Prashanthi Vemuri

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Brain beta-amyloid measures and magnetic resonance imaging atrophy both predict time-to-progression from mild cognitive impairment to Alzheimer's disease
    Clifford R Jack
    Department of Radiology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Brain 133:3336-48. 2010
  2. doi request reprint Vascular and amyloid pathologies are independent predictors of cognitive decline in normal elderly
    Prashanthi Vemuri
    1 Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN, USA
    Brain 138:761-71. 2015
  3. pmc Effect of lifestyle activities on Alzheimer disease biomarkers and cognition
    Prashanthi Vemuri
    Department of Radiology, Mayo Clinic and Foundation, 200 First St SW, Rochester, MN 55905, USA
    Ann Neurol 72:730-8. 2012
  4. pmc Resting state functional MRI in Alzheimer's Disease
    Prashanthi Vemuri
    Department of Radiology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Alzheimers Res Ther 4:2. 2012
  5. pmc Cognitive reserve and Alzheimer's disease biomarkers are independent determinants of cognition
    Prashanthi Vemuri
    Department of Radiology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Brain 134:1479-92. 2011
  6. pmc Role of structural MRI in Alzheimer's disease
    Prashanthi Vemuri
    Aging and Dementia Imaging Research Laboratory, Department of Radiology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Alzheimers Res Ther 2:23. 2010
  7. pmc Antemortem differential diagnosis of dementia pathology using structural MRI: Differential-STAND
    Prashanthi Vemuri
    Department of Radiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Neuroimage 55:522-31. 2011
  8. pmc Shapes of the trajectories of 5 major biomarkers of Alzheimer disease
    Clifford R Jack
    Department of Radiology, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Arch Neurol 69:856-67. 2012
  9. pmc An operational approach to National Institute on Aging-Alzheimer's Association criteria for preclinical Alzheimer disease
    Clifford R Jack
    Department of Radiology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Ann Neurol 71:765-75. 2012
  10. pmc The GGGGCC repeat expansion in C9ORF72 in a case with discordant clinical and FDG-PET findings: PET trumps syndrome
    Anahita Adeli
    a Department of Neurology, Mayo Clinic, Rochester, Minnesota
    Neurocase 20:110-20. 2014

Detail Information

Publications49

  1. pmc Brain beta-amyloid measures and magnetic resonance imaging atrophy both predict time-to-progression from mild cognitive impairment to Alzheimer's disease
    Clifford R Jack
    Department of Radiology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Brain 133:3336-48. 2010
    ....
  2. doi request reprint Vascular and amyloid pathologies are independent predictors of cognitive decline in normal elderly
    Prashanthi Vemuri
    1 Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN, USA
    Brain 138:761-71. 2015
    ....
  3. pmc Effect of lifestyle activities on Alzheimer disease biomarkers and cognition
    Prashanthi Vemuri
    Department of Radiology, Mayo Clinic and Foundation, 200 First St SW, Rochester, MN 55905, USA
    Ann Neurol 72:730-8. 2012
    ....
  4. pmc Resting state functional MRI in Alzheimer's Disease
    Prashanthi Vemuri
    Department of Radiology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Alzheimers Res Ther 4:2. 2012
    ..Then we present the current state of knowledge in this area by summarizing various AD resting-state fMRI studies presented in the first section and end with a discussion of future developments and open questions in the field...
  5. pmc Cognitive reserve and Alzheimer's disease biomarkers are independent determinants of cognition
    Prashanthi Vemuri
    Department of Radiology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Brain 134:1479-92. 2011
    ....
  6. pmc Role of structural MRI in Alzheimer's disease
    Prashanthi Vemuri
    Aging and Dementia Imaging Research Laboratory, Department of Radiology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Alzheimers Res Ther 2:23. 2010
    ....
  7. pmc Antemortem differential diagnosis of dementia pathology using structural MRI: Differential-STAND
    Prashanthi Vemuri
    Department of Radiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Neuroimage 55:522-31. 2011
    ..8%). The proposed approach establishes a direct a priori relationship between specific topographic patterns on MRI and "gold standard" of pathology which can then be used to predict underlying dementia pathology in new incoming patients...
