Liang Wang

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Leukocyte DNA methylation signature differentiates pancreatic cancer patients from healthy controls
    Katrina S Pedersen
    Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
    PLoS ONE 6:e18223. 2011
  2. ncbi request reprint Mitochondrial genetic polymorphisms and pancreatic cancer risk
    Liang Wang
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street Southwest, Stabile 241, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 16:1455-9. 2007
  3. pmc Genome-wide transcriptional profiling reveals microRNA-correlated genes and biological processes in human lymphoblastoid cell lines
    Liang Wang
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
    PLoS ONE 4:e5878. 2009
  4. pmc Gene networks and microRNAs implicated in aggressive prostate cancer
    Liang Wang
    Department of Laboratory Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Cancer Res 69:9490-7. 2009
  5. ncbi request reprint Androgen receptor (AR) NH2- and COOH-terminal interactions result in the differential influences on the AR-mediated transactivation and cell growth
    Cheng Lung Hsu
    The George H Whipple Laboratory for Cancer Research, Department of Pathology, and the Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA
    Mol Endocrinol 19:350-61. 2005
  6. pmc miRNA expression in colon polyps provides evidence for a multihit model of colon cancer
    Ann L Oberg
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 6:e20465. 2011
  7. pmc Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states
    Aaron L Sarver
    Biostatistics and Informatics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA
    BMC Cancer 9:401. 2009
  8. ncbi request reprint BRAF mutations in colon cancer are not likely attributable to defective DNA mismatch repair
    Liang Wang
    Department of Laboratory Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Cancer Res 63:5209-12. 2003
  9. pmc Polymorphisms in mitochondrial genes and prostate cancer risk
    Liang Wang
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 17:3558-66. 2008
  10. ncbi request reprint Induction of androgen receptor expression by phosphatidylinositol 3-kinase/Akt downstream substrate, FOXO3a, and their roles in apoptosis of LNCaP prostate cancer cells
    Lin Yang
    George Whipple Laboratory for Cancer Research, Department of Pathology, The Cancer Center, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 280:33558-65. 2005

Collaborators

Detail Information

Publications55

  1. pmc Leukocyte DNA methylation signature differentiates pancreatic cancer patients from healthy controls
    Katrina S Pedersen
    Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
    PLoS ONE 6:e18223. 2011
    ..The methylation differences at certain CpG sites are partially attributable to genetic variation. This study strongly supports future epigenome-wide association study using leukocyte DNA for biomarker discovery in human diseases...
  2. ncbi request reprint Mitochondrial genetic polymorphisms and pancreatic cancer risk
    Liang Wang
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street Southwest, Stabile 241, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 16:1455-9. 2007
    ..Investigation of other mitochondrial genetic variations (i.e., nuclear-encoded mitochondrial proteins) would be necessary to elucidate any role of mitochondrial DNA variation in PC...
  3. pmc Genome-wide transcriptional profiling reveals microRNA-correlated genes and biological processes in human lymphoblastoid cell lines
    Liang Wang
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
    PLoS ONE 4:e5878. 2009
    ..However, past studies have focused on the miRNA target genes and used loss- or gain-of-function approach that may not reflect natural association between miRNA and mRNAs...
  4. pmc Gene networks and microRNAs implicated in aggressive prostate cancer
    Liang Wang
    Department of Laboratory Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Cancer Res 69:9490-7. 2009
    ....
  5. ncbi request reprint Androgen receptor (AR) NH2- and COOH-terminal interactions result in the differential influences on the AR-mediated transactivation and cell growth
    Cheng Lung Hsu
    The George H Whipple Laboratory for Cancer Research, Department of Pathology, and the Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA
    Mol Endocrinol 19:350-61. 2005
    ..Therefore, drugs designed by targeting AR N-C interaction as a therapeutic intervention for prostate cancer treatment may face unpredictable in vivo effects...
  6. pmc miRNA expression in colon polyps provides evidence for a multihit model of colon cancer
    Ann L Oberg
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 6:e20465. 2011
    ..The comparison between pMMR and dMMR tumors identified four miRNAs (miR-31, miR-552, miR-592 and miR-224) with statistically significant expression differences (≥2-fold change)...
  7. pmc Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states
    Aaron L Sarver
    Biostatistics and Informatics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA
    BMC Cancer 9:401. 2009
    ..Differential miRNA expression in cancer versus normal tissue is a common event and may be pivotal for tumor onset and progression...
