Raul A Urrutia

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Functional characterization of EZH2β reveals the increased complexity of EZH2 isoforms involved in the regulation of mammalian gene expression
    Adrienne Grzenda
    Laboratory of Epigenetics and Chromatin Dynamics, Mayo Clinic, Rochester, MN, 55905, USA
    Epigenetics Chromatin 6:3. 2013
  2. pmc The Heterochromatin Protein 1 family
    Gwen Lomberk
    Gastroenterology Research Unit, Saint Mary s Hospital, Mayo Clinic, Rochester, MN 55905, USA
    Genome Biol 7:228. 2006
  3. pmc Sp1- and Krüppel-like transcription factors
    Joanna Kaczynski
    Gastroenterology Research Unit, Mayo Clinic, Rochester, MN 55901, USA
    Genome Biol 4:206. 2003
  4. pmc The future of pancreatology: how to go where we have never been before
    Raul Urrutia
    Gastroenterology Research Unit, Saint Mary s Hospital, Mayo Clinic College of Medicine, 2 445 Alfred Building, Rochester, MN 55905, USA
    Am J Surg 194:S153-7. 2007
  5. pmc KRAB-containing zinc-finger repressor proteins
    Raul Urrutia
    Gastroenterology Research Unit, Saint Mary s Hospital and Department of Biochemistry and Molecular Biology and Tumor Biology Program, Mayo Clinic, Rochester, MN 55905, USA
    Genome Biol 4:231. 2003
  6. pmc Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoter
    Joanna A Kaczynski
    Gastroenterology Research Unit, Saint Mary s Hospital, Mayo Clinic, Rochester, MN 55905, USA
    Biochem J 366:873-82. 2002
  7. pmc Signaling disrupts mSin3A binding to the Mad1-like Sin3-interacting domain of TIEG2, an Sp1-like repressor
    Volker Ellenrieder
    Gastroenterology Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    EMBO J 21:2451-60. 2002
  8. pmc MODY7 gene, KLF11, is a novel p300-dependent regulator of Pdx-1 (MODY4) transcription in pancreatic islet beta cells
    Martin E Fernandez-Zapico
    Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 284:36482-90. 2009
  9. ncbi request reprint A novel functional interaction between the Sp1-like protein KLF13 and SREBP-Sp1 activation complex underlies regulation of low density lipoprotein receptor promoter function
    Sekar Natesampillai
    Endocrine Research Unit and Gastroenterology Research Unit, Department of Internal Medicine, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Biol Chem 281:3040-7. 2006
  10. pmc An mSin3A interaction domain links the transcriptional activity of KLF11 with its role in growth regulation
    Martin E Fernandez-Zapico
    Gastroenterology Research Unit, Saint Mary s Hospital, Mayo Clinic, Rochester, MN 55905, USA
    EMBO J 22:4748-58. 2003

Collaborators

Detail Information

Publications43

  1. pmc Functional characterization of EZH2β reveals the increased complexity of EZH2 isoforms involved in the regulation of mammalian gene expression
    Adrienne Grzenda
    Laboratory of Epigenetics and Chromatin Dynamics, Mayo Clinic, Rochester, MN, 55905, USA
    Epigenetics Chromatin 6:3. 2013
    ..Deregulation of EZH2 expression is implicated in numerous complex human diseases. To date, most EZH2-mediated function has been primarily ascribed to a single protein product of the EZH2 locus...
  2. pmc The Heterochromatin Protein 1 family
    Gwen Lomberk
    Gastroenterology Research Unit, Saint Mary s Hospital, Mayo Clinic, Rochester, MN 55905, USA
    Genome Biol 7:228. 2006
    ..HP1 proteins are amenable to posttranslational modifications that probably regulate these distinct functions, thereby creating a subcode within the context of the 'histone code' of histone posttranslational modifications...
