Research Topics
Genomes and Genes | Raul A UrrutiaSummaryAffiliation: Mayo Clinic Country: USA Publications
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Publications
Functional characterization of EZH2β reveals the increased complexity of EZH2 isoforms involved in the regulation of mammalian gene expressionAdrienne Grzenda
Laboratory of Epigenetics and Chromatin Dynamics, Mayo Clinic, Rochester, MN, 55905, USA
Epigenetics Chromatin 6:3. 2013..Deregulation of EZH2 expression is implicated in numerous complex human diseases. To date, most EZH2-mediated function has been primarily ascribed to a single protein product of the EZH2 locus...- The Heterochromatin Protein 1 familyGwen Lomberk
Gastroenterology Research Unit, Saint Mary's Hospital, Mayo Clinic, Rochester, MN 55905, USA
Genome Biol 7:228. 2006..HP1 proteins are amenable to posttranslational modifications that probably regulate these distinct functions, thereby creating a subcode within the context of the 'histone code' of histone posttranslational modifications... - Sp1- and Krüppel-like transcription factorsJoanna Kaczynski
Gastroenterology Research Unit, Mayo Clinic, Rochester, MN 55901, USA
Genome Biol 4:206. 2003..Sp1-like/KLF proteins have highly conserved carboxy-terminal zinc-finger domains that function in DNA binding. The amino terminus, containing the transcription activation domain, can vary significantly between family members... 
The future of pancreatology: how to go where we have never been beforeRaul Urrutia
Gastroenterology Research Unit, Saint Mary s Hospital, Mayo Clinic College of Medicine, 2 445 Alfred Building, Rochester, MN 55905, USA
Am J Surg 194:S153-7. 2007..Never forget--the lives of our patients depend on what we do...- KRAB-containing zinc-finger repressor proteinsRaul Urrutia
Gastroenterology Research Unit, Saint Mary s Hospital and Department of Biochemistry and Molecular Biology and Tumor Biology Program, Mayo Clinic, Rochester, MN 55905, USA
Genome Biol 4:231. 2003..Members of the family are involved in maintenance of the nucleolus, cell differentiation, cell proliferation, apoptosis, and neoplastic transformation... - Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoterJoanna A Kaczynski
Gastroenterology Research Unit, Saint Mary s Hospital, Mayo Clinic, Rochester, MN 55905, USA
Biochem J 366:873-82. 2002..Furthermore, our results demonstrate that the BTEB subfamily can repress the CYP1A1 gene promoter via the BTE site... - Signaling disrupts mSin3A binding to the Mad1-like Sin3-interacting domain of TIEG2, an Sp1-like repressorVolker Ellenrieder
Gastroenterology Research Unit, Mayo Clinic, Rochester, MN 55905, USA
EMBO J 21:2451-60. 2002.... - MODY7 gene, KLF11, is a novel p300-dependent regulator of Pdx-1 (MODY4) transcription in pancreatic islet beta cellsMartin E Fernandez-Zapico
Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota 55905, USA
J Biol Chem 284:36482-90. 2009..Furthermore, because KLF11 like most MODY-associated transcription factors uses p300, these data further support a role for this coactivator as a critical chromatin link in forms of type 2 diabetes... - A novel functional interaction between the Sp1-like protein KLF13 and SREBP-Sp1 activation complex underlies regulation of low density lipoprotein receptor promoter functionSekar Natesampillai
Endocrine Research Unit and Gastroenterology Research Unit, Department of Internal Medicine, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
J Biol Chem 281:3040-7. 2006.... - An mSin3A interaction domain links the transcriptional activity of KLF11 with its role in growth regulationMartin E Fernandez-Zapico
Gastroenterology Research Unit, Saint Mary s Hospital, Mayo Clinic, Rochester, MN 55905, USA
EMBO J 22:4748-58. 2003..These results demonstrate that SID-containing KLF repressor proteins can inhibit cell growth and neoplastic transformation, and outline for the first time cellular and molecular mechanisms by which these functions may be achieved... - Evidence for the existence of an HP1-mediated subcode within the histone codeGwen Lomberk
Gastroenterology Research Unit, Department of Medicine, and Mayo Clinic Cancer Center, Rochester, MN 55605, USA
Nat Cell Biol 8:407-15. 2006.... - Silencing of the transforming growth factor-beta (TGFbeta) receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signalingMark J Truty
Department of Biochemistry and Molecular Biology, Gastroenterology Research Unit, Mayo Clinic, Rochester, MN 55905, USA
J Biol Chem 284:6291-300. 2009.... 
