Research Topics
Species | J L WhitwellSummaryAffiliation: Mayo Clinic Country: USA Publications
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Publications
A longitudinal study of brain volume changes in normal aging using serial registered magnetic resonance imagingRachael I Scahill
Dementia Research Group, Department of Clinical Neurology, Institute of Neurology, University College London, England
Arch Neurol 60:989-94. 2003..To investigate the effect of age on global and regional brain volumes and rates of atrophy, and to compare directly results based on cross-sectional and longitudinal data...- Neuroimaging in dementiaJennifer L Whitwell
Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
Neurol Clin 25:843-57, viii. 2007..The most important development in the field over the past decade is the ability to image amyloid in the brain. This technique will revolutionize patient management and care... 
Neuroimaging comparison of primary progressive apraxia of speech and progressive supranuclear palsyJ L Whitwell
Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
Eur J Neurol 20:629-37. 2013..We aimed to compare, for the first time, atrophy patterns, as well as white matter tract degeneration, between these two syndromes...
Imaging measures predict progression in progressive supranuclear palsyJennifer L Whitwell
Department of Radiology, Mayo Clinic, Rochester, Minnesota 55905, USA
Mov Disord 27:1801-4. 2012..The aim of this work was to determine whether the progressive supranuclear palsy rating scale, a measure of disease severity, is associated with neuroanatomical changes in progressive supranuclear palsy...- Frontal asymmetry in behavioral variant frontotemporal dementia: clinicoimaging and pathogenetic correlatesJennifer L Whitwell
Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
Neurobiol Aging 34:636-9. 2013..These findings therefore suggest that neuroanatomical patterns of frontal lobe atrophy in bvFTD are influenced by specific gene mutations... - Recent advances in the imaging of frontotemporal dementiaJennifer L Whitwell
Department of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
Curr Neurol Neurosci Rep 12:715-23. 2012..Importantly, neuroimaging signatures have been identified that will improve the clinician's ability to predict underlying genetic and pathological features, and hence ultimately improve patient diagnosis... - Comparison of imaging biomarkers in the Alzheimer Disease Neuroimaging Initiative and the Mayo Clinic Study of AgingJennifer L Whitwell
Department of Radiology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
Arch Neurol 69:614-22. 2012..To determine whether magnetic resonance imaging measurements observed in the Alzheimer Disease Neuroimaging Initiative (ADNI) convenience sample differ from those observed in the Mayo Clinic Study of Aging (MCSA) population-based sample... - Neuroimaging correlates of pathologically defined subtypes of Alzheimer's disease: a case-control studyJennifer L Whitwell
Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
Lancet Neurol 11:868-77. 2012..We aimed to determine whether MRI patterns of atrophy differ between these subtypes and whether structural neuroimaging could be a useful predictor of pathological subtype at autopsy... - Rates of brain atrophy and clinical decline over 6 and 12-month intervals in PSP: determining sample size for treatment trialsJennifer L Whitwell
Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
Parkinsonism Relat Disord 18:252-6. 2012..Sample size estimates suggest that treatment trials could be performed over this interval, with rate of midbrain atrophy providing the best outcome measure... - Neuroimaging signatures of frontotemporal dementia genetics: C9ORF72, tau, progranulin and sporadicsJennifer L Whitwell
Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
Brain 135:794-806. 2012..Our analysis suggested that imaging has the potential to be useful to help differentiate C9ORF72 from these other groups at the single-subject level... - Progression of atrophy in Alzheimer's disease and related disordersJennifer L Whitwell
Department of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
Neurotox Res 18:339-46. 2010..Hence, longitudinal MRI shows promise as a biomarker of disease progression in neurodegenerative disease... - Gray and white matter water diffusion in the syndromic variants of frontotemporal dementiaJ L Whitwell
Department of Radiology, Mayo Clinic, Rochester MN 55905, USA
Neurology 74:1279-87. 2010..To use diffusion tensor imaging (DTI) to assess gray matter and white matter tract diffusion in behavioral variant frontotemporal dementia (bvFTD), semantic dementia (SMD), and progressive nonfluent aphasia (PNFA)... - The protective role of brain size in Alzheimer's diseaseJennifer L Whitwell
