Scott E Strome

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi request reprint Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family
    In Hak Choi
    Department of Immunology, Mayo Graduate and Medical Schools, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 171:4650-4. 2003
  2. ncbi request reprint A pilot study of high-dose intraarterial cisplatin chemotherapy with concomitant accelerated radiotherapy for patients with previously untreated T4 and selected patients with T3N0-N3M0 squamous cell carcinoma of the upper aerodigestive tract
    Robert L Foote
    Division of Radiation Oncology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
    Cancer 103:559-68. 2005
  3. ncbi request reprint Costimulation-based immunotherapy for head and neck cancer
    Scott E Strome
    Department of Otolaryngology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Curr Treat Options Oncol 5:27-33. 2004
  4. ncbi request reprint Reassessment of CD62L as a marker of pre-effector T cells in the tumor draining lymph nodes of head and neck cancer patients
    Scott E Strome
    Department of Otorhinolaryngology, Mayo Graduate and Medical Schools, Mayo Clinic, Rochester, Minnesota 55905, USA
    Otolaryngol Head Neck Surg 126:180-7. 2002
  5. ncbi request reprint B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma
    Scott E Strome
    Department of Otolaryngology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Cancer Res 63:6501-5. 2003
  6. ncbi request reprint Strategies for antigen loading of dendritic cells to enhance the antitumor immune response
    Scott E Strome
    Department of Otolaryngology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Res 62:1884-9. 2002
  7. ncbi request reprint Advanced larynx cancer
    Scott E Strome
    Mayo Clinic, Department of Otorhinolaryngology, 200 First Street SW, Rochester, MN 55906, USA
    Curr Treat Options Oncol 3:11-20. 2002
  8. ncbi request reprint Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
    Haidong Dong
    Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA
    Nat Med 8:793-800. 2002
  9. pmc Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors
    Ryan A Wilcox
    Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Invest 109:651-9. 2002
  10. pmc Costimulating aberrant T cell responses by B7-H1 autoantibodies in rheumatoid arthritis
    Haidong Dong
    Department of Immunology, Mayo Medical School and Graduate School, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Invest 111:363-70. 2003

Detail Information

Publications39

  1. ncbi request reprint Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family
    In Hak Choi
    Department of Immunology, Mayo Graduate and Medical Schools, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 171:4650-4. 2003
    ..Our results indicate a tight regulation of B7-H4 expression in the translational level in normal peripheral tissues and a potential role of B7-H4 in the evasion of tumor immunity...
  2. ncbi request reprint A pilot study of high-dose intraarterial cisplatin chemotherapy with concomitant accelerated radiotherapy for patients with previously untreated T4 and selected patients with T3N0-N3M0 squamous cell carcinoma of the upper aerodigestive tract
    Robert L Foote
    Division of Radiation Oncology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
    Cancer 103:559-68. 2005
    ....
  3. ncbi request reprint Costimulation-based immunotherapy for head and neck cancer
    Scott E Strome
    Department of Otolaryngology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Curr Treat Options Oncol 5:27-33. 2004
    ....
  4. ncbi request reprint Reassessment of CD62L as a marker of pre-effector T cells in the tumor draining lymph nodes of head and neck cancer patients
    Scott E Strome
    Department of Otorhinolaryngology, Mayo Graduate and Medical Schools, Mayo Clinic, Rochester, Minnesota 55905, USA
    Otolaryngol Head Neck Surg 126:180-7. 2002
    ..CD62L was evaluated as a determinant of human pre-effector T cells...
  5. ncbi request reprint B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma
    Scott E Strome
    Department of Otolaryngology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Cancer Res 63:6501-5. 2003
    ..These data support B7-H1 blockade as a new approach to enhance the efficacy of T-cell immunotherapy...
  6. ncbi request reprint Strategies for antigen loading of dendritic cells to enhance the antitumor immune response
    Scott E Strome
    Department of Otolaryngology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Res 62:1884-9. 2002
    ..Correlation of in vitro data with the generation of protective immunity in vivo suggests the utility of irradiated tumor-primed DCs as a means to generate protective immunity in patients with solid malignancies...
