Research Topics
Genomes and Genes
| Liang WangSummaryAffiliation: Mayo Clinic Country: USA Publications
Research Grants
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Detail Information
Publications
Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative statesAaron L Sarver
Biostatistics and Informatics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA
BMC Cancer 9:401. 2009..Differential miRNA expression in cancer versus normal tissue is a common event and may be pivotal for tumor onset and progression...- Genome-wide transcriptional profiling reveals microRNA-correlated genes and biological processes in human lymphoblastoid cell linesLiang Wang
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
PLoS ONE 4:e5878. 2009..However, past studies have focused on the miRNA target genes and used loss- or gain-of-function approach that may not reflect natural association between miRNA and mRNAs... 
Mitochondrial genetic polymorphisms and pancreatic cancer riskLiang Wang
Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street Southwest, Stabile 241, Rochester, MN 55905, USA
Cancer Epidemiol Biomarkers Prev 16:1455-9. 2007..Investigation of other mitochondrial genetic variations (i.e., nuclear-encoded mitochondrial proteins) would be necessary to elucidate any role of mitochondrial DNA variation in PC...- Gene networks and microRNAs implicated in aggressive prostate cancerLiang Wang
Department of Laboratory Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Cancer Res 69:9490-7. 2009.... - Androgen receptor (AR) NH2- and COOH-terminal interactions result in the differential influences on the AR-mediated transactivation and cell growthCheng Lung Hsu
The George H Whipple Laboratory for Cancer Research, Department of Pathology, and the Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA
Mol Endocrinol 19:350-61. 2005..Therefore, drugs designed by targeting AR N-C interaction as a therapeutic intervention for prostate cancer treatment may face unpredictable in vivo effects... - Polymorphisms in mitochondrial genes and prostate cancer riskLiang Wang
Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN 55905, USA
Cancer Epidemiol Biomarkers Prev 17:3558-66. 2008..Overall, these results suggest that polymorphisms in the mitochondrial genome and those in the nuclear-encoded mitochondrial genes evaluated are not substantial risk factors for prostate cancer... - BRAF mutations in colon cancer are not likely attributable to defective DNA mismatch repairLiang Wang
Department of Laboratory Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
Cancer Res 63:5209-12. 2003..Furthermore, BRAF mutations were strongly associated with the epigenetic alteration of hMLH1. Overall, these data suggest that BRAF mutations are not a consequence of defective mismatch repair per se... - Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancerYueh Chiang Hu
George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester, Rochester, New York 14642, USA
J Biol Chem 279:33438-46. 2004.... - Induction of androgen receptor expression by phosphatidylinositol 3-kinase/Akt downstream substrate, FOXO3a, and their roles in apoptosis of LNCaP prostate cancer cellsLin Yang
George Whipple Laboratory for Cancer Research, Department of Pathology, The Cancer Center, University of Rochester, Rochester, New York 14642, USA
J Biol Chem 280:33558-65. 2005..Together, our data provide the first model to explain how PI3K/Akt and AR can cooperate to control LNCaP cell growth and death under normal conditions... - Two common chromosome 8q24 variants are associated with increased risk for prostate cancerLiang Wang
Departments of Laboratory Medicine and Pathology, Health Sciences Research, and Urology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Cancer Res 67:2944-50. 2007..00005). These results further confirm the importance of these two polymorphic variants (rs1447295 and DG8S737) as risk factors for PC. However, the mechanism explaining this increased risk has not yet been established... - miRNA expression in colon polyps provides evidence for a multihit model of colon cancerAnn L Oberg
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America
PLoS ONE 6:e20465. 2011..The comparison between pMMR and dMMR tumors identified four miRNAs (miR-31, miR-552, miR-592 and miR-224) with statistically significant expression differences (≥2-fold change)... - Regulation of interleukin-6-mediated PI3K activation and neuroendocrine differentiation by androgen signaling in prostate cancer LNCaP cellsShaozhen Xie
George H Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester, Rochester, New York 14642, USA
Prostate 60:61-7. 2004..In this study, we investigate how androgen plays a role in IL-6-mediated NE differentiation in LNCaP cell line... 