  8. pmc Shapes of the trajectories of 5 major biomarkers of Alzheimer disease
    Clifford R Jack
    Department of Radiology, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Arch Neurol 69:856-67. 2012
    ..To characterize the shape of the trajectories of Alzheimer disease biomarkers as a function of Mini-Mental State Examination (MMSE) score...
  9. pmc An operational approach to National Institute on Aging-Alzheimer's Association criteria for preclinical Alzheimer disease
    Clifford R Jack
    Department of Radiology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Ann Neurol 71:765-75. 2012
    ..A workgroup commissioned by the Alzheimer's Association (AA) and the National Institute on Aging (NIA) recently published research criteria for preclinical Alzheimer disease (AD). We performed a preliminary assessment of these guidelines...
  10. pmc The GGGGCC repeat expansion in C9ORF72 in a case with discordant clinical and FDG-PET findings: PET trumps syndrome
    Anahita Adeli
    a Department of Neurology, Mayo Clinic, Rochester, Minnesota
    Neurocase 20:110-20. 2014
    ....
  11. pmc Selective worsening of brain injury biomarker abnormalities in cognitively normal elderly persons with β-amyloidosis
    David S Knopman
    Mayo Clinic Alzheimer s Disease Research Center, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    JAMA Neurol 70:1030-8. 2013
    ....
  12. pmc Association of hypometabolism and amyloid levels in aging, normal subjects
    Val J Lowe
    From the Departments of Radiology V J L, M L S, P V, L J, K K, C R J, Health Sciences Research S D W, and Neurology B B, D K, R C P, Mayo Clinic, Rochester, MN
    Neurology 82:1959-67. 2014
    ....
  13. pmc Antemortem MRI findings associated with microinfarcts at autopsy
    Mekala R Raman
    From the Departments of Neurology M R R, B F B, D S K, R C P, Radiology G M P, J L G, M L S, P V, M C M, C R J, K K, Health Sciences Research S A P, and Pathology J E P, Mayo Clinic, Rochester, MN and Department of Neuroscience M E M, D W D, Mayo Clinic, Jacksonville, FL
    Neurology 82:1951-8. 2014
    ..To determine antemortem MRI findings associated with microinfarcts at autopsy...
  14. pmc Indicators of amyloid burden in a population-based study of cognitively normal elderly
    Michelle M Mielke
    Division of Epidemiology, College of Medicine, Mayo Clinic, Rochester, MN, USA
    Neurology 79:1570-7. 2012
    ..The identification of inexpensive and noninvasive screening variables that can identify individuals who have significant amyloid accumulation would reduce screening costs...
  15. pmc Rates of β-amyloid accumulation are independent of hippocampal neurodegeneration
    Clifford R Jack
    From the Departments of Radiology C R J, P V, M L S, J L G, V L, B E G, Health Sciences Research H J W, M M M, S D W, V S P, and Neurology D S K, R C P, Mayo Clinic and Foundation, Rochester, MN
    Neurology 82:1605-12. 2014
    ....
  16. pmc MRI and pathology of REM sleep behavior disorder in dementia with Lewy bodies
    Melissa E Murray
    From the Department of Neuroscience M E M, A M L, B N D, D W D, Psychiatry and Psychology T J F, and Neurology N R G R, Mayo Clinic, Jacksonville, FL and Department of Neurology B F B, D S K, M H S, R C P, Biomedical Statistics S A P, T G L, Radiology M L S, J L G, G M P, P V, C R J, K K, Nuclear Medicine V J L, Psychology G E S, Laboratory Medicine and Pathology J E P, and Center for Sleep Medicine M H S, Mayo Clinic, Rochester, MN
    Neurology 81:1681-9. 2013
    ..To determine structural MRI and digital microscopic characteristics of REM sleep behavior disorder in individuals with low-, intermediate-, and high-likelihood dementia with Lewy bodies (DLB) at autopsy...
