Mark Stegall

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi request reprint ABO-incompatible kidney transplantation
    Mark D Stegall
    Department of Surgery, Division of Transplantation Surgery, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Transplantation 78:635-40. 2004
  2. ncbi request reprint The rationale for the new deceased donor pancreas allocation schema
    Mark D Stegall
    Department of Surgery, Division of Transplantation Surgery, Mayo Clinic, Rochester, MN 55905, USA
    Transplantation 83:1156-61. 2007
  3. ncbi request reprint What can be learned using microarrays?
    M D Stegall
    Department of Surgery, Division of Transplant Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Kidney Int 72:783-4. 2007
  4. doi request reprint The role of complement in antibody-mediated rejection in kidney transplantation
    Mark D Stegall
    Department of Surgery, Division of Transplantation Surgery and von Liebig Transplant Center, 200 First Street SW, Mayo Clinic, Rochester, MN 55905, USA
    Nat Rev Nephrol 8:670-8. 2012
  5. pmc A meta-analysis of kidney microarray datasets: investigation of cytokine gene detection and correlation with rt-PCR and detection thresholds
    Walter D Park
    Department of Surgery, Mayo Clinic College of Medicine, Rochester, MN, USA
    BMC Genomics 8:88. 2007
  6. doi request reprint Deciphering antibody-mediated rejection: new insights into mechanisms and treatment
    Mark D Stegall
    Mayo Foundation and Clinic, Rochester, Minnesota 55905, USA
    Curr Opin Organ Transplant 15:8-10. 2010
  7. doi request reprint Mechanisms of alloantibody production in sensitized renal allograft recipients
    M D Stegall
    Division of Transplantation, Department of Surgery, Mayo Clinic, Rochester, MN, USA
    Am J Transplant 9:998-1005. 2009
  8. doi request reprint The (re)emergence of B cells in organ transplantation
    Mark D Stegall
    Division of Transplantation Surgery, Department of Surgery, Von Liebig Transplant Center, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Curr Opin Organ Transplant 15:451-5. 2010
  9. ncbi request reprint Kidney transplantation without calcineurin inhibitors using sirolimus
    M D Stegall
    Department of Surgery, Mayo Foundation and Clinic, Rochester, Minnesota, USA
    Transplant Proc 35:125S-127S. 2003
  10. ncbi request reprint Gene expression during acute allograft rejection: novel statistical analysis of microarray data
    Mark Stegall
    Department of Surgery, Division of Transplantation, Mayo Foundation and Clinic, 200 First St SW, Rochester, MN 55905, USA
    Am J Transplant 2:913-25. 2002

Research Grants

Detail Information

Publications85

  1. ncbi request reprint ABO-incompatible kidney transplantation
    Mark D Stegall
    Department of Surgery, Division of Transplantation Surgery, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Transplantation 78:635-40. 2004
    ..Here we review the therapeutic options for patients whose only living kidney donor is ABO incompatible, with a specific emphasis on the rationale for and the current outcomes of ABO incompatible living donor kidney transplantation...
  2. ncbi request reprint The rationale for the new deceased donor pancreas allocation schema
    Mark D Stegall
    Department of Surgery, Division of Transplantation Surgery, Mayo Clinic, Rochester, MN 55905, USA
    Transplantation 83:1156-61. 2007
    ..To ensure the continued success of whole organ pancreas and islet transplantation, deceased donor pancreas allocation policy must continue to evolve...
  3. ncbi request reprint What can be learned using microarrays?
    M D Stegall
    Department of Surgery, Division of Transplant Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Kidney Int 72:783-4. 2007
    ..Although understanding this enormous volume of esoteric data is difficult, a few basic concepts regarding microarray studies can significantly improve the general reader's comprehension...
  4. doi request reprint The role of complement in antibody-mediated rejection in kidney transplantation
    Mark D Stegall
    Department of Surgery, Division of Transplantation Surgery and von Liebig Transplant Center, 200 First Street SW, Mayo Clinic, Rochester, MN 55905, USA
    Nat Rev Nephrol 8:670-8. 2012
    ..In this Review, we discuss the different roles that the complement system might have in antibody-mediated allograft rejection, with specific emphasis on renal transplantation...