Department of Radiology, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA
Expert Rev Neurother 10:1799-801. 2010..Therefore, these findings support the brain reserve hypothesis. This article will discuss the brain reserve concept and potential limitations and significance of this study... - Imaging correlates of pathology in corticobasal syndromeJ L Whitwell
Department of Radiology, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA
Neurology 75:1879-87. 2010..The aim of this study was to determine whether patterns of atrophy on imaging could be useful to help predict underlying pathology in CBS... - Comparisons between Alzheimer disease, frontotemporal lobar degeneration, and normal aging with brain mappingJennifer L Whitwell
Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
Top Magn Reson Imaging 16:409-25. 2005..This article will review the findings of these studies and discuss the role of VBM in these neurodegenerative diseases... - Distinct anatomical subtypes of the behavioural variant of frontotemporal dementia: a cluster analysis studyJennifer L Whitwell
Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Brain 132:2932-46. 2009..Our findings suggest behavioural variant of frontotemporal dementia can therefore be subdivided into four different anatomical subtypes... - Altered functional connectivity in asymptomatic MAPT subjects: a comparison to bvFTDJ L Whitwell
Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
Neurology 77:866-74. 2011.... - Assessing subtle structural changes in Alzheimer's disease patientsJennifer L Whitwell
Department of Radiology, Mayo Clinic, Rochester, MN, USA
Methods Mol Biol 711:535-50. 2011.... - Disrupted thalamocortical connectivity in PSP: a resting-state fMRI, DTI, and VBM studyJennifer L Whitwell
Department of Radiology, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA
Parkinsonism Relat Disord 17:599-605. 2011..PSP is therefore associated with disrupted thalamocortical connectivity that is associated with degeneration of the dentatorubrothalamic tract and the presence of cortical atrophy... - Trajectories of brain and hippocampal atrophy in FTD with mutations in MAPT or GRNJ L Whitwell
Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Neurology 77:393-8. 2011..To use multiple serial MRI to assess rates and trajectories of brain and hippocampal atrophy in subjects with frontotemporal dementia (FTD) with progranulin (GRN) or microtubule-associated protein tau (MAPT) gene mutations... - Longitudinal imaging: change and causalityJennifer L Whitwell
Department of Radiology, Mayo Clinic, Rochester, Minnesota 55905, USA
Curr Opin Neurol 21:410-6. 2008..Longitudinal studies that use MRI scans performed over multiple time-points have been increasingly employed in the study of different neurological disorders, including degenerative dementia, multiple sclerosis, and epilepsy... - Abnormal TDP-43 immunoreactivity in AD modifies clinicopathologic and radiologic phenotypeK A Josephs
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
Neurology 70:1850-7. 2008.... - Two distinct subtypes of right temporal variant frontotemporal dementiaK A Josephs
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
Neurology 73:1443-50. 2009..We aimed to determine whether right temporal FTD is a homogeneous clinical, imaging, and pathologic/genetic entity... - Atrophy patterns in IVS10+16, IVS10+3, N279K, S305N, P301L, and V337M MAPT mutationsJ L Whitwell
Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
Neurology 73:1058-65. 2009..To use a case-control study to assess and compare patterns of gray matter loss across groups of subjects with different mutations in the microtubule-associated protein tau (MAPT) gene... - Risk of dementia in MCI: combined effect of cerebrovascular disease, volumetric MRI, and 1H MRSK Kantarci
Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Neurology 72:1519-25. 2009..To investigate the combined ability of hippocampal volumes, 1H magnetic resonance spectroscopy (MRS) metabolites, and cerebrovascular disease to predict the risk of progression to dementia in mild cognitive impairment (MCI)... - Voxel-based morphometry patterns of atrophy in FTLD with mutations in MAPT or PGRNJ L Whitwell
Department of Radiology Research, Mayo Clinic, Rochester, MN 55905, USA
Neurology 72:813-20. 2009..To compare patterns of gray matter loss in subjects with mutations in the progranulin (PGRN) gene to subjects with mutations in the microtubule-associated protein tau (MAPT) gene... - Caudate atrophy on MRI is a characteristic feature of FTLD-FUSK A Josephs
Department of Neurology Behavioral Neurology, Mayo Clinic, Rochester, MN 55905, USA