  17. pmc Amyloid-first and neurodegeneration-first profiles characterize incident amyloid PET positivity
    Clifford R Jack
    From the Departments of Radiology C R J, V L, P V, D T J, M L S, J L G, B E G, Health Sciences Research H J W, S D W, M M M, V S P, and Neurology D S K, R C P, Mayo Clinic and Foundation, Rochester, MN
    Neurology 81:1732-40. 2013
    ..To estimate the incidence of and to characterize cognitive and imaging findings associated with incident amyloid PET positivity...
  18. pmc Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers
    Clifford R Jack
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Lancet Neurol 12:207-16. 2013
    ....
  19. pmc Head trauma and in vivo measures of amyloid and neurodegeneration in a population-based study
    Michelle M Mielke
    From the Divisions of Epidemiology M M Mielke, R O R, R C P, Y E G and Biomedical Statistics and Informatics H J W, S D W, Department of Health Sciences Research Departments of Neurology R S, D S K, R O R, R C P, Psychiatry and Psychology M M Machulda, and Radiology P V, V J L, C R J, Mayo Clinic, Rochester, MN and Departments of Psychiatry, Psychology, and Neurology Y E G, Mayo Clinic, Scottsdale, AZ
    Neurology 82:70-6. 2014
    ..We determined whether head trauma was associated with amyloid deposition and neurodegeneration among individuals who were cognitively normal (CN) or had mild cognitive impairment (MCI)...
  20. pmc Brain injury biomarkers are not dependent on β-amyloid in normal elderly
    David S Knopman
    Department of Neurology, Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, MN Mayo Clinic Alzheimer s Disease Research Center, Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, MN
    Ann Neurol 73:472-80. 2013
    ..The characteristics of the sNAP group are poorly understood...
  21. pmc Evidence for ordering of Alzheimer disease biomarkers
    Clifford R Jack
    Department of Radiology, Mayo Clinic and Mayo Foundation for Medical Education and Research, 200 First St, SW, Rochester, MN 55905, USA
    Arch Neurol 68:1526-35. 2011
    ..To empirically assess the concept that Alzheimer disease (AD) biomarkers significantly depart from normality in a temporally ordered manner...
  22. pmc Effect of apolipoprotein E on biomarkers of amyloid load and neuronal pathology in Alzheimer disease
    Prashanthi Vemuri
    Aging and Dementia Imaging Research Laboratory, Department of Radiology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Ann Neurol 67:308-16. 2010
    ....
  23. pmc Effect of APOE ε4 status on intrinsic network connectivity in cognitively normal elderly subjects
    Mary M Machulda
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA
    Arch Neurol 68:1131-6. 2011
    ..To examine default mode and salience network functional connectivity as a function of APOE ε4 status in a group of cognitively normal age-, sex-, and education-matched older adults...
  24. pmc Application of the National Institute on Aging-Alzheimer's Association AD criteria to ADNI
    Val J Lowe
    Department of Radiology, Mayo Clinic, Rochester, MN, USA
    Neurology 80:2130-7. 2013
    ..We describe the operationalization of the National Institute on Aging-Alzheimer's Association (NIA-AA) workgroup diagnostic guidelines pertaining to Alzheimer disease (AD) dementia in a large multicenter group of subjects with AD dementia...
  25. pmc Brain β-amyloid load approaches a plateau
    Clifford R Jack
    From the Departments of Radiology, Mayo Clinic, Rochester, MN, USA
    Neurology 80:890-6. 2013
    ..To model the temporal trajectory of β-amyloid accumulation using serial amyloid PET imaging...
  26. pmc Characterization of a family with c9FTD/ALS associated with the GGGGCC repeat expansion in C9ORF72
    Rodolfo Savica
    Department of Neurology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Arch Neurol 69:1164-9. 2012
    ..We report the clinical, neuropsychologic, and neuroimaging findings of a family with the C9ORF72 mutation and clinical diagnoses bridging the FTD, parkinsonism, and ALS spectrum...
  27. pmc Focal atrophy on MRI and neuropathologic classification of dementia with Lewy bodies
    Kejal Kantarci
    Departments of Radiology, Mayo Clinic, Rochester, MN, USA
    Neurology 79:553-60. 2012
    ..To determine the association between the focal atrophy measures on antemortem MRI and postmortem neuropathologic classification of dementia with Lewy bodies (DLB) using the Third Report of the DLB Consortium criteria...