  3. pmc Sp1- and Krüppel-like transcription factors
    Joanna Kaczynski
    Gastroenterology Research Unit, Mayo Clinic, Rochester, MN 55901, USA
    Genome Biol 4:206. 2003
    ..Sp1-like/KLF proteins have highly conserved carboxy-terminal zinc-finger domains that function in DNA binding. The amino terminus, containing the transcription activation domain, can vary significantly between family members...
  4. pmc The future of pancreatology: how to go where we have never been before
    Raul Urrutia
    Gastroenterology Research Unit, Saint Mary s Hospital, Mayo Clinic College of Medicine, 2 445 Alfred Building, Rochester, MN 55905, USA
    Am J Surg 194:S153-7. 2007
    ..Never forget--the lives of our patients depend on what we do...
  5. pmc KRAB-containing zinc-finger repressor proteins
    Raul Urrutia
    Gastroenterology Research Unit, Saint Mary s Hospital and Department of Biochemistry and Molecular Biology and Tumor Biology Program, Mayo Clinic, Rochester, MN 55905, USA
    Genome Biol 4:231. 2003
    ..Members of the family are involved in maintenance of the nucleolus, cell differentiation, cell proliferation, apoptosis, and neoplastic transformation...
  6. pmc Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoter
    Joanna A Kaczynski
    Gastroenterology Research Unit, Saint Mary s Hospital, Mayo Clinic, Rochester, MN 55905, USA
    Biochem J 366:873-82. 2002
    ..Furthermore, our results demonstrate that the BTEB subfamily can repress the CYP1A1 gene promoter via the BTE site...
  7. pmc Signaling disrupts mSin3A binding to the Mad1-like Sin3-interacting domain of TIEG2, an Sp1-like repressor
    Volker Ellenrieder
    Gastroenterology Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    EMBO J 21:2451-60. 2002
    ....
  8. pmc MODY7 gene, KLF11, is a novel p300-dependent regulator of Pdx-1 (MODY4) transcription in pancreatic islet beta cells
    Martin E Fernandez-Zapico
    Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 284:36482-90. 2009
    ..Furthermore, because KLF11 like most MODY-associated transcription factors uses p300, these data further support a role for this coactivator as a critical chromatin link in forms of type 2 diabetes...
  9. ncbi request reprint A novel functional interaction between the Sp1-like protein KLF13 and SREBP-Sp1 activation complex underlies regulation of low density lipoprotein receptor promoter function
    Sekar Natesampillai
    Endocrine Research Unit and Gastroenterology Research Unit, Department of Internal Medicine, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Biol Chem 281:3040-7. 2006
    ....
  10. pmc An mSin3A interaction domain links the transcriptional activity of KLF11 with its role in growth regulation
    Martin E Fernandez-Zapico
    Gastroenterology Research Unit, Saint Mary s Hospital, Mayo Clinic, Rochester, MN 55905, USA
    EMBO J 22:4748-58. 2003
    ..These results demonstrate that SID-containing KLF repressor proteins can inhibit cell growth and neoplastic transformation, and outline for the first time cellular and molecular mechanisms by which these functions may be achieved...
  11. ncbi request reprint Evidence for the existence of an HP1-mediated subcode within the histone code
    Gwen Lomberk
    Gastroenterology Research Unit, Department of Medicine, and Mayo Clinic Cancer Center, Rochester, MN 55605, USA
    Nat Cell Biol 8:407-15. 2006
    ....
  12. pmc Silencing of the transforming growth factor-beta (TGFbeta) receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signaling
    Mark J Truty
    Department of Biochemistry and Molecular Biology, Gastroenterology Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    J Biol Chem 284:6291-300. 2009
    ....
  13. doi request reprint Characterization of the CXCR4 signaling in pancreatic cancer cells
    Daniel D Billadeau
    Oncology Research Department, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Int J Gastrointest Cancer 37:110-9. 2006
    ....
  14. pmc Sin3: master scaffold and transcriptional corepressor
    Adrienne Grzenda
    Department of Biochemistry, Mayo Clinic, Rochester, MN 55905, USA
    Biochim Biophys Acta 1789:443-50. 2009
    ..Abnormal recruitment of this complex or alteration of its enzymatic activity has been implicated in neoplastic transformation...
