Research Topics
Genomes and GenesSpecies | Elizabeth A StewartSummaryAffiliation: Mayo Clinic Country: USA Publications
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Detail Information
Publications
Uterine artery embolization versus myomectomy: a multicenter comparative studyScott C Goodwin
Department of Veterans Affairs, The University of California, Los Angeles, California, USA
Fertil Steril 85:14-21. 2006..To determine whether there is significant quality of life score improvement after uterine artery embolization (UAE) and to compare UAE and myomectomy outcomes...
Magnetic resonance-guided focused ultrasound surgerySusan B A Hudson
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, College of Medicine, Mayo Clinic, Rochester, Minnesota 55901, USA
Clin Obstet Gynecol 51:159-66. 2008..Magnetic resonance-guided focused ultrasound surgery is a new noninvasive therapy that has been proven to be both safe and efficacious in the treatment of fibroids...- Sustained relief of leiomyoma symptoms by using focused ultrasound surgeryElizabeth A Stewart
Departments of Obstetrics, Gynecology and Reproductive Biology and Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Obstet Gynecol 110:279-87. 2007..To assess several measures of the long-term outcome of magnetic resonance-guided focused ultrasound surgery for symptomatic uterine leiomyomata... 
Magnetic resonance elastography of uterine leiomyomas: a feasibility studyElizabeth A Stewart
Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota 55905, USA
Fertil Steril 95:281-4. 2011..To determine the feasibility of performing in vivo magnetic resonance elastography (MRE) for uterine leiomyoma...- Expression profiling of uterine leiomyomata cytogenetic subgroups reveals distinct signatures in matched myometrium: transcriptional profilingof the t(12;14) and evidence in support of predisposing genetic heterogeneityJennelle C Hodge
Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Boston, MA 02115, USA
Hum Mol Genet 21:2312-29. 2012..This suggests an underlying constitutional genetic predisposition to these somatic changes which could potentially lead to improved personalized management and treatment... - Clinical outcomes of focused ultrasound surgery for the treatment of uterine fibroidsElizabeth A Stewart
Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Fertil Steril 85:22-9. 2006..To assess outcomes at 6 and 12 months after magnetic resonance-guided focused ultrasound surgery (MRgFUS) for symptomatic uterine leiomyomas... - Identifying the molecular signature of the interstitial deletion 7q subgroup of uterine leiomyomata using a paired analysisJennelle C Hodge
Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Boston, MA 02115, USA
Genes Chromosomes Cancer 48:865-85. 2009..This study provides a molecular signature of the del(7q) UL subgroup and will serve as a platform for future studies of tumor pathogenesis... - Uterine leiomyomas: MR imaging-based thermometry and thermal dosimetry during focused ultrasound thermal ablationNathan Mcdannold
Department of Radiology, Harvard Medical School, Brigham and Women s Hospital, 221 Longwood Ave LMRC, 007c, Boston, MA 02115, USA
Radiology 240:263-72. 2006..To retrospectively evaluate magnetic resonance (MR) imaging-based thermometry and thermal dosimetry during focused ultrasound treatments of uterine leiomyomas (ie, fibroids)... - Understanding cellular leiomyomas: a case-control studyF Andrei Taran
Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN 55905, USA
Am J Obstet Gynecol 203:109.e1-6. 2010..Reports exist in which cellular leiomyomas (CLs) appear to have clinical characteristics or genetic profiles similar to leiomyosarcomas. This study aimed to determine whether most CLs differ clinically from typical uterine leiomyomas (ULs)... - Influence of body size and body fat distribution on risk of uterine leiomyomata in U.S. black womenLauren A Wise
Department of Epidemiology, Harvard School of Public Health, 1010 Commonwealth Avenue, Boston, MA 02215, USA
Epidemiology 16:346-54. 2005..We prospectively investigated the risk of self-reported uterine leiomyomata in relation to body mass index (BMI), weight change, height, waist and hip circumferences, and waist-to-hip ratio in a large cohort of U.S black women... - Risk of uterine leiomyomata in relation to tobacco, alcohol and caffeine consumption in the Black Women's Health StudyLauren A Wise
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Hum Reprod 19:1746-54. 2004..Tobacco, alcohol and caffeine consumption may influence risk of uterine leiomyomata via changes in ovarian function or hormone metabolism... - Age-specific incidence rates for self-reported uterine leiomyomata in the Black Women's Health StudyLauren A Wise