  28. pmc Time-to-event voxel-based techniques to assess regional atrophy associated with MCI risk of progression to AD
    Prashanthi Vemuri
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Neuroimage 54:985-91. 2011
    ..We also compared the power required to detect an association using time-to-event methods versus two-sample approaches...
  29. pmc Transforming cerebrospinal fluid Aβ42 measures into calculated Pittsburgh Compound B units of brain Aβ amyloid
    Stephen D Weigand
    Division of Biomedical Statistics and Informatics, Mayo Clinic and Foundation, Rochester, MN, USA
    Alzheimers Dement 7:133-41. 2011
    ..The objectives of this study were to develop a method to transform CSF Aβ42 measures into calculated PIB measures (PIBcalc) of Aβ amyloid load, and to partially validate the method in an independent sample of subjects...
  30. doi request reprint Working memory and language network dysfunctions in logopenic aphasia: a task-free fMRI comparison with Alzheimer's dementia
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN, USA Electronic address
    Neurobiol Aging 36:1245-52. 2015
    ..Patterns of network dysfunction differ across these 2 clinical variants of Alzheimer's disease, with lvPPA particularly associated with disruptions in the language and left working memory networks. ..
  31. pmc Age-specific population frequencies of cerebral β-amyloidosis and neurodegeneration among people with normal cognitive function aged 50-89 years: a cross-sectional study
    Clifford R Jack
    Department of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA Electronic address
    Lancet Neurol 13:997-1005. 2014
    ..We aimed to characterise how typical ageing and preclinical Alzheimer's disease overlap in terms of β-amyloidosis and neurodegeneration...
  32. pmc Non-stationarity in the "resting brain's" modular architecture
    David T Jones
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 7:e39731. 2012
    ..DMN dwell time in specific modular configurations may also underlie the TF-fMRI findings that have been described in mild cognitive impairment and cognitively normal subjects who are at risk for Alzheimer's dementia...
  33. pmc MRI and MRS predictors of mild cognitive impairment in a population-based sample
    Kejal Kantarci
    Department of Radiology, Mayo Clinic, Rochester, MN, USA
    Neurology 81:126-33. 2013
    ..To investigate MRI and proton magnetic resonance spectroscopy (MRS) predictors of mild cognitive impairment (MCI) in cognitively normal older adults...
  34. pmc Distinct anatomical subtypes of the behavioural variant of frontotemporal dementia: a cluster analysis study
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Brain 132:2932-46. 2009
    ..Our findings suggest behavioural variant of frontotemporal dementia can therefore be subdivided into four different anatomical subtypes...
  35. pmc Independent comparison of CogState computerized testing and a standard cognitive battery with neuroimaging
    Michelle M Mielke
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA Department of Neurology, Mayo Clinic, Rochester, MN, USA Electronic address
    Alzheimers Dement 10:779-89. 2014
    ..Inexpensive, non-invasive tools for assessing Alzheimer-type pathophysiologies are needed. Computerized cognitive assessments are prime candidates...
  36. pmc 18F-fluorodeoxyglucose positron emission tomography, aging, and apolipoprotein E genotype in cognitively normal persons
    David S Knopman
    Department of Neurology, Mayo Clinic and Foundation, Rochester, MN, USA Mayo Clinic Alzheimer s Disease Research Center, Mayo Clinic and Foundation, Rochester, MN, USA Electronic address
    Neurobiol Aging 35:2096-106. 2014
    ..The posterior cingulate and/or precuneus and lateral parietal regions have a unique vulnerability to reductions in glucose metabolic rate as a function both of age and carriage of an APOE ε4 allele...
  37. pmc Imaging and acetylcholinesterase inhibitor response in dementia with Lewy bodies
    Jonathan Graff-Radford
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Brain 135:2470-7. 2012
    ..Patients with dementia with Lewy bodies who do not have the imaging features of coexistent Alzheimer's disease-related pathology are more likely to cognitively improve with acetylcholinesterase inhibitor treatment...