  15. pmc Alterations in expression of p11 and SERT in mucosal biopsy specimens of patients with irritable bowel syndrome
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research C E N T E R Group and Gastroenterology Research Unit, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Gastroenterology 132:17-25. 2007
    ..We explored the hypothesis that expression of these 2 proteins in colonic and rectal mucosa is abnormal in patients with IBS as compared with healthy controls...
  16. doi request reprint Primers on molecular pathways--notch
    Gwen Lomberk
    Gastroenterology Research Unit, Saint Mary s Hospital, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Pancreatology 8:103-4. 2008
    ....
  17. pmc Nitric oxide regulates tumor cell cross-talk with stromal cells in the tumor microenvironment of the liver
    Ningling Kang Decker
    Department of Physiology, Mayo Clinic Rochester, MN 55905, USA
    Am J Pathol 173:1002-12. 2008
    ..Thus, a NO gradient within the tumor microenvironment influences tumor progression through orchestrated molecular interactions between tumor cells and stroma...
  18. doi request reprint Primers on molecular pathways--caspase pathway
    Gwen Lomberk
    Division of Gastroenterology, Mayo Clinic, Rochester, MN 55905, USA
    Pancreatology 9:6-8. 2009
    ..Thus, it is for these reasons that in the current 'Primers on Molecular Pathways,' we take a closer look at the pathway cascade that is triggered during apoptosis...
  19. pmc Polycomb and the emerging epigenetics of pancreatic cancer
    Adrienne Grzenda
    Laboratory of Chromatin Dynamics and Epigenetics, Gastroenterology Research Unit, Departments of Biochemistry and Molecular Biology, Biophysics, and Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Gastrointest Cancer 42:100-11. 2011
    ..Disruption of chromatin organization can directly and indirectly precipitate genomic instability and transformation...
  20. doi request reprint Primers on molecular pathways--the insulin pathway
    Gwen Lomberk
    GI Research Unit, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA
    Pancreatology 9:203-5. 2009
    ..In this 'Primers on Molecular Pathways', we discuss this important signaling pathway, which is central to pancreas biology...
  21. pmc Distinct role of Kruppel-like factor 11 in the regulation of prostaglandin E2 biosynthesis
    Navtej S Buttar
    Division of Gastroenterology, Mayo Clinic, Rochester, Minnesota 55902, USA
    J Biol Chem 285:11433-44. 2010
    ....
  22. pmc The sunset of somatic genetics and the dawn of epigenetics: a new frontier in pancreatic cancer research
    Gwen Lomberk
    Laboratory of Chromatin Dynamics and Epigenetics, Gastroenterology Research Unit, Departments of Biochemistry and Molecular Biology, Biophysics and Medicine, Mayo Clinic, Rochester, MN 55901, USA
    Curr Opin Gastroenterol 24:597-602. 2008
    ..Therefore, epigenetics with its molecular basis (DNA methylation and chromatin modification) is among the most promising areas of cancer research and is a nascent field in pancreatic cancer research...
  23. ncbi request reprint Disruption of an SP2/KLF6 repression complex by SHP is required for farnesoid X receptor-induced endothelial cell migration
    Amitava Das
    Gastroenterology Research Unit, Department of Physiology and Cancer Cell Biology Program, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 281:39105-13. 2006
    ..Thus, together, these studies identify a mechanism for antagonizing Sp/KLF protein repression function via SHP, with this process regulating endothelial cell motility...
  24. ncbi request reprint Serotonin-transporter polymorphism pharmacogenetics in diarrhea-predominant irritable bowel syndrome
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Foundation, Rochester, Minnesota 55905, USA
    Gastroenterology 123:425-32. 2002
    ..Our hypothesis is that polymorphisms of the promoter region for the SERT influence colonic transit in response to treatment with alosetron in D-IBS...
