C M Weyand

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Homozygosity for the HLA-DRB1 allele selects for extraarticular manifestations in rheumatoid arthritis
    C M Weyand
    Department of Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905
    J Clin Invest 89:2033-9. 1992
  2. ncbi request reprint HLA polymorphisms and T cells in rheumatoid arthritis
    C M Weyand
    Department of Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Int Rev Immunol 18:37-59. 1999
  3. ncbi request reprint Central role of thrombospondin-1 in the activation and clonal expansion of inflammatory T cells
    A N Vallejo
    Division of Rheumatology, Department of Internal Medicine, Mayo Clinic Foundation, Rochester, MN 55905, USA
    J Immunol 164:2947-54. 2000
  4. ncbi request reprint Synoviocyte-mediated expansion of inflammatory T cells in rheumatoid synovitis is dependent on CD47-thrombospondin 1 interaction
    Abbe N Vallejo
    Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 171:1732-40. 2003
  5. pmc Activation of arterial wall dendritic cells and breakdown of self-tolerance in giant cell arteritis
    Wei Ma-Krupa
    Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Exp Med 199:173-83. 2004
  6. ncbi request reprint Giant-cell arteritis and polymyalgia rheumatica
    Cornelia M Weyand
    Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Intern Med 139:505-15. 2003
  7. ncbi request reprint The role of T cells in rheumatoid arthritis
    C M Weyand
    Division of Rheumatology, Mayo Foundation, Rochester, MN, USA
    Arch Immunol Ther Exp (Warsz) 48:429-35. 2000
  8. ncbi request reprint T-cell immunity in acute coronary syndromes
    C M Weyand
    Division of Rheumatology and Internal Medicine, Mayo Clinic, Rochester, Minn 55905, USA
    Mayo Clin Proc 76:1011-20. 2001
  9. ncbi request reprint Therapeutic effects of acetylsalicylic acid in giant cell arteritis
    Cornelia M Weyand
    Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Arthritis Rheum 46:457-66. 2002
  10. ncbi request reprint Premature immunosenescence in rheumatoid arthritis
    Cornelia M Weyand
    Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    J Rheumatol 29:1141-6. 2002

Collaborators

Detail Information

Publications90

  1. pmc Homozygosity for the HLA-DRB1 allele selects for extraarticular manifestations in rheumatoid arthritis
    C M Weyand
    Department of Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905
    J Clin Invest 89:2033-9. 1992
    ..The finding of a codominant function of HLA-DRB1 alleles suggests that the biological function of HLA-DR molecules in thymic selection might be important in the pathogenesis of RA...
  2. ncbi request reprint HLA polymorphisms and T cells in rheumatoid arthritis
    C M Weyand
    Department of Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Int Rev Immunol 18:37-59. 1999
    ....
  3. ncbi request reprint Central role of thrombospondin-1 in the activation and clonal expansion of inflammatory T cells
    A N Vallejo
    Division of Rheumatology, Department of Internal Medicine, Mayo Clinic Foundation, Rochester, MN 55905, USA
    J Immunol 164:2947-54. 2000
    ....
  4. ncbi request reprint Synoviocyte-mediated expansion of inflammatory T cells in rheumatoid synovitis is dependent on CD47-thrombospondin 1 interaction
    Abbe N Vallejo
    Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 171:1732-40. 2003
    ..Because TSP1 is abundantly expressed in the rheumatoid synovium, CD47-TSP1 interaction is proposed to be a key component of an FLS/T cell regulatory circuit that perpetuates the inflammatory process in the rheumatoid joint...
  5. pmc Activation of arterial wall dendritic cells and breakdown of self-tolerance in giant cell arteritis
    Wei Ma-Krupa
    Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Exp Med 199:173-83. 2004
    ..Activation of adventitial DCs initiates and maintains T cell responses in the artery and breaks tissue tolerance in the perivascular space...
  6. ncbi request reprint Giant-cell arteritis and polymyalgia rheumatica
    Cornelia M Weyand
    Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Intern Med 139:505-15. 2003
    ..In general, the clinical outcome of giant-cell arteritis is excellent, and efforts must now concentrate on tailoring therapies to the needs of the individual patient...
  7. ncbi request reprint The role of T cells in rheumatoid arthritis
    C M Weyand
    Division of Rheumatology, Mayo Foundation, Rochester, MN, USA
    Arch Immunol Ther Exp (Warsz) 48:429-35. 2000
    ..Understanding the mechanisms underlying the loss of T cell diversity and the emergence of pro-inflammatory CD4(+)CD28null T cell clonotypes may have implications for other autoimmune syndromes...
