Kenneth Wang

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc The role of cellular senescence in the gastrointestinal mucosa
    Joshua D Penfield
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA
    Gut Liver 7:270-7. 2013
  2. doi request reprint Medical and endoscopic management of high-grade dysplasia in Barrett's esophagus
    K K Wang
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55934, USA
    Dis Esophagus 25:349-55. 2012
  3. ncbi request reprint Photodynamic therapy in Barrett's esophagus
    Kenneth K Wang
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Mayo Graduate School of Medicine, 200 2nd Street SW, Rochester, MN 55905, USA
    Gastrointest Endosc Clin N Am 13:483-9, vii. 2003
  4. pmc Esophageal adenocarcinoma
    Kenneth K Wang
    Barrett s Esophagus Unit, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 4:1221-4. 2006
  5. pmc Photodynamic therapy for Barrett's esophagus: does light still have a role?
    K K Wang
    Mayo Clinic and Foundation, Mayo College of Medicine, Rochester, Minnesota 55905, USA
    Endoscopy 40:1021-5. 2008
  6. pmc Endoscopic mucosal resection and endoscopic submucosal dissection in esophageal and gastric cancers
    Kenneth K Wang
    Barrett s Esophagus Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    Curr Opin Gastroenterol 26:453-8. 2010
  7. pmc Current Strategies in the management of Barrett's esophagus
    Kenneth K Wang
    Division of Gastroenterology and Hepatology, Main Alfred Gastroenterology Unit, Saint Mary s Hospital, Mayo Clinic and College of Medicine, Rochester, MN 55905, USA
    Curr Gastroenterol Rep 7:196-201. 2005
  8. pmc Endoscopic evaluation and advanced imaging of Barrett's esophagus
    Kenneth K Wang
    Division of Gastroenterology, Mayo Clinic, Rochester, MN, USA
    Gastrointest Endosc Clin N Am 21:39-51. 2011
  9. ncbi request reprint Multimodality therapy for gastroesophageal cancers
    Kenneth K Wang
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Graduate School of Medicine, Rochester, MN 55905, USA
    J Gastrointest Surg 6:527-31. 2002
  10. ncbi request reprint Combined endoscopic mucosal resection and photodynamic therapy versus esophagectomy for management of early adenocarcinoma in Barrett's esophagus
    Rodney J Pacifico
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Mayo Graduate School of Medicine, Rochester, MN 55905, USA
    Clin Gastroenterol Hepatol 1:252-7. 2003

Detail Information

Publications74

  1. pmc The role of cellular senescence in the gastrointestinal mucosa
    Joshua D Penfield
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA
    Gut Liver 7:270-7. 2013
    ..Understanding the pathogenic mechanisms involved in cellular senescence is important for the development of agents targeted toward the treatment of gastrointestinal tumors...
  2. doi request reprint Medical and endoscopic management of high-grade dysplasia in Barrett's esophagus
    K K Wang
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55934, USA
    Dis Esophagus 25:349-55. 2012
    ..However, even with excellent long-term results similar to surgical resection, the risk of recurrence is present in over 14% of patients, which indicates that there will be a need to continue surveillance endoscopy in these patients...
  3. ncbi request reprint Photodynamic therapy in Barrett's esophagus
    Kenneth K Wang
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Mayo Graduate School of Medicine, 200 2nd Street SW, Rochester, MN 55905, USA
    Gastrointest Endosc Clin N Am 13:483-9, vii. 2003
    ..Unfortunately, there are significant adverse events, including cutaneous photosensitivity, odynophagia, stricture formation, and lack of response...
  4. pmc Esophageal adenocarcinoma
    Kenneth K Wang
    Barrett s Esophagus Unit, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 4:1221-4. 2006
  5. pmc Photodynamic therapy for Barrett's esophagus: does light still have a role?
    K K Wang
    Mayo Clinic and Foundation, Mayo College of Medicine, Rochester, Minnesota 55905, USA
    Endoscopy 40:1021-5. 2008
    ..By combining knowledge of tissue biology, optical properties of the tissue, and dosimetry issues with ablation, photodynamic therapy can still have a potentially bright future...
  6. pmc Endoscopic mucosal resection and endoscopic submucosal dissection in esophageal and gastric cancers
    Kenneth K Wang
    Barrett s Esophagus Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    Curr Opin Gastroenterol 26:453-8. 2010
    ..This is an area that has rapidly advanced in terms of new procedures and techniques with a large body of outcomes that support their use...