  25. ncbi request reprint Differential binding of Sin3 interacting repressor domains to the PAH2 domain of Sin3A
    Yuan Ping Pang
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Foundation for Medical Education and Research, 200 First Street SW, Rochester, MN 55905, USA
    FEBS Lett 548:108-12. 2003
    ..It also provides the structural basis for developing selective modulators of Sin3...
  26. ncbi request reprint KLF11-mediated repression antagonizes Sp1/sterol-responsive element-binding protein-induced transcriptional activation of caveolin-1 in response to cholesterol signaling
    Sheng Cao
    Gastroenterology Research Unit and Tumor Biology Program, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Biol Chem 280:1901-10. 2005
    ....
  27. ncbi request reprint Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis
    Martin E Fernandez-Zapico
    Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Cancer Cell 7:39-49. 2005
    ..Thus, the discovery of prooncogenic pathways regulated by Vav1 makes it an attractive target for therapeutic intervention...
  28. ncbi request reprint Antianoikis effect of nuclear factor-kappaB through up-regulated expression of osteoprotegerin, BCL-2, and IAP-1
    Murat Toruner
    Gastroenterology Research Unit and Molecular Medicine Program, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 281:8686-96. 2006
    ..Together, these findings have identified the molecular components of a previously unrecognized antianoikis pathway in intestinal epithelial cells...
  29. ncbi request reprint Bioinformatics tools to understand human diseases
    Jose D Debes
    Gastroenterology Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Surgery 135:579-85. 2004
  30. ncbi request reprint A study of candidate genotypes associated with dyspepsia in a U.S. community
    Christopher E Camilleri
    Gastroenterology Research Unit, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Am J Gastroenterol 101:581-92. 2006
    ..The role of genetic predisposition to the development of dyspepsia is unclear. Recently, a significant association was reported with CC genotype of GNbeta3...
  31. ncbi request reprint Is there an association between GNbeta3-C825T genotype and lower functional gastrointestinal disorders?
    Viola Andresen
    Clinical Enteric Neuroscience Translational and Epidemiological Research C E N T E R Program, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Gastroenterology 130:1985-94. 2006
    ....
  32. pmc Ephrin B2/EphB4 pathway in hepatic stellate cells stimulates Erk-dependent VEGF production and sinusoidal endothelial cell recruitment
    Amitava Das
    Gastroenterology Research Unit, Mayo Clinic and Foundation, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Gastrointest Liver Physiol 298:G908-15. 2010
    ..These studies identify EphrinB2 or EphB4 as a key intermediary that links HSC signal transduction pathways with angiogenesis and sinusoidal remodeling...
  33. ncbi request reprint Fundamentals of transcription factors and their impact on pancreatic development and cancer
    Martin E Fernandez-Zapico
    Gastroenterology Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Pancreatology 3:276-83. 2003
    ..In this article we review this field of research with a particular emphasis on the role of transcription factors in pancreatic development and cancer...
  34. ncbi request reprint Effect of CCK-1 antagonist, dexloxiglumide, in female patients with irritable bowel syndrome: a pharmacodynamic and pharmacogenomic study
    Filippo Cremonini
    Clinical Enteric Neuroscience Translational and Epidemiological Research C E N T E R Program, Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, Minnesota
    Am J Gastroenterol 100:652-63. 2005
    ..Cholecystokinin (CCK) is involved in gastrointestinal motor response to meals. The potential role of CCK receptor antagonists in functional gastrointestinal disorders is unclear...
  35. pmc The family feud: turning off Sp1 by Sp1-like KLF proteins
    Gwen Lomberk
    Gastroenterology Research Unit, Mayo Clinic, Rochester, MN 55901, USA
    Biochem J 392:1-11. 2005
    ..The existence of these transcriptional repressors provides a tightly regulated mechanism for silencing a large number of genes that are already known to be activated by Sp1...