  8. ncbi request reprint T-cell immunity in acute coronary syndromes
    C M Weyand
    Division of Rheumatology and Internal Medicine, Mayo Clinic, Rochester, Minn 55905, USA
    Mayo Clin Proc 76:1011-20. 2001
    ..Natural killer T cells have proinflammatory properties and the capability of directly contributing to vascular injury...
  9. ncbi request reprint Therapeutic effects of acetylsalicylic acid in giant cell arteritis
    Cornelia M Weyand
    Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Arthritis Rheum 46:457-66. 2002
    ..The current study explored whether acetylsalicylic acid (ASA) had cytokine-repressing activity in GCA and could function as a steroid-sparing agent...
  10. ncbi request reprint Premature immunosenescence in rheumatoid arthritis
    Cornelia M Weyand
    Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    J Rheumatol 29:1141-6. 2002
  11. ncbi request reprint Pathogenic mechanisms in giant cell arteritis
    Cornelia M Weyand
    Department of Medicine, Mayo Medical and Graduate Schools, Rochester, MN, USA
    Cleve Clin J Med 69:SII28-32. 2002
    ....
  12. ncbi request reprint Immunosenescence, autoimmunity, and rheumatoid arthritis
    Cornelia M Weyand
    Department of Medicine and Immunology, Mayo Clinic, Guggenheim 401, 200 First Street SW, Rochester, MN 55905, USA
    Exp Gerontol 38:833-41. 2003
    ..We propose that autoimmunity in rheumatoid arthritis is a consequence of immunodegeneration that is associated with age-inappropriate remodeling of the T-cell pool...
  13. ncbi request reprint The power of the third dimension: tissue architecture and autoimmunity in rheumatoid arthritis
    C M Weyand
    Departments of Medicine and Immunology, Mayo Clinic Rochester, Rochester, Minnesota 55905, USA
    Curr Opin Rheumatol 15:259-66. 2003
    ..Recent data support the concept that the tissue organization in the rheumatoid joint fosters a breakdown in self-tolerance by promoting a phase transition from self-limited immune responses to self-perpetuating autoimmune responses...
  14. ncbi request reprint Ectopic germinal center formation in rheumatoid synovitis
    Cornelia M Weyand
    Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann N Y Acad Sci 987:140-9. 2003
    ..Follicle-sustaining CD8 T cells were located at the edge of or within the mantle zone. Cell-cell communication in the mantle zone, including CD8 T cells, appears to be critical for ectopic GC formation in rheumatoid synovitis...
  15. pmc Association of MHC and rheumatoid arthritis. HLA polymorphisms in phenotypic variants of rheumatoid arthritis
    C M Weyand
    Department of Medicine, Mayo Clinic Foundation, Rochester, Minnesota 55905, USA
    Arthritis Res 2:212-6. 2000
    ....
  16. ncbi request reprint Pathogenic principles in giant cell arteritis
    C M Weyand
    Department of Medicine, Mayo Clinic, 401 Guggenheim Building, 200 First Street SW, Rochester, MN 55905, USA
    Int J Cardiol 75:S9-S15; discussion S17-9. 2000
    ..Heterogeneity in the immune insult and the resulting arterial response patterns correlate with variations in clinical disease...
  17. pmc Cell-cell interactions in synovitis. Interactions between T cells and B cells in rheumatoid arthritis
    C M Weyand
    Division of Rheumatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Arthritis Res 2:457-63. 2000
    ..B cells have a critical role in lymphoid organogenesis. Their contribution to synovial inflammation extends beyond antibody secretion and includes the activation and regulation of effector T cells...
  18. ncbi request reprint Functional properties of CD4+ CD28- T cells in the aging immune system
    C M Weyand
    Mayo Clinic, Rochester, MN 55905, USA
    Mech Ageing Dev 102:131-47. 1998
    ..We propose that the emergence of CD28-deficient CD4 T cells in the elderly can partially explain age-specific aberrations in immune responsiveness...
  19. ncbi request reprint Corticosteroid requirements in polymyalgia rheumatica
    C M Weyand
    Department of Medicine, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    Arch Intern Med 159:577-84. 1999
    ..Guidelines for the optimal use of corticosteroids that maximize relief of symptoms but minimize adverse effects of the therapy are needed...