Characterization of the CXCR4 signaling in pancreatic cancer cellsDaniel D Billadeau
Oncology Research Department, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Int J Gastrointest Cancer 37:110-9. 2006....- Sin3: master scaffold and transcriptional corepressorAdrienne Grzenda
Department of Biochemistry, Mayo Clinic, Rochester, MN 55905, USA
Biochim Biophys Acta 1789:443-50. 2009..Abnormal recruitment of this complex or alteration of its enzymatic activity has been implicated in neoplastic transformation... - Alterations in expression of p11 and SERT in mucosal biopsy specimens of patients with irritable bowel syndromeMichael Camilleri
Clinical Enteric Neuroscience Translational and Epidemiological Research C E N T E R Group and Gastroenterology Research Unit, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
Gastroenterology 132:17-25. 2007..We explored the hypothesis that expression of these 2 proteins in colonic and rectal mucosa is abnormal in patients with IBS as compared with healthy controls... - Primers on molecular pathways--notchGwen Lomberk
Gastroenterology Research Unit, Saint Mary s Hospital, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Pancreatology 8:103-4. 2008.... - Nitric oxide regulates tumor cell cross-talk with stromal cells in the tumor microenvironment of the liverNingling Kang Decker
Department of Physiology, Mayo Clinic Rochester, MN 55905, USA
Am J Pathol 173:1002-12. 2008..Thus, a NO gradient within the tumor microenvironment influences tumor progression through orchestrated molecular interactions between tumor cells and stroma... - Primers on molecular pathways--caspase pathwayGwen Lomberk
Division of Gastroenterology, Mayo Clinic, Rochester, MN 55905, USA
Pancreatology 9:6-8. 2009..Thus, it is for these reasons that in the current 'Primers on Molecular Pathways,' we take a closer look at the pathway cascade that is triggered during apoptosis... - Polycomb and the emerging epigenetics of pancreatic cancerAdrienne Grzenda
Laboratory of Chromatin Dynamics and Epigenetics, Gastroenterology Research Unit, Departments of Biochemistry and Molecular Biology, Biophysics, and Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
J Gastrointest Cancer 42:100-11. 2011..Disruption of chromatin organization can directly and indirectly precipitate genomic instability and transformation... - Primers on molecular pathways--the insulin pathwayGwen Lomberk
GI Research Unit, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA
Pancreatology 9:203-5. 2009..In this 'Primers on Molecular Pathways', we discuss this important signaling pathway, which is central to pancreas biology... - Distinct role of Kruppel-like factor 11 in the regulation of prostaglandin E2 biosynthesisNavtej S Buttar
Division of Gastroenterology, Mayo Clinic, Rochester, Minnesota 55902, USA
J Biol Chem 285:11433-44. 2010.... - The sunset of somatic genetics and the dawn of epigenetics: a new frontier in pancreatic cancer researchGwen Lomberk
Laboratory of Chromatin Dynamics and Epigenetics, Gastroenterology Research Unit, Departments of Biochemistry and Molecular Biology, Biophysics and Medicine, Mayo Clinic, Rochester, MN 55901, USA
Curr Opin Gastroenterol 24:597-602. 2008..Therefore, epigenetics with its molecular basis (DNA methylation and chromatin modification) is among the most promising areas of cancer research and is a nascent field in pancreatic cancer research... - Disruption of an SP2/KLF6 repression complex by SHP is required for farnesoid X receptor-induced endothelial cell migrationAmitava Das
Gastroenterology Research Unit, Department of Physiology and Cancer Cell Biology Program, Mayo Clinic, Rochester, Minnesota 55905, USA
J Biol Chem 281:39105-13. 2006..Thus, together, these studies identify a mechanism for antagonizing Sp/KLF protein repression function via SHP, with this process regulating endothelial cell motility... - Serotonin-transporter polymorphism pharmacogenetics in diarrhea-predominant irritable bowel syndromeMichael Camilleri
Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Foundation, Rochester, Minnesota 55905, USA
