroimaging...
  61. pmc Beta-amyloid burden is not associated with rates of brain atrophy
    Keith A Josephs
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Ann Neurol 63:204-12. 2008
    ..To test the hypothesis that beta-amyloid (Abeta) burden is associated with rates of brain atrophy...
  62. pmc Alzheimer disease: postmortem neuropathologic correlates of antemortem 1H MR spectroscopy metabolite measurements
    Kejal Kantarci
    Departments of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Radiology 248:210-20. 2008
    ..To determine the neuropathologic correlates of antemortem hydrogen 1 ((1)H) magnetic resonance (MR) spectroscopy metabolite measurements in subjects with Alzheimer disease (AD)-type pathology...
  63. pmc Antemortem differential diagnosis of dementia pathology using structural MRI: Differential-STAND
    Prashanthi Vemuri
    Department of Radiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Neuroimage 55:522-31. 2011
    ..8%). The proposed approach establishes a direct a priori relationship between specific topographic patterns on MRI and "gold standard" of pathology which can then be used to predict underlying dementia pathology in new incoming patients...
  64. pmc Clinical and imaging features of Othello's syndrome
    J Graff-Radford
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Eur J Neurol 19:38-46. 2012
    ..Our objective was to document the clinical and imaging features of Othello's syndrome (delusional jealousy)...
  65. pmc Predicting survival in frontotemporal dementia with motor neuron disease
    E A Coon
    Department of Behavioral Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 76:1886-93. 2011
    ..To determine whether clinical and demographic features are associated with prognosis in patients with frontotemporal dementia and motor neuron disease (FTD-MND)...
  66. pmc Patterns of atrophy in pathologically confirmed FTLD with and without motor neuron degeneration
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 66:102-4. 2006
    ..Patterns of atrophy were distinct and different from each other. A localized pattern of frontal lobe atrophy was found in FTLD-MND with a more widespread pattern of atrophy affecting the frontal and temporal lobes in FTLD-U...
  67. pmc Antemortem MRI based STructural Abnormality iNDex (STAND)-scores correlate with postmortem Braak neurofibrillary tangle stage
    Prashanthi Vemuri
    Department of Radiology, Mayo Clinic Rochester, Rochester, MN 55905, USA
    Neuroimage 42:559-67. 2008
    ....
  68. pmc MRI correlates of protein deposition and disease severity in postmortem frontotemporal lobar degeneration
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic Rochester, Rochester, Minn 55905, USA
    Neurodegener Dis 6:106-17. 2009
    ..Future treatments will likely target these proteins, therefore it is important to identify biomarkers to help predict protein biochemistry...
  69. pmc Argyrophilic grains: a distinct disease or an additive pathology?
    Keith A Josephs
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurobiol Aging 29:566-73. 2008
    ..Argyrophilic grains (AG) are silver-positive spindle-shaped lesions found at postmortem. Their significance is controversial...
  70. pmc Alzheimer's disease diagnosis in individual subjects using structural MR images: validation studies
    Prashanthi Vemuri
    Department of Radiology, Mayo Clinic 200 1st St SW, Rochester, MN 55905, USA
    Neuroimage 39:1186-97. 2008
    ..To develop and validate a tool for Alzheimer's disease (AD) diagnosis in individual subjects using support vector machine (SVM)-based classification of structural MR (sMR) images...
  71. ncbi request reprint Voxel-based morphometry and its application to movement disorders
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Parkinsonism Relat Disord 13:S406-16. 2007
    ..This article will review the findings of these studies and discuss the role of VBM in movement disorders...
  72. ncbi request reprint A volumetric magnetic resonance imaging study of the amygdala in frontotemporal lobar degeneration and Alzheimer's disease
    Jennifer L Whitwell
    Dementia Research Centre, Institute of Neurology, University College London, London, UK
    Dement Geriatr Cogn Disord 20:238-44. 2005
    ..Despite an overlap between clinical and radiological features of FTLD and AD, marked amygdala atrophy points towards a diagnosis of FTLD, with left greater than right atrophy suggestive of one of the language variants...
  73. pmc 3D characterization of brain atrophy in Alzheimer's disease and mild cognitive impairment using tensor-based morphometry
    Xue Hua
    Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Neuroscience Research Building 225E, Los Angeles, CA 90095 1769, USA
    Neuroimage 41:19-34. 2008
    ..In the future, TBM may help to (1) identify factors that resist or accelerate the disease process, and (2) measure disease burden in treatment trials...