  7. pmc Current Strategies in the management of Barrett's esophagus
    Kenneth K Wang
    Division of Gastroenterology and Hepatology, Main Alfred Gastroenterology Unit, Saint Mary s Hospital, Mayo Clinic and College of Medicine, Rochester, MN 55905, USA
    Curr Gastroenterol Rep 7:196-201. 2005
    ..Promising future tools and techniques for surveillance and treatment are described in this review...
  8. pmc Endoscopic evaluation and advanced imaging of Barrett's esophagus
    Kenneth K Wang
    Division of Gastroenterology, Mayo Clinic, Rochester, MN, USA
    Gastrointest Endosc Clin N Am 21:39-51. 2011
    ..Once detected, it is hoped that either magnification techniques, such as confocal laser endomicroscopy, or spectroscopic techniques can be of value in allowing in vivo real-time diagnostic capabilities...
  9. ncbi request reprint Multimodality therapy for gastroesophageal cancers
    Kenneth K Wang
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Graduate School of Medicine, Rochester, MN 55905, USA
    J Gastrointest Surg 6:527-31. 2002
  10. ncbi request reprint Combined endoscopic mucosal resection and photodynamic therapy versus esophagectomy for management of early adenocarcinoma in Barrett's esophagus
    Rodney J Pacifico
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Mayo Graduate School of Medicine, Rochester, MN 55905, USA
    Clin Gastroenterol Hepatol 1:252-7. 2003
    ..For these patients, the multimodal approach of endoscopic mucosal resection and photodynamic therapy (EMR/PDT) may be a viable, less invasive option...
  11. ncbi request reprint Preliminary experience comparing routine cytology results with the composite results of digital image analysis and fluorescence in situ hybridization in patients undergoing EUS-guided FNA
    Michael J Levy
    Division of Gastroenterology and Hepatology, Department of Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Gastrointest Endosc 66:483-90. 2007
    ..These tumor markers have not been applied to EUS-guided FNA...
  12. pmc Significance of neoplastic involvement of margins obtained by endoscopic mucosal resection in Barrett's esophagus
    Ganapathy A Prasad
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Am J Gastroenterol 102:2380-6. 2007
    ..The aim of this study was to assess the accuracy of tumor staging by EMR using esophagectomy as the standard...
  13. pmc Endocytoscopy in esophageal cancer
    Yutaka Tomizawa
    St Mary s Hospital, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Gastrointest Endosc Clin N Am 19:273-81. 2009
    ..Endocytoscopy is a new imaging and magnification technology. It has been developed for observation of cellular structure and applied in the esophageal cancer. In this article we summarize the important aspects of this new modality...
  14. doi request reprint Development of subsquamous high-grade dysplasia and adenocarcinoma after successful radiofrequency ablation of Barrett's esophagus
    Mohammad Titi
    Division of Gastroenterology, Veterans Affairs Medical Center, University of Kansas School of Medicine, 4801 East Linwood Boulevard, Kansas City, Missouri 64128, USA
    Gastroenterology 143:564-6.e1. 2012
    ....
  15. pmc Changes in screening, prognosis and therapy for esophageal adenocarcinoma in Barrett's esophagus
    Yutaka Tomizawa
    Barrett s Esophagus Unit, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA
    Curr Opin Gastroenterol 25:358-65. 2009
    ..We summarize the important changes in this regard...
  16. pmc Endoscopic and surgical treatment of mucosal (T1a) esophageal adenocarcinoma in Barrett's esophagus
    Ganapathy A Prasad
    Barrett s Esophagus Unit, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Gastroenterology 137:815-23. 2009
    ..Long-term outcomes of patients treated endoscopically and surgically for mucosal EAC are unknown. We compared long-term outcomes of patients with mucosal EAC treated endoscopically and surgically...
  17. pmc Prevalence and predictors of recurrent neoplasia after ablation of Barrett's esophagus
    Rami J Badreddine
    Barrett s Esophagus Unit, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA
    Gastrointest Endosc 71:697-703. 2010
    ..The incidence and risk factors for recurrence of dysplasia after ablation of Barrett's esophagus (BE) have not been well defined...