  5. pmc A meta-analysis of kidney microarray datasets: investigation of cytokine gene detection and correlation with rt-PCR and detection thresholds
    Walter D Park
    Department of Surgery, Mayo Clinic College of Medicine, Rochester, MN, USA
    BMC Genomics 8:88. 2007
    ..In the kidney this is a concern for genes such as cytokines which dramatically influence the immune response but are often considered low abundance genes produced by a small number of cells...
  6. doi request reprint Deciphering antibody-mediated rejection: new insights into mechanisms and treatment
    Mark D Stegall
    Mayo Foundation and Clinic, Rochester, Minnesota 55905, USA
    Curr Opin Organ Transplant 15:8-10. 2010
    ..To outline recent studies describing the mechanisms of antibody-mediated rejection (AMR) and new clinical protocols aimed at prevention and/or treatment of this difficult clinical entity...
  7. doi request reprint Mechanisms of alloantibody production in sensitized renal allograft recipients
    M D Stegall
    Division of Transplantation, Department of Surgery, Mayo Clinic, Rochester, MN, USA
    Am J Transplant 9:998-1005. 2009
    ..The goal of this review is to outline recent studies regarding antibody production in general and specific studies that illustrate what is known about alloantibody production in sensitized patients...
  8. doi request reprint The (re)emergence of B cells in organ transplantation
    Mark D Stegall
    Division of Transplantation Surgery, Department of Surgery, Von Liebig Transplant Center, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Curr Opin Organ Transplant 15:451-5. 2010
    ..To outline recent advances in our understanding of the role of B cells in transplantation...
  9. ncbi request reprint Kidney transplantation without calcineurin inhibitors using sirolimus
    M D Stegall
    Department of Surgery, Mayo Foundation and Clinic, Rochester, Minnesota, USA
    Transplant Proc 35:125S-127S. 2003
    ..The aim of this study is to compare the safety and efficacy of calcineurin inhibitor (CI) free immunosuppression in a prospective, randomized trial comparing sirolimus-mycophenolate mofetil (MMF)-prednisone to tacrolimus- MMF-prednisone...
  10. ncbi request reprint Gene expression during acute allograft rejection: novel statistical analysis of microarray data
    Mark Stegall
    Department of Surgery, Division of Transplantation, Mayo Foundation and Clinic, 200 First St SW, Rochester, MN 55905, USA
    Am J Transplant 2:913-25. 2002
    ..Results were reproducible and correlated well with both RT-PCR and prior studies. Most importantly, these results provide new insights into the pathogenesis of acute rejection and suggest new molecules for future studies...
  11. doi request reprint The histology of solitary renal allografts at 1 and 5 years after transplantation
    M D Stegall
    Von Liebig Transplant Center, Division of Transplantation Surgery, Division of Nephrology and Hypertension, Department of Anatomic Pathology, Mayo Clinic, Rochester, MN, USA
    Am J Transplant 11:698-707. 2011
    ..These results in the recent era of transplantation demonstrate fewer, less severe and less progressive chronic histologic changes in the first 5 years after transplantation than previously reported...
  12. ncbi request reprint Changes in intragraft gene expression secondary to ischemia reperfusion after cardiac transplantation
    Mark D Stegall
    Department of Surgery, Division of Transplantation, Mayo Foundation and Clinic, Rochester, MN 55905, USA
    Transplantation 74:924-30. 2002
    ..The aim of this study was to perform a comprehensive analysis of gene expression in cardiac grafts secondary to I/R using microarray technology...
  13. ncbi request reprint A comparison of plasmapheresis versus high-dose IVIG desensitization in renal allograft recipients with high levels of donor specific alloantibody
    M D Stegall
    Department of Surgery, Division of Transplantation Surgery, Mayo Clinic, Rochester, MN, USA
    Am J Transplant 6:346-51. 2006
    ..PP). We conclude that multiple PP treatments leads to more reproducible desensitization and lower humoral rejection rates than a single high-dose of IVIG, but that no regimen was completely effective in preventing humoral rejection...
  14. doi request reprint Improving long-term renal allograft survival via a road less traveled by
    M D Stegall
    Von Liebig Transplant Center, Department of Surgery, Division of Transplant Surgery, Mayo Clinic, Rochester, MN, USA
    Am J Transplant 11:1382-7. 2011
    ....