  8. ncbi request reprint BRAF mutations in colon cancer are not likely attributable to defective DNA mismatch repair
    Liang Wang
    Department of Laboratory Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Cancer Res 63:5209-12. 2003
    ..Furthermore, BRAF mutations were strongly associated with the epigenetic alteration of hMLH1. Overall, these data suggest that BRAF mutations are not a consequence of defective mismatch repair per se...
  9. pmc Polymorphisms in mitochondrial genes and prostate cancer risk
    Liang Wang
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 17:3558-66. 2008
    ..Overall, these results suggest that polymorphisms in the mitochondrial genome and those in the nuclear-encoded mitochondrial genes evaluated are not substantial risk factors for prostate cancer...
  10. ncbi request reprint Induction of androgen receptor expression by phosphatidylinositol 3-kinase/Akt downstream substrate, FOXO3a, and their roles in apoptosis of LNCaP prostate cancer cells
    Lin Yang
    George Whipple Laboratory for Cancer Research, Department of Pathology, The Cancer Center, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 280:33558-65. 2005
    ..Together, our data provide the first model to explain how PI3K/Akt and AR can cooperate to control LNCaP cell growth and death under normal conditions...
  11. ncbi request reprint Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer
    Yueh Chiang Hu
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 279:33438-46. 2004
    ....
  12. ncbi request reprint Two common chromosome 8q24 variants are associated with increased risk for prostate cancer
    Liang Wang
    Departments of Laboratory Medicine and Pathology, Health Sciences Research, and Urology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Cancer Res 67:2944-50. 2007
    ..00005). These results further confirm the importance of these two polymorphic variants (rs1447295 and DG8S737) as risk factors for PC. However, the mechanism explaining this increased risk has not yet been established...
  13. ncbi request reprint Regulation of interleukin-6-mediated PI3K activation and neuroendocrine differentiation by androgen signaling in prostate cancer LNCaP cells
    Shaozhen Xie
    George H Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester, Rochester, New York 14642, USA
    Prostate 60:61-7. 2004
    ..In this study, we investigate how androgen plays a role in IL-6-mediated NE differentiation in LNCaP cell line...
  14. doi request reprint The value of MUTYH testing in patients with early onset microsatellite stable colorectal cancer referred for hereditary nonpolyposis colon cancer syndrome testing
    Douglas L Riegert-Johnson
    Department of Gastroenterology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Genet Test 11:361-5. 2007
    ..Thus, MUTYH mutation testing may be a reasonable cascade test in early onset CRC found to have proficient DNA mismatch repair, regardless of pattern of family history or number of polyps...
  15. ncbi request reprint Interleukin-6 differentially regulates androgen receptor transactivation via PI3K-Akt, STAT3, and MAPK, three distinct signal pathways in prostate cancer cells
    Lin Yang
    George Whipple Lab for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 305:462-9. 2003
    ..Together, our results indicate that the balance of these various pathways may then determine the overall effect of IL-6 on AR transactivation...
  16. ncbi request reprint Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancer
    Julie M Cunningham
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 16:969-78. 2007
    ..Given that the point estimates for the odds ratio for each of these polymorphisms are <2.0, much larger sample sizes will be required for confirmation...
  17. ncbi request reprint Higher frequency of diploidy in young-onset microsatellite-stable colorectal cancer
    Lisa A Boardman
    Department of Gastroenterology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Cancer Res 13:2323-8. 2007
    ..The clinicopathologic features of MSS CIN- CRC are not well delineated. We assessed the relationship between age and chromosomal instability (CIN) status as measured by ploidy and allelic imbalance in a series of MSS tumors...
  18. ncbi request reprint Highly methylated genes in colorectal neoplasia: implications for screening
    Hongzhi Zou
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 16:2686-96. 2007
    ..Comethylation of these genes is common, and pursuit of complementary markers for methylation-negative neoplasms is a rational strategy to optimize screening sensitivity...
  19. pmc Mitochondrial genetic polymorphisms do not predict survival in patients with pancreatic cancer
    Thorvardur R Halfdanarson
    Department of Internal Medicine, Division of Hematology, Oncology and Blood and Marrow Transplantation, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    Cancer Epidemiol Biomarkers Prev 17:2512-3. 2008
    ..After adjusting for covariates and multiple comparisons, no association between any of the mitochondrial single nucleotide polymorphisms or haplogroups and survival was observed...
  20. ncbi request reprint APPL suppresses androgen receptor transactivation via potentiating Akt activity
    Lin Yang
    Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 278:16820-7. 2003
    ..Together, our data indicate that APPL may suppress AR transactivation via potentiating Akt activity...