  18. ncbi request reprint Utility of biomarkers in prediction of response to ablative therapy in Barrett's esophagus
    Ganapathy A Prasad
    Barrett s Esophagus Unit, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Gastroenterology 135:370-9. 2008
    ..We aimed to determine if biomarkers known to be associated with neoplasia in BE can predict loss of dysplasia in patients treated with ablative therapy for HGD/intramucosal cancer...
  19. pmc A comparison of conventional cytology, DNA ploidy analysis, and fluorescence in situ hybridization for the detection of dysplasia and adenocarcinoma in patients with Barrett's esophagus
    Emily G Barr Fritcher
    Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Hum Pathol 39:1128-35. 2008
    ..Additional studies are needed to further evaluate the clinical use of FISH...
  20. doi request reprint Secondary linitis plastica of the rectum: EUS features and tissue diagnosis (with video)
    Ferga C Gleeson
    Division of Gastroenterology and Hepatology, Department of Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Gastrointest Endosc 68:591-6. 2008
    ..Luminal metastases to the GI tract may be seen at the time of the primary diagnosis or may represent evidence of a distant recurrence...
  21. pmc Correlation of histology with biomarker status after photodynamic therapy in Barrett esophagus
    Ganapathy A Prasad
    Barrett Esophagus Unit, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Cancer 113:470-6. 2008
    ..The objectives of the current study were 1) to assess biomarkers in a prospective cohort of patients with HGD/mucosal cancer before and after PDT and 2) to correlate biomarker status after PDT with histology...
  22. pmc Frozen section analysis of esophageal endoscopic mucosal resection specimens in the real-time management of Barrett's esophagus
    Ganapathy A Prasad
    Division of Gastroenterology and Hepatology, 200 First Street SW, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Clin Gastroenterol Hepatol 4:173-8. 2006
    ..Frozen sections help to give immediate feedback for surgical procedures. It has not been determined whether EMR can be adequately interpreted by using frozen sections to aid endoscopists in completely resecting neoplastic lesions...
  23. ncbi request reprint Initial evaluation of the efficacy and safety of endoscopic ultrasound-guided direct Ganglia neurolysis and block
    Michael J Levy
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Am J Gastroenterol 103:98-103. 2008
    ..The recent recognition that celiac ganglia can be visualized by endoscopic ultrasound (EUS) now allows direct injection into celiac ganglia for neurolysis (CGN) and block (CGB)...
  24. ncbi request reprint Factors associated with increased survival after photodynamic therapy for cholangiocarcinoma
    Ganapathy A Prasad
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN, USA
    Clin Gastroenterol Hepatol 5:743-8. 2007
    ..Recent studies have shown a survival advantage using photodynamic therapy (PDT) in patients with unresectable cholangiocarcinoma. Factors associated with increased survival after PDT are unknown...
  25. doi request reprint Prospective cytological assessment of gastrointestinal luminal fluid acquired during EUS: a potential source of false-positive FNA and needle tract seeding
    Michael J Levy
    Division of Gastroenterology and Hepatology, Miles and Shirley Fiterman Center for Digestive Disease, Mayo Clinic Foundation, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 105:1311-8. 2010
    ..Our goal was to evaluate a potential cause, namely, the presence of malignant cells within gastrointestinal (GI) luminal fluid, either as a result of tumor sloughing from luminal cancers or secondary to FNA of extraluminal sites...
  26. pmc Predictors of progression in Barrett's esophagus: current knowledge and future directions
    Ganapathy A Prasad
    Division of Gastroenterology and Hepatology, Barrett s Esophagus Unit, Mayo Clinic, Rochester, MN 55905, USA
    Am J Gastroenterol 105:1490-1502. 2010
    ..Although it would be challenging, creation of such a score has the potential to improve outcomes and make the management of patients with BE more cost-effective...
  27. ncbi request reprint Pilot study to assess patient outcomes following endoscopic application of photodynamic therapy for advanced cholangiocarcinoma
    Gavin C Harewood
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA
    J Gastroenterol Hepatol 20:415-20. 2005
    ..The aim of this pilot study was to assess the outcome in patients with non-resectable cholangiocarcinoma following endoscopic application of PDT directly into the biliary tract...
  28. doi request reprint Muscularis mucosae duplication and the musculo-fibrous anomaly in endoscopic mucosal resections for barrett esophagus: implications for staging of adenocarcinoma
    Jason T Lewis
    Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Surg Pathol 32:566-71. 2008
    ....