  15. doi request reprint Terminal complement inhibition decreases antibody-mediated rejection in sensitized renal transplant recipients
    M D Stegall
    William J von Liebig Transplant Center, Division of Transplantation Surgery, Mayo Clinic, Rochester, MN, USA
    Am J Transplant 11:2405-13. 2011
    ..7% (15/42) of control patients (p = 0.044). Inhibition of terminal complement activation with eculizumab decreases the incidence of early AMR in sensitized renal transplant recipients (ClincalTrials.gov number NCT006707)...
  16. doi request reprint The right kidney for the right recipient: the status of deceased donor kidney allocation reform
    Mark D Stegall
    Von Liebig Transplant Center, Mayo Clinic, Rochester, Minnesota 55905, USA
    Semin Dial 23:248-52. 2010
    ..Most of the major stakeholders have expressed their viewpoints in a series of recent publications. This manuscript aims to examine some of the most important issues in this discussion and to outline a possible path forward...
  17. ncbi request reprint Blood pressure and renal function after kidney donation from hypertensive living donors
    Stephen C Textor
    Department of Medicine, Divisions of Nephrology and Hypertension, W9A, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Transplantation 78:276-82. 2004
    ..This study reports outcomes of hypertensive donors 1 year after kidney donation...
  18. ncbi request reprint Complications, resource utilization, and cost of ABO-incompatible living donor kidney transplantation
    Jason Schwartz
    Department of Surgery, Division of Transplant Surgery, Mayo Clinic, Rochester, MN 55905, USA
    Transplantation 82:155-63. 2006
    ..These protocols lead to an increase in resource utilization and cost of transplantation and may result in increased complications...
  19. ncbi request reprint Wound-healing complications after kidney transplantation: a prospective, randomized comparison of sirolimus and tacrolimus
    Patrick G Dean
    Department of Surgery, Division of Transplant Surgery, Mayo Clinic College of Medicine, 200 First Street S W, Rochester, MN 55905, USA
    Transplantation 77:1555-61. 2004
    ..The authors compared the rates of wound-healing complications in renal allograft recipients in a prospective, randomized trial of sirolimus-mycophenolate mofetil-prednisone versus tacrolimus-mycophenolate mofetil-prednisone...
  20. ncbi request reprint Molecular evidence of injury and inflammation in normal and fibrotic renal allografts one year posttransplant
    Walter Park
    Department of Surgery, Division of Transplant Surgery, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Transplantation 83:1466-76. 2007
    ..Factors contributing to kidney transplant fibrosis remain incompletely understood, particularly in the absence of acute complications...
  21. ncbi request reprint Histologic findings of antibody-mediated rejection in ABO blood-group-incompatible living-donor kidney transplantation
    Mary E Fidler
    Department of Laboratory Medicine, Division of Anatomic Pathology, Mayo Foundation and Clinic, Rochester, MN, USA
    Am J Transplant 4:101-7. 2004
    ..Glomerular thrombi appear early in AMR and may appear prior to graft dysfunction...
  22. ncbi request reprint ABO-incompatible kidney transplantation using both A2 and non-A2 living donors
    James M Gloor
    Division of Nephrology and Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Transplantation 75:971-7. 2003
    ..Given the scarcity of cadaveric organs, efforts are intensifying to increase the availability of living donors. The current study assessed the feasibility of using ABO-incompatible living-donor kidneys to expand the donor pool...
  23. ncbi request reprint Decreased incidence of acute rejection in adolescent kidney transplant recipients using antithymocyte induction and triple immunosuppression
    Jason J Schwartz
    Department of Surgery, Division of General Surgery, Section of Transplant Surgery, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Transplantation 84:715-21. 2007
    ..Recent data from the North American Pediatric Renal Transplant Cooperative Study indicates that the rate of acute rejection remains high despite current immunosuppressive regimens...
  24. ncbi request reprint Obesity in living kidney donors: clinical characteristics and outcomes in the era of laparoscopic donor nephrectomy
    Julie K Heimbach
    Mayo Clinic College of Medicine, Department of Transplant Surgery, Rochester, Minnesota, USA
    Am J Transplant 5:1057-64. 2005
    ..While early results are encouraging, we advocate careful study of obese donors and do not support their widespread use until longer follow-up is available...
  25. ncbi request reprint Accommodation in ABO-incompatible kidney allografts, a novel mechanism of self-protection against antibody-mediated injury
    Walter D Park
    Department of Surgery, Mayo Clinic, Rochester, MN, USA
    Am J Transplant 3:952-60. 2003
    ..This self-protection against antibody-mediated damage may involve several novel mechanisms including the disruption of normal signal transduction, attenuation of cellular adhesion and the prevention of apoptosis...