  20. ncbi request reprint CD4+,CD28- T cells in rheumatoid arthritis patients combine features of the innate and adaptive immune systems
    K J Warrington
    Mayo Clinic, Rochester, Minnesota 55905, USA
    Arthritis Rheum 44:13-20. 2001
    ....
  21. ncbi request reprint Down-regulation of CD28 expression by TNF-alpha
    E Bryl
    Department of Medicine and Immunology, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 167:3231-8. 2001
    ..These results demonstrate that TNF-alpha directly influences CD28 gene transcription. We propose that the emergence of CD4(+)CD28(null) T cells in vivo is facilitated by increased production of TNF-alpha...
  22. ncbi request reprint Lymphoid neogenesis in rheumatoid synovitis
    S Takemura
    Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Immunol 167:1072-80. 2001
    ....
  23. ncbi request reprint Molecular fingerprint of interferon-gamma signaling in unstable angina
    G Liuzzo
    Department of Medicine, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Circulation 103:1509-14. 2001
    ..IFN-gamma may derive from stimulated T lymphocytes, which implicates specific immune responses in the pathogenesis of acute coronary syndromes...
  24. ncbi request reprint Modulation of CD28 expression: distinct regulatory pathways during activation and replicative senescence
    A N Vallejo
    Division of Rheumatology, Department of Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Immunol 162:6572-9. 1999
    ..In vivo expanded CD4+CD28null and CD8+CD28null T cells uniformly lack alpha- and beta-bound complexes, resembling the pattern seen in chronically activated cells and not of senescent cells...
  25. ncbi request reprint Clonality and longevity of CD4+CD28null T cells are associated with defects in apoptotic pathways
    A N Vallejo
    Departments of Medicine and Immunology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Immunol 165:6301-7. 2000
    ....
  26. ncbi request reprint Thymic function and peripheral T-cell homeostasis in rheumatoid arthritis
    J J Goronzy
    Departments of Medicine and Immunology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Trends Immunol 22:251-5. 2001
    ..Increased risk of autoimmunity, as a consequence of abnormal T-cell population dynamics, could be a common mechanism in chronic inflammatory diseases...
  27. pmc Glucocorticoid-mediated repression of cytokine gene transcription in human arteritis-SCID chimeras
    A Brack
    Department of Medicine, Division of Rheumatology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Clin Invest 99:2842-50. 1997
    ..The persistence of TGF-beta1-transcribing macrophages, despite paralysis of T cell function, may provide an explanation for the chronicity of the disease, and may identify a novel therapeutic target in this inflammatory vasculopathy...
  28. pmc Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals
    J J Goronzy
    Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Virol 75:12182-7. 2001
    ..Frequencies of CD8(+) CD28(null) T cells are useful biological markers of compromised immunocompetence, identifying individuals at risk for insufficient antibody responses...
  29. ncbi request reprint T cell activation in rheumatoid synovium is B cell dependent
    S Takemura
    Department of Medicine and Immunology, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 167:4710-8. 2001
    ..The central role of B cells in synovial inflammation identifies them as excellent targets for immunosuppressive therapy...
  30. pmc Major histocompatibility complex class I-recognizing receptors are disease risk genes in rheumatoid arthritis
    J H Yen
    Department of Medicine and the Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Exp Med 193:1159-67. 2001
    ..Specifically, KIR2DS2 in conjunction with the appropriate HLA-C ligand may have a role in vascular damage by regulating CD4(+)CD28(null) T cells...
  31. ncbi request reprint Functional disruption of the CD28 gene transcriptional initiator in senescent T cells
    A N Vallejo
    Departments of Medicine and Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Biol Chem 276:2565-70. 2001
    ..Rather, initiators can have a direct role in regulating the expression of specific genes. The gain or loss of initiator activity can be an important determinant of cell phenotypes...
  32. ncbi request reprint How aggressive should initial therapy for rheumatoid arthritis be? Factors associated with response to 'non-aggressive' DMARD treatment and perspective from a 2-yr open label trial
    E L Matteson
    Division of Rheumatology, Mayo Clinic and Mayo Graduate School of Medicine, Rochester, MN 55905, USA
    Rheumatology (Oxford) 43:619-25. 2004
    ..To determine what baseline factors might be associated with response to an initial mild treatment regimen in patients with early rheumatoid arthritis (RA)...
  33. pmc T cell homeostasis in patients with rheumatoid arthritis
    K Koetz
    Departments of Medicine and Immunology, and Section of Biostatistics, Mayo Clinic, Rochester, MN 55905, USA
    Proc Natl Acad Sci U S A 97:9203-8. 2000
    ..Alternatively, RA patients may have impaired thymic function with the increased turnover of peripheral T cells being a secondary compensatory event...