  7. ncbi request reprint Advanced larynx cancer
    Scott E Strome
    Mayo Clinic, Department of Otorhinolaryngology, 200 First Street SW, Rochester, MN 55906, USA
    Curr Treat Options Oncol 3:11-20. 2002
    ..For those patients who would likely require a total laryngectomy or who are not suitable for surgical conservation, organ preservation should be used as a primary option in a controlled setting...
  8. ncbi request reprint Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
    Haidong Dong
    Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA
    Nat Med 8:793-800. 2002
    ..These findings have implications for the design of T cell-based cancer immunotherapy...
  9. pmc Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors
    Ryan A Wilcox
    Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Invest 109:651-9. 2002
    ..Our results suggest a new approach for immunotherapy of human cancers...
  10. pmc Costimulating aberrant T cell responses by B7-H1 autoantibodies in rheumatoid arthritis
    Haidong Dong
    Department of Immunology, Mayo Medical School and Graduate School, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Invest 111:363-70. 2003
    ....
  11. ncbi request reprint Characterization of antigen processing machinery and Survivin expression in tonsillar squamous cell carcinoma
    Eric C Weinman
    Department of Otorhinolaryngology, Mayo Clinic, Rochester, Minnesota 55906, USA
    Cancer 97:2203-11. 2003
    ....
  12. ncbi request reprint B7-H1-targeted immunotherapy for head and neck cancer
    Xiaoyu Zhang
    Department of Otolaryngology Head and Neck Surgery, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Expert Opin Biol Ther 4:1577-83. 2004
    ..This review focuses on the role of a recently discovered costimulatory molecule, B7-H1, as a model for the development of novel strategies for immunotherapy of head and neck cancer...
  13. ncbi request reprint Signaling through NK cell-associated CD137 promotes both helper function for CD8+ cytolytic T cells and responsiveness to IL-2 but not cytolytic activity
    Ryan A Wilcox
    Department of Immunology, Mayo Graduate and Medical Schools, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    J Immunol 169:4230-6. 2002
    ..Taken together with previous findings that CD137 is a critical receptor for costimulation of T cells, our findings suggest that CD137 is a stimulatory receptor for NK cells involved in the crosstalk between innate and adaptive immunity...
  14. ncbi request reprint Organ preservation for advanced laryngeal carcinoma
    Robert L Foote
    Department of Radiation Oncology, Mayo Clinic College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Head Neck 28:689-96. 2006
    ..Inclusion of patients with mobile vocal cords on larynx preservation trials may lead to overstatement of larynx preservation (LPR) and survival (OS) rates...
  15. pmc Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target
    R Houston Thompson
    Department of Urology, Mayo Medical School, Mayo Clinic, Rochester, MN 55905, USA
    Proc Natl Acad Sci U S A 101:17174-9. 2004
    ..In addition, B7-H1 may represent a promising target to facilitate more favorable responses in patients who require immunotherapy for treatment of advanced RCC...
  16. doi request reprint Tumor-induced senescent T cells with suppressor function: a potential form of tumor immune evasion
    Carolina L Montes
    Department of Otorhinolaryngology, University of Maryland School of Medicine, Baltimore, Maryland 21202, USA
    Cancer Res 68:870-9. 2008
    ..Our observations support the novel concept that tumor can induce senescent T cells with suppressor function and may effect both the diagnosis and treatment of cancer...
  17. ncbi request reprint Informed consent in advanced laryngeal cancer
    Robert L Foote
    Department of Radiation Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Head Neck 29:230-5. 2007
    ..This study was designed to evaluate the relationship between the informed consent process and the treatment received by patients with advanced laryngeal cancer...
  18. ncbi request reprint Swallow function in patients before and after intra-arterial chemoradiation
    Darlene E Graner
    Department of Neurology, Division of Radiation Oncology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    Laryngoscope 113:573-9. 2003
    ..To prospectively evaluate swallow function in patients with advanced head and neck cancer before and after completion of intra-arterial chemoradiation therapy and planned neck dissection...