  26. ncbi request reprint Overcoming a positive crossmatch in living-donor kidney transplantation
    James M Gloor
    Department of Medicine, Division of Nephrology, Mayo Foundation and Clinic, 200 First St SW, Rochester, MN 55905, USA
    Am J Transplant 3:1017-23. 2003
    ..Longer follow-up will be needed, but the absence of anti-donor antibody and good early outcomes are encouraging...
  27. ncbi request reprint Survival of mandatorily shared cadaveric kidneys and their paybacks in the zero mismatch era
    Mark D Stegall
    Department of Surgery, Division of Transplantation Surgery, Mayo Clinic, Rochester, MN 55905, USA
    Transplantation 74:670-5. 2002
    ..To address these concerns, we analyzed the effects of this system on graft survival, cold ischemia time, and the transplantation of highly sensitized patients during the 0-MM era...
  28. ncbi request reprint Persistence of low levels of alloantibody after desensitization in crossmatch-positive living-donor kidney transplantation
    James M Gloor
    Department of Nephrology and Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Transplantation 78:221-7. 2004
    ..Desensitization protocols have been developed to allow successful kidney transplantation in sensitized recipients. However, a detailed analysis of the impact of these protocols on alloantibody has not been performed...
  29. ncbi request reprint Outcome of untreated grade II rejection on solitary pancreas allograft biopsy specimens
    Edward T Casey
    Division of Nephrology and Department of Internal Medicine, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Transplantation 79:1717-22. 2005
    ..The authors therefore report the outcomes of untreated grade II (minimal) rejection of solitary pancreas biopsy specimens...
  30. pmc Fibrosis with inflammation at one year predicts transplant functional decline
    Walter D Park
    Department of Surgery, Division of Transplantation Surgery, Mayo Clinic, Rochester, Minnesota, USA
    J Am Soc Nephrol 21:1987-97. 2010
    ..Early interventions aimed at altering rejection-like inflammation may improve long-term survival of kidney allografts...
  31. ncbi request reprint Pancreas-after-kidney transplantation: an increasingly attractive alternative to simultaneous pancreas-kidney transplantation
    Timothy S Larson
    Department of Internal Medicine, Division of Nephrology, Mayo Clinic, Rochester, MN 559805, USA
    Transplantation 77:838-43. 2004
    ..The purpose of this study was to compare PAK transplantation to SPK transplantation in the Thymoglobulin induction era...
  32. ncbi request reprint Influence of surveillance renal allograft biopsy on diagnosis and prognosis of polyomavirus-associated nephropathy
    Christopher K Buehrig
    Department of Internal Medicine, Division of Nephrology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Kidney Int 64:665-73. 2003
    ..Polyomavirus-associated nephropathy (PVAN) is an increasingly prevalent cause of allograft dysfunction...
  33. doi request reprint A prospective, randomized, double-blind, placebo-controlled multicenter trial comparing early (7 day) corticosteroid cessation versus long-term, low-dose corticosteroid therapy
    E Steve Woodle
    Division of Transplantation, Department of Surgery, University of Cincinnati, Cincinnati, OH 45267, USA
    Ann Surg 248:564-77. 2008
    ..To compare outcomes with early corticosteroid withdrawal (CSWD) and chronic low dose corticosteroid therapy (CCS)...
  34. doi request reprint Antibody-mediated rejection following transplantation from an HLA-identical sibling
    Carrie A Grafft
    Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA
    Nephrol Dial Transplant 25:307-10. 2010
    ..A biopsy for allograft dysfunction suggested AMR, but DSA could not be detected. Treatment for rejection was transiently successful. Undetectable minor histocompatibility antibodies may have contributed...
  35. ncbi request reprint Hand-assisted laparoscopic donor nephrectomy for pediatric kidney allograft recipients
    Dean Y Kim
    Department of Surgery, Division of Transplantation Surgery, William J von Liebig Transplant Center, Mayo Medical School, Foundation and Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Pediatr Transplant 8:460-3. 2004
    ..In conclusion, hand-assisted LDN is a safe method of procuring kidneys from potential donors with no significant negative outcomes to the pediatric recipients...
  36. ncbi request reprint Prospective, randomized trial of the effect of antibody induction in simultaneous pancreas and kidney transplantation: three-year results
    George W Burke
    Department of Surgery, University of Miami, Miami, Florida 33136, USA
    Transplantation 77:1269-75. 2004
    ..Induction agents included T-cell-depleting and interleukin-2 receptor antibodies...