The value of MUTYH testing in patients with early onset microsatellite stable colorectal cancer referred for hereditary nonpolyposis colon cancer syndrome testingDouglas L Riegert-Johnson
Department of Gastroenterology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Genet Test 11:361-5. 2007..Thus, MUTYH mutation testing may be a reasonable cascade test in early onset CRC found to have proficient DNA mismatch repair, regardless of pattern of family history or number of polyps...- Interleukin-6 differentially regulates androgen receptor transactivation via PI3K-Akt, STAT3, and MAPK, three distinct signal pathways in prostate cancer cellsLin Yang
George Whipple Lab for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA
Biochem Biophys Res Commun 305:462-9. 2003..Together, our results indicate that the balance of these various pathways may then determine the overall effect of IL-6 on AR transactivation... - Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancerJulie M Cunningham
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Cancer Epidemiol Biomarkers Prev 16:969-78. 2007..Given that the point estimates for the odds ratio for each of these polymorphisms are <2.0, much larger sample sizes will be required for confirmation... - Higher frequency of diploidy in young-onset microsatellite-stable colorectal cancerLisa A Boardman
Department of Gastroenterology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Clin Cancer Res 13:2323-8. 2007..The clinicopathologic features of MSS CIN- CRC are not well delineated. We assessed the relationship between age and chromosomal instability (CIN) status as measured by ploidy and allelic imbalance in a series of MSS tumors... - Leukocyte DNA methylation signature differentiates pancreatic cancer patients from healthy controlsKatrina S Pedersen
Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
PLoS ONE 6:e18223. 2011..The methylation differences at certain CpG sites are partially attributable to genetic variation. This study strongly supports future epigenome-wide association study using leukocyte DNA for biomarker discovery in human diseases... - Highly methylated genes in colorectal neoplasia: implications for screeningHongzhi Zou
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA
Cancer Epidemiol Biomarkers Prev 16:2686-96. 2007..Comethylation of these genes is common, and pursuit of complementary markers for methylation-negative neoplasms is a rational strategy to optimize screening sensitivity... - APPL suppresses androgen receptor transactivation via potentiating Akt activityLin Yang
Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
J Biol Chem 278:16820-7. 2003..Together, our data indicate that APPL may suppress AR transactivation via potentiating Akt activity... - Genetic variants and risk of lung cancer in never smokers: a genome-wide association studyYafei Li
Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Lancet Oncol 11:321-30. 2010..Lung cancer in individuals who have never smoked tobacco products is an increasing medical and public-health issue. We aimed to unravel the genetic basis of lung cancer in never smokers... - No association of germline alteration of MSR1 with prostate cancer riskLiang Wang
Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, 920 Hilton Building, Mayo Clinic and Foundation, Rochester, Minnesota, USA
Nat Genet 35:128-9. 2003..Our results do not support MSR1 as a risk factor for prostate cancer... - Mutations in CHEK2 associated with prostate cancer riskXiangyang Dong
Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic Mayo Medical School, Rochester, MN 55905, USA
Am J Hum Genet 72:270-80. 2003..Overall, our data suggest that mutations in CHEK2 may contribute to prostate cancer risk and that the DNA-damage-signaling pathway may play an important role in the development of prostate cancer... - Human checkpoint protein hRad9 functions as a negative coregulator to repress androgen receptor transactivation in prostate cancer cellsLiang Wang
George H Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
Mol Cell Biol 24:2202-13. 2004..Together, our data provide the first linkage between androgen-AR signals and radiation-induced responses. Further studies of the influence of hRad9 on prostate cancer growth may provide potential new therapeutic approaches... - MYH mutations in patients with attenuated and classic polyposis and with young-onset colorectal cancer without polypsLiang Wang
Department of Laboratory Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Gastroenterology 127:9-16. 2004.... - BRAF V600E disrupts AZD6244-induced abrogation of negative feedback pathways between extracellular signal-regulated kinase and Raf proteinsBret B Friday
Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA
Cancer Res 68:6145-53. 2008..These data suggest an approach to identifying cells that may be sensitive to AZD6244 and other MEK inhibitors... - Truncating variants in p53AIP1 disrupting DNA damage-induced apoptosis are associated with prostate cancer riskXianshu Wang
Department of Laboratory Medicine, Mayo Clinic/Mayo Clinical Medical College, Rochester, Minnesota 55905, USA
Cancer Res 66:10302-7. 2006.... - Androgen receptor corepressors: an overviewLiang Wang
George H. Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, New York, USA
Prostate 63:117-30. 2005..The potential impact and future directions of AR corepressors are also discussed... - Analysis of the RNASEL gene in familial and sporadic prostate cancerLiang Wang
Department of Laboratory Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
