Nicholas E Vlahakis

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi request reprint Role of deformation-induced lipid trafficking in the prevention of plasma membrane stress failure
    Nicholas E Vlahakis
    Pulmonary and Critical Care Medicine Division, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Respir Crit Care Med 166:1282-9. 2002
  2. ncbi request reprint Diagnosis of vocal cord dysfunction: the utility of spirometry and plethysmography
    Nicholas E Vlahakis
    Department of Internal Medicine, Stabile Building Room 8 62, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Chest 122:2246-9. 2002
  3. ncbi request reprint Response of alveolar cells to mechanical stress
    Nicholas E Vlahakis
    University of California San Francisco, Lung Biology Center, 1001 Potrero Avenue, San Francisco, 94110, USA
    Curr Opin Crit Care 9:2-8. 2003
  4. ncbi request reprint Osteoarticular infection complicating enterococcal endocarditis
    Nicholas E Vlahakis
    Division of Pulmonary and Critical Care Medicine and Internal Medicine, Mayo Clinic, Rochester, Minn 55905, USA
    Mayo Clin Proc 78:623-8. 2003
  5. ncbi request reprint Sirolimus-associated diffuse alveolar hemorrhage
    Nicholas E Vlahakis
    Division of Pulmonary and Critical Care Medicine and Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 79:541-5. 2004
  6. ncbi request reprint Integrin alpha9beta1 directly binds to vascular endothelial growth factor (VEGF)-A and contributes to VEGF-A-induced angiogenesis
    Nicholas E Vlahakis
    Lung Biology Center, University of California, San Francisco, California 94143 2922, USA
    J Biol Chem 282:15187-96. 2007
  7. pmc Cellular stress failure in ventilator-injured lungs
    Nicholas E Vlahakis
    Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Am J Respir Crit Care Med 171:1328-42. 2005
  8. pmc Vascular endothelial growth factor A (VEGF-A) induces endothelial and cancer cell migration through direct binding to integrin {alpha}9{beta}1: identification of a specific {alpha}9{beta}1 binding site
    Saji Oommen
    Thoracic Disease Research Unit, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 286:1083-92. 2011
  9. pmc The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1
    Nicholas E Vlahakis
    Lung Biology Center, University of California San Francisco, San Francisco, California, 94143 2922, USA
    J Biol Chem 280:4544-52. 2005
  10. pmc Vascular endothelial growth factors C and D induces proliferation of lymphangioleiomyomatosis cells through autocrine crosstalk with endothelium
    Rachel B Issaka
    Thoracic Disease Research Unit, Division of Pulmonary, Mayo Clinic, Rochester, MN 55905, USA
    Am J Pathol 175:1410-20. 2009