Slone Epidemiology Center, Boston University, Boston, Massachusetts 02215, USA
Obstet Gynecol 105:563-8. 2005..We estimated overall and age-specific incidence rates for self-reported uterine leiomyomata in a large cohort of African-American women in the United States... - Genome-wide linkage and association analyses implicate FASN in predisposition to Uterine LeiomyomataStacey L Eggert
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Am J Hum Genet 91:621-8. 2012..FASN represents the initial UL risk allele identified in white women by a genome-wide, unbiased approach and opens a path to management and potential therapeutic intervention... - Uterine leiomyomas: MR imaging-guided focused ultrasound surgery--results of different treatment protocolsFiona M Fennessy
Department of Radiology, Harvard Medical School Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
Radiology 243:885-93. 2007..To prospectively assess patient response (after 12 months) to magnetic resonance (MR) imaging-guided focused ultrasound surgery in treatment of uterine leiomyomas by using two treatment protocols... - Uterine leiomyomas: MR imaging-guided focused ultrasound surgery--imaging predictors of successZsuzsanna M Lénárd
Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
Radiology 249:187-94. 2008..To retrospectively assess the magnetic resonance (MR) imaging predictors of success at reducing uterine leiomyoma volume and achieving patient symptom relief 12 months after MR imaging-guided focused ultrasound surgery... - Understanding adenomyosis: a case control studyF Andrei Taran
Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota 55905, USA
Fertil Steril 94:1223-8. 2010..To elucidate the clinical profile of adenomyosis by comparison with uterine leiomyomas... - Comparing focused ultrasound and uterine artery embolization for uterine fibroids-rationale and design of the Fibroid Interventions: reducing symptoms today and tomorrow (FIRSTT) trialEsther V A Bouwsma
Center for Uterine Fibroids, Mayo Clinic, Rochester, Minnesota Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota 55901, USA
Fertil Steril 96:704-10. 2011..To present the rationale, design, and methodology of the Fibroid Interventions: Reducing Symptoms Today and Tomorrow (FIRSTT) study... - Uterine leiomyomata and decreased height: a common HMGA2 predisposition alleleJennelle C Hodge
Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Boston, MA 02115, USA
Hum Genet 125:257-63. 2009..These results indicate HMGA2 has a role in two growth-related phenotypes, UL predisposition and height, of which the former may affect future medical management decisions for many women... - MRI-based thermal dosimetry and diffusion-weighted imaging of MRI-guided focused ultrasound thermal ablation of uterine fibroidsMagdalini C Pilatou
Department of Radiology, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts, USA
J Magn Reson Imaging 29:404-11. 2009.... - Perceived racial discrimination and risk of uterine leiomyomataLauren A Wise
Slone Epidemiology Center, Boston University, Boston, MA 02215, USA
Epidemiology 18:747-57. 2007..Black women also report higher levels of racial discrimination. We evaluated the hypothesis that greater exposure to racism increases myoma risk in black women... - Molecular and cytogenetic characterization of plexiform leiomyomata provide further evidence for genetic heterogeneity underlying uterine fibroidsJennelle C Hodge
Brigham and Women s Hospital, Department of Obstetrics and Gynecology and Reproductive Biology, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Am J Pathol 172:1403-10. 2008..We further suggest that plexiform UL should be classified among tumors with extensive hyalinization rather than with "true" epithelioid smooth muscle neoplasms... - Does the phase of menstrual cycle affect MR-guided focused ultrasound surgery of uterine leiomyomas?Minna J So
Department of Radiology, Brigham and Women s Hospital Harvard Medical School, Boston, MA, USA
Eur J Radiol 59:203-7. 2006..To determine whether the phase of menstrual cycle at the time of MR-guided focused ultrasound surgery (MRgFUS) treatment for uterine leiomyomas affects treatment outcome... - Polycystic ovary syndrome and risk of uterine leiomyomataLauren A Wise
Slone Epidemiology Center, Boston University, Boston, Massachusetts 02215, USA
Fertil Steril 87:1108-15. 2007..To examine the association between polycystic ovary syndrome (PCOS) and the risk of uterine leiomyomata (UL)... - Characteristics indicating adenomyosis coexisting with leiomyomas: a case-control studyF Andrei Taran
Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Mayo Clinic, 200 First St, SW, Rochester, MN 55905, USA
Hum Reprod 25:1177-82. 2010..Adenomyosis is rarely diagnosed before hysterectomy and commonly coexists with uterine leiomyomas. The objective of this study was to identify distinct features of a concurrent diagnosis of adenomyosis in women with uterine leiomyomas... - Magnetic resonance-guided focused ultrasound of uterine leiomyomas: review of a 12-month outcome of 130 clinical patientsKrzysztof R Gorny
Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
J Vasc Interv Radiol 22:857-64. 2011..To assess 12-month outcomes and safety of clinical magnetic resonance (MR)-guided focused ultrasound (US) treatments of uterine leiomyomas... - Reassessing hysterectomyElizabeth A Stewart
Department of Obstetrics and Gynecology, Mayo Clinic, USA
Minn Med 95:36-9. 2012..Individualizing therapy and discussing appropriate alternatives to hysterectomy is an important responsibility for all health care providers... - The relation of annual surgeon case volume to clinical outcomes and resource utilization in abdominal hysterectomyMiriam M F Hanstede
Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital and Harvard Medical School, USA
J Reprod Med 54:193-202. 2009..To study the relationship of annual surgeon case volume to surgical outcome following hysterectomy... - Racial diversity in uterine leiomyoma clinical studiesF Andrei Taran
Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota 55905, USA
Fertil Steril 94:1500-3. 2010..To examine racial diversity in clinical studies on uterine leiomyomas included in a review of evidence-based practice because of the disproportionate burden of fibroids in Black women... - Outcomes for abdominal myomectomies among high-volume surgeonsMiriam M F Hanstede
Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
J Reprod Med 53:941-6. 2008..To examine the relationship between surgical volume and complications and resource utilization for myomectomy... - MR imaging-guided focused ultrasound surgery of uterine leiomyomas: a feasibility studyClare M C Tempany
Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
Radiology 226:897-905. 2003..MR imaging-guided focused ultrasound causes thermocoagulation and necrosis in uterine leiomyomas and is feasible and safe, without serious consequences... - Avoiding treatment of leiomyosarcomas: the role of magnetic resonance in focused ultrasound surgeryAmber Samuel
Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Fertil Steril 90:850.e9-12. 2008..To report early diagnosis of a uterine leiomyosarcoma during screening for magnetic resonance imaging-guided focused ultrasound surgery (MRgFUS) for leiomyomas... - Focused ultrasound treatment of uterine fibroid tumors: safety and feasibility of a noninvasive thermoablative techniqueElizabeth A Stewart
Departments of Obstetrics, Gynecology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Am J Obstet Gynecol 189:48-54. 2003..The purpose of this study was to determine the safety and efficacy of focused ultrasound surgery with magnetic resonance imaging guidance for the noninvasive treatment of uterine leiomyomas... - Reproductive factors, hormonal contraception, and risk of uterine leiomyomata in African-American women: a prospective studyLauren A Wise
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02215, USA
Am J Epidemiol 159:113-23. 2004..No consistent patterns were observed for other forms of hormonal contraception. Reproductive history is an important determinant of leiomyomata risk in premenopausal US Black women. Progestin-only injectables may reduce risk... - Magnetic resonance-guided focused ultrasound surgery for leiomyoma-associated infertilityEsther V A Bouwsma
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, Mayo Clinic, Rochester, Minnesota, USA
Fertil Steril 96:e9-e12. 2011..To describe magnetic resonance-guided focused ultrasound surgery (FUS) as a treatment for a case of leiomyoma-associated infertility... - Focused ultrasound surgery of intramural leiomyomas may facilitate fertility: a case reportMiriam M F Hanstede
Department of Obstetrics, Gynecology, and Reproductive Biology, Boston, Massachusetts, USA
Fertil Steril 88:497.e5-7. 2007..To describe a successful pregnancy after a change in configuration of the endometrial cavity after magnetic resonance imaging-guided focused ultrasound surgery (MRgFUS) for leiomyomas... - The genetics of uterine leiomyomata: what clinicians need to knowElizabeth A Stewart