  37. ncbi request reprint Acute nephrotoxicity of tacrolimus and sirolimus in renal isografts: differential intragraft expression of transforming growth factor-beta1 and alpha-smooth muscle actin
    Dora Ninova
    Department of Surgery, Division of Transplant Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Transplantation 78:338-44. 2004
    ..This study assesses the acute nephrotoxicity of tacrolimus (Tac) and sirolimus (Sir) in a rat renal isograft model...
  38. ncbi request reprint United Network for Organ Sharing's expanded criteria donors: is stratification useful?
    Edwina S Baskin-Bey
    Division of Transplantation Surgery, William J von Liebig Transplant Center, Mayo Clinic, Rochester, MN 55905, USA
    Clin Transplant 19:406-12. 2005
    ..Knowledge obtained by stratification of deceased donor kidneys can allow for improved utilization of marginal kidneys which is not achieved by the UNOS ECD definition alone...
  39. pmc Prevalence of renal artery and kidney abnormalities by computed tomography among healthy adults
    Elizabeth C Lorenz
    Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA
    Clin J Am Soc Nephrol 5:431-8. 2010
    ..Therefore, the prevalence and management of these abnormalities were determined among a large cohort of potential kidney donors undergoing protocol evaluations...
  40. ncbi request reprint Collapsing and non-collapsing focal segmental glomerulosclerosis in kidney transplants
    Sundararaman Swaminathan
    Department of Medicine, Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Nephrol Dial Transplant 21:2607-14. 2006
    ..In this study, post-transplant cFSGS and non-collapsing FSGS (ncFSGS) were compared in recent KTx recipients. Evidence for intragraft viral infection was sought...
  41. pmc Association of kidney function and metabolic risk factors with density of glomeruli on renal biopsy samples from living donors
    Andrew D Rule
    Division of Nephrology and Hypertension, Mayo Clinic, 200 First St SW, Rochester, MN 55905
    Mayo Clin Proc 86:282-90. 2011
    ..To test the hypothesis that kidney function and metabolic risk factors are associated with glomerular density on renal biopsy samples from healthy adults...
  42. ncbi request reprint Diurnal blood pressure changes one year after kidney transplantation: relationship to allograft function, histology, and resistive index
    Hani M Wadei
    Department of Medicine, Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    J Am Soc Nephrol 18:1607-15. 2007
    ..Further studies are needed to determine whether restoration of normal BP pattern will confer better allograft outcome...
  43. doi request reprint Significance and implications of capillaritis during acute rejection of kidney allografts
    Fernando G Cosio
    Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA
    Transplantation 89:1088-94. 2010
    ..CONCLUSIONS.: DSA-I increases the risk of C4d-AR. The presence of DSA-I or II is associated with capillaritis during AR. Capillaritis is associated with reduced graft survival...
  44. doi request reprint Kidney transplant histology after one year of continuous therapy with sirolimus compared with tacrolimus
    Patrick G Dean
    1 Department of Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Transplantation 85:1212-5. 2008
    ..This potential benefit is offset by lower success rate in maintaining the regimen and was not accompanied by superior glomerular filtration rate at 1 year...
  45. ncbi request reprint The effect of antithymocyte globulin on anti-human leukocyte antigen antibody detection assays
    James M Gloor
    Department of Nephrology and Internal Medicine, Mayo Clinic, Rochester, MN, USA
    Transplantation 84:258-64. 2007
    ..We evaluated the effect of antithymocyte globulin (ATG) on anti-human leukocyte antigen (HLA) antibody assays...
  46. ncbi request reprint ABO incompatible kidney transplantation
    James M Gloor
    Department of Internal Medicine, Division of Nephrology and Hypertension and Transplant Center, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Curr Opin Nephrol Hypertens 16:529-34. 2007
    ..Although ABO incompatible kidney transplantation is increasingly recognized as effective, the procedure is still evolving. The purpose of this review is to summarize recent advances in this area...
  47. doi request reprint Long-term benefits of pancreas transplantation
    Patrick G Dean
    Division of Transplant Surgery, Department of Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Curr Opin Organ Transplant 13:85-90. 2008
    ..With more recipients enjoying normoglycemia for longer periods of time, the opportunity to study more closely the effects of pancreas transplantation has arisen. This review will focus on these long-term benefits...