  19. ncbi request reprint Two cases of coincident carcinomas of the head and neck and the uterine cervix
    Bobbie S Gostout
    Department of Obstetrics and Gynecology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Gynecol Oncol 85:376-80. 2002
    ..Human papillomavirus (HPV) is an independent risk factor for select head and neck carcinomas and most uterine cervix carcinomas. We report two patients with synchronous diagnoses of cervical cancer and HPV-related head and neck cancer...
  20. ncbi request reprint Interleukin 4 receptor-directed cytotoxin therapy for human head and neck squamous cell carcinoma in animal models
    Scott E Strome
    Department of Otolaryngology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Clin Cancer Res 8:281-6. 2002
    ..These data demonstrate that IL-4 (38-37)-PE38KDEL is effective in mediating significant antitumor effects in SCCHN and may represent an attractive therapeutic option for patients with advanced cancers of the upper aerodigestive tract...
  21. ncbi request reprint A mechanistic perspective of monoclonal antibodies in cancer therapy beyond target-related effects
    Scott E Strome
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201 1619, USA
    Oncologist 12:1084-95. 2007
    ..Accordingly, all monoclonal antibodies directed against a given target should not be considered equivalent in their ability to stimulate immune-mediated effector functions...
  22. doi request reprint CD137 promotes proliferation and survival of human B cells
    Xiaoyu Zhang
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 184:787-95. 2010
    ..Our study suggests that CD137 costimulation may play a role in defining the fate of Ag-stimulated human B cells...
  23. ncbi request reprint Merkel cell carcinoma of the head and neck: a retrospective case series
    Anthony E Brissett
    Department of Otorhinolaryngology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Head Neck 24:982-8. 2002
    ..Eighty-five percent of all Merkel cell carcinomas appear on sun-exposed areas, with 50% to 55% occurring on the head and neck...
  24. ncbi request reprint Identification of NY-ESO-1, MAGE-1, and MAGE-3 in head and neck squamous cell carcinoma
    Matthew A Kienstra
    Department of Otorhinolaryngology, University of South Florida, MCC HN PROG, 12902 Magnolia Drive, Tampa, Florida, 33612 9497, USA
    Head Neck 25:457-63. 2003
    ..NY-ESO-1, MAGE-1, and MAGE-3 are such antigens. This study was undertaken to determine their presence or absence in head and neck squamous cell cancers and to correlate this with patient characteristics...
  25. ncbi request reprint HSulf-1 modulates HGF-mediated tumor cell invasion and signaling in head and neck squamous carcinoma
    Jin Ping Lai
    Division of Gastroenterology and Hepatology, Mayo Clinic Cancer Center, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Oncogene 23:1439-47. 2004
    ....
  26. ncbi request reprint Autoimmune inner ear disease: diagnostic and therapeutic approaches in a multidisciplinary setting
    Eric L Matteson
    Department of Internal Medicine, Division of Rheumatology Mayo Clinic and Mayo Graduate School of Medicine Rochester, Minnesota 55905, USA
    J Am Acad Audiol 14:225-30. 2003
    ..One of our conclusions is that many of these patients respond favorably to the treatment Methotrexate...
  27. pmc Antitumor immunity can be uncoupled from autoimmunity following heat shock protein 70-mediated inflammatory killing of normal pancreas
    Timothy Kottke
    Departments of Molecular Medicine, Ophthalmology and Ocular Oncology, and Immunology, Mayo Clinic, Rochester, Minnesota, USA
    Cancer Res 69:7767-74. 2009
    ....
  28. ncbi request reprint Her-2/neu expression in ovarian cancer: pre- and postexposure to platinum chemotherapy
    Prema P Peethambaram
    Mayo Clinic, Rochester, MN 55905, USA
    Gynecol Oncol 89:99-104. 2003
    ..Our objective was to determine if the level of Her-2/neu expression in advanced ovarian cancer changed after platinum-based chemotherapy...