Am J Hum Genet 71:116-23. 2002..82; P=.03), as well as in the subset analyses. These results suggest that polymorphic changes within the RNASEL gene may be associated with increased risk of familial but not sporadic PC... - Loss of testicular orphan receptor 4 impairs normal myelination in mouse forebrainYanqing Zhang
George Whipple Laboratory for Cancer Research, University of Rochester Medical Center, Rochester, New York 14642, USA
Mol Endocrinol 21:908-20. 2007..The altered Jagged1-Notch signaling in TR4(-/-) forebrain underlies a potential mechanism that contributes to the reduced myelination in the forebrain... - Methylation markers for small cell lung cancer in peripheral blood leukocyte DNALiang Wang
Department of Laboratory Medicine and Pathology, Mayo Clinic, College of Medicine, Rochester, Minnesota 55905, USA
J Thorac Oncol 5:778-85. 2010..Small cell lung cancer (SCLC) is the most aggressive form of lung malignancy... - Isolation and characterization of androgen receptor mutant, AR(M749L), with hypersensitivity to 17-beta estradiol treatmentTin Htwe Thin
George Whipple Laboratory for Cancer Research Department of Pathology, University of Rochester, Rochester, New York 14642, USA
J Biol Chem 278:7699-708. 2003..Therefore, amino acid 749 may represent an important site within the AR-LBD that is involved in interaction with E(2) that, when mutated, allows E(2) induction of AR transactivation... - Network-based approach identified cell cycle genes as predictor of overall survival in lung adenocarcinoma patientsYafei Li
Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, Chongqing, People s Republic of China
Lung Cancer 80:91-8. 2013..02-2.24) of death than patients with a low-risk gene signature. These results suggest that a network-based approach may facilitate discovery of key genes that are closely linked to survival in patients with lung adenocarcinoma... - Predictors of survival in never-smokers with non-small cell lung cancer: a large-scale, two-phase genetic studyXia Pu
Department of Epidemiology, Thoracic Head and Neck Medical Oncology, and Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 18:5983-91. 2012..Therefore, we aimed to identify prognostic markers specific for LCINS... - Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligaseHui Kuan Lin
George H Whipple Laboratory for Cancer Research, Department of Pathology and The Cancer Center, University of Rochester, Rochester, NY 14642, USA
EMBO J 21:4037-48. 2002..These results suggest that phosphorylation-dependent AR ubiquitylation and degradation by Akt require the involvement of Mdm2 E3 ligase activity, a novel mechanism that provides insight into how AR is targeted for degradation... - Low-density lipoprotein receptor-related protein 5 (LRP5) gene polymorphisms are associated with bone mass in both Chinese and whitesDong Hai Xiong
Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, NE, USA
J Bone Miner Res 22:385-93. 2007..These data support the concept that LRP5 variation can contribute to minor and major variation in bone structure... - Genome-wide association scans identified CTNNBL1 as a novel gene for obesityYong Jun Liu
School of Medicine, University of Missouri Kansas City, Kansas City, MO 64108, USA
Hum Mol Genet 17:1803-13. 2008..Our study also provided supportive evidence for previously identified associations between obesity and INSIG2 and PFKP, but not FTO... - Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancerJulius Gudmundsson
deCODE Genetics, 101 Reykjavik, Iceland
Nat Genet 40:281-3. 2008..23 and 1.15; P = 3.9 x 10(-13) and 7.7 x 10(-9), respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease... - Mitochondrial genetic polymorphisms do not predict survival in patients with pancreatic cancerThorvardur R Halfdanarson
Department of Internal Medicine, Division of Hematology, Oncology and Blood and Marrow Transplantation, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
Cancer Epidemiol Biomarkers Prev 17:2512-3. 2008..After adjusting for covariates and multiple comparisons, no association between any of the mitochondrial single nucleotide polymorphisms or haplogroups and survival was observed... - [Expression of p120ctn and its significance in non-small cell lung cancer]Cheng-yao Xie
Department of Pathology, College of Basic Medical Science, China Medical University, Shenyang 110001, China
Zhonghua Bing Li Xue Za Zhi 34:206-10. 2005..CONCLUSION: The expression of p120(ctn) is abnormal in NSCLC; p120(ctn) may serve as a useful prognostic marker for NSCLC... - The role of preoperative endorectal magnetic resonance imaging in the decision regarding whether to preserve or resect neurovascular bundles during radical retropubic prostatectomyHedvig Hricak
Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cancer 100:2655-63. 2004..In the current study, the authors determined the incremental value of endorectal magnetic resonance imaging (eMRI) in making this decision... - Perihepatic lymph node assessment in patients undergoing partial hepatectomy for malignancyStephen R Grobmyer
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Ann Surg 244:260-4. 2006..Routine sampling of perihepatic lymph nodes will therefore have a low yield in patients without some evidence of disease on preoperative CT or PET scans or at the time of exploration... - Prediction of organ-confined prostate cancer: incremental value of MR imaging and MR spectroscopic imaging to staging nomogramsLiang Wang
Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