  48. doi request reprint Transplant glomerulopathy: risk and prognosis related to anti-human leukocyte antigen class II antibody levels
    Naim Issa
    Division of Nephrology and Hypertension and Transplant Center, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Transplantation 86:681-5. 2008
    ..The goal of this study was to determine the relationships among antibody characteristics (level and specificity), risk for TG, and graft survival...
  49. doi request reprint Kidney transplantation for primary focal segmental glomerulosclerosis: outcomes and response to therapy for recurrence
    Latonya J Hickson
    Department of Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA
    Transplantation 87:1232-9. 2009
    ..Predicting recurrence and response to plasmapheresis (PP) or other interventions remains problematic...
  50. doi request reprint Sensitized renal transplant recipients: current protocols and future directions
    James Gloor
    Department of Nephrology and Internal Medicine, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA
    Nat Rev Nephrol 6:297-306. 2010
    ..New interventions for preventing acute AMR, such as anti-C5 antibody-mediated complement blockade and proteasome inhibitor-mediated plasma cell depletion, are promising therapeutic avenues currently under investigation...
  51. ncbi request reprint Comparison of low versus high tacrolimus levels in kidney transplantation: assessment of efficacy by protocol biopsies
    Fernando G Cosio
    Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA
    Transplantation 83:411-6. 2007
    ..The use of calcineurin inhibitors is generally guided by drug blood levels. However, those levels are chosen based on clinical experience, lacking adequate titration studies...
  52. ncbi request reprint New onset hyperglycemia and diabetes are associated with increased cardiovascular risk after kidney transplantation
    Fernando G Cosio
    Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Kidney Int 67:2415-21. 2005
    ..Post-transplant diabetes (PTDM) is a common and serious complication of kidney transplantation. The implications of developing hyperglycemia of lesser severity are not well understood...
  53. ncbi request reprint Patient and graft outcomes from older living kidney donors are similar to those from younger donors despite lower GFR
    Lourdes S Peña de la Vega
    Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Kidney Int 66:1654-61. 2004
    ..Donor age adversely affects deceased-donor kidney transplant outcomes, but its influence on living-donor transplantation is less well characterized...
  54. ncbi request reprint Improved scoring system to assess adult donors for cadaver renal transplantation
    Scott L Nyberg
    Division of Transplantation Surgery, Mayo Clinic, Rochester, MN, USA
    Am J Transplant 3:715-21. 2003
    ..The improved system provides a quantitative approach to evaluation of marginal kidneys and may improve allocation of these organs in cadaver renal transplantation...
  55. ncbi request reprint Kidney allograft fibrosis and atrophy early after living donor transplantation
    Fernando G Cosio
    Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Am J Transplant 5:1130-6. 2005
    ..GIF frequently develops in the absence of risk factors. Lower GFR post-transplant identify patients at highest risk of GIF...
  56. ncbi request reprint Pancreas transplants: experience with 232 percutaneous US-guided biopsy procedures in 88 patients
    Thomas D Atwell
    Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Radiology 231:845-9. 2004
    ..To retrospectively assess the authors' experience with percutaneous ultrasonographic (US)-guided biopsy of pancreas transplants...
  57. ncbi request reprint Living donor kidney and autologous stem cell transplantation for primary systemic amyloidosis (AL) with predominant renal involvement
    Nelson Leung
    Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic and Foundation, Rochester, MN, USA
    Am J Transplant 5:1660-70. 2005
    ..This experience supports the feasibility of sequential living donor KTx and autologous SCT for carefully selected patients with ESRD due to AL...
  58. ncbi request reprint Early subclinical coronary artery calcification in young adults who were pediatric kidney transplant recipients
    Michael B Ishitani
    William J von Liebig Transplant Center, Mayo Medical School, Foundation and Clinic, Rochester, MN, USA
    Am J Transplant 5:1689-93. 2005
    ..These data suggest young adults who received pediatric kidney transplants are at increased risk for developing early CAC and need close monitoring to detect early CAD so as to prevent premature cardiac morbidity and mortality...
  59. ncbi request reprint Predicting subsequent decline in kidney allograft function from early surveillance biopsies
    Fernando G Cosio
    Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic and Foundation, Rochester, Minnnesota, USA
    Am J Transplant 5:2464-72. 2005
    ..In conclusion, inflammation and glomerulopathy 1 year post-transplant predict loss of graft function and graft failure independently of function and other variables...