  29. ncbi request reprint Glomus jugulare tumor: tumor control and complications after stereotactic radiosurgery
    Robert L Foote
    Division of Radiation Oncology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Head Neck 24:332-8; discussion 338-9. 2002
    ..We evaluated toxicity and long-term efficacy of stereotactic radiosurgery in patients with symptomatic or progressive glomus jugulare tumors...
  30. ncbi request reprint Squamous cell carcinoma of the tonsils: a molecular analysis of HPV associations
    Scott E Strome
    Department of Otorhinolaryngology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Clin Cancer Res 8:1093-100. 2002
    ..The role of human papilloma virus (HPV) in the pathogenesis and biological behavior of tonsillar squamous cell carcinoma (TSCC) are areas of intense investigation...
  31. ncbi request reprint Effacing of the T cell compartment by cardiac transplantation in infancy
    Brenda M Ogle
    Transplantation Biology Program, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Immunol 176:1962-7. 2006
    ..Our findings demonstrate a novel approach to measuring lymphocyte diversity and suggest that understanding how these subjects resist infection could yield important insights into immune fitness...
  32. ncbi request reprint Coronoid-temporalis pedicled rotation flap for orbital floor reconstruction of the total maxillectomy defect
    Shepherd G Pryor
    Mayo Clinic, Department of Otorhinolaryngology, Rochester, Minnesota 55905, USA
    Laryngoscope 114:2051-5. 2004
    ..Successful reconstruction of the deficit requires repair of the orbital floor to prevent early and late complications. This paper describes the recreation of the orbital floor using a coronoid-temporalis sling...
  33. ncbi request reprint The value of quantifying 18F-FDG uptake in thyroid nodules found incidentally on whole-body PET-CT
    Trond V Bogsrud
    Division of Nuclear Medicine, Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Nucl Med Commun 28:373-81. 2007
    ....
  34. pmc Isopentenyl pyrophosphate-activated CD56+ {gamma}{delta} T lymphocytes display potent antitumor activity toward human squamous cell carcinoma
    Alan A Z Alexander
    Department of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, MD 21201, USA
    Clin Cancer Res 14:4232-40. 2008
    ..CD56 is also expressed on a subset of gammadelta T cells. However, antitumor effector functions of CD56(+) gammadelta T cells are poorly characterized...
  35. ncbi request reprint CD8+ memory T lymphocytes from bone marrow--immune function and therapeutic potential
    Aaron H D Wood
    Department of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Crit Rev Immunol 27:527-37. 2007
    ....
  36. pmc Oral lactoferrin results in T cell-dependent tumor inhibition of head and neck squamous cell carcinoma in vivo
    Jeffrey S Wolf
    Department of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Clin Cancer Res 13:1601-10. 2007
    ..Human lactoferrin is a naturally occurring glycoprotein that inhibits cancer growth. Our purpose was to evaluate recombinant human lactoferrin as a chemotherapeutic agent against head and neck squamous cell carcinoma...
  37. ncbi request reprint Development and immunophenotyping of squamous cell carcinoma xenografts: tools for translational immunology
    Wei Lin
    Department of Otorhinolaryngology Head and Neck Surgery, University of Maryland Medical Center, Baltimore, Maryland 21201, USA
    Laryngoscope 115:1154-62. 2005
    ....
  38. pmc Fc-dependent expression of CD137 on human NK cells: insights into "agonistic" effects of anti-CD137 monoclonal antibodies
    Wei Lin
    Department of Otorhinolaryngology Head and Neck Surgery, University of Maryland, Baltimore, MD 21201 168, USA
    Blood 112:699-707. 2008
    ..Our data suggest that CD137 can be enhanced on NK cells in an Fc-dependent fashion and that expression correlates with phenotypic and functional parameters of activation...
  39. ncbi request reprint Interleukin-13 receptor alpha2 chain in human head and neck cancer serves as a unique diagnostic marker
    Mariko Kawakami
    Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    Clin Cancer Res 9:6381-8. 2003
    ..Taken together, this study suggests that IL-13R may be involved in SCCHN tumor progression, and 33% of IL-13Ralpha2-positive SCCHN cases may be targeted by IL-13 cytotoxin and IL-13R-targeted agent...