Eugenia Trushina

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Comprehensive Method for Culturing Embryonic Dorsal Root Ganglion Neurons for Seahorse Extracellular Flux XF24 Analysis
    Miranda Lange
    Department of Neurology, Mayo Clinic Rochester, MN, USA
    Front Neurol 3:175. 2012
  2. pmc Identification of altered metabolic pathways in plasma and CSF in mild cognitive impairment and Alzheimer's disease using metabolomics
    Eugenia Trushina
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
    PLoS ONE 8:e63644. 2013
  3. pmc Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer's disease
    Eugenia Trushina
    Department of Molecular Pharmacology and Experimental Therapeutics and Neurology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 7:e32737. 2012
  4. pmc Tricyclic pyrone compounds prevent aggregation and reverse cellular phenotypes caused by expression of mutant huntingtin protein in striatal neurons
    Eugenia Trushina
    Department of Chemistry, CBC Building, Kansas State University, Manhattan, KS 66506, USA
    BMC Neurosci 10:73. 2009
  5. ncbi request reprint Mutant huntingtin inhibits clathrin-independent endocytosis and causes accumulation of cholesterol in vitro and in vivo
    Eugenia Trushina
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA
    Hum Mol Genet 15:3578-91. 2006
  6. pmc Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro
    Eugenia Trushina
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo ClinicFoundation, Rochester, Minnesota 55905, USA
    Mol Cell Biol 24:8195-209. 2004
  7. ncbi request reprint Neurological abnormalities in caveolin-1 knock out mice
    Eugenia Trushina
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA
    Behav Brain Res 172:24-32. 2006
  8. pmc Microtubule destabilization and nuclear entry are sequential steps leading to toxicity in Huntington's disease
    Eugenia Trushina
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic and Foundation, Second Street SW, Rochester, MN 55905, USA
    Proc Natl Acad Sci U S A 100:12171-6. 2003
  9. pmc Bortezomib alters microtubule polymerization and axonal transport in rat dorsal root ganglion neurons
    Nathan P Staff
    Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN, USA Electronic address
    Neurotoxicology 39:124-31. 2013

Collaborators

Detail Information

Publications9

  1. pmc Comprehensive Method for Culturing Embryonic Dorsal Root Ganglion Neurons for Seahorse Extracellular Flux XF24 Analysis
    Miranda Lange
    Department of Neurology, Mayo Clinic Rochester, MN, USA
    Front Neurol 3:175. 2012
    ..Here we describe a highly reproducible method to obtain neuron-enriched monolayers of securely attached dissociated primary embryonic (E15) rat DRG neurons suitable for analysis with the Seahorse XF24 platform...
  2. pmc Identification of altered metabolic pathways in plasma and CSF in mild cognitive impairment and Alzheimer's disease using metabolomics
    Eugenia Trushina
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
    PLoS ONE 8:e63644. 2013
    ..Our data suggest metabolomics could advance our understanding of the early disease mechanisms shared in progression from CN to MCI and to AD...
  3. pmc Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer's disease
    Eugenia Trushina
    Department of Molecular Pharmacology and Experimental Therapeutics and Neurology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 7:e32737. 2012
    ....
  4. pmc Tricyclic pyrone compounds prevent aggregation and reverse cellular phenotypes caused by expression of mutant huntingtin protein in striatal neurons
    Eugenia Trushina
    Department of Chemistry, CBC Building, Kansas State University, Manhattan, KS 66506, USA
    BMC Neurosci 10:73. 2009
    ..In the present study, we aimed to determine whether TP compounds could prevent aggregation and restore early cellular defects in primary embryonic striatal neurons from animal model representing HD...
  5. ncbi request reprint Mutant huntingtin inhibits clathrin-independent endocytosis and causes accumulation of cholesterol in vitro and in vivo
    Eugenia Trushina
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA
    Hum Mol Genet 15:3578-91. 2006
    ..These data provide the first direct link between mhtt and caveolar-related endocytosis and also suggest a possible mechanism for HD neurotoxicity where cholesterol homeostasis is perturbed...
  6. pmc Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro
    Eugenia Trushina
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo ClinicFoundation, Rochester, Minnesota 55905, USA
    Mol Cell Biol 24:8195-209. 2004
    ..Data provide a model for how loss of htt function causes toxicity; mhtt-mediated aggregation sequesters htt and components of trafficking machinery leading to loss of mitochondrial motility and eventual mitochondrial dysfunction...
  7. ncbi request reprint Neurological abnormalities in caveolin-1 knock out mice
    Eugenia Trushina
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA
    Behav Brain Res 172:24-32. 2006
    ..These data suggest that cav-1 is involved in maintaining cortico-striato-pallido-thalamo-pontine pathways associated with motor control...
  8. pmc Microtubule destabilization and nuclear entry are sequential steps leading to toxicity in Huntington's disease
    Eugenia Trushina
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic and Foundation, Second Street SW, Rochester, MN 55905, USA
    Proc Natl Acad Sci U S A 100:12171-6. 2003
    ..Primary and reversible toxic events involve destabilization of microtubules mediated by full-length mhtt before cleavage. Restoration of microtubule structure by taxol inhibits nuclear entry and increases cell survival...
  9. pmc Bortezomib alters microtubule polymerization and axonal transport in rat dorsal root ganglion neurons
    Nathan P Staff
    Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN, USA Electronic address
    Neurotoxicology 39:124-31. 2013
    ..This robust model will be used in future mechanistic studies of BIPN and its prevention. ..