Research Topics
Species | Robert VassalloSummaryAffiliation: Mayo Clinic Country: USA Publications
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Publications
Diffuse lung diseases in cigarette smokersRobert Vassallo
Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Semin Respir Crit Care Med 33:533-42. 2012..Understanding mechanisms by which tobacco induces diffuse lung pathology is critical in the pursuit of novel therapeutic approaches for these diseases...- Clinical outcomes of pulmonary Langerhans'-cell histiocytosis in adultsRobert Vassallo
Thoracic Diseases Research Unit, Division of Pulmonary, Critical Care, and Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
N Engl J Med 346:484-90. 2002..Pulmonary Langerhans'-cell histiocytosis is an uncommon interstitial lung disease in adults. It has an unpredictable course and may be associated with an increased susceptibility to the development of malignant neoplasms... 
Cigarette smoke promotes dendritic cell accumulation in COPD; a Lung Tissue Research Consortium studyRobert Vassallo
The Thoracic Diseases Research Unit, Division of Pulmonary Critical Care, Department of Internal Medicine, the Clinical Immunology and Immunotherapeutics Program, Mayo Clinic and Foundation, Rochester, Minnesota, 55905, USA
Respir Res 11:45. 2010..Although evident that cigarette smoke, the primary cause of COPD, significantly influences dendritic cell functions, little is known about the roles of dendritic cells in the pathogenesis of COPD...- Selective suppression of dendritic cell functions by cigarette smoke extractRobert Vassallo
Mayo Clinic, Rochester, MN 55905, USA
Chest 125:107S. 2004 - Advances in the treatment of rheumatic interstitial lung diseaseRobert Vassallo
Thoracic Diseases Research Unit, Division of Pulmonary Critical Care, Department of Internal Medicine, Mayo Clinic and Foundation, Stabile Building 8 54, 200 First Street SW, Rochester, MN 55905, USA
Curr Opin Rheumatol 16:186-91. 2004..Interstitial lung disease frequently complicates the rheumatic diseases. The purpose of this review is to outline recent advances and current concepts regarding the management of these interstitial lung diseases... - Cigarette smoke extract suppresses human dendritic cell function leading to preferential induction of Th-2 primingRobert Vassallo
Thoracic Diseases Research Unit, Division of Pulmonary Critical Care, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
J Immunol 175:2684-91. 2005..These data provide evidence that soluble components extracted from cigarette smoke suppress key DC functions and favor the development of Th-2 immunity... - The overlap between respiratory bronchiolitis and desquamative interstitial pneumonia in pulmonary Langerhans cell histiocytosis: high-resolution CT, histologic, and functional correlationsRobert Vassallo
Thoracic Diseases Research Unit, Division of Pulmonary, Critical Care and Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
Chest 124:1199-205. 2003.... - Nicotine and oxidative cigarette smoke constituents induce immune-modulatory and pro-inflammatory dendritic cell responsesRobert Vassallo
Thoracic Diseases Research Unit, Mayo Clinic and Foundation, Rochester, MN 55905, USA
Mol Immunol 45:3321-9. 2008..Certain pharmacologic strategies such as anti-oxidant therapy may be only partially effective in mitigating cigarette smoke-induced pro-inflammatory DC-mediated responses in smokers... - Viral-induced inflammation in interstitial lung diseasesRobert Vassallo
Thoracic Diseases Research Unit, Mayo Clinic, Rochester, MN 55905, USA
Semin Respir Infect 18:55-60. 2003.... - Pneumocystis cell wall beta-glucans induce dendritic cell costimulatory molecule expression and inflammatory activation through a Fas-Fas ligand mechanismEva M Carmona
Thoracic Diseases Research Unit, Division of Pulmonary Critical Care and Internal Medicine, Department of Medicine, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
J Immunol 177:459-67. 2006..This suggests that dysregulation of FasL could further enhance exuberant and prolonged cytokine production by DCs following DC-T cell interactions, further promoting lung inflammation typical of Pneumocystis pneumonia... 