  34. pmc Correlation of the topographical arrangement and the functional pattern of tissue-infiltrating macrophages in giant cell arteritis
    C M Weyand
    Department of Medicine, Division of Rheumatology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Clin Invest 98:1642-9. 1996
    ..These data indicate that the microenvironment controls the topographical arrangement as well as the functional commitment of macrophages...
  35. ncbi request reprint Eosinophil-active cytokine from mononuclear cells cultured with L-tryptophan products: an unexpected consequence of endotoxin contamination
    H Kita
    Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA
    J Allergy Clin Immunol 95:1261-7. 1995
    ..Endotoxin contamination must be considered as a possible cause of eosinophil-active cytokine production by peripheral blood mononuclear cells...
  36. ncbi request reprint Genetic similarity in inflammatory and degenerative abdominal aortic aneurysms: a study of human leukocyte antigen class II disease risk genes
    T E Rasmussen
    Division of Vascular Surgery, Mayo Clinic and Mayo Medical School, Rochester, MN 55905, USA
    J Vasc Surg 34:84-9. 2001
    ..The purpose of this study was to compare HLA class II genes in patients with degenerative versus classic inflammatory AAAs and to quantify their impact as disease risk factors...
  37. ncbi request reprint Immune-mediated mechanisms in atherosclerosis: prevention and treatment of clinical manifestations
    A Niessner
    Lowance Center for Human Immunology, Department of Medicine, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Curr Pharm Des 13:3701-10. 2007
    ..These therapeutic approaches can be classified as (1) immunomodulatory effects of existing therapies, (2) therapies targeting inflammatory triggers, and (3) agents inhibiting specific immune mechanisms...
  38. ncbi request reprint T cell costimulation by fractalkine-expressing synoviocytes in rheumatoid arthritis
    Hirokazu Sawai
    Emory University School of Medicine, Atlanta, Georgia, USA
    Arthritis Rheum 52:1392-401. 2005
    ..This study explored whether interactions between CX(3)CR1 and FKN are relevant for T cell functions in rheumatoid synovitis...
  39. pmc The impact of HLA-DRB1 genes on extra-articular disease manifestations in rheumatoid arthritis
    Carl Turesson
    Department of Rheumatology, Malmo University Hospital, Södra Förstadsgatan 101, 205 02 Malmo, Sweden
    Arthritis Res Ther 7:R1386-93. 2005
    ..This confirms that SE genes contribute to RA disease severity and ExRA. Other genetic and environmental factors may have a more specific impact on individual ExRA manifestations...
  40. pmc BLyS and APRIL in rheumatoid arthritis
    Thorsten M Seyler
    Department of Medicine, Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Clin Invest 115:3083-92. 2005
    ..We propose that BLyS and APRIL regulate B cell as well as T cell function and have pro- and antiinflammatory activities in RA...
  41. pmc Rheumatoid arthritis is an independent risk factor for multi-vessel coronary artery disease: a case control study
    Kenneth J Warrington
    Division of Rheumatology, Mayo Clinic, Rochester, MN, USA
    Arthritis Res Ther 7:R984-91. 2005
    ..Expansion of CD4+CD28null T cells in these patients may contribute to the progression of atherosclerosis...
  42. ncbi request reprint Modulation of CD28 expression with anti-tumor necrosis factor alpha therapy in rheumatoid arthritis
    Ewa Bryl
    Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Arthritis Rheum 52:2996-3003. 2005
    ..Because reduced expression of CD28 in T cells compromises immunocompetence, we examined whether CD28 expression is reduced in patients with RA in vivo and whether the reduction is related to TNFalpha...
  43. ncbi request reprint Increased CD4+ T cell infiltrates in rheumatoid arthritis-associated interstitial pneumonitis compared with idiopathic interstitial pneumonitis
    Carl Turesson
    Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Arthritis Rheum 52:73-9. 2005
    ..To study lymphocyte markers in rheumatoid arthritis (RA)-associated interstitial pneumonitis (IP) compared with idiopathic IP...
  44. ncbi request reprint T cell development and receptor diversity during aging
    Jorg J Goronzy
    Kathleen B and Mason I Lowance Center for Human Immunology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Curr Opin Immunol 17:468-75. 2005
    ..Elucidation of the underlying mechanisms will allow for extending this turning point to later in life; ultimately, interventions have to aim at restoring thymic function and complementary modes of T cell reconstitution...