  21. pmc Genetic variants and risk of lung cancer in never smokers: a genome-wide association study
    Yafei Li
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Lancet Oncol 11:321-30. 2010
    ..Lung cancer in individuals who have never smoked tobacco products is an increasing medical and public-health issue. We aimed to unravel the genetic basis of lung cancer in never smokers...
  22. pmc Human checkpoint protein hRad9 functions as a negative coregulator to repress androgen receptor transactivation in prostate cancer cells
    Liang Wang
    George H Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Mol Cell Biol 24:2202-13. 2004
    ..Together, our data provide the first linkage between androgen-AR signals and radiation-induced responses. Further studies of the influence of hRad9 on prostate cancer growth may provide potential new therapeutic approaches...
  23. pmc Mutations in CHEK2 associated with prostate cancer risk
    Xiangyang Dong
    Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic Mayo Medical School, Rochester, MN 55905, USA
    Am J Hum Genet 72:270-80. 2003
    ..Overall, our data suggest that mutations in CHEK2 may contribute to prostate cancer risk and that the DNA-damage-signaling pathway may play an important role in the development of prostate cancer...
  24. ncbi request reprint No association of germline alteration of MSR1 with prostate cancer risk
    Liang Wang
    Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, 920 Hilton Building, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Nat Genet 35:128-9. 2003
    ..Our results do not support MSR1 as a risk factor for prostate cancer...
  25. ncbi request reprint MYH mutations in patients with attenuated and classic polyposis and with young-onset colorectal cancer without polyps
    Liang Wang
    Department of Laboratory Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Gastroenterology 127:9-16. 2004
    ....
  26. ncbi request reprint BRAF V600E disrupts AZD6244-induced abrogation of negative feedback pathways between extracellular signal-regulated kinase and Raf proteins
    Bret B Friday
    Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA
    Cancer Res 68:6145-53. 2008
    ..These data suggest an approach to identifying cells that may be sensitive to AZD6244 and other MEK inhibitors...
  27. ncbi request reprint Truncating variants in p53AIP1 disrupting DNA damage-induced apoptosis are associated with prostate cancer risk
    Xianshu Wang
    Department of Laboratory Medicine, Mayo Clinic Mayo Clinical Medical College, Rochester, Minnesota 55905, USA
    Cancer Res 66:10302-7. 2006
    ....
  28. pmc Methylation markers for small cell lung cancer in peripheral blood leukocyte DNA
    Liang Wang
    Department of Laboratory Medicine and Pathology, Mayo Clinic, College of Medicine, Rochester, Minnesota 55905, USA
    J Thorac Oncol 5:778-85. 2010
    ..Small cell lung cancer (SCLC) is the most aggressive form of lung malignancy...
  29. ncbi request reprint Loss of testicular orphan receptor 4 impairs normal myelination in mouse forebrain
    Yanqing Zhang
    George Whipple Laboratory for Cancer Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    Mol Endocrinol 21:908-20. 2007
    ..The altered Jagged1-Notch signaling in TR4(-/-) forebrain underlies a potential mechanism that contributes to the reduced myelination in the forebrain...
  30. ncbi request reprint Androgen receptor corepressors: an overview
    Liang Wang
    George H Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, New York, USA
    Prostate 63:117-30. 2005
    ..The potential impact and future directions of AR corepressors are also discussed...
  31. pmc Analysis of the RNASEL gene in familial and sporadic prostate cancer
    Liang Wang
    Department of Laboratory Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Am J Hum Genet 71:116-23. 2002
    ..82; P=.03), as well as in the subset analyses. These results suggest that polymorphic changes within the RNASEL gene may be associated with increased risk of familial but not sporadic PC...
  32. ncbi request reprint Isolation and characterization of androgen receptor mutant, AR(M749L), with hypersensitivity to 17-beta estradiol treatment
    Tin Htwe Thin
    George Whipple Laboratory for Cancer Research Department of Pathology, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 278:7699-708. 2003
    ..Therefore, amino acid 749 may represent an important site within the AR-LBD that is involved in interaction with E(2) that, when mutated, allows E(2) induction of AR transactivation...
  33. pmc Network-based approach identified cell cycle genes as predictor of overall survival in lung adenocarcinoma patients
    Yafei Li
    Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, Chongqing, People s Republic of China
    Lung Cancer 80:91-8. 2013
    ..02-2.24) of death than patients with a low-risk gene signature. These results suggest that a network-based approach may facilitate discovery of key genes that are closely linked to survival in patients with lung adenocarcinoma...