  29. ncbi request reprint Optical detection and eradication of dysplastic Barrett's esophagus
    Louis Michael Wong Kee Song
    Barrett s Esophagus Unit, Mayo Clinic, 200 1st Street S W, Rochester, Minnesota 55905, USA
    Technol Cancer Res Treat 2:289-302. 2003
    ..This article reviews the current status and future prospects of optical-based modalities for diagnosis and therapy of dysplastic Barrett's esophagus...
  30. doi request reprint Prospective assessment of EUS criteria for lymphadenopathy associated with rectal cancer
    Ferga C Gleeson
    Division of Gastroenterology and Hepatology, Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Gastrointest Endosc 69:896-903. 2009
    ..There are few data that assess the accuracy of echo characteristics for predicting lymph-node (LN) metastases in patients with rectal cancer...
  31. pmc Long-term survival following endoscopic and surgical treatment of high-grade dysplasia in Barrett's esophagus
    Ganapathy A Prasad
    Barrett s Esophagus Unit, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Gastroenterology 132:1226-33. 2007
    ..Critical information regarding overall survival of patients followed up long-term after these therapies is lacking. Our aim was to compare the long-term survival of patients treated with PDT with patients treated with esophagectomy...
  32. ncbi request reprint Prospective study of bacteremia and complications With EUS FNA of rectal and perirectal lesions
    Michael J Levy
    Division of Gastroenterology and Hepatology, Mayo Clinic Foundation, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 5:684-9. 2007
    ..As a result, antibiotics are not recommended for prophylaxis against endocarditis. Our aim was to prospectively evaluate the risk of bacteremia and other infectious complications in patients undergoing EUS FNA of lower GI tract lesions...
  33. ncbi request reprint Endoscopic ultrasound-guided trucut biopsy of the cyst wall for diagnosing cystic pancreatic tumors
    Michael J Levy
    Division of Gastroenterology and Hepatology, Mayo Clinic School of Medicine, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 3:974-9. 2005
    ..The aim of this study was to determine whether the tissue obtained by endoscopic ultrasound-guided trucut biopsy (EUS TCB) is sufficient for histologic diagnosis of cystic pancreatic tumors (CPTs)...
  34. ncbi request reprint Role of mucosal ablative therapy in the treatment of the columnar-lined esophagus
    Rodney J Pacifico
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA
    Chest Surg Clin N Am 12:185-203. 2002
    ..In the future, there will be more information to justify the application of mucosal ablative therapy in selected patients...
  35. pmc Distinct role of Kruppel-like factor 11 in the regulation of prostaglandin E2 biosynthesis
    Navtej S Buttar
    Division of Gastroenterology, Mayo Clinic, Rochester, Minnesota 55902, USA
    J Biol Chem 285:11433-44. 2010
    ....
  36. ncbi request reprint Preoperative diagnosis of extrapancreatic neural invasion in pancreatic cancer
    Michael J Levy
    Developmental Endoscopy Unit, Division of Gastroenterology and Hepatology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 4:1479-82. 2006
    ..We report the preoperative diagnosis of cancer infiltration into celiac ganglia. We hypothesized that microscopic pancreatic cancer metastasis to neural ganglia can be detected by EUS-guided biopsy examination...
  37. pmc Combinatorial chemoprevention reveals a novel smoothened-independent role of GLI1 in esophageal carcinogenesis
    Sumera Rizvi
    Division of Gastroenterology and Hepatology, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, MN, USA
    Cancer Res 70:6787-96. 2010
    ..Collectively, these results identify a novel GLI1-to-CDK2 pathway in esophageal carcinogenesis, which is a bona fide target for effective combinatorial chemoprevention with Urso and Aspirin...
  38. pmc Depth of submucosal invasion does not predict lymph node metastasis and survival of patients with esophageal carcinoma
    Rami J Badreddine
    Barrett s Esophagus Unit, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Clin Gastroenterol Hepatol 8:248-53. 2010
    ..We evaluated the impact of depth of submucosal invasion on the presence of metastatic lymphadenopathy and survival in patients with esophageal adenocarcinoma...