  45. pmc B cells in rheumatoid synovitis
    Cornelia M Weyand
    Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, Georgia, USA
    Arthritis Res Ther 7:S9-12. 2005
    ..Furthermore, studies of rheumatoid lesions implanted in immunodeficient mice suggest that T cell activation in synovitis is B cell dependent, indicating the role played by B cells in presenting antigens and providing survival signals...
  46. ncbi request reprint Distinct transcriptional control mechanisms of killer immunoglobulin-like receptors in natural killer (NK) and in T cells
    Jing Xu
    Department of Medicine, Lowance Center for Human Immunology, Emory School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 280:24277-85. 2005
    ..We suggest that the regulated expression of KIRs in T cells profoundly influences peripheral tolerance and antigen-specific immune responses...
  47. ncbi request reprint The influence of age on T cell generation and TCR diversity
    Keith Naylor
    Department of Medicine, Mayo Clinic and Graduate School, Rochester, MN 55905, USA
    J Immunol 174:7446-52. 2005
    ..The collapse in CD4 T cell diversity during the seventh and eighth decades indicates substantial T cell loss and implies that therapeutic measures to improve vaccine responses will have to include strategies for T cell replenishment...
  48. ncbi request reprint Cell-based immunotherapy with suppressor CD8+ T cells in rheumatoid arthritis
    Eduardo Davila
    Department of Medicine, Kathleen B and Mason I Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 174:7292-301. 2005
    ..We propose that rheumatoid synovitis can be suppressed by cell-based immunotherapy with immunoregulatory CD8(+) T cells...
  49. ncbi request reprint Opposite effects of CX3CR1 receptor polymorphisms V249I and T280M on the development of acute coronary syndrome. A possible implication of fractalkine in inflammatory activation
    Alexander Niessner
    Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Austria
    Thromb Haemost 93:949-54. 2005
    ..The presence of I249 not "balanced" by M280 confers an elevated risk of ACS. A FKN-mediated enhanced inflammatory activation might explain this increased risk...
  50. ncbi request reprint Toll-like receptors in giant cell arteritis
    Wei Ma-Krupa
    Department of Medicine, Lowance Center for Human Immunology, Emory University School of Medicine, Woodruff Memorial Research Building, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Clin Immunol 115:38-46. 2005
    ..These data identify tissue-residing DCs as gatekeepers in vasculitis and support the model that TLR ligands function as instigators of vessel wall inflammation...
  51. ncbi request reprint Tissue trafficking patterns of effector memory CD4+ T cells in rheumatoid arthritis
    Xiaoyu Zhang
    Mayo Clinic, Rochester, Minnesota, USA
    Arthritis Rheum 52:3839-49. 2005
    ..We undertook this study to examine the tissue niche for CD4+,CD28- T cells and the signals regulating their survival and tissue homing patterns...
  52. pmc Occurrence of giant cell arteritis...suddenly
    Brian R Younge
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA
    Trans Am Ophthalmol Soc 105:141-4; discussion 144-5. 2007
    ..To define the kinetics and mechanisms of frank arteritis onset in patients with giant cell arteritis...
  53. pmc T cell subset-specific susceptibility to aging
    Marta Czesnikiewicz-Guzik
    Kathleen B and Mason I Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA30322, USA
    Clin Immunol 127:107-18. 2008
    ..The data show that CD8 T cells are age sensitive by at least two partially independent mechanisms: fragile homeostatic control and gene expression instability in a large set of regulatory cell surface molecules...
  54. ncbi request reprint Synoviocyte stimulation by the LFA-1-intercellular adhesion molecule-2-Ezrin-Akt pathway in rheumatoid arthritis
    Karnail Singh
    Kathleen B and Mason I Lowance Center for Human Immunology, Emory University, Atlanta, GA 30322, USA
    J Immunol 180:1971-8. 2008
    ..These findings identify ICAM-2 as a potential therapeutic target to inhibit FLS activation in RA, allowing for a more selective intervention than broad LFA-1 inhibition...
  55. doi request reprint Vessel wall-embedded dendritic cells induce T-cell autoreactivity and initiate vascular inflammation
    Ji W Han
    Kathleen B and Mason I Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Circ Res 102:546-53. 2008
    ..DCs are superior in sensing pathogen-derived motifs and are highly efficient in breaking T-cell tolerance, guiding T cells toward proinflammatory and tissue-invasive behavior...