Eur J Neurol 17:969-75. 2010..We have observed severe caudate atrophy at autopsy in FTLD-FUS, and hence, we aimed to determine whether caudate atrophy on MRI is a feature that can distinguish FTLD-FUS from FTLD-TDP and FTLD-TAU... - MRS in presymptomatic MAPT mutation carriers: a potential biomarker for tau-mediated pathologyK Kantarci
Departmentsof Radiology, Mayo Clinic, Rochester, MN 55905, USA
Neurology 75:771-8. 2010..To determine the proton magnetic resonance spectroscopy ((1)H MRS) changes in carriers of microtubule-associated protein (MAPT) mutations in a case-control study... - The anatomic correlate of prosopagnosia in semantic dementiaK A Josephs
Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Neurology 71:1628-33. 2008..To determine the anatomic correlate of prosopagnosia in subjects with semantic dementia... - Clinicopathologic analysis of frontotemporal and corticobasal degenerations and PSPK A Josephs
Division of Movement Disorders, Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
Neurology 66:41-8. 2006..To examine the relationship between early clinical features, pathologies, and biochemistry of the frontotemporal lobar degenerations (FTLDs), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD)... - MRI patterns of atrophy associated with progression to AD in amnestic mild cognitive impairmentJ L Whitwell
Department of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
Neurology 70:512-20. 2008..To compare the patterns of gray matter loss in subjects with amnestic mild cognitive impairment (aMCI) who progress to Alzheimer disease (AD) within a fixed clinical follow-up time vs those who remain stable... - Does TDP-43 type confer a distinct pattern of atrophy in frontotemporal lobar degeneration?J L Whitwell
Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
Neurology 75:2212-20. 2010..To determine whether TDP-43 type is associated with distinct patterns of brain atrophy on MRI in subjects with pathologically confirmed frontotemporal lobar degeneration (FTLD)... - MRI correlates of neurofibrillary tangle pathology at autopsy: a voxel-based morphometry studyJ L Whitwell
Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Neurology 71:743-9. 2008..We aimed to determine whether patterns of gray matter atrophy from antemortem MRI correlate with Braak staging of NFT pathology... - Progressive aphasia secondary to Alzheimer disease vs FTLD pathologyK A Josephs
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
Neurology 70:25-34. 2008..The pathology causing progressive aphasia is typically a variant of frontotemporal lobar degeneration, especially with ubiquitin-positive inclusions (FTLD-U). Less commonly the underlying pathology is Alzheimer disease (AD)... - Survival in two variants of tau-negative frontotemporal lobar degeneration: FTLD-U vs FTLD-MNDK A Josephs
Department of Neurology, Mayo Clinic, 200 First St S W, Rochester, MN 55905, USA
Neurology 65:645-7. 2005..An analysis of patient outcomes in these cases reveals that FTLD-MND has significantly shorter survival than FTLD-U, suggesting that FTLD-MND is a more aggressive disease process... - Voxel-based morphometry in patients with obsessive-compulsive behaviors in behavioral variant frontotemporal dementiaD C Perry
Department of Neurology, Mayo Clinic, Rochester, MN, USA
Eur J Neurol 19:911-7. 2012..Obsessions and compulsive (OC) behaviors are a frequent feature of behavioral variant frontotemporal dementia (bvFTD), but their structural correlates have not been definitively established... - 3D maps from multiple MRI illustrate changing atrophy patterns as subjects progress from mild cognitive impairment to Alzheimer's diseaseJennifer L Whitwell
Department of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
Brain 130:1777-86. 2007..These results also suggest that 3D patterns of grey matter atrophy may help to predict the time to the first diagnosis of AD in subjects with aMCI... - Rates of cerebral atrophy differ in different degenerative pathologiesJennifer L Whitwell
Department of Radiology, Mayo Clinic Rochester, Rochester, MN 55905, USA
Brain 130:1148-58. 2007.... - Rates of brain atrophy over time in autopsy-proven frontotemporal dementia and Alzheimer diseaseJennifer L Whitwell
Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
Neuroimage 39:1034-40. 2008..The trajectories of brain and ventricular changes were similar in AD and FTLD-U suggesting that it is independent of pathology, although subjects with FTLD-U show a more rapidly progressive decline... - Focal atrophy in dementia with Lewy bodies on MRI: a distinct pattern from Alzheimer's diseaseJennifer L Whitwell
Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