  38. pmc Alzheimer's disease diagnosis in individual subjects using structural MR images: validation studies
    Prashanthi Vemuri
    Department of Radiology, Mayo Clinic 200 1st St SW, Rochester, MN 55905, USA
    Neuroimage 39:1186-97. 2008
    ..To develop and validate a tool for Alzheimer's disease (AD) diagnosis in individual subjects using support vector machine (SVM)-based classification of structural MR (sMR) images...
  39. pmc Association of lifetime intellectual enrichment with cognitive decline in the older population
    Prashanthi Vemuri
    Department of Radiology, Mayo Clinic, Rochester, Minnesota
    JAMA Neurol 71:1017-24. 2014
    ..Intellectual lifestyle enrichment throughout life is increasingly viewed as a protective strategy against commonly observed cognitive decline in the older population...
  40. pmc Antemortem MRI based STructural Abnormality iNDex (STAND)-scores correlate with postmortem Braak neurofibrillary tangle stage
    Prashanthi Vemuri
    Department of Radiology, Mayo Clinic Rochester, Rochester, MN 55905, USA
    Neuroimage 42:559-67. 2008
    ....
  41. pmc A quantitative postmortem MRI design sensitive to white matter hyperintensity differences and their relationship with underlying pathology
    Melissa E Murray
    Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, USA
    J Neuropathol Exp Neurol 71:1113-22. 2012
    ..Vacuolation enables interstitial fluid to accumulate, which contributes to the prolonged T2 relaxation and elevated FLAIR intensity in the WM...
  42. pmc Improved DTI registration allows voxel-based analysis that outperforms tract-based spatial statistics
    Christopher G Schwarz
    Department of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA Electronic address
    Neuroimage 94:65-78. 2014
    ..The proposed pipeline produces more plausible results according to each disease's pathophysiology. ..
  43. pmc Disrupted thalamocortical connectivity in PSP: a resting-state fMRI, DTI, and VBM study
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA
    Parkinsonism Relat Disord 17:599-605. 2011
    ..PSP is therefore associated with disrupted thalamocortical connectivity that is associated with degeneration of the dentatorubrothalamic tract and the presence of cortical atrophy...
  44. pmc Thrombogenic microvesicles and white matter hyperintensities in postmenopausal women
    Limor Raz
    Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA
    Neurology 80:911-8. 2013
    ..To determine the association of conventional cardiovascular risk factors, markers of platelet activation, and thrombogenic blood-borne microvesicles with white matter hyperintensity (WMH) load and progression in recently menopausal women...
  45. pmc Progranulin-associated PiB-negative logopenic primary progressive aphasia
    Keith A Josephs
    Department of Neurology Division of Behavioral Neurology, Mayo Clinic, Rochester, MN, USA
    J Neurol 261:604-14. 2014
    ..Identification of such patients, however, should prompt testing for GRN mutations, since GRN-positive patients do not have distinctive features, yet account for 50 % of this patient population...
  46. pmc Characterization of frontotemporal dementia and/or amyotrophic lateral sclerosis associated with the GGGGCC repeat expansion in C9ORF72
    Bradley F Boeve
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Brain 135:765-83. 2012
    ..While variability exists, most cases with this mutation have a characteristic spectrum of demographic, clinical, neuropsychological, neuroimaging and especially neuropathological findings...
  47. pmc Sex and gender differences in the causes of dementia: a narrative review
    Walter A Rocca
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street, Rochester, MN 55905, USA Department of Neurology, Mayo Clinic, 200 First Street, Rochester, MN 55905, USA Electronic address
    Maturitas 79:196-201. 2014
    ..Similarly, future preventive interventions for dementia should be tailored to men and women separately. ..
  48. doi request reprint Assessing subtle structural changes in Alzheimer's disease patients
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN, USA
    Methods Mol Biol 711:535-50. 2011
    ....
  49. pmc Mild cognitive impairment: baseline and longitudinal structural MR imaging measures improve predictive prognosis
    Linda K McEvoy
    Department of Radiology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
    Radiology 259:834-43. 2011
    ..To assess whether single-time-point and longitudinal volumetric magnetic resonance (MR) imaging measures provide predictive prognostic information in patients with amnestic mild cognitive impairment (MCI)...