Incidence and mortality of interstitial lung disease in rheumatoid arthritis: a population-based studyTim Bongartz
Rheumatology Department, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Arthritis Rheum 62:1583-91. 2010..Interstitial lung disease (ILD) has been recognized as an important comorbidity in rheumatoid arthritis (RA). We undertook the current study to assess incidence, predictors, and mortality of RA-associated ILD...- Cigarette smoke-induced oxidative stress suppresses generation of dendritic cell IL-12 and IL-23 through ERK-dependent pathwaysPaula R Kroening
Department of Internal Medicine, Thoracic Diseases Research Unit, Division of Pulmonary Critical Care, Mayo Clinic and Foundation, Rochester, MN 55905, USA
J Immunol 181:1536-47. 2008..Some of the cigarette smoke-induced inhibitory effects on DC function may be mitigated by antioxidants... - Desquamative interstitial pneumonia and respiratory bronchiolitis-associated interstitial lung diseaseJay H Ryu
Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN 55905, USA
Chest 127:178-84. 2005..Desquamative interstitial pneumonia (DIP) and respiratory bronchiolitis-associated interstitial lung disease (RB-ILD) are uncommon forms of interstitial lung disease and have been incompletely characterized... - Tobacco smoke-related diffuse lung diseasesRobert Vassallo
Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Semin Respir Crit Care Med 29:643-50. 2008.... - Smoking-related interstitial lung diseasesRobert Vassallo
Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN 55905, USA
Clin Chest Med 33:165-78. 2012..The role of pharmacotherapy with corticosteroids or other immunomodulating agents is not well established but may be considered in patients with progressive forms of smoking-related interstitial lung diseases... - Pulmonary Langerhans' cell histiocytosisRobert Vassallo
Division of Pulmonary and Critical Care and Internal Medicine, Mayo Clinic and Foundation, 200 First Street Southwest, Rochester, MN, 55905, USA
Clin Chest Med 25:561-71, vii. 2004..This article summarizes recent advances and current understanding of PLCH... - Echocardiographic and clinical characteristics of pulmonary hypertension complicating pulmonary Langerhans cell histiocytosisNithima Chaowalit
Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
Mayo Clin Proc 79:1269-75. 2004..9; P < .001). CONCLUSION: Severe PH occurs in PLCH, correlates with the forced vital capacity, and has a significant impact on survival. Clinicians should consider echocardiographic screening for PH in all dyspneic patients with PLCH... - Increased CD4+ T cell infiltrates in rheumatoid arthritis-associated interstitial pneumonitis compared with idiopathic interstitial pneumonitisCarl Turesson
Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
Arthritis Rheum 52:73-9. 2005..To study lymphocyte markers in rheumatoid arthritis (RA)-associated interstitial pneumonitis (IP) compared with idiopathic IP... - Pulmonary langerhans cell histiocytosisHarpreet S Suri
Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA
Orphanet J Rare Dis 7:16. 2012..Complications like pneumothoraces and secondary pulmonary hypertension may shorten life expectancy. Patients with progressive disease may require lung transplantation... - Follicular bronchiolitis in surgical lung biopsies: clinical implications in 12 patientsMichelle R Aerni
Division of Pulmonary and Critical Care Medicine, Desk East 18, Mayo Clinic, 200 1st St SW, Rochester, MN, USA
Respir Med 102:307-12. 2008..Follicular bronchiolitis is a histopathologic finding that occurs in diverse clinical contexts. The current study was conducted to characterize clinico-radiologic features, and assess outcomes associated with follicular bronchiolitis... - Brain-derived neurotrophic factor in cigarette smoke-induced airway hyperreactivityVenkatachalem Sathish
Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA
Am J Respir Cell Mol Biol 48:431-8. 2013..These data suggest that cigarette smoke is a potent inducer of BDNF and TrkB expression and signaling in ASM, which then contribute to cigarette smoke-induced airway hyperresponsiveness... - Pneumothorax in pulmonary Langerhans cell histiocytosisJose L Mendez
Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN 55905, USA
Chest 125:1028-32. 2004..CONCLUSIONS: These data support the early use of surgical therapy with pleurodesis in managing patients with PLCH and spontaneous pneumothorax... - Diffuse bronchiolar disease due to chronic occult aspirationTerrance W Barnes
Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Mayo Clin Proc 81:172-6. 2006..Radiological features associated with this disorder are distinctively different from those seen in aspiration pneumonia... - Cigarette smoking and diffuse lung diseaseRajesh R Patel
Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
Drugs 68:1511-27. 2008.... - Asthma-related environmental fungus, Alternaria, activates dendritic cells and produces potent Th2 adjuvant activityTakao Kobayashi
Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
J Immunol 182:2502-10. 2009..Such immunogenic properties of certain environmental fungi may explain their strong relationships with human asthma and allergic diseases... - Abnormal fluorodeoxyglucose PET in pulmonary Langerhans cell histiocytosisBryan J Krajicek
Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN 55905, USA
Chest 135:1542-9. 2009..Although the chest CT scan characteristics of PLCH are well recognized, the PET scan characteristics of adults with PLCH are unknown... - Complete remission of nodular pulmonary Langerhans cell histiocytosis lesions induced by 2-chlorodeoxyadenosine in a non-smokerMichelle R Aerni
Department of Pulmonary and Critical Care Medicine and Thoracic Diseases Research Unit, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Respir Med 102:316-9. 2008..We propose that, in selected cases, 2-CdA should be considered in the management of pulmonary LCH... - Thymic stromal lymphopoietin in cigarette smoke-exposed human airway smooth muscleDan F Smelter
Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
J Immunol 185:3035-40. 2010..Overall, these novel data suggest that cigarette smoke, TSLP, and ASM are functionally linked and that cigarette smoke-induced increase in airway contractility may be mediated via ASM-derived increases in TSLP signaling... - Lack of FDG uptake in small cell carcinoma associated with ANNA-1 positive paraneoplastic autonomic neuropathyMatthew S Block
Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA
J Thorac Oncol 3:542-4. 2008.... - Intrathoracic manifestations of Rosai-Dorfman diseaseRodrigo Cartin-Ceba
Mayo Clinic, 200, Rochester, MN 55905, USA
Respir Med 104:1344-9. 2010..Although cutaneous and lymph node involvement are relatively well-described, intrathoracic manifestations of RDD have only occasionally been reported... - Pneumocystis carinii cell wall beta-glucans initiate macrophage inflammatory responses through NF-kappaB activationFrances Lebron
Department of Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
J Biol Chem 278:25001-8. 2003..carinii beta-glucan. These data demonstrate that P. carinii beta-glucan acts as potent inducer of macrophage activation through NF-kappaB utilizing cellular receptors and signaling pathways distinct from LPS... - Clinical response of rheumatoid arthritis-associated pulmonary fibrosis to tumor necrosis factor-alpha inhibitionRobert Vassallo
Thoracic Diseases Research Unit, Division of Pulmonary, Critical Care and Internal Medicine, Mayo Clinic and Foundation, Rochester, MN, USA
Chest 122:1093-6. 2002..This report suggests that inhibition of TNF-alpha may be of significant benefit to patients with fibrosing lung conditions in the setting of RA... - Chronic obstructive pulmonary disease after myocardial infarction in the communityFrancesca Bursi
Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
Am Heart J 160:95-101. 2010..We examined, in a geographically defined community, the prevalence of COPD in patients with MI, its impact on mortality, and how these associations changed over time... - A 40-year-old man with hemolytic anemia, Ig deficiency, and bilateral pulmonary infiltratesElisabetta Balestro
Respiratory Disease Department, Hospital S Bassiano, Bassano del Grappa, Italy
Chest 133:1517-23. 2008