  56. ncbi request reprint Fractalkine mediates T cell-dependent proliferation of synovial fibroblasts in rheumatoid arthritis
    Hirokazu Sawai
    Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Arthritis Rheum 56:3215-25. 2007
    ..The aim of this study was to examine the mechanisms through which CD4 T cells, the dominant lymphocyte population in patients with rheumatoid synovitis, regulate synoviocyte proliferation...
  57. pmc Unchecked CD70 expression on T cells lowers threshold for T cell activation in rheumatoid arthritis
    Won Woo Lee
    Kathleen B and Mason I Lowance Center for Human Immunology, Emory University, Atlanta, GA 30322, USA
    J Immunol 179:2609-15. 2007
    ..The data support a model in which CD70 expressed on T cells causes degeneracy in T cell responses and undermines tolerance mechanisms that normally control T cell autoreactivity...
  58. ncbi request reprint Immunopathologic aspects of rheumatoid arthritis: who is the conductor and who plays the immunologic instrument?
    Cornelia M Weyand
    Emory University, Atlanta, Georgia, USA
    J Rheumatol Suppl 79:9-14. 2007
    ....
  59. pmc Aging and T-cell diversity
    Jorg J Goronzy
    Lowance Center for Human Immunology, Emory University School of Medicine, 101 Woodruff Circle 1003, Atlanta, GA 30322, USA
    Exp Gerontol 42:400-6. 2007
    ..Research efforts need to aim at understanding T-cell homeostatic control mechanisms to ultimately expand the time period of repertoire stability...
  60. ncbi request reprint Immunosuppression in atherosclerosis: mobilizing the opposition within
    Jorg J Goronzy
    Circulation 114:1901-4. 2006
  61. ncbi request reprint Association of HLA-C3 and smoking with vasculitis in patients with rheumatoid arthritis
    Carl Turesson
    Department of Rheumatology, Malmo University Hospital, Malmo, Sweden
    Arthritis Rheum 54:2776-83. 2006
    ..To compare HLA-C genotypes and smoking habits in patients with vasculitis or other severe extraarticular manifestations of rheumatoid arthritis (ExRA) with those in RA patients without extraarticular disease...
  62. ncbi request reprint Costimulatory pathways in rheumatoid synovitis and T-cell senescence
    Jorg J Goronzy
    Kathleen B and Mason I Lowance Center for Human Immunology, Emory University School of Medicine, Rm 1003, Woodruff Memorial Research Bldg, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Ann N Y Acad Sci 1062:182-94. 2005
    ..By acquiring a new set of regulatory receptors, senescent CD4 T cells become responsive to novel environmental cues and find ideal stimulatory conditions in the synovial microenvironment...
  63. ncbi request reprint Telomeres, immune aging and autoimmunity
    Jorg J Goronzy
    Lowance Center for Human Immunology, Department of Medicine, Emory University School of Medicine, Room 1003 Woodruff Memorial Research Building, 101 Woodruff Cricle, Atlanta, GA 30322, USA
    Exp Gerontol 41:246-51. 2006
    ..Equally interestingly, accelerated T-cell aging combined with telomeric shortening may predispose for autoimmune responses and thereby explain the increased susceptibility for chronic inflammatory diseases in the elderly...
  64. pmc Epigenetic mechanisms of age-dependent KIR2DL4 expression in T cells
    Guangjin Li
    Kathleen B and Mason I Lowance Center for Human Immunology and Rheumatology, Emory University School of Medicine, 101 Woodruff Circle, 1003, Atlanta, GA 30322, USA
    J Leukoc Biol 84:824-34. 2008
    ..The partially accessible promoter is sensitive to DNMT inhibition, which is sufficient to induce full transcription without further histone acetylation and methylation...
  65. pmc Thrombospondin 2 functions as an endogenous regulator of angiogenesis and inflammation in rheumatoid arthritis
    Yong Wook Park
    Department of Medicine, Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Pathol 165:2087-98. 2004
    ..We propose that TSP2 is an endogenous regulator of angiogenesis and autoimmune inflammation in the synovium and represents a protective mechanism preventing ectopic lympho-organogenesis and persistent inflammation in this tissue site...
