Christopher Ward

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Epitope-tagged Pkhd1 tracks the processing, secretion, and localization of fibrocystin
    Jason L Bakeberg
    Division of Nephrology and Hypertension, Mayo Clinic, 703 Stabile Building, 200 First Street SW, Rochester, MN 55905, USA
    J Am Soc Nephrol 22:2266-77. 2011
  2. pmc Germline PKHD1 mutations are protective against colorectal cancer
    Christopher J Ward
    Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Hum Genet 129:345-9. 2011
  3. ncbi request reprint Analysis of the polycystins in aortic vascular smooth muscle cells
    Qi Qian
    Division of Nephrology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Soc Nephrol 14:2280-7. 2003
  4. pmc Ciliary and centrosomal defects associated with mutation and depletion of the Meckel syndrome genes MKS1 and MKS3
    Rachaneekorn Tammachote
    Department of Biochemistry Molecular Biology, Mayo Clinic, Rochester, MN, USA
    Hum Mol Genet 18:3311-23. 2009
  5. ncbi request reprint Cellular and subcellular localization of the ARPKD protein; fibrocystin is expressed on primary cilia
    Christopher J Ward
    Division of Nephrology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Hum Mol Genet 12:2703-10. 2003
  6. ncbi request reprint Identification, characterization, and localization of a novel kidney polycystin-1-polycystin-2 complex
    Linda J Newby
    Sheffield Kidney Institute, University Section of Medicine, Division of Clinical Sciences, University of Sheffield, Sheffield S5 7AU, United Kingdom
    J Biol Chem 277:20763-73. 2002
  7. ncbi request reprint Functional characterization of PKDREJ, a male germ cell-restricted polycystin
    Keith A Sutton
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 209:493-500. 2006
  8. ncbi request reprint Proteolytic cleavage and nuclear translocation of fibrocystin is regulated by intracellular Ca2+ and activation of protein kinase C
    Thomas Hiesberger
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 75390, USA
    J Biol Chem 281:34357-64. 2006
  9. ncbi request reprint Lowering of Pkd1 expression is sufficient to cause polycystic kidney disease
    Irma S Lantinga-van Leeuwen
    Center for Human and Clinical Genetics, Leiden University Medical Center, 2333 AL Leiden, The Netherlands
    Hum Mol Genet 13:3069-77. 2004
  10. pmc A polycystin-1 multiprotein complex is disrupted in polycystic kidney disease cells
    Tamara Roitbak
    Department of Pathology, University of New Mexico, Health Science Center, Albuquerque, New Mexico 87131, USA
    Mol Biol Cell 15:1334-46. 2004

Research Grants

  1. Analysis of ARPKD by Targeted Manipulation of Pkhd1
    Christopher Ward; Fiscal Year: 2007

Collaborators

  • Vicente Torres
  • P C Harris
  • Ming Li
  • S Somlo
  • M C Hogan
  • Roser Torra
  • Qi Qian
  • JEFFREY SALISBURY
  • A C Ong
  • H J Baelde
  • Peter Igarashi
  • Rachaneekorn Tammachote
  • Jason L Bakeberg
  • Vincent H Gattone
  • Caroline A Miller
  • Thomas Hiesberger
  • Keith A Sutton
  • Ursula M Smith
  • Tamara Roitbak
  • Irma S Lantinga-van Leeuwen
  • Linda J Newby
  • Han Fang Tuan
  • Yanhong Wu
  • Bing Q Huang
  • Jan M van Deursen
  • John R Woollard
  • Cynthia J Hommerding
  • Peter G Czarnecki
  • Rachel M Sinders
  • Amanda C Leightner
  • Louise J Tee
  • Martine Bucourt
  • Tania Attie-Bitach
  • Eric Gourley
  • Deirdre A Kelly
  • Mark Consugar
  • Carole McKeown
  • Esther N Maina
  • Nicholas F Larusso
  • Peter Koulen
  • Paul Gissen
  • Christopher P Bennett
  • Eamonn R Maher
  • Tatyana V Masyuk
  • C Geoffrey Woods
  • Richard C Trembath
  • Harvey M Florman
  • Erin Goranson
  • Phillip Cox
  • Rachaneekorn Punyashthiti
  • Lihadh Algazali
  • Colin A Johnson
  • Melissa K Jungnickel
  • Brandy M McKee
  • Stacie Lilliquist
  • Shelly Whelan
  • Neil V Morgan
  • Philip A Batman
  • Irene A Aligianis
  • Saghira Malik Sharif
  • Shanaz Pasha
  • Andrea Erickson
  • Wouter N Leonhard
  • Johannes G Dauwerse
  • Annemieke van de Wal
  • Martijn H Breuning
  • Dorien J M Peters
  • Sjef Verbeek
  • Robert Bacallao
  • Emile De Heer
  • Scott A Ness
  • Angela Wandinger-Ness
  • Marco C DeRuiter
  • Yan Zhao
  • Andrew J Streets