Brain 130:708-19. 2007..Damage to this network of structures in DLB may affect a number of different neurotransmitter systems which in turn may contribute to a number of the core clinical features of DLB... - Patterns of atrophy differ among specific subtypes of mild cognitive impairmentJennifer L Whitwell
Department of Radiology, Mayo Clinic, Rochester, Minnesota 55905, USA
Arch Neurol 64:1130-8. 2007..It follows, however, that subjects with MCI who have impairment in nonmemory domains may progress to non-AD degenerative dementias... - Frontotemporal lobar degeneration without lobar atrophyKeith A Josephs
Department of Neurology, Division of Behavioral Neurology and Movement Disorders, Mayo Clinic, Rochester, MN 55905, USA
Arch Neurol 63:1632-8. 2006..Neuronal loss and gliosis in cornu ammonis 1 and the subiculum of the hippocampus are features of hippocampal sclerosis (HpScl), which occurs in many cases of FTLD-U... - Gray matter correlates of behavioral severity in progressive supranuclear palsyKeith A Josephs
Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
Mov Disord 26:493-8. 2011..Behavioral changes occur in progressive supranuclear palsy. This study aimed to identify the anatomic correlate of behavioral severity in progressive supranuclear palsy... - Fluorodeoxyglucose F18 positron emission tomography in progressive apraxia of speech and primary progressive aphasia variantsKeith A Josephs
Department of Neurology, Division of Behavioral Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
Arch Neurol 67:596-605. 2010.... - Anatomical differences between CBS-corticobasal degeneration and CBS-Alzheimer's diseaseKeith A Josephs
Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
Mov Disord 25:1246-52. 2010..In subjects presenting with CBS, prominent temporoparietal, especially posterior temporal and inferior parietal, atrophy may be a clue to the presence of underlying AD pathology... - Voxel-based morphometry in autopsy proven PSP and CBDKeith A Josephs
Department of Neurology Movement Disorders, Mayo Clinic, Rochester, MN 55905, USA
Neurobiol Aging 29:280-9. 2008..These results show regional differences between PSP and CBD that are useful in predicting the underlying pathology, and help to shed light on the in vivo distribution of regional atrophy in PSP and CBD... - Visual hallucinations in posterior cortical atrophyKeith A Josephs
Divisions of Movement Disorders and Behavioral Neurology, Department of Neurology, Mayo Clinic, Rochester, Minn, USA
Arch Neurol 63:1427-32. 2006..It is not known, however, whether patients who meet the criteria for PCA and have hallucinations are different from those who meet the criteria and do not have hallucinations... - Predicting functional decline in behavioural variant frontotemporal dementiaKeith A Josephs
Department of Neurology Behavioural Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
Brain 134:432-48. 2011.... - Imaging correlates of posterior cortical atrophyJennifer L Whitwell
Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
Neurobiol Aging 28:1051-61. 2007..1)H MRS suggested loss of neuronal integrity and glial activation in subjects with PCA and typical AD. The differing patterns of atrophy on MRI suggest that PCA should be considered a distinct entity from typical AD... - Clinicopathological and imaging correlates of progressive aphasia and apraxia of speechKeith A Josephs
Department of Neurology, Division of Movement Disorders and Behavioral Neurology, Mayo Clinic, Rochester, MN 55905
Brain 129:1385-98. 2006..Refining the classification of the degenerative aphasias and AOS may be necessary to improve our understanding of the relationships among behavioural, pathological and imaging correlations... - Rates of cerebral atrophy in autopsy-confirmed progressive supranuclear palsyKeith A Josephs
Department of Neurology, Mayo Clinic, 200 First Street NW, Rochester, MN 55905, USA
Ann Neurol 59:200-3. 2006..To determine the rates of cerebral atrophy and ventricular expansion in six patients with autopsy confirmed progressive supranuclear palsy (PSP) and multiple antemortem volumetric head MRI scans... - Voxel-based morphometry in frontotemporal lobar degeneration with ubiquitin-positive inclusions with and without progranulin mutationsJennifer L Whitwell
Division of Behavioral Neurology, Department of Neurology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Arch Neurol 64:371-6. 2007..Mutations in the progranulin gene (PGRN) have recently been identified as a cause of frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) in some families... - Symmetric corticobasal degeneration (S-CBD)Anhar Hassan
Department of Neurology, Mayo Clinic, Rochester, MN, USA
Parkinsonism Relat Disord 16:208-14. 2010..Asymmetry is also emphasized on neuroimaging... - Anatomic correlates of stereotypies in frontotemporal lobar degenerationKeith A Josephs