  66. ncbi request reprint Medium- and large-vessel vasculitis
    Cornelia M Weyand
    Department of Medicine, Mayo Clinic, Rochester, Minn, USA
    N Engl J Med 349:160-9. 2003
  67. ncbi request reprint De novo expression of killer immunoglobulin-like receptors and signaling proteins regulates the cytotoxic function of CD4 T cells in acute coronary syndromes
    Takako Nakajima
    Departments of Medicine, Mayo Clinic, Rochester, Minn 55905, USA
    Circ Res 93:106-13. 2003
    ..Consequently, these T cells acquire cytolytic capability that can bypass the need for T-cell receptor triggering and, thus, impose a threat to self-tolerance...
  68. pmc B cells as a therapeutic target in autoimmune disease
    Jorg J Goronzy
    Departments of Medicine and Immunology, Mayo Clinic, Rochester, MN, USA
    Arthritis Res Ther 5:131-5. 2003
    ..Studies exploring which mechanisms are functional in which subset of patients hold the promise of providing new and rational treatment approaches for autoimmune syndromes...
  69. ncbi request reprint Homeostatic control of T-cell generation in neonates
    Stefan O Schonland
    Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Blood 102:1428-34. 2003
    ..Maintaining optimal clonal size instead of filling the space in a lymphopenic host appears to regulate homeostatic T-cell proliferation during fetal development...
  70. pmc Selective activation of the c-Jun NH2-terminal protein kinase signaling pathway by stimulatory KIR in the absence of KARAP/DAP12 in CD4+ T cells
    Melissa R Snyder
    Department of Medicine Rheumatology and Immunology, Mayo Clinic, Rochester, MN 55905, USA
    J Exp Med 197:437-49. 2003
    ..Our data suggest that CD158j in T cells functions as a costimulatory molecule through the JNK pathway independent of KARAP/DAP12 and DAP10. Costimulation by CD158j may contribute to the autoreactivity of CD4(+)CD28(null) T cells in RA...
  71. ncbi request reprint CD28 loss in senescent CD4+ T cells: reversal by interleukin-12 stimulation
    Kenneth J Warrington
    Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Blood 101:3543-9. 2003
    ..The re-expressed CD28 was functional and restored the ability of CD4(+)CD28(null) T cells to express CD25 and CD40 ligand. Our data suggest that IL-12 may, in part, functionally rescue senescent CD4(+) T cells...
  72. ncbi request reprint Molecular basis for the loss of CD28 expression in senescent T cells
    Abbe N Vallejo
    Department of Medicine and Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 277:46940-9. 2002
    ..The present data also provide evidence for INR-regulated transcription that is independent of the known components of the basal transcription complex...
  73. ncbi request reprint Cytokines in giant-cell arteritis
    Jorg J Goronzy
    Department of Medicine, Mayo Medical and Graduate Schools, Mayo Clinic, Rochester, MN 55905, USA
    Cleve Clin J Med 69:SII91-4. 2002
    ..IFN-gamma appears to be critically involved in modulating the process of intimal hyperplasia, the most destructive consequence of vasculitis, and, as such, emerges as a prime target for novel therapeutic approaches...
  74. pmc CD8 T cells are required for the formation of ectopic germinal centers in rheumatoid synovitis
    Young Mo Kang
    Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Exp Med 195:1325-36. 2002
    ..We propose that CD8+ T cells regulate the structural integrity and functional activity of GCs in ectopic lymphoid follicles...
  75. ncbi request reprint Formation of the killer Ig-like receptor repertoire on CD4+CD28null T cells
    Melissa R Snyder
    Department of Medicine Rheumatology and Immunology, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 168:3839-46. 2002
    ..The computer simulations favored a model in which KIR gene expression is inducible for a limited time during the initial stages of clonal expansion...
  76. ncbi request reprint T-cell-mediated lysis of endothelial cells in acute coronary syndromes
    Takako Nakajima
    Department of Medicine, Division of Cardiology, Mayo Clinic, Rochester, Minnesota, USA
    Circulation 105:570-5. 2002
    ..CD4 T lymphocytes accumulate in unstable plaque. The direct and indirect involvement of these T cells in tissue injury and plaque instability is not understood...
  77. pmc Reactive nitrogen intermediates in giant cell arteritis: selective nitration of neocapillaries
    Astrid Borkowski
    Department of Medicine and Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Pathol 161:115-23. 2002
    ..Heterogeneity of microvessels in NOS-3 regulation may be an additional determinant contributing to this compartmentalization and could explain the preferential targeting of newly generated capillary beds...
  78. pmc Aging, autoimmunity and arthritis: T-cell senescence and contraction of T-cell repertoire diversity - catalysts of autoimmunity and chronic inflammation
    Jorg J Goronzy
    Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Arthritis Res Ther 5:225-34. 2003
    ..These cells are under the regulatory control of nonconventional costimulatory molecules, display potent effector functions, and appear to be critical in the synovial and extra-articular manifestations of RA...