  36. ncbi request reprint Transforming growth factor-beta: what every pancreatic surgeon should know
    Mark J Truty
    Department of Surgery, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Surgery 141:1-6. 2007
  37. doi request reprint Interplay of tumor microenvironment cell types with parenchymal cells in pancreatic cancer development and therapeutic implications
    Praveen Guturu
    Gastroenterology Research Unit and Fiterman Center for Digestive Diseases, Mayo Clinic Rochester MN, 200 First Street SW, Rochester, MN 55905, USA
    J Gastrointest Cancer 40:1-9. 2009
    ..The process of "induction," namely, the formation of a tissue by the functional interaction between the epithelial layer and the stroma, is key for the development of many organs, in particular to the pancreas...
  38. ncbi request reprint Basics of TGF-beta and pancreatic cancer
    Mark J Truty
    Department of Surgery, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Pancreatology 7:423-35. 2007
    ..The purpose of this review is to provide the practicing clinician a thorough review of this molecule and its associated signaling partners in the context of its duplicitous role and behavior in patients with pancreatic cancer...
  39. ncbi request reprint Invasive cancer and survival of intraductal papillary mucinous tumors of the pancreas
    Massimo Raimondo
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 97:2553-8. 2002
    ..We compared survival after resection and determined whether K-ras mutations predicted survival in IPMT patients without or with invasive cancer...
  40. pmc Conservation of the TGFbeta/Labial homeobox signaling loop in endoderm-derived cells between Drosophila and mammals
    Gwen A Lomberk
    Department of Medicine, Mayo Clinic, Rochester, Minn, USA
    Pancreatology 10:74-84. 2010
    ..Interestingly, although Labial-like homeobox genes are present in mammals, their participation in endoderm morphogenesis is not clearly understood...
  41. ncbi request reprint When developmental signaling pathways go wrong and their impact on pancreatic cancer development
    Gwen Lomberk
    Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    Curr Opin Gastroenterol 21:555-60. 2005
    ..To describe recent studies of developmental signal pathways and their relation to the development of pancreatic cancer...
  42. ncbi request reprint Intraductal papillary mucinous neoplasm: did it exist prior to 1980?
    Matthew K Tollefson
    Department of Surgery, Mayo Clinic, Rochester, MN 55905, USA
    Pancreas 26:e55-8. 2003
    ..Intraductal papillary mucinous neoplasm (IPMN) of the pancreas was first reported in 1982. It is not clear whether the appearance of this neoplasm is a new epidemic or an old disease previously overlooked...
  43. ncbi request reprint Key role of Krüppel-like factor proteins in pancreatic cancer and other gastrointestinal neoplasias
    Navtej S Buttar
    Gastroenterology Research Unit, Saint Mary s Hospital, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Curr Opin Gastroenterol 22:505-11. 2006
    ..To describe recent studies on Krüppel-like factor transcription factors and their relationship with gastrointestinal neoplasias, in particular pancreatic cancer...

Research Grants15

  1. The Role of Zinc Finger Genes in Pancreatic Cell Growth
    Raul Urrutia; Fiscal Year: 2009
    ..However, we are optimistic that our studies will build the foundation for future treatment and perhaps even the prevention of this disease. ..
  2. The Role of Zinc Finger Genes in Pancreatic Cell Growth
    Raul Urrutia; Fiscal Year: 2006
    ..abstract_text> ..
  3. KS1, A NOVEL SUPPRESSOR OF NEOPLASTIC TRANSFORMATION
    Raul Urrutia; Fiscal Year: 2003
    ..This knowledge will serve as the foundation for future studies aimed at using these proteins as therapeutic tools for controlling abnormal cell growth. ..
  4. ZINC FINGER GENES AND PANCREATIC CELL GROWTH
    Raul Urrutia; Fiscal Year: 2001
    ..Furthermore, this information will be crucial as a theoretical framework for future studies on the role of zinc finger transcription factors in pancreatic development and cancer. ..
  5. The Role of Zinc Finger Genes in Pancreatic Cell Growth
    Raul A Urrutia; Fiscal Year: 2010
    ..However, we are optimistic that our studies will build the foundation for future treatment and perhaps even the prevention of this disease. ..