  39. ncbi request reprint Balloon-based, circumferential, endoscopic radiofrequency ablation of Barrett's esophagus: 1-year follow-up of 100 patients
    Virender K Sharma
    Division of Gastroenterology and Hepatology, Mayo Clinic Scottsdale Phoenix, Scottsdale, Arizona, USA
    Gastrointest Endosc 65:185-95. 2007
    ..To assess the dose-response, safety, and efficacy of circumferential endoscopic ablation of Barrett's esophagus (BE) by using an endoscopic balloon-based ablation device (HALO360 System)...
  40. ncbi request reprint Predictors of stricture formation after photodynamic therapy for high-grade dysplasia in Barrett's esophagus
    Ganapathy A Prasad
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Gastrointest Endosc 65:60-6. 2007
    ..Stricture formation is the leading cause of long-term morbidity after photodynamic therapy (PDT). Risk factors for stricture formation have not been studied...
  41. ncbi request reprint Nonsurgical management of Barrett's esophagus with high-grade dysplasia
    Rodney J Pacifico
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Graduate School of Medicine, 200 2nd St S W, Rochester, MN 55905, USA
    Surg Oncol Clin N Am 11:321-36. 2002
    ..Future advances in nonsurgical techniques such as new photosensitizers in PDT and improvements in diagnostic techniques may allow patients a greater opportunity to preserve their esophagus...
  42. doi request reprint Endoscopic ablation of Barrett's esophagus: a multicenter study with 2.5-year follow-up
    David E Fleischer
    Mayo Clinic, Scottsdale, Arizona 85259, USA
    Gastrointest Endosc 68:867-76. 2008
    ..Various endoscopic therapies have been used to eradicate BE. Recently circumferential radiofrequency ablation has been used with encouraging short-term results...
  43. ncbi request reprint Management of Barrett's esophagus with high-grade dysplasia
    Rodney J Pacifico
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Mayo Graduate School of Medicine, Main Alfred Gastroenterology Unit, St Mary s Hospital, 1216 Second Street SW, Rochester, MN 55905, USA
    Surg Clin North Am 82:683-95. 2002
    ..These modalities do show promise and may be a good option in the future for patients who are poor surgical candidates. At the present time, the standard of care for BE with HGD in good surgical candidates is still esophagectomy...
  44. doi request reprint False positive endoscopic ultrasound fine needle aspiration cytology: incidence and risk factors
    Ferga C Gleeson
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Gut 59:586-93. 2010
    ..It was hypothesised that the FP and false suspicious (FS) rates for EUS FNA are greater than reported. A study was undertaken to establish the rate and root cause of discordant interpretation...
  45. pmc Endoscopic mucosal resection in the management of esophageal neoplasia: current status and future directions
    Vikneswaran Namasivayam
    Barrett s Esophagus Unit, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 8:743-54; quiz e96. 2010
    ..Training requirements to achieve proficiency in endoscopic mucosal resection as well as potential quality measures to assess competence also are proposed in this review...
  46. ncbi request reprint Endoscopic therapy in patients with Barrett's esophagus and portal hypertension
    Ganapathy A Prasad
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Gastrointest Endosc 65:527-31. 2007
    ..Endoscopic mucosal resection has been used to stage and treat early neoplasia in Barrett's esophagus. The ability to do this in the setting of portal hypertension has not been reported...
  47. pmc Screening, surveillance, and prevention for esophageal cancer
    Yutaka Tomizawa
    Barrett s Esophagus Unit, Alfred Main, Gastroenterology Diagnostic Unit, St Mary s Hospital, 200 2nd Street SW, Rochester, MN 55905, USA
    Gastroenterol Clin North Am 38:59-73, viii. 2009
    ..Recently developed biomarkers such as FISH and improved imaging techniques, may help overcome current problems and provide improved screening and surveillance for esophageal cancer...
  48. ncbi request reprint Chemoprevention of esophageal adenocarcinoma by COX-2 inhibitors in an animal model of Barrett's esophagus
    Navtej S Buttar
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Mayo Graduate School of Medicine, Rochester, Minnesota, USA
    Gastroenterology 122:1101-12. 2002
    ..However, there has been no direct evidence that inhibition of COX-2 prevents cancer in BE. We studied the effect of MF-Tricyclic, a selective COX-2 inhibitor, on the development of BE and adenocarcinoma in a rat model...
