Research Topics
| Scott E StromeSummaryAffiliation: Mayo Clinic Country: USA Publications
| Collaborators
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Detail Information
Publications
Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 familyIn Hak Choi
Department of Immunology, Mayo Graduate and Medical Schools, Mayo Clinic, Rochester, MN 55905, USA
J Immunol 171:4650-4. 2003..Our results indicate a tight regulation of B7-H4 expression in the translational level in normal peripheral tissues and a potential role of B7-H4 in the evasion of tumor immunity...- A pilot study of high-dose intraarterial cisplatin chemotherapy with concomitant accelerated radiotherapy for patients with previously untreated T4 and selected patients with T3N0-N3M0 squamous cell carcinoma of the upper aerodigestive tractRobert L Foote
Division of Radiation Oncology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
Cancer 103:559-68. 2005..3-100%). CONCLUSIONS: The results of this study suggest that concurrent intraarterial cisplatin chemotherapy at a dose of 150 mg/m(2) with concomitant boost accelerated radiation therapy is not feasible... - Costimulation-based immunotherapy for head and neck cancerScott E Strome
Department of Otolaryngology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Curr Treat Options Oncol 5:27-33. 2004.... - Reassessment of CD62L as a marker of pre-effector T cells in the tumor draining lymph nodes of head and neck cancer patientsScott E Strome
Department of Otorhinolaryngology, Mayo Graduate and Medical Schools, Mayo Clinic, Rochester, Minnesota 55905, USA
Otolaryngol Head Neck Surg 126:180-7. 2002..CD62L was evaluated as a determinant of human pre-effector T cells... - B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinomaScott E Strome
Department of Otolaryngology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Cancer Res 63:6501-5. 2003..These data support B7-H1 blockade as a new approach to enhance the efficacy of T-cell immunotherapy... - Strategies for antigen loading of dendritic cells to enhance the antitumor immune responseScott E Strome
Department of Otolaryngology, Mayo Clinic, Rochester, Minnesota 55905, USA
Cancer Res 62:1884-9. 2002..Correlation of in vitro data with the generation of protective immunity in vivo suggests the utility of irradiated tumor-primed DCs as a means to generate protective immunity in patients with solid malignancies... - Advanced larynx cancerScott E Strome
Mayo Clinic, Department of Otorhinolaryngology, 200 First Street SW, Rochester, MN 55906, USA
Curr Treat Options Oncol 3:11-20. 2002..For those patients who would likely require a total laryngectomy or who are not suitable for surgical conservation, organ preservation should be used as a primary option in a controlled setting... - Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasionHaidong Dong
Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA
Nat Med 8:793-800. 2002..These findings have implications for the design of T cell-based cancer immunotherapy... 
Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumorsRyan A Wilcox
Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA
J Clin Invest 109:651-9. 2002..Our results suggest a new approach for immunotherapy of human cancers...- Costimulating aberrant T cell responses by B7-H1 autoantibodies in rheumatoid arthritisHaidong Dong
Department of Immunology, Mayo Medical School and Graduate School, Mayo Clinic, Rochester, Minnesota 55905, USA
J Clin Invest 111:363-70. 2003.... - B7-H1-targeted immunotherapy for head and neck cancerXiaoyu Zhang
Department of Otolaryngology - Head and Neck Surgery, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Expert Opin Biol Ther 4:1577-83. 2004..This review focuses on the role of a recently discovered costimulatory molecule, B7-H1, as a model for the development of novel strategies for immunotherapy of head and neck cancer... - Characterization of antigen processing machinery and Survivin expression in tonsillar squamous cell carcinomaEric C Weinman
Department of Otorhinolaryngology, Mayo Clinic, Rochester, Minnesota 55906, USA
Cancer 97:2203-11. 2003..CONCLUSIONS: For TSCC that maintain the expression of HLA Class I antigen, overexpression of Survivin may provide an alternative explanation for tumor progression... - Signaling through NK cell-associated CD137 promotes both helper function for CD8+ cytolytic T cells and responsiveness to IL-2 but not cytolytic activityRyan A Wilcox
Department of Immunology, Mayo Graduate and Medical Schools, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
J Immunol 169:4230-6. 2002..Taken together with previous findings that CD137 is a critical receptor for costimulation of T cells, our findings suggest that CD137 is a stimulatory receptor for NK cells involved in the crosstalk between innate and adaptive immunity... - Organ preservation for advanced laryngeal carcinomaRobert L Foote
Department of Radiation Oncology, Mayo Clinic College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Head Neck 28:689-96. 2006..Inclusion of patients with mobile vocal cords on larynx preservation trials may lead to overstatement of larynx preservation (LPR) and survival (OS) rates... - Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic targetR Houston Thompson
Department of Urology, Mayo Medical School, Mayo Clinic, Rochester, MN 55905, USA
Proc Natl Acad Sci U S A 101:17174-9. 2004..In addition, B7-H1 may represent a promising target to facilitate more favorable responses in patients who require immunotherapy for treatment of advanced RCC... 