  79. ncbi request reprint Genetics of rheumatoid arthritis: Is there a pattern predicting extraarticular manifestations?
    Carl Turesson
    Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Arthritis Rheum 51:853-63. 2004
  80. ncbi request reprint Stimulatory killer Ig-like receptors modulate T cell activation through DAP12-dependent and DAP12-independent mechanisms
    Melissa R Snyder
    Departments of Medicine and Immunology, Mayo Clinic, Rochester, MN 55905
    J Immunol 173:3725-31. 2004
    ....
  81. ncbi request reprint Stem cell aging and autoimmunity in rheumatoid arthritis
    Cornelia M Weyand
    Department of Medicine, Kathleen B and Mason I Lowance Center for Human Immunology, Emory School of Medicine, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Trends Mol Med 10:426-33. 2004
  82. ncbi request reprint Lymphotoxin beta-mediated stimulation of synoviocytes in rheumatoid arthritis
    Andrea Braun
    Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Arthritis Rheum 50:2140-50. 2004
    ..Because resident fibroblast-like synoviocytes (FLS) express receptors for LTbeta, we examined the consequences of FLS activation by LTbeta...
  83. ncbi request reprint Tumor necrosis factor-alpha and CD80 modulate CD28 expression through a similar mechanism of T-cell receptor-independent inhibition of transcription
    Dorothy E Lewis
    Department of Immunology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 279:29130-8. 2004
    ..T cell lines with transient expression of CD28 are invaluable in the dissection of the biochemical processes involved in the transactivation of the CD28 INR, the silencing of which is a key event in the ontogenesis of senescent T cells...
  84. ncbi request reprint T-cell regulation in rheumatoid arthritis
    Jorg J Goronzy
    Lowance Center for Human Immunology, Emory University School of Medicine, 1364 Clifton Road NE, Atlanta, GA 30322, USA
    Curr Opin Rheumatol 16:212-7. 2004
    ..This review summarizes recent insights in pathways that are functional in RA and that favor continuous and pathogenic T-cell activation...
  85. ncbi request reprint T-cell senescence: a culprit of immune abnormalities in chronic inflammation and persistent infection
    Abbe N Vallejo
    Division of Rheumatology, Department of Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Trends Mol Med 10:119-24. 2004
    ..Indeed, studies on the molecular basis for the loss of CD28 are already providing information on methods to functionally rescue senescent T cells...
  86. ncbi request reprint Biology of T lymphocytes
    Abbe N Vallejo
    Departments of Medicine and Immunology, Guggenheim 401, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Rheum Dis Clin North Am 30:135-57. 2004
    ..How we translate the cellular and molecular details of this regulation into innovation and development of therapies for disease management remains a fundamental, but exciting, challenge...
  87. ncbi request reprint Immunopathways in giant cell arteritis and polymyalgia rheumatica
    Cornelia M Weyand
    Department of Immunology, Guggenheim 401, Mayo Clinic, Rochester, MN, USA
    Autoimmun Rev 3:46-53. 2004
    ..Immunologically most interesting is polymyalgia rheumatica, in which the systemic component is combined with aborted vasculitis, suggesting a role for artery-specific tolerance mechanisms...
  88. ncbi request reprint Prognostic markers of radiographic progression in early rheumatoid arthritis
    Jorg J Goronzy
    Mayo Clinic, Rochester, Minnesota 55905, USA
    Arthritis Rheum 50:43-54. 2004
    ..To identify prognostic markers that are predictive of progressive erosive disease in patients with early rheumatoid arthritis (RA)...
  89. pmc Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages
    Stefan O Schonland
    Department of Medicine and Immunology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Proc Natl Acad Sci U S A 100:13471-6. 2003
    ..We propose that HLA-DRB1*04 alleles or genes in linkage disequilibrium regulate stem cell replication and contribute to the accumulation of senescent and autoreactive T cells in rheumatoid arthritis...
  90. ncbi request reprint Bi-directional modulation of T cell-dependent antibody production by prostaglandin E(2)
    Xiaowen He
    Research Service 151, VA Medical Center Memphis, 1030 Jefferson Avenue, TN 38104, USA
    Int Immunol 14:69-77. 2002
    ..The outcome of the effects can be up-regulatory or down-regulatory, depending whether resistant or sensitive T cells are involved...