  49. ncbi request reprint Adequacy of endoscopic ultrasound core needle biopsy specimen of nonmalignant hepatic parenchymal disease
    Ferga C Gleeson
    Fiterman Centre for Digestive Disease, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 6:1437-40. 2008
    ..Therefore, our aim was to determine the adequacy of endoscopic ultrasound (EUS)-guided Trucut liver biopsy for histopathologic evaluation to include the number of complete portal tracts contained per millimeter of acquired tissue...
  50. ncbi request reprint Knowledge of indications for EUS among gastroenterologists and non-gastroenterologists
    Tony E Yusuf
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Gastrointest Endosc 60:575-9. 2004
    ..This study assessed knowledge of the indications and the utility of EUS among gastroenterologists and non-gastroenterologists in a large multispecialty academic practice...
  51. ncbi request reprint The effect of selective cyclooxygenase-2 inhibition in Barrett's esophagus epithelium: an in vitro study
    Navtej S Buttar
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Mayo Graduate School of Medicine, Rochester, MN 55905, USA
    J Natl Cancer Inst 94:422-9. 2002
    ..Cyclooxygenase (COX)-2 is the rate-limiting enzyme involved in prostaglandin synthesis. We examined the effect of inhibiting COX-2 activity in Barrett's esophageal cells...
  52. ncbi request reprint Utility of endoscopic ultrasound in the diagnosis of aberrant right subclavian artery
    Tony E Yusuf
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Gastroenterol Hepatol 22:1717-21. 2007
    ..The aim of this study was to determine the prevalence of ARSA in patients undergoing upper endoscopic ultrasound (EUS) and to describe the EUS characteristics of ARSA...
  53. doi request reprint Barrett's esophagus: pathogenesis, treatment, and prevention
    Rami J Badreddine
    Barrett s Esophagus Unit, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA
    Gastrointest Endosc Clin N Am 18:495-512, ix. 2008
    ..This article focuses on the pathogenesis, treatment, and prevention of BE...
  54. pmc The development of a fluorescence in situ hybridization assay for the detection of dysplasia and adenocarcinoma in Barrett's esophagus
    Shannon M Brankley
    Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, MN 55902, USA
    J Mol Diagn 8:260-7. 2006
    ....
  55. ncbi request reprint Age-related changes in the pancreas identified by EUS: a prospective evaluation
    Elizabeth Rajan
    Division of Gastroenterology and Hepatology, Charlton 8 A, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Gastrointest Endosc 61:401-6. 2005
    ..Secondary aims were to define demographic and clinical factors associated with identifiable pancreatic parenchymal and ductular changes, and to determine the main pancreatic-duct diameter and pancreatic-gland width according to age...
  56. ncbi request reprint American Gastroenterological Association technical review on the role of the gastroenterologist in the management of esophageal carcinoma
    Kenneth K Wang
    Barrett s Esophagus Unit, St Mary s Hospital, Mayo Clinic, Rochester, Minnesota, USA
    Gastroenterology 128:1471-505. 2005
  57. ncbi request reprint American Gastroenterological Association medical position statement: Role of the gastroenterologist in the management of esophageal carcinoma
    Kenneth K Wang
    Mayo Clinic, Rochester, Minnesota, USA
    Gastroenterology 128:1468-70. 2005
  58. ncbi request reprint Mechanisms of disease: Carcinogenesis in Barrett's esophagus
    Navtej S Buttar
    Mayo Clinic, Rochester, MN 55905, USA
    Nat Clin Pract Gastroenterol Hepatol 1:106-12. 2004
    ..Having a greater understanding of the pathogenesis of this condition can only help to develop more management options in the future...
  59. pmc Biomarkers in gastrointestinal cancers
    Rami Badreddine
    Barrett s Esophagus Unit, Division of Gastroenterology and Hepatology, St Mary s Hospital, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 103:2106-10. 2008
  60. ncbi request reprint Photodynamic therapy with porfimer sodium for ablation of high-grade dysplasia in Barrett's esophagus: international, partially blinded, randomized phase III trial
    Bergein F Overholt
    Thompson Cancer Survival Center, Knoxville, Tennessee, USA
    Gastrointest Endosc 62:488-98. 2005
    ..The objective was to examine the impact of treating patients with BE and with HGD by using porfimer sodium (POR) and photodynamic therapy (PDT) for ablating HGD and reducing the incidence of esophageal adenocarcinoma...