  74. ncbi request reprint Change in rates of cerebral atrophy over time in early-onset Alzheimer's disease: longitudinal MRI study
    Dennis Chan
    Dementia Research Group, Department of Clinical Neurology, Institute of Neurology, University College London, London, UK
    Lancet 362:1121-2. 2003
    ..8% (95% CI 2.3-3.3), which rose by 0.32% per year (0.15-0.50). Our findings reinforce the need for early diagnosis and therapeutic intervention in Alzheimer's disease...
  75. ncbi request reprint Using nine degrees-of-freedom registration to correct for changes in voxel size in serial MRI studies
    Jennifer L Whitwell
    Dementia Research Group, Institute of Neurology, University College London, WCIN 3BG, UK
    Magn Reson Imaging 22:993-9. 2004
    ..It is important that such changes are adjusted for: 9dof registration, which is automated and computationally inexpensive, may be superior to the more labour-intensive TIV correction for this purpose...
  76. ncbi request reprint How fast will it go, doc? New tools for an old question from patients with Alzheimer disease
    Giovanni B Frisoni
    Neurology 70:2194-5. 2008
  77. ncbi request reprint Magnetic resonance imaging signatures of tissue pathology in frontotemporal dementia
    Jennifer L Whitwell
    Dementia Research Centre, Institute of Neurology, University College London, England
    Arch Neurol 62:1402-8. 2005
    ..The pathologic substrates of frontotemporal dementia (FTD) are difficult to predict in vivo...
  78. ncbi request reprint Measurements of the amygdala and hippocampus in pathologically confirmed Alzheimer disease and frontotemporal lobar degeneration
    Josephine Barnes
    Dementia Research Centre, University College London, Institute of Neurology, London, England
    Arch Neurol 63:1434-9. 2006
    ..Patterns of atrophy on magnetic resonance imaging may help distinguish these diseases and aid diagnosis...
  79. doi request reprint Volumetric MRI and cognitive measures in Alzheimer disease : comparison of markers of progression
    Basil H Ridha
    Dementia Research Centre, Institute of Neurology, University College London, 8 11 Queen Square, London, WC1N 3BG, UK
    J Neurol 255:567-74. 2008
    ..Both cognitive tests and MRI-based measures have been suggested as outcomes in trials assessing disease-modifying therapies in Alzheimer's disease (AD)...
  80. pmc Longitudinal stability of MRI for mapping brain change using tensor-based morphometry
    Alex D Leow
    Laboratory of Neuro Imaging, Brain Mapping Division, Department of Neurology and Semel Institute of Neuroscience, UCLA School of Medicine, 635 Charles E Young Drive South, Suite 225E, Los Angeles, CA 90095 7332, USA
    Neuroimage 31:627-40. 2006
    ..No strong evidence favored B0 correction. Although SPGR/FLASH images showed least deviation here, pulse sequence selection for the ADNI project was based on multiple additional image analyses, to be reported elsewhere...
  81. ncbi request reprint Longitudinal patterns of regional change on volumetric MRI in frontotemporal lobar degeneration
    Jennifer L Whitwell
    Dementia Research Group, Institute of Neurology, University College London and Imperial College London, London, UK
    Dement Geriatr Cogn Disord 17:307-10. 2004
    ..The different FTLD syndromes displayed different patterns of change. This technique gives an insight into disease evolution over time in these disorders and may be useful as a method of tracking change in clinical trials...
  82. ncbi request reprint VBM signatures of abnormal eating behaviours in frontotemporal lobar degeneration
    Jennifer L Whitwell
    Dementia Research Centre, Institute of Neurology, 8 11 Queen Square, London WC1N 3BG, UK
    Neuroimage 35:207-13. 2007
    ..In accord with emerging evidence in humans and other species, our findings implicate distinct components of a multi-component brain network in the control of specific aspects of eating behaviour...
  83. ncbi request reprint Voxel-based morphometry in tau-positive and tau-negative frontotemporal lobar degenerations
    Jennifer L Whitwell
    Dementia Research Centre, Institute of Neurology, London, UK
    Neurodegener Dis 1:225-30. 2004
    ..Correlations between regional patterns of tissue loss and specific proteinopathies have not been established...