I M Tleyjeh

..We report the first case of Fournier's gangrene caused by a low-virulence organism, Lactobacillus gasseri...

..Emerging epidemiological evidence suggests that proton pump inhibitor (PPI) acid-suppression therapy is associated with an increased risk of Clostridium difficile infection (CDI)...

..However, the trend toward statistical significance for this association indicates that further investigation is warranted...

..Treatment guidelines vary on optimal treatment strategies. We aimed to determine the effects of different antifungal therapies on global response rates, mortality and safety...

..We examined the association between valve surgery and all-cause 6-month mortality among patients with left-sided infective endocarditis...

..We sought to summarize and critically appraise the literature on the epidemiology of infective endocarditis (IE) in the general population...

..The optimal timing of valve surgery in left-sided infective endocarditis (IE) is undefined. We aimed to examine the association between the timing of valve surgery after IE diagnosis and 6-month mortality among patients with left-sided IE...

..Our objective was to examine the association between statin use and the risk of infections and related outcomes...

..We sought to quantify the effect of survivor bias on the association between valve surgery and mortality in infective endocarditis (IE)...

..VisualDx also increases clinician awareness of, knowledge about, and skills in the recognition of chemical warfare, bioterrorism, and radiation injuries...

..A search of the medical literature revealed no previous case of this kind...

..We performed a meta-analysis of prospective cohort studies to examine the association between penicillin resistance and short-term all-cause mortality for pneumococcal pneumonia...

..We describe a case of C. jeikeium PJIs successfully treated with partial removal of the prosthesis and administration of 6 weeks vancomycin followed by chronic suppression with minocycline...

..Limited data exist regarding population-based epidemiologic changes in incidence of infective endocarditis (IE)...

..With the small number of patients in each group, a multicenter study with a larger cohort of patients is needed to better define optimal postoperative treatment regimens in this population...

..On the basis of the above data, it is recommended that infective endocarditis should be strongly suspected when Propionibacterium species are isolated from multiple blood cultures, particularly in the presence of a cardiovascular device...

..To provide a contemporary profile of epidemiological trends of infective endocarditis (IE) in Olmsted County, Minnesota...

..However, a large randomized controlled trial is needed for confirmation. Additionally, in future studies, owing to the wide spectrum of severity of veno-occlusive disease, outcomes such as 100-day mortality should strongly be considered...

..Abdominal wall cellulitis is a unique infectious complication in patients with morbid obesity. Further study is needed to better define the pathogenesis of this illness to develop strategies in treatment and prevention...

..Although recent literature suggests a changing spectrum for infectious pericarditis (IP), this view has not been proven. In this report, we aim to review the features of IP in cases from a large tertiary centre...

..No randomized trials have been conducted to date; accordingly, some studies use propensity score analysis (PSA) to minimize selection bias in observational studies...

..To determine the population-based incidence of lower-extremity cellulitis...

..Because of the paucity of data, it has been difficult to define optimal treatment regimens for this syndrome. Thus, recommendations for therapy have largely been made on the basis of consensus opinion...

..Most such infections occurred in immunocompetent patients, often after facial trauma. Survival in ROCM caused by A. elegans is favorable in reported cases, with prompt surgical debridement and antifungal therapy...

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..Cellulitis is common and recurs in some patients. The study described herein derived a predictive model for the recurrence of lower extremity cellulitis in a population-based cohort...

..jeikeium is a rare cause of endocarditis and it more commonly infects prosthetic valves. Careful scrutiny is required when C. jeikeium is isolated from a blood culture, particularly in patients with underlying prosthetic cardiac valves...

..We performed a population-based study to further investigate this emerging concern...

..We evaluated the hypothesis that the case-fatality and mortality rates for invasive pneumococcal disease have also decreased since 2000...

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..Limited data exist regarding temporal trends in permanent pacemaker (PPM) implantation. To describe trends in incidence and comorbidities of PPM recipients, we conducted a retrospective population-based cohort study over a 30-year period...

..Significant toxicity may be associated with its use. We describe a case of cerebral blastomycoma that was successfully treated with voriconazole...

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..The entire pacing system was removed and the patient was treated successfully with a multidrug regimen for a total of 6 months...

..To systematically assess the effect of the adjunctive administration of corticosteroids in the treatment of acute bacterial meningitis...

..To estimate the association between antioxidant use and primary cancer incidence and mortality and to evaluate these effects across specific antioxidant compounds, target organs, and participant subgroups...

..The effect of G-CSF therapy on left ventricular (LV) function and structure in these patients remains unclear...