Tumor-induced senescent T cells with suppressor function: a potential form of tumor immune evasionCarolina L Montes
Department of Otorhinolaryngology, University of Maryland School of Medicine, Baltimore, Maryland 21202, USA
Cancer Res 68:870-9. 2008..Our observations support the novel concept that tumor can induce senescent T cells with suppressor function and may effect both the diagnosis and treatment of cancer...- Informed consent in advanced laryngeal cancerRobert L Foote
Department of Radiation Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Head Neck 29:230-5. 2007..This study was designed to evaluate the relationship between the informed consent process and the treatment received by patients with advanced laryngeal cancer... - Swallow function in patients before and after intra-arterial chemoradiationDarlene E Graner
Department of Neurology, Division of Radiation Oncology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
Laryngoscope 113:573-9. 2003..To prospectively evaluate swallow function in patients with advanced head and neck cancer before and after completion of intra-arterial chemoradiation therapy and planned neck dissection... - Two cases of coincident carcinomas of the head and neck and the uterine cervixBobbie S Gostout
Department of Obstetrics and Gynecology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Gynecol Oncol 85:376-80. 2002..Human papillomavirus (HPV) is an independent risk factor for select head and neck carcinomas and most uterine cervix carcinomas. We report two patients with synchronous diagnoses of cervical cancer and HPV-related head and neck cancer... - Interleukin 4 receptor-directed cytotoxin therapy for human head and neck squamous cell carcinoma in animal modelsScott E Strome
Department of Otolaryngology, Mayo Clinic, Rochester, Minnesota 55905, USA
Clin Cancer Res 8:281-6. 2002..These data demonstrate that IL-4 (38-37)-PE38KDEL is effective in mediating significant antitumor effects in SCCHN and may represent an attractive therapeutic option for patients with advanced cancers of the upper aerodigestive tract... - A mechanistic perspective of monoclonal antibodies in cancer therapy beyond target-related effectsScott E Strome
Department of Otorhinolaryngology, Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201 1619, USA
Oncologist 12:1084-95. 2007..Accordingly, all monoclonal antibodies directed against a given target should not be considered equivalent in their ability to stimulate immune-mediated effector functions... - CD137 promotes proliferation and survival of human B cellsXiaoyu Zhang
Department of Otorhinolaryngology, Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Immunol 184:787-95. 2010..Our study suggests that CD137 costimulation may play a role in defining the fate of Ag-stimulated human B cells... - Merkel cell carcinoma of the head and neck: a retrospective case seriesAnthony E Brissett
Department of Otorhinolaryngology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
Head Neck 24:982-8. 2002..CONCLUSIONS: WLE and dissection of the lymphatic drainage basin provided the best overall survival... - Identification of NY-ESO-1, MAGE-1, and MAGE-3 in head and neck squamous cell carcinomaMatthew A Kienstra
Department of Otorhinolaryngology, University of South Florida, MCC HN PROG, 12902 Magnolia Drive, Tampa, Florida, 33612 9497, USA
Head Neck 25:457-63. 2003..NY-ESO-1, MAGE-1, and MAGE-3 are such antigens. This study was undertaken to determine their presence or absence in head and neck squamous cell cancers and to correlate this with patient characteristics... - HSulf-1 modulates HGF-mediated tumor cell invasion and signaling in head and neck squamous carcinomaJin-Ping Lai
Division of Gastroenterology and Hepatology, Mayo Clinic Cancer Center, Mayo Clinic and Foundation, Rochester, MN 55905, USA
Oncogene 23:1439-47. 2004.... - Autoimmune inner ear disease: diagnostic and therapeutic approaches in a multidisciplinary settingEric L Matteson
Department of Internal Medicine, Division of Rheumatology Mayo Clinic and Mayo Graduate School of Medicine Rochester, Minnesota 55905, USA
J Am Acad Audiol 14:225-30. 2003..One of our conclusions is that many of these patients respond favorably to the treatment Methotrexate... - Antitumor immunity can be uncoupled from autoimmunity following heat shock protein 70-mediated inflammatory killing of normal pancreasTimothy Kottke
Departments of Molecular Medicine, Ophthalmology and Ocular Oncology, and Immunology, Mayo Clinic, Rochester, Minnesota, USA