  34. pmc Predictors of survival in never-smokers with non-small cell lung cancer: a large-scale, two-phase genetic study
    Xia Pu
    Department of Epidemiology, Thoracic Head and Neck Medical Oncology, and Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 18:5983-91. 2012
    ..Therefore, we aimed to identify prognostic markers specific for LCINS...
  35. pmc Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase
    Hui Kuan Lin
    George H Whipple Laboratory for Cancer Research, Department of Pathology and The Cancer Center, University of Rochester, Rochester, NY 14642, USA
    EMBO J 21:4037-48. 2002
    ..These results suggest that phosphorylation-dependent AR ubiquitylation and degradation by Akt require the involvement of Mdm2 E3 ligase activity, a novel mechanism that provides insight into how AR is targeted for degradation...
  36. ncbi request reprint Low-density lipoprotein receptor-related protein 5 (LRP5) gene polymorphisms are associated with bone mass in both Chinese and whites
    Dong Hai Xiong
    Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, NE, USA
    J Bone Miner Res 22:385-93. 2007
    ..These data support the concept that LRP5 variation can contribute to minor and major variation in bone structure...
  37. pmc Genome-wide association scans identified CTNNBL1 as a novel gene for obesity
    Yong Jun Liu
    School of Medicine, University of Missouri Kansas City, Kansas City, MO 64108, USA
    Hum Mol Genet 17:1803-13. 2008
    ..Our study also provided supportive evidence for previously identified associations between obesity and INSIG2 and PFKP, but not FTO...
  38. pmc Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer
    Julius Gudmundsson
    deCODE Genetics, 101 Reykjavik, Iceland
    Nat Genet 40:281-3. 2008
    ..23 and 1.15; P = 3.9 x 10(-13) and 7.7 x 10(-9), respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease...
  39. ncbi request reprint The role of preoperative endorectal magnetic resonance imaging in the decision regarding whether to preserve or resect neurovascular bundles during radical retropubic prostatectomy
    Hedvig Hricak
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer 100:2655-63. 2004
    ..In the current study, the authors determined the incremental value of endorectal magnetic resonance imaging (eMRI) in making this decision...
  40. ncbi request reprint [Expression of p120ctn and its significance in non-small cell lung cancer]
    Cheng Yao Xie
    Department of Pathology, College of Basic Medical Science, China Medical University, Shenyang 110001, China
    Zhonghua Bing Li Xue Za Zhi 34:206-10. 2005
    ..To investigate the expression of p120(ctn) in non-small cell lung cancer (NSCLC) and its correlation with the clinical and pathologic parameters...
  41. pmc Perihepatic lymph node assessment in patients undergoing partial hepatectomy for malignancy
    Stephen R Grobmyer
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Surg 244:260-4. 2006
    ..To assess the value of preoperative imaging studies and the intraoperative assessment of perihepatic lymph nodes in patients undergoing partial hepatectomy for malignancy...
  42. ncbi request reprint [Correlation of invasion, metastasis, and prognosis in low and middle rectal cancer]
    Wei jie He
    Department of General Surgery, Suzhou University Hospital, Suzhou 215006, P R China
    Ai Zheng 21:1222-5. 2002
    ..Based on these variables, a new classification system has been recommended. This study was designed to evaluate prognostic significance and risk factors of neoplasm in low and middle rectal cancer...
  43. ncbi request reprint Prediction of organ-confined prostate cancer: incremental value of MR imaging and MR spectroscopic imaging to staging nomograms
    Liang Wang
    Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Radiology 238:597-603. 2006
    ..To assess retrospectively the incremental value of endorectal coil magnetic resonance (MR) imaging and combined endorectal MR imaging-MR spectroscopic imaging to the staging nomograms for predicting organ-confined prostate cancer (OCPC)...
  44. ncbi request reprint [Expressions of Axin and beta-catenin in non-small cell lung cancer]
    Hong Tao Xu
    Department of Pathology, College of Basic Medical Science, China Medical University, Shenyang 110001, China
    Zhonghua Bing Li Xue Za Zhi 34:519-23. 2005
    ..To investigate the protein expression of Axin and beta-catenin, the exon 3 mutation status of beta-catenin and their clinicopathological correlations in non-small cell lung cancer (NSCLC)...