Center for Uterine Fibroids, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Obstet Gynecol 107:917-21. 2006..The current role of family medical history and future implications of genes relevant to leiomyoma biology will be reviewed... - What factors currently limit magnetic resonance-guided focused ultrasound of leiomyomas? A survey conducted at the first international symposium devoted to clinical magnetic resonance-guided focused ultrasoundF Andrei Taran
Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota 55905, USA
Fertil Steril 94:331-4. 2010..To see if clinicians' impressions were influenced by expert opinion on patient selection criteria that influence magnetic resonance-guided focused ultrasound (MRgFUS) leiomyoma treatment... - Hysterectomy, oophorectomy, estrogen, and the risk of dementiaWalter A Rocca
Department of Neurology, College of Medicine, Mayo Clinic, Rochester, Minn 55905, USA
Neurodegener Dis 10:175-8. 2012..The long-term cognitive effects of hysterectomy and oophorectomy remain controversial... - Magnetic resonance-guided focused ultrasound surgeryMariam M Al Hilli
Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota 55905, USA
Semin Reprod Med 28:242-9. 2010..MRgFUS has been deemed a safe and effective method of fibroid treatment and offers the advantages of no incisions or blood loss, speedy recovery, and a cost-effective means of treatment... - Predictors of subsequent surgery for uterine leiomyomata after abdominal myomectomyElizabeth A Stewart
Center for Uterine Fibroids and Ob Gyn Epidemiology Center, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Obstet Gynecol 99:426-32. 2002..To study factors associated with an increased risk of subsequent surgery in a cohort of women undergoing abdominal myomectomy... - The impact of race as a risk factor for symptom severity and age at diagnosis of uterine leiomyomata among affected sistersKaren L Huyck
Department of Pathology, University of Vermont College of Medicine, Burlington, VT, USA
Am J Obstet Gynecol 198:168.e1-9. 2008..The objective of the study was to identify risk factors for uterine leiomyomata (UL) in a racially diverse population of women with a family history of UL, and to evaluate their contribution to disease severity and age at diagnosis... - Uterine fibroids: the elephant in the roomCheryl Lyn Walker
Department of Carcinogenesis, University of Texas and MD Anderson Cancer Center, Park Road 1C, Smithville, TX 78957, USA
Science 308:1589-92. 2005..As new therapies are developed, the heterogeneity of this disease becomes therapeutically relevant. An awareness of the role of genetics, the extracellular matrix, and hormones in tumor etiology is key to understanding this disease... - The direct and indirect cost burden of clinically significant and symptomatic uterine fibroidsDavid W Lee
Health Economics and Outcomes Research, GE Healthcare, Waukesha, WI, USA
J Occup Environ Med 49:493-506. 2007..To estimate direct medical costs and indirect (productivity related) for women age 25 to 54 who had clinically significant and symptomatic uterine fibroids (UF)... - Involvement of fumarate hydratase in nonsyndromic uterine leiomyomas: genetic linkage analysis and FISH studiesKaren L Gross
Department of Pathology, University of Vermont, Burlington, Vermont, USA
Genes Chromosomes Cancer 41:183-90. 2004..7 at D1S547, P = 0.04). FISH results showed that one copy of FH was absent in 9 of 11 ULs. These data indicate that loss of FH might be a significant event in the pathogenesis of a subset of nonsyndromic ULs... - Development of a research agenda for uterine artery embolization: proceedings from a multidisciplinary research consensus panelJames B Spies
Department of Radiology, Georgetown University Hospital, Washington, DC 20007-2113, USA
J Vasc Interv Radiol 17:1871-9. 2006 - New interventional techniques for adenomyosisJaron Rabinovici
Department of Obstetrics and Gynecology, The Chaim Sheba Medical Center, Senior Lecturer, Sackler Medical School, Tel Aviv University, Tel Hashomer 52621, Israel
Best Pract Res Clin Obstet Gynaecol 20:617-36. 2006..Based on the evidence presented in this chapter it seems that adenomyosis has become an entity that might be treatable by new, minimally invasive or non-invasive treatments...
Research Grants
- The FIRSTT Trial: Assessing Outcomes of Minimally Invasive Leiomyoma TherapiesElizabeth A Stewart; Fiscal Year: 2010..This study proposes to study the outcomes and limitations of two widely used alternatives to hysterectomy for fibroids: uterine artery embolization (UAE) and magnetic resonance imaging guided focused ultrasound surgery (MRgFUS). ..