Department of Neurology, Behavioral Neurology and Movement Disorders, Mayo Clinic, Rochester, MN 55905, United States
Neurobiol Aging 29:1859-63. 2008..Stereotypies in FTLD are therefore associated with a greater proportion of striatal to cortical volume loss than those without stereotypies... - Alzheimer disease: postmortem neuropathologic correlates of antemortem 1H MR spectroscopy metabolite measurementsKejal Kantarci
Departments of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Radiology 248:210-20. 2008..To determine the neuropathologic correlates of antemortem hydrogen 1 ((1)H) magnetic resonance (MR) spectroscopy metabolite measurements in subjects with Alzheimer disease (AD)-type pathology... - Beta-amyloid burden is not associated with rates of brain atrophyKeith A Josephs
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
Ann Neurol 63:204-12. 2008..To test the hypothesis that beta-amyloid (Abeta) burden is associated with rates of brain atrophy... - Hippocampal volumes, proton magnetic resonance spectroscopy metabolites, and cerebrovascular disease in mild cognitive impairment subtypesKejal Kantarci
Department of Diagnostic Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Arch Neurol 65:1621-8. 2008..Noninvasive imaging surrogates for underlying pathological findings in MCI would be clinically useful for identifying patients who may benefit from disease-specific treatments at the prodromal stage of dementia... - Antemortem differential diagnosis of dementia pathology using structural MRI: Differential-STANDPrashanthi Vemuri
Department of Radiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
Neuroimage 55:522-31. 2011.... - Clinical and imaging features of Othello's syndromeJ Graff-Radford
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
Eur J Neurol 19:38-46. 2012..Our objective was to document the clinical and imaging features of Othello's syndrome (delusional jealousy)... - Predicting survival in frontotemporal dementia with motor neuron diseaseE A Coon
Department of Behavioral Neurology, Mayo Clinic, Rochester, MN 55905, USA
Neurology 76:1886-93. 2011..To determine whether clinical and demographic features are associated with prognosis in patients with frontotemporal dementia and motor neuron disease (FTD-MND)... - Patterns of atrophy in pathologically confirmed FTLD with and without motor neuron degenerationJennifer L Whitwell
Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
Neurology 66:102-4. 2006..Patterns of atrophy were distinct and different from each other. A localized pattern of frontal lobe atrophy was found in FTLD-MND with a more widespread pattern of atrophy affecting the frontal and temporal lobes in FTLD-U... - MRI correlates of protein deposition and disease severity in postmortem frontotemporal lobar degenerationJennifer L Whitwell
Department of Radiology, Mayo Clinic Rochester, Rochester, Minn 55905, USA
Neurodegener Dis 6:106-17. 2009..Future treatments will likely target these proteins, therefore it is important to identify biomarkers to help predict protein biochemistry... - Argyrophilic grains: a distinct disease or an additive pathology?Keith A Josephs
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
Neurobiol Aging 29:566-73. 2008..Argyrophilic grains (AG) are silver-positive spindle-shaped lesions found at postmortem. Their significance is controversial... - Antemortem MRI based STructural Abnormality iNDex (STAND)-scores correlate with postmortem Braak neurofibrillary tangle stagePrashanthi Vemuri
Department of Radiology, Mayo Clinic Rochester, Rochester, MN 55905, USA
Neuroimage 42:559-67. 2008.... - Neuroanatomical correlates of the progressive supranuclear palsy corticobasal syndrome hybridK A Josephs
Department of Neurology, Mayo Clinic, Rochester, MN, USA
Eur J Neurol 19:1440-6. 2012..We refer to subjects with this presentation as Hybrids. The hybrid presentation is not rare, yet there are no studies that have assessed the neuroanatomical correlates of the hybrid syndrome to explain its occurrence... - Alzheimer's disease diagnosis in individual subjects using structural MR images: validation studiesPrashanthi Vemuri
Department of Radiology, Mayo Clinic 200 1st St SW, Rochester, MN 55905, USA
Neuroimage 39:1186-97. 2008..To develop and validate a tool for Alzheimer's disease (AD) diagnosis in individual subjects using support vector machine (SVM)-based classification of structural MR (sMR) images... - Voxel-based morphometry and its application to movement disordersJennifer L Whitwell
Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
Parkinsonism Relat Disord 13:S406-16. 2007..This article will review the findings of these studies and discuss the role of VBM in movement disorders... - Change in rates of cerebral atrophy over time in early-onset Alzheimer's disease: longitudinal MRI studyDennis Chan
