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..These elements often determine the role and timing for revascularization. In this respect, atherosclerotic renal artery stenosis is analogous to progressive carotid or aortic aneurysmal disease...

..Detailed evaluations of ABPM findings, GFR, and urinary protein levels are warranted for Caucasian subjects with high clinic BP readings who are otherwise suitable potential donors...

..Studies to closely track the impact of donor nephrectomy in the current era with changing population demographics and expectations are essential...

..These results suggest that BOLD MR coupled with a method to suppress tubular oxygen consumption can be used to evaluate regional tissue oxygenation in the human kidney affected by vascular occlusive disease...

..Most important, nephrologists await development of tools to predict reliably when renal parenchymal injury is beyond recovery and/or when revascularization can produce meaningful salvage of kidney function...

..This study reports outcomes of hypertensive donors 1 year after kidney donation...

..Further research should be directed toward identification of critical disease, regulation of fibrogenesis, and the interaction with other atherosclerotic processes...

..Renal revascularization should be considered in viable individuals before the development of advanced renal insufficiency...

..Recognizing renal artery disease and directing revascularization procedures to those with the most benefit remains a premier challenge for the clinician...

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..Attention must be paid to interactions between antihypertensive agents and calcineurin inhibitor blood levels...

..The decision to recommend revascularization remains a difficult balance between the risks and expense of the procedure and the undoubted benefits that accrue if renal function is successfully stabilized...

..Until additional staging tools become available, clinicians will be forced to individualize therapy carefully to optimize the potential benefits regarding both blood pressure and renal function for such patients...

..The CORAL study and others seek to randomly assign subjects with high-grade renovascular lesions to optimal medical management with and without stenting...

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..Although we strongly believe in our proposal, more multicenter long-term clinical pharmacological trials are needed to evaluate the efficacy and safety of the antihypertensive approaches in the treatment of obesity hypertension...

..08). From these data, our studies detected subtle differences in donor organs obtained from obese compared to non-obese individuals. Further studies should be carried out to quantify the long-term impact of these findings...

..5%, normal 13%), usually absent early after transplantation. Our results demonstrate the ability of hemodynamic measurements to predict the symptomatic response to antihypertensive therapy in the posttransplant setting...

..Improvement in the dialysis patients was all partial. Successful KTx did not insure improvement in NSF and in fact appeared to have no significant benefit over dialysis...

..These observations underscore the direct intrarenal effect of atherogenic factors on the kidneys...

..iii) Fibrosis at the time of diagnosis predicts subsequent functional decline. Further elucidation of the natural history of PVAN and its response to individual interventions will require prospective clinical trials...

..While early results are encouraging, we advocate careful study of obese donors and do not support their widespread use until longer follow-up is available...

..Both immunosuppressive regimens led to a loss of nocturnal blood pressure fall, as compared to ESLD patients or normotensive controls.(ABSTRACT TRUNCATED AT 250 WORDS)..

..These alterations might contribute to renal disease progression in ARVD and might account for the increased propensity for end-stage renal disease...

..Glomerular thrombi appear early in AMR and may appear prior to graft dysfunction...

..1+/-2.2 versus 58.1+/-1.2; P=0.006). These data indicate that, although stenosis reduced blood flow and volume, cortical and medullary oxygenation was preserved under these conditions...

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..To describe restenosis and clinical outcomes with drug-eluting stents (DESs) and compare them to those of bare metal stents (BMSs) in the treatment of symptomatic atherosclerotic renal artery stenosis (RAS) in the same patients...

..To present clinical outcomes with the use of embolic protection devices (EPDs) and renal artery stents in patients with chronic renal insufficiency (CRI) and renal artery stenosis (RAS)...

..This approach may allow more detailed physiologic evaluation of poststenotic kidneys in renovascular hypertension than previously possible...

..Identification of specific pathways producing progressive renal injury may enable development of targeted interventions to block these pathways and preserve the stenotic kidney...

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..Therefore, screening abdominal aortography should be considered in these patients to better define their risk of cardiovascular complications...

..To test the hypothesis that kidney function and metabolic risk factors are associated with glomerular density on renal biopsy samples from healthy adults...

..Chronic kidney disease is common with older age and is characterized on renal biopsy by global glomerulosclerosis, tubular atrophy, interstitial fibrosis, and arteriosclerosis...

..Further studies are needed to determine whether restoration of normal BP pattern will confer better allograft outcome...

..This experience supports the feasibility of sequential living donor KTx and autologous SCT for carefully selected patients with ESRD due to AL...

..Post-transplant diabetes (PTDM) is a common and serious complication of kidney transplantation. The implications of developing hyperglycemia of lesser severity are not well understood...

..Donor age adversely affects deceased-donor kidney transplant outcomes, but its influence on living-donor transplantation is less well characterized...

..Although the shorter waiting time and the ability to use living-donor kidneys make PAK an increasingly attractive alternative to SPK transplantation, its effect on renal allograft function deserves further attention...

..GIF frequently develops in the absence of risk factors. Lower GFR post-transplant identify patients at highest risk of GIF...

..This important trial employs distal embolic protection to prevent deterioration of renal function. Understanding the optimal role for renal revascularization depends heavily upon the successful conduct of such trials...

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..Therefore, the adjunct use of diuretics that inhibit Na reabsorption selectively in PT and TAL, Az and furosemide, respectively, may help discern tubular function by using BOLD MRI to detect changes in tissue oxygenation...

..46, P = .01; r = 0.34, P = .03). The current study indicates that abnormal circadian BP pattern at 1 year identifies a group of kidney recipients at risk for increased kidney function loss and lower GFR 3-4 years from transplantation...

..Improved understanding of these mechanisms is essential in preventing irreversible interstitial fibrosis and restoring renal perfusion...

..We sought to define the differences between regions within kidneys and to optimize selection of regions of interest for study with 1.5 and 3 Tesla systems...

..Notably, an unexpected proliferative response occurs in the stenotic kidney that undergoes atrophy...

..The aims of this study were to determine the risk factors for restenosis and to evaluate the blood pressure outcomes of patients who underwent repeat PTRA...

..Notably, many of these pathways may be reversible in hypercholesterolemia, and crucial targets could potentially be identified for early interventions to preserve the kidney...

..Longer follow-up will be needed, but the absence of anti-donor antibody and good early outcomes are encouraging...

..Hence, management of such patients requires close attention and periodic review regarding restenosis and progression of vascular disease...

..The aim of this study was to assess the results of gadolinium use to facilitate PTRA in patients with chronic kidney disease...

..This study suggests novel renoprotective effects of ET-A blockers and supports further exploration of strategies that target the ET pathway in HC and atherosclerosis...

..This study shows that a CNI-free regimen using sirolimus-MMF-prednisone produces similar acute rejection rates, graft survival and renal function 1-2 years after transplantation compared to tacrolimus-MMF-prednisone...

..Importantly, manipulation of homing signals may potentially allow therapeutic opportunities to increase endogenous EPC recruitment...

..These data suggest the need for strategies to prevent or minimize the decline in renal function after PTA...

..0 mg/dL are at higher risk than nondiabetic patients, whereas all patients with a serum Cr >2.0 are at high risk for ARF. ARF was highly correlated with death during the index hospitalization and after dismissal...

..No patient developed acute or chronic renal failure. Surgical reconstruction for RFMD has excellent short-term patency. Failed PTRA or complex reconstructions did not adversely affect outcome...