Cancer Res 69:7767-74. 2009.... - Her-2/neu expression in ovarian cancer: pre- and postexposure to platinum chemotherapyPrema P Peethambaram
Mayo Clinic, Rochester, MN 55905, USA
Gynecol Oncol 89:99-104. 2003..Our objective was to determine if the level of Her-2/neu expression in advanced ovarian cancer changed after platinum-based chemotherapy... - Glomus jugulare tumor: tumor control and complications after stereotactic radiosurgeryRobert L Foote
Division of Radiation Oncology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
Head Neck 24:332-8; discussion 338-9. 2002..We evaluated toxicity and long-term efficacy of stereotactic radiosurgery in patients with symptomatic or progressive glomus jugulare tumors... - Squamous cell carcinoma of the tonsils: a molecular analysis of HPV associationsScott E Strome
Department of Otorhinolaryngology, Mayo Clinic, Rochester, Minnesota 55905, USA
Clin Cancer Res 8:1093-100. 2002..Identification of HPV in the histologically positive and negative lymph nodes of patients with HPV-positive TSCC/metastatic disease supports the role of HPV in the oncogenesis of TSCC... - Effacing of the T cell compartment by cardiac transplantation in infancyBrenda M Ogle
Transplantation Biology Program, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
J Immunol 176:1962-7. 2006..Our findings demonstrate a novel approach to measuring lymphocyte diversity and suggest that understanding how these subjects resist infection could yield important insights into immune fitness... - Coronoid-temporalis pedicled rotation flap for orbital floor reconstruction of the total maxillectomy defectShepherd G Pryor
Mayo Clinic, Department of Otorhinolaryngology, Rochester, Minnesota 55905, USA
Laryngoscope 114:2051-5. 2004..It offers similar results to those previously described techniques in this area without need for further extensive surgery... - The value of quantifying 18F-FDG uptake in thyroid nodules found incidentally on whole-body PET-CTTrond V Bogsrud
Division of Nuclear Medicine, Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
Nucl Med Commun 28:373-81. 2007.... - Isopentenyl pyrophosphate-activated CD56+ {gamma}{delta} T lymphocytes display potent antitumor activity toward human squamous cell carcinomaAlan A Z Alexander
Department of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, MD 21201, USA
Clin Cancer Res 14:4232-40. 2008..CD56 is also expressed on a subset of gammadelta T cells. However, antitumor effector functions of CD56(+) gammadelta T cells are poorly characterized... - CD8+ memory T lymphocytes from bone marrow--immune function and therapeutic potentialAaron H D Wood
Department of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Crit Rev Immunol 27:527-37. 2007.... - Oral lactoferrin results in T cell-dependent tumor inhibition of head and neck squamous cell carcinoma in vivoJeffrey S Wolf
Department of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Clin Cancer Res 13:1601-10. 2007..Human lactoferrin is a naturally occurring glycoprotein that inhibits cancer growth. Our purpose was to evaluate recombinant human lactoferrin as a chemotherapeutic agent against head and neck squamous cell carcinoma... - Development and immunophenotyping of squamous cell carcinoma xenografts: tools for translational immunologyWei Lin
Department of Otorhinolaryngology--Head and Neck Surgery, University of Maryland Medical Center, Baltimore, Maryland 21201, USA
Laryngoscope 115:1154-62. 2005..Characterization of select patterns of protein expression in established xenografts is a precursor to the development of a mouse model for SCCHN using tumor bearing animals reconstituted with autologous patient leukocytes... - Fc-dependent expression of CD137 on human NK cells: insights into "agonistic" effects of anti-CD137 monoclonal antibodiesWei Lin
Department of Otorhinolaryngology Head and Neck Surgery, University of Maryland, Baltimore, MD 21201 168, USA
Blood 112:699-707. 2008..Our data suggest that CD137 can be enhanced on NK cells in an Fc-dependent fashion and that expression correlates with phenotypic and functional parameters of activation... - Interleukin-13 receptor alpha2 chain in human head and neck cancer serves as a unique diagnostic markerMariko Kawakami
Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
Clin Cancer Res 9:6381-8. 2003..Taken together, this study suggests that IL-13R may be involved in SCCHN tumor progression, and 33% of IL-13Ralpha2-positive SCCHN cases may be targeted by IL-13 cytotoxin and IL-13R-targeted agent...