  61. ncbi request reprint Five-year efficacy and safety of photodynamic therapy with Photofrin in Barrett's high-grade dysplasia
    Bergein F Overholt
    Thompson Cancer Survival Center, Knoxville, Tennessee 37909, USA
    Gastrointest Endosc 66:460-8. 2007
    ..Barrett's esophagus (BE) with high-grade dysplasia (HGD) is a risk factor for development of esophageal carcinoma. Photodynamic therapy (PDT) with Photofrin (PHO) has been used to eliminate HGD in BE...
  62. ncbi request reprint Gains and amplifications of c-myc, EGFR, and 20.q13 loci in the no dysplasia-dysplasia-adenocarcinoma sequence of Barrett's esophagus
    Agnieszka M Rygiel
    Laboratory of Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Cancer Epidemiol Biomarkers Prev 17:1380-5. 2008
    ..Gains of the loci might be of value as prognostic markers because they are already present in nondysplasia cases and may precede the later event of the amplification as observed in high-grade dysplasia and esophageal adenocarcinoma...
  63. ncbi request reprint EMR for early stage esophageal cancer: setting the stage for improved patient outcomes
    James M Scheiman
    Gastrointest Endosc 58:244-6. 2003
  64. pmc Endoscopic confocal microscopy: imaging to facilitate the dawn of endoluminal surgery
    Kenneth K Wang
    Clin Gastroenterol Hepatol 5:1259-60. 2007
  65. ncbi request reprint The wizards of odds: cost-effectiveness, Barrett's screening, and surveillance guidelines
    David G Perdue
    Clin Gastroenterol Hepatol 2:865-7. 2004
  66. doi request reprint Paget cells in the esophagus: assessment of their histopathologic features and near-universal association with underlying esophageal adenocarcinoma
    Susan C Abraham
    Department of Pathology, M D Anderson Cancer Center, Houston, TX, USA
    Am J Surg Pathol 32:1068-74. 2008
    ..A commonality among cases with Paget cells is the presence of focal or diffuse, poorly differentiated adenocarcinoma with discohesive cells. E-cadherin alterations seem to play a less significant role...
  67. ncbi request reprint A comparative analysis by SAGE of gene expression profiles of Barrett's esophagus, normal squamous esophagus, and gastric cardia
    Jantine W P M van Baal
    Laboratory of Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Gastroenterology 129:1274-81. 2005
    ....
  68. pmc Bile acid exposure up-regulates tuberous sclerosis complex 1/mammalian target of rapamycin pathway in Barrett's-associated esophageal adenocarcinoma
    Chia Jui Yen
    Department of Molecular and Cellular Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 68:2632-40. 2008
    ..In addition, Bay 11-7082 and rapamycin may potentially be chemopreventive drugs against Barrett's esophagus-associated EAC...
  69. pmc Three-tiered risk stratification model to predict progression in Barrett's esophagus using epigenetic and clinical features
    Fumiaki Sato
    Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 3:e1890. 2008
    ..In this study, we developed a 3-tiered risk stratification strategy, based on systematically selected epigenetic and clinical parameters, to improve Barrett's esophagus surveillance efficiency...
  70. ncbi request reprint Allelic imbalance of 7q32.3-q36.1 during tumorigenesis in Barrett's esophagus
    Peter H J Riegman
    Departments of Pathology, Josephine Nefkens Institute, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands
    Cancer Res 62:1531-3. 2002
    ..1. These data suggest that markers from this area can be used as a diagnostic tool in Barrett's esophagus, i.e., to distinguish between watchful waiting and active treatment...
  71. ncbi request reprint Bone morphogenetic protein 4 expressed in esophagitis induces a columnar phenotype in esophageal squamous cells
    Francesca Milano
    Laboratory of Experimental Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Gastroenterology 132:2412-21. 2007
    ..In this study, the role of the BMP pathway in the metaplastic transformation of normal squamous cells into columnar cells was examined...
  72. ncbi request reprint Progress in chemoprevention drug development: the promise of molecular biomarkers for prevention of intraepithelial neoplasia and cancer--a plan to move forward
    Gary J Kelloff
    National Cancer Institute, Bethesda, Maryland 20852, USA
    Clin Cancer Res 12:3661-97. 2006
    ....