Gastroenterology 123:425-32. 2002..Our hypothesis is that polymorphisms of the promoter region for the SERT influence colonic transit in response to treatment with alosetron in D-IBS... - Differential binding of Sin3 interacting repressor domains to the PAH2 domain of Sin3AYuan Ping Pang
Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Foundation for Medical Education and Research, 200 First Street SW, Rochester, MN 55905, USA
FEBS Lett 548:108-12. 2003..It also provides the structural basis for developing selective modulators of Sin3... - KLF11-mediated repression antagonizes Sp1/sterol-responsive element-binding protein-induced transcriptional activation of caveolin-1 in response to cholesterol signalingSheng Cao
Gastroenterology Research Unit and Tumor Biology Program, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
J Biol Chem 280:1901-10. 2005.... - Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesisMartin E Fernandez-Zapico
Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Cancer Cell 7:39-49. 2005..Thus, the discovery of prooncogenic pathways regulated by Vav1 makes it an attractive target for therapeutic intervention... - Antianoikis effect of nuclear factor-kappaB through up-regulated expression of osteoprotegerin, BCL-2, and IAP-1Murat Toruner
Gastroenterology Research Unit and Molecular Medicine Program, Mayo Clinic, Rochester, Minnesota 55905, USA
J Biol Chem 281:8686-96. 2006..Together, these findings have identified the molecular components of a previously unrecognized antianoikis pathway in intestinal epithelial cells... - Bioinformatics tools to understand human diseasesJose D Debes
Gastroenterology Research Unit, Mayo Clinic, Rochester, MN 55905, USA
Surgery 135:579-85. 2004 - A study of candidate genotypes associated with dyspepsia in a U.S. communityChristopher E Camilleri
Gastroenterology Research Unit, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
Am J Gastroenterol 101:581-92. 2006..The role of genetic predisposition to the development of dyspepsia is unclear. Recently, a significant association was reported with CC genotype of GNbeta3... - Is there an association between GNbeta3-C825T genotype and lower functional gastrointestinal disorders?Viola Andresen
Clinical Enteric Neuroscience Translational and Epidemiological Research C E N T E R Program, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Gastroenterology 130:1985-94. 2006.... - Ephrin B2/EphB4 pathway in hepatic stellate cells stimulates Erk-dependent VEGF production and sinusoidal endothelial cell recruitmentAmitava Das
Gastroenterology Research Unit, Mayo Clinic and Foundation, 200 First St SW, Rochester, MN 55905, USA
Am J Physiol Gastrointest Liver Physiol 298:G908-15. 2010..These studies identify EphrinB2 or EphB4 as a key intermediary that links HSC signal transduction pathways with angiogenesis and sinusoidal remodeling... - Fundamentals of transcription factors and their impact on pancreatic development and cancerMartin E Fernandez-Zapico
Gastroenterology Research Unit, Mayo Clinic, Rochester, MN 55905, USA
Pancreatology 3:276-83. 2003..In this article we review this field of research with a particular emphasis on the role of transcription factors in pancreatic development and cancer... - Effect of CCK-1 antagonist, dexloxiglumide, in female patients with irritable bowel syndrome: a pharmacodynamic and pharmacogenomic studyFilippo Cremonini
Clinical Enteric Neuroscience Translational and Epidemiological Research C E N T E R Program, Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, Minnesota
Am J Gastroenterol 100:652-63. 2005..Cholecystokinin (CCK) is involved in gastrointestinal motor response to meals. The potential role of CCK receptor antagonists in functional gastrointestinal disorders is unclear... - The family feud: turning off Sp1 by Sp1-like KLF proteinsGwen Lomberk
Gastroenterology Research Unit, Mayo Clinic, Rochester, MN 55901, USA
Biochem J 392:1-11. 2005..The existence of these transcriptional repressors provides a tightly regulated mechanism for silencing a large number of genes that are already known to be activated by Sp1... - Transforming growth factor-beta: what every pancreatic surgeon should knowMark J Truty