Radiology 238:597-603. 2006..To assess retrospectively the incremental value of endorectal coil magnetic resonance (MR) imaging and combined endorectal MR imaging-MR spectroscopic imaging to the staging nomograms for predicting organ-confined prostate cancer (OCPC)... - [Correlation of invasion, metastasis, and prognosis in low and middle rectal cancer]Wei jie He
Department of General Surgery, Suzhou University Hospital, Suzhou 215006, P R China
Ai Zheng 21:1222-5. 2002..Based on these variables, a new classification system has been recommended. This study was designed to evaluate prognostic significance and risk factors of neoplasm in low and middle rectal cancer... - [Expressions of Axin and beta-catenin in non-small cell lung cancer]Hong-Tao Xu
Department of Pathology, College of Basic Medical Science, China Medical University, Shenyang 110001, China
Zhonghua Bing Li Xue Za Zhi 34:519-23. 2005..The expression of Axin is inversely correlated with the degree of tumor differentiation and nuclear expression of beta-catenin. The exon 3 mutations do not contribute to the abnormal protein expression of beta-catenin in NSCLCs... - Combined endorectal and phased-array MRI in the prediction of pelvic lymph node metastasis in prostate cancerLiang Wang
Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Rm. C-278, New York, NY 10021, USA
AJR Am J Roentgenol 186:743-8. 2006..01). CONCLUSION: Incorporation of the Partin nomogram results and MRI findings regarding both extracapsular extension and seminal vesicle invasion improves the MR prediction of LNM in patients with prostate cancer... - Alteration of focal adhesion kinase expression in eutopic endometrium of women with endometriosisLin Mu
Department of Gynecology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, China
Fertil Steril 89:529-37. 2008..To investigate whether focal adhesion kinase (FAK) expression is altered in eutopic endometrium of women with endometriosis... - Chromosome 2q32 may harbor a QTL affecting BMD variation at different skeletal sitesLiang Wang
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an, Shaanxi, China
J Bone Miner Res 22:1672-8. 2007..BMDs at different skeletal sites share some common genetic determinants. Using PCA and bivariate linkage analysis, we identified a QTL on chromosome 2q32 with significant pleiotropic effects on BMDs at different skeletal sites... - Sex-specific association of the glucocorticoid receptor gene with extreme BMDYu Mei Peng
The Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an, China
J Bone Miner Res 23:247-52. 2008..To study the role of the GR gene on BMD regulation in the Chinese, a sex-specific association study was performed. The results indicated that GR variation contributed to the extreme BMD variation in the Chinese... - [Hydroxycamptothecin promotes the apoptosis of prostate cancer cell line PC-3]Yu Wu
Department of Urology, Union Hospital, Tongii Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China
Zhonghua Nan Ke Xue 13:890-4. 2007..To observe the effects of hydroxycamptothecin (HCPT) on the apoptosis of prostate cancer cell line PC-3 and to explore the possible mechanism... - Fine mapping of familial prostate cancer families narrows the interval for a susceptibility locus on chromosome 22q12.3 to 1.36 MbBo Johanneson
Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
Hum Genet 123:65-75. 2008..Combining these results with data from the earlier ICPCG study reduces the three-recombination interval at 22q12.3 to approximately 1.36 Mb... - Prediction of seminal vesicle invasion in prostate cancer: incremental value of adding endorectal MR imaging to the Kattan nomogramLiang Wang
Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
Radiology 242:182-8. 2007..To retrospectively determine whether endorectal magnetic resonance (MR) imaging findings contribute incremental value to the Kattan nomogram for predicting seminal vesicle invasion (SVI) in patients with prostate cancer... - Smac/DIABLO promotes mitomycin C-induced apoptosis of bladder cancer T24 cellsLiang Wang
Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
J Huazhong Univ Sci Technolog Med Sci 26:317-8, 328. 2006..05 or 0.005 mg/mL mitomycin C (P < 0.05). It was concluded that Smac could enhance the apoptosis of T24 by mitomycin C, which could provide a useful experimental evidence for bladder cancer therapy... - Focal adhesion kinase expression in ovarian endometriosisLin Mu
Department of Gynecology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
Int J Gynaecol Obstet 101:161-5. 2008..To investigate whether focal adhesion kinase (FAK) is expressed in endometriotic ovarian tissue... - Surface electromyography of pelvic floor muscles in stress urinary incontinenceQiong Zhang
Department of Gynecology, Second Affiliated Hospital, Zhejiang University, College of Medicine, Zhejiang Hangzhou, China
Int J Gynaecol Obstet 95:177-8. 2006 - Default mode network as revealed with multiple methods for resting-state functional MRI analysisXiang Yu Long
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China
J Neurosci Methods 171:349-55. 2008..Moreover, the current results provided evidences that the brain areas within the two anti-correlated networks are highly integrated at both the intra- and inter-regional level...
Research Grants
- Genetics of Germline Gene Expression Phenotype in Aggressive Prostate CancerLiang Wang; Fiscal Year: 2007..More importantly, characterization of inherited gene expression signature could point to targets for screening, preventive and therapeutic studies. ..