  73. doi request reprint Updated guidelines 2008 for the diagnosis, surveillance and therapy of Barrett's esophagus
    Kenneth K Wang
    Gastroenterology, College of Medicine, Tucson, AZ 85724, USA
    Am J Gastroenterol 103:788-97. 2008
  74. ncbi request reprint Efficient automated assessment of genetic abnormalities detected by fluorescence in situ hybridization on brush cytology in a Barrett esophagus surveillance population
    Agnieszka M Rygiel
    Department of Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Cancer 109:1980-8. 2007
    ....

Research Grants18

  1. A NOVEL TECHNIQUE FOR SCREENING BARRETT'S ESOSPHAGUS
    Kenneth Wang; Fiscal Year: 2000
    ..The development of a screening device for Barrett's esophagus that could be operated by paramedical personnel would enable large-scale low cost screening to identify patients at risk for esophageal cancer. ..
  2. Biomarkers in Phototherapy of Barrett's Esophagus
    Kenneth Wang; Fiscal Year: 2009
    ..These studies will provide an improved understanding regarding the response of Barrett's esophagus to ablation therapy. ..
  3. Endoscopic Therapy of Early Cancer in Barretts Esophagus
    Kenneth Wang; Fiscal Year: 2009
    ..Diagnostic and therapeutic techniques developed in this study can be applied to other gastrointestinal tumors. ..
  4. Novel Method of Surveillance in Barrett's Esophagus
    Kenneth Wang; Fiscal Year: 2007
    ..This is an innovative method by which a physician can diagnose hidden areas of cancer within patients who are at a high risk of developing esophageal cancer. ..
  5. Endoscopic Therapy of Early Cancer in Barretts Esophagus
    Kenneth Wang; Fiscal Year: 2007
    ..Diagnostic and therapeutic techniques developed in this study can be applied to other gastrointestinal tumors. ..
  6. Endoscopic Therapy of Early Cancer in Barretts Esophagus
    Kenneth Wang; Fiscal Year: 2006
    ..Diagnostic and therapeutic techniques developed in this study can be applied to other gastrointestinal tumors. ..
  7. Biomarkers in Phototherapy of Barrett's Esophagus
    Kenneth Wang; Fiscal Year: 2006
    ..These observations can be extended to other forms of ablative therapy in future studies. ..
  8. Endoscopic Therapy of Early Cancer in Barretts Esophagus
    Kenneth Wang; Fiscal Year: 2005
    ..Diagnostic and therapeutic techniques developed in this study can be applied to other gastrointestinal tumors. ..
  9. Biomarkers in Phototherapy of Barrett's Esophagus
    Kenneth Wang; Fiscal Year: 2005
    ..These observations can be extended to other forms of ablative therapy in future studies. ..
  10. Biomarkers in Phototherapy of Barrett's Esophagus
    Kenneth Wang; Fiscal Year: 2004
    ..These observations can be extended to other forms of ablative therapy in future studies. ..
  11. Biomarkers in Phototherapy of Barrett's Esophagus
    Kenneth Wang; Fiscal Year: 2003
    ..These observations can be extended to other forms of ablative therapy in future studies. ..
  12. A NOVEL TECHNIQUE FOR SCREENING BARRETT'S ESOSPHAGUS
    Kenneth Wang; Fiscal Year: 2003
    ..The development of a screening device for Barrett's esophagus that could be operated by paramedical personnel would enable large-scale low cost screening to identify patients at risk for esophageal cancer. ..
  13. Biomarkers in Phototherapy of Barrett's Esophagus
    Kenneth Wang; Fiscal Year: 2002
    ..These observations can be extended to other forms of ablative therapy in future studies. ..
  14. A NOVEL TECHNIQUE FOR SCREENING BARRETT'S ESOSPHAGUS
    Kenneth Wang; Fiscal Year: 2002
    ..The development of a screening device for Barrett's esophagus that could be operated by paramedical personnel would enable large-scale low cost screening to identify patients at risk for esophageal cancer. ..
  15. A NOVEL TECHNIQUE FOR SCREENING BARRETT'S ESOSPHAGUS
    Kenneth Wang; Fiscal Year: 2001
    ..The development of a screening device for Barrett's esophagus that could be operated by paramedical personnel would enable large-scale low cost screening to identify patients at risk for esophageal cancer. ..
  16. Biomarkers in Phototherapy of Barrett's Esophagus
    Kenneth K Wang; Fiscal Year: 2010
    ..These studies will provide an improved understanding regarding the response of Barrett's esophagus to ablation therapy. ..