Research Grants

  1. Role of a9b1 Integrin in lymphangiogenesis
    Nicholas Vlahakis; Fiscal Year: 2007

Detail Information

Publications17

  1. ncbi request reprint Role of deformation-induced lipid trafficking in the prevention of plasma membrane stress failure
    Nicholas E Vlahakis
    Pulmonary and Critical Care Medicine Division, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Respir Crit Care Med 166:1282-9. 2002
    ..We also conclude that in deformation experiments, tests of cell membrane integrity cannot be interpreted as tests of cell viability because an intact plasma membrane after deformation does not mean that no injury had occurred...
  2. ncbi request reprint Diagnosis of vocal cord dysfunction: the utility of spirometry and plethysmography
    Nicholas E Vlahakis
    Department of Internal Medicine, Stabile Building Room 8 62, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Chest 122:2246-9. 2002
  3. ncbi request reprint Response of alveolar cells to mechanical stress
    Nicholas E Vlahakis
    University of California San Francisco, Lung Biology Center, 1001 Potrero Avenue, San Francisco, 94110, USA
    Curr Opin Crit Care 9:2-8. 2003
    ..This dynamic process was a stronger determinant of cell breaks than the prestress properties of the cytoskeleton. All of these exciting findings provide further potential treatment targets for ventilator-induced lung injury...
  4. ncbi request reprint Osteoarticular infection complicating enterococcal endocarditis
    Nicholas E Vlahakis
    Division of Pulmonary and Critical Care Medicine and Internal Medicine, Mayo Clinic, Rochester, Minn 55905, USA
    Mayo Clin Proc 78:623-8. 2003
    ..This report highlights the rare occurrence of osteoarticular infection in the setting of enterococcal endocarditis and emphasizes early recognition and treatment...
  5. ncbi request reprint Sirolimus-associated diffuse alveolar hemorrhage
    Nicholas E Vlahakis
    Division of Pulmonary and Critical Care Medicine and Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 79:541-5. 2004
    ..Our case highlights an uncommon but potentially lethal manifestation of sirolimus pulmonary toxicity...
  6. ncbi request reprint Integrin alpha9beta1 directly binds to vascular endothelial growth factor (VEGF)-A and contributes to VEGF-A-induced angiogenesis
    Nicholas E Vlahakis
    Lung Biology Center, University of California, San Francisco, California 94143 2922, USA
    J Biol Chem 282:15187-96. 2007
    ....
  7. pmc Cellular stress failure in ventilator-injured lungs
    Nicholas E Vlahakis
    Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Am J Respir Crit Care Med 171:1328-42. 2005
    ....
  8. pmc Vascular endothelial growth factor A (VEGF-A) induces endothelial and cancer cell migration through direct binding to integrin {alpha}9{beta}1: identification of a specific {alpha}9{beta}1 binding site
    Saji Oommen
    Thoracic Disease Research Unit, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 286:1083-92. 2011
    ..This interaction is biologically important because it mediates in vitro endothelial cell tube formation, wound healing, and cancer cell invasion. These novel findings identify EYP as a potential site for directed pharmacotherapy...
  9. pmc The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1
    Nicholas E Vlahakis
    Lung Biology Center, University of California San Francisco, San Francisco, California, 94143 2922, USA
    J Biol Chem 280:4544-52. 2005
    ..The interaction between alpha9beta1 and VEGF-C and/or -D may begin to explain the abnormal lymphatic phenotype of the alpha9 knock-out mice...
  10. pmc Vascular endothelial growth factors C and D induces proliferation of lymphangioleiomyomatosis cells through autocrine crosstalk with endothelium
    Rachel B Issaka
    Thoracic Disease Research Unit, Division of Pulmonary, Mayo Clinic, Rochester, MN 55905, USA
    Am J Pathol 175:1410-20. 2009
    ....
  11. pmc Integrin alpha9beta1 mediates enhanced cell migration through nitric oxide synthase activity regulated by Src tyrosine kinase
    Shiv K Gupta
    Thoracic Disease Research Unit, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Cell Sci 122:2043-54. 2009
    ..When taken together, our results describe a novel and unique mechanism of coordinated interactions of the integrin alpha9 cytoplasmic domain, Src tyrosine kinase and iNOS to transduce integrin-alpha9beta1-mediated cell migration...
  12. pmc Integrin alpha9beta1: Unique signaling pathways reveal diverse biological roles
    Shiv K Gupta
    Thoracic Disease Research Unit, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA
    Cell Adh Migr 4:194-8. 2010
    ..Furthermore, we have also described a role for FAK, Erk and Rac1 in alpha9beta1 signal transduction. Here we provide an over view of known integrin alpha9beta1 signaling pathways and highlight its roles in diverse biological conditions...
  13. ncbi request reprint B-type natriuretic peptide in the assessment of acute lung injury and cardiogenic pulmonary edema
    Rimki Rana
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
    Crit Care Med 34:1941-6. 2006
    ..We postulated that a low BNP level would exclude cardiac dysfunction as the principal cause of pulmonary edema and therefore help in the diagnosis of acute lung injury...
  14. ncbi request reprint Fetal outcomes of critically ill pregnant women admitted to the intensive care unit for nonobstetric causes
    Rodrigo Cartin-Ceba
    Mayo Clinic of Medicine, Rochester, MN, USA
    Crit Care Med 36:2746-51. 2008
    ..We evaluated the risk factors for adverse fetal outcomes in critically ill pregnant women admitted to the intensive care unit for nonobstetrical reasons...
  15. ncbi request reprint Six-month survival of patients with acute lung injury: prospective cohort study
    Murat Yilmaz
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Crit Care Med 35:2303-7. 2007
    ..We sought to determine the outcome of consecutive acute lung injury patients after the implementation of these interventions...
  16. ncbi request reprint Infective endocarditis due to community-associated methicillin-resistant Staphylococcus aureus in injection drug users may be associated with Panton-Valentine leukocidin-negative strains
    Constantine Tsigrelis
    Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Scand J Infect Dis 39:299-302. 2007
    ..We present a case of CA-MRSA infective endocarditis, review pertinent cases previously published, and describe the molecular characteristics of strains from IDUs and patients with skin and soft tissue infections...
  17. ncbi request reprint Acute pancreatitis due to hereditary angioedema
    Damir Matesic
    Department of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55901, USA
    Ann Allergy Asthma Immunol 97:611-4. 2006
    ..When swelling involves the gastrointestinal mucosa, patients may present with nausea, vomiting, diarrhea, and severe abdominal pain. However, HAE is almost never suspected as a potential cause of acute pancreatitis...

Research Grants2

  1. Role of a9b1 Integrin in lymphangiogenesis
    Nicholas Vlahakis; Fiscal Year: 2007
    ..End of Abstract) ..