Detail Information

Publications11

  1. pmc Epitope-tagged Pkhd1 tracks the processing, secretion, and localization of fibrocystin
    Jason L Bakeberg
    Division of Nephrology and Hypertension, Mayo Clinic, 703 Stabile Building, 200 First Street SW, Rochester, MN 55905, USA
    J Am Soc Nephrol 22:2266-77. 2011
    ..In summary, tagging of the endogenous Pkhd1 gene facilitates the study of the glycosylation, proteolytic cleavage, and shedding of fibrocystin...
  2. pmc Germline PKHD1 mutations are protective against colorectal cancer
    Christopher J Ward
    Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Hum Genet 129:345-9. 2011
    ..0002). We also show that the carriage rate for PKHD1 mutations in the European population is higher than previous accepted at 3.2% (1:31 genomes)...
  3. ncbi request reprint Analysis of the polycystins in aortic vascular smooth muscle cells
    Qi Qian
    Division of Nephrology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Soc Nephrol 14:2280-7. 2003
    ..These observations are consistent with an important role of the polycystins in the development, maintenance, and function of the myoelastic arterial organization and with the vascular phenotype associated with ADPKD...
  4. pmc Ciliary and centrosomal defects associated with mutation and depletion of the Meckel syndrome genes MKS1 and MKS3
    Rachaneekorn Tammachote
    Department of Biochemistry Molecular Biology, Mayo Clinic, Rochester, MN, USA
    Hum Mol Genet 18:3311-23. 2009
    ..MKS1 and MKS3 functions are required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication...
  5. ncbi request reprint Cellular and subcellular localization of the ARPKD protein; fibrocystin is expressed on primary cilia
    Christopher J Ward
    Division of Nephrology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Hum Mol Genet 12:2703-10. 2003
    ..The localization of fibrocystin to cilia further strengthens that correlation and indicates that the primary defect in ARPKD may be linked to ciliary dysfunction...
  6. ncbi request reprint Identification, characterization, and localization of a novel kidney polycystin-1-polycystin-2 complex
    Linda J Newby
    Sheffield Kidney Institute, University Section of Medicine, Division of Clinical Sciences, University of Sheffield, Sheffield S5 7AU, United Kingdom
    J Biol Chem 277:20763-73. 2002
    ....
  7. ncbi request reprint Functional characterization of PKDREJ, a male germ cell-restricted polycystin
    Keith A Sutton
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 209:493-500. 2006
    ..These interactions, as well as polycystin-2 association with TRPC channels, are consistent with a role of this protein in the regulation of the acrosome reaction and in other aspects of sperm physiology...
  8. ncbi request reprint Proteolytic cleavage and nuclear translocation of fibrocystin is regulated by intracellular Ca2+ and activation of protein kinase C
    Thomas Hiesberger
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 75390, USA
    J Biol Chem 281:34357-64. 2006
    ..These results identify a novel Ca2+-dependent pathway that signals from fibrocystin located in the cell membrane to the nucleus...
  9. ncbi request reprint Lowering of Pkd1 expression is sufficient to cause polycystic kidney disease
    Irma S Lantinga-van Leeuwen
    Center for Human and Clinical Genetics, Leiden University Medical Center, 2333 AL Leiden, The Netherlands
    Hum Mol Genet 13:3069-77. 2004
    ..We propose that in patients reduced PKD1 expression of the normal allele below a critical level, due to genetic, environmental or stochastic factors, may lead to cyst formation in the kidneys and other clinical features of ADPKD...
  10. pmc A polycystin-1 multiprotein complex is disrupted in polycystic kidney disease cells
    Tamara Roitbak
    Department of Pathology, University of New Mexico, Health Science Center, Albuquerque, New Mexico 87131, USA
    Mol Biol Cell 15:1334-46. 2004
    ....
  11. ncbi request reprint The transmembrane protein meckelin (MKS3) is mutated in Meckel-Gruber syndrome and the wpk rat
    Ursula M Smith
    Section of Medical and Molecular Genetics, Division of Reproductive and Child Health, University of Birmingham Medical School, Birmingham B15 2TT, UK
    Nat Genet 38:191-6. 2006
    ..It encodes a 995-amino acid seven-transmembrane receptor protein of unknown function that we have called meckelin...

Research Grants5

  1. Analysis of ARPKD by Targeted Manipulation of Pkhd1
    Christopher Ward; Fiscal Year: 2007
    ..These are essential prerequisites before rational therapies can be developed for this disorder. ..