Department of Surgery, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Surgery 141:1-6. 2007 - Interplay of tumor microenvironment cell types with parenchymal cells in pancreatic cancer development and therapeutic implicationsPraveen Guturu
Gastroenterology Research Unit and Fiterman Center for Digestive Diseases, Mayo Clinic Rochester MN, 200 First Street SW, Rochester, MN 55905, USA
J Gastrointest Cancer 40:1-9. 2009..The process of "induction," namely, the formation of a tissue by the functional interaction between the epithelial layer and the stroma, is key for the development of many organs, in particular to the pancreas... - Basics of TGF-beta and pancreatic cancerMark J Truty
Department of Surgery, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
Pancreatology 7:423-35. 2007..The purpose of this review is to provide the practicing clinician a thorough review of this molecule and its associated signaling partners in the context of its duplicitous role and behavior in patients with pancreatic cancer... - Invasive cancer and survival of intraductal papillary mucinous tumors of the pancreasMassimo Raimondo
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
Am J Gastroenterol 97:2553-8. 2002..K-ras mutations did not correlate with survival. CONCLUSIONS: Invasive cancer in IPMT reduces the 2.5-yr survival after surgery from 93% to 24%. K-ras mutations occur before invasive cancer, and do not predict postoperative survival... - Conservation of the TGFbeta/Labial homeobox signaling loop in endoderm-derived cells between Drosophila and mammalsGwen A Lomberk
Department of Medicine, Mayo Clinic, Rochester, Minn, USA
Pancreatology 10:74-84. 2010..Interestingly, although Labial-like homeobox genes are present in mammals, their participation in endoderm morphogenesis is not clearly understood... - When developmental signaling pathways go wrong and their impact on pancreatic cancer developmentGwen Lomberk
Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
Curr Opin Gastroenterol 21:555-60. 2005..SUMMARY: This conceptual validation of previous experiments has fuelled new studies, the results of which will be the focus of this review... - Intraductal papillary mucinous neoplasm: did it exist prior to 1980?Matthew K Tollefson
Department of Surgery, Mayo Clinic, Rochester, MN 55905, USA
Pancreas 26:e55-8. 2003..Intraductal papillary mucinous neoplasm (IPMN) of the pancreas was first reported in 1982. It is not clear whether the appearance of this neoplasm is a new epidemic or an old disease previously overlooked... - Key role of Krüppel-like factor proteins in pancreatic cancer and other gastrointestinal neoplasiasNavtej S Buttar
Gastroenterology Research Unit, Saint Mary's Hospital, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Curr Opin Gastroenterol 22:505-11. 2006..SUMMARY: This article will focus on the results of studies in the field published in the last year...
Research Grants
- The Role of Zinc Finger Genes in Pancreatic Cell GrowthRaul Urrutia; Fiscal Year: 2009..However, we are optimistic that our studies will build the foundation for future treatment and perhaps even the prevention of this disease. ..
- The Role of Zinc Finger Genes in Pancreatic Cell GrowthRaul Urrutia; Fiscal Year: 2006..abstract_text> ..
- KS1, A NOVEL SUPPRESSOR OF NEOPLASTIC TRANSFORMATIONRaul Urrutia; Fiscal Year: 2003..This knowledge will serve as the foundation for future studies aimed at using these proteins as therapeutic tools for controlling abnormal cell growth. ..
- ZINC FINGER GENES AND PANCREATIC CELL GROWTHRaul Urrutia; Fiscal Year: 2001..Furthermore, this information will be crucial as a theoretical framework for future studies on the role of zinc finger transcription factors in pancreatic development and cancer. ..
- The Role of Zinc Finger Genes in Pancreatic Cell GrowthRaul A Urrutia; Fiscal Year: 2010..However, we are optimistic that our studies will build the foundation for future treatment and perhaps even the prevention of this disease. ..