Dementia Research Group, Department of Clinical Neurology, Institute of Neurology, University College London, London, UK
Lancet 362:1121-2. 2003..8% (95% CI 2.3-3.3), which rose by 0.32% per year (0.15-0.50). Our findings reinforce the need for early diagnosis and therapeutic intervention in Alzheimer's disease... - Using nine degrees-of-freedom registration to correct for changes in voxel size in serial MRI studiesJennifer L Whitwell
Dementia Research Group, Institute of Neurology, University College London, WCIN 3BG, UK
Magn Reson Imaging 22:993-9. 2004..It is important that such changes are adjusted for: 9dof registration, which is automated and computationally inexpensive, may be superior to the more labour-intensive TIV correction for this purpose... - A volumetric magnetic resonance imaging study of the amygdala in frontotemporal lobar degeneration and Alzheimer's diseaseJennifer L Whitwell
Dementia Research Centre, Institute of Neurology, University College London, London, UK
Dement Geriatr Cogn Disord 20:238-44. 2005..Despite an overlap between clinical and radiological features of FTLD and AD, marked amygdala atrophy points towards a diagnosis of FTLD, with left greater than right atrophy suggestive of one of the language variants... - Magnetic resonance imaging signatures of tissue pathology in frontotemporal dementiaJennifer L Whitwell
Dementia Research Centre, Institute of Neurology, University College London, England
Arch Neurol 62:1402-8. 2005..The VBM findings were supported by blinded visual assessment. CONCLUSION: These findings suggest that MRI patterns of regional gray matter atrophy constitute signatures of tissue pathology in FTD... - How fast will it go, doc? New tools for an old question from patients with Alzheimer diseaseGiovanni B Frisoni
Neurology 70:2194-5. 2008 - Measurements of the amygdala and hippocampus in pathologically confirmed Alzheimer disease and frontotemporal lobar degenerationJosephine Barnes
Dementia Research Centre, University College London, Institute of Neurology, London, England
Arch Neurol 63:1434-9. 2006..Patterns of atrophy on magnetic resonance imaging may help distinguish these diseases and aid diagnosis... - 3D characterization of brain atrophy in Alzheimer's disease and mild cognitive impairment using tensor-based morphometryXue Hua
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Neuroscience Research Building 225E, Los Angeles, CA 90095 1769, USA
Neuroimage 41:19-34. 2008..In the future, TBM may help to (1) identify factors that resist or accelerate the disease process, and (2) measure disease burden in treatment trials... - Volumetric MRI and cognitive measures in Alzheimer disease : comparison of markers of progressionBasil H Ridha
Dementia Research Centre, Institute of Neurology, University College London, 8 11 Queen Square, London, WC1N 3BG, UK
J Neurol 255:567-74. 2008..Both cognitive tests and MRI-based measures have been suggested as outcomes in trials assessing disease-modifying therapies in Alzheimer's disease (AD)... - Longitudinal patterns of regional change on volumetric MRI in frontotemporal lobar degenerationJennifer L Whitwell
Dementia Research Group, Institute of Neurology, University College London and Imperial College London, London, UK
Dement Geriatr Cogn Disord 17:307-10. 2004..The different FTLD syndromes displayed different patterns of change. This technique gives an insight into disease evolution over time in these disorders and may be useful as a method of tracking change in clinical trials... - VBM signatures of abnormal eating behaviours in frontotemporal lobar degenerationJennifer L Whitwell
Dementia Research Centre, Institute of Neurology, 8 11 Queen Square, London WC1N 3BG, UK
Neuroimage 35:207-13. 2007..In accord with emerging evidence in humans and other species, our findings implicate distinct components of a multi-component brain network in the control of specific aspects of eating behaviour... - Voxel-based morphometry in tau-positive and tau-negative frontotemporal lobar degenerationsJennifer L Whitwell
Dementia Research Centre, Institute of Neurology, London, UK
Neurodegener Dis 1:225-30. 2004.... - Longitudinal stability of MRI for mapping brain change using tensor-based morphometryAlex D Leow
Laboratory of Neuro Imaging, Brain Mapping Division, Department of Neurology and Semel Institute of Neuroscience, UCLA School of Medicine, 635 Charles E. Young Drive South, Suite 225E, Los Angeles, CA 90095-7332, USA
Neuroimage 31:627-40. 2006..No strong evidence favored B0 correction. Although SPGR/FLASH images showed least deviation here, pulse sequence selection for the ADNI project was based on multiple additional image analyses, to be reported elsewhere...