  45. ncbi request reprint Alteration of focal adhesion kinase expression in eutopic endometrium of women with endometriosis
    Lin Mu
    Department of Gynecology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, China
    Fertil Steril 89:529-37. 2008
    ..To investigate whether focal adhesion kinase (FAK) expression is altered in eutopic endometrium of women with endometriosis...
  46. ncbi request reprint Combined endorectal and phased-array MRI in the prediction of pelvic lymph node metastasis in prostate cancer
    Liang Wang
    Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Rm C 278, New York, NY 10021, USA
    AJR Am J Roentgenol 186:743-8. 2006
    ....
  47. ncbi request reprint Surface electromyography of pelvic floor muscles in stress urinary incontinence
    Qiong Zhang
    Department of Gynecology, Second Affiliated Hospital, Zhejiang University, College of Medicine, Zhejiang Hangzhou, China
    Int J Gynaecol Obstet 95:177-8. 2006
  48. ncbi request reprint Smac/DIABLO promotes mitomycin C-induced apoptosis of bladder cancer T24 cells
    Liang Wang
    Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    J Huazhong Univ Sci Technolog Med Sci 26:317-8, 328. 2006
    ..05 or 0.005 mg/mL mitomycin C (P < 0.05). It was concluded that Smac could enhance the apoptosis of T24 by mitomycin C, which could provide a useful experimental evidence for bladder cancer therapy...
  49. doi request reprint Focal adhesion kinase expression in ovarian endometriosis
    Lin Mu
    Department of Gynecology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
    Int J Gynaecol Obstet 101:161-5. 2008
    ..To investigate whether focal adhesion kinase (FAK) is expressed in endometriotic ovarian tissue...
  50. ncbi request reprint Prediction of seminal vesicle invasion in prostate cancer: incremental value of adding endorectal MR imaging to the Kattan nomogram
    Liang Wang
    Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Radiology 242:182-8. 2007
    ..To retrospectively determine whether endorectal magnetic resonance (MR) imaging findings contribute incremental value to the Kattan nomogram for predicting seminal vesicle invasion (SVI) in patients with prostate cancer...
  51. ncbi request reprint Fine mapping of familial prostate cancer families narrows the interval for a susceptibility locus on chromosome 22q12.3 to 1.36 Mb
    Bo Johanneson
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
    Hum Genet 123:65-75. 2008
    ..Combining these results with data from the earlier ICPCG study reduces the three-recombination interval at 22q12.3 to approximately 1.36 Mb...
  52. ncbi request reprint [Hydroxycamptothecin promotes the apoptosis of prostate cancer cell line PC-3]
    Yu Wu
    Department of Urology, Union Hospital, Tongii Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China
    Zhonghua Nan Ke Xue 13:890-4. 2007
    ..To observe the effects of hydroxycamptothecin (HCPT) on the apoptosis of prostate cancer cell line PC-3 and to explore the possible mechanism...
  53. pmc Sex-specific association of the glucocorticoid receptor gene with extreme BMD
    Yu Mei Peng
    The Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an, China
    J Bone Miner Res 23:247-52. 2008
    ..To study the role of the GR gene on BMD regulation in the Chinese, a sex-specific association study was performed. The results indicated that GR variation contributed to the extreme BMD variation in the Chinese...
  54. ncbi request reprint Chromosome 2q32 may harbor a QTL affecting BMD variation at different skeletal sites
    Liang Wang
    The Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an, Shaanxi, China
    J Bone Miner Res 22:1672-8. 2007
    ..BMDs at different skeletal sites share some common genetic determinants. Using PCA and bivariate linkage analysis, we identified a QTL on chromosome 2q32 with significant pleiotropic effects on BMDs at different skeletal sites...
  55. doi request reprint Default mode network as revealed with multiple methods for resting-state functional MRI analysis
    Xiang Yu Long
    State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China
    J Neurosci Methods 171:349-55. 2008
    ..Moreover, the current results provided evidences that the brain areas within the two anti-correlated networks are highly integrated at both the intra- and inter-regional level...

Research Grants2

  1. Genetics of Germline Gene Expression Phenotype in Aggressive Prostate Cancer
    Liang Wang; Fiscal Year: 2007
    ..More importantly, characterization of inherited gene expression signature could point to targets for screening, preventive and therapeutic studies. [unreadable] [unreadable] [unreadable]..
  2. Genetics of Germline Gene Expression Phenotype in Aggressive Prostate Cancer
    Liang Wang; Fiscal Year: 2008
    ..More importantly, characterization of inherited gene expression signature could point to targets for screening, preventive and therapeutic studies. [unreadable] [unreadable] [unreadable]..