  60. ncbi request reprint Chronic renal dysfunction late after liver transplantation
    Ari J Cohen
    Department of Surgery, Division of Transplantation, Mayo Clinic, Rochester, MN 55905, USA
    Liver Transpl 8:916-21. 2002
    ..Patients with a low GFR at 1 year (< 40 mL/min/BSA) are a high-risk group that might benefit from early therapeutic interventions aimed at preventing subsequent renal failure...
  61. ncbi request reprint Improving the prediction of donor kidney quality: deceased donor score and resistive indices
    Scott L Nyberg
    Division of Transplantation Surgery, Wilhelm Von Liebig Transplant Center, Mayo Clinic, Rochester, MN 55905, USA
    Transplantation 80:925-9. 2005
    ..This study was designed to compare DDS, ECD status, and RI as predictors of outcome after deceased donor transplantation. We were also interested to see if DDS or ECD could identify kidneys most likely to benefit from MP...
  62. ncbi request reprint Subclinical rejection in tacrolimus-treated renal transplant recipients
    James M Gloor
    Transplant Center, Mayo Foundation and Clinic, Rochester, Minnesota 55905, USA
    Transplantation 73:1965-8. 2002
    ..The intent of our study was to determine the incidence of subclinical rejection in tacrolimus-treated renal allograft recipients...
  63. ncbi request reprint A Comparison of splenectomy versus intensive posttransplant antidonor blood group antibody monitoring without splenectomy in ABO-incompatible kidney transplantation
    James M Gloor
    Department of Nephrology and Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Transplantation 80:1572-7. 2005
    ....
  64. ncbi request reprint Can a transplanted living donor kidney function equivalently to its native partner?
    Jorge A Velosa
    Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Am J Transplant 2:252-9. 2002
    ..Therapy with cyclosporine does not significantly inhibit early physiological adaptation of renal transplants...
  65. ncbi request reprint Immunomodulation through inhibition of multiple adhesion molecules generates resistance to autoimmune diabetes in NOD mice
    Dora Ninova
    Transplantation Immunology Research Laboratory, Division of Transplantation, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    J Autoimmun 23:201-9. 2004
    ..These findings suggest that adhesion molecule blockade does not prevent homing and may affect effector cell action through activation of immunoregulatory suppressor cells, leading to protection against development of diabetes...
  66. doi request reprint Abnormal circadian blood pressure pattern 1-year after kidney transplantation is associated with subsequent lower glomerular filtration rate in recipients without rejection
    Hani M Wadei
    Department of Transplantation, Mayo Clinic, Jacksonville, FL, USA
    J Am Soc Hypertens 5:39-47. 2011
    ..46, P = .01; r = 0.34, P = .03). The current study indicates that abnormal circadian BP pattern at 1 year identifies a group of kidney recipients at risk for increased kidney function loss and lower GFR 3-4 years from transplantation...
  67. pmc The association between age and nephrosclerosis on renal biopsy among healthy adults
    Andrew D Rule
    Mayo Clinic, Rochester, Minnesota, USA
    Ann Intern Med 152:561-7. 2010
    ..Chronic kidney disease is common with older age and is characterized on renal biopsy by global glomerulosclerosis, tubular atrophy, interstitial fibrosis, and arteriosclerosis...
  68. ncbi request reprint Preemptive living donor kidney transplantation: do the benefits extend to all recipients?
    Giulio R Innocenti
    William J von Liebig Transplant Center, Mayo Clinic and Foundation, Rochester, MN, USA
    Transplantation 83:144-9. 2007
    ..The aim of the current study was to compare recent outcomes of preemptive (P) versus nonpreemptive (NP) living donor kidney transplantation with an emphasis on high-risk recipients...
  69. ncbi request reprint Measured and estimated GFR in healthy potential kidney donors
    Andrew D Rule
    Division of Nephrology and Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Am J Kidney Dis 43:112-9. 2004
    ..Objectives of this study are to define the normal range of nonradiolabeled iothalamate clearance in potential kidney donors and assess whether creatinine-based GFR estimates are accurate in this population...
  70. ncbi request reprint Correlation of quantitative digital image analysis with the glomerular filtration rate in chronic allograft nephropathy
    Montserrat M Diaz Encarnacion
    Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Am J Transplant 4:248-56. 2004
    ..Validation of the SR-nonpolarized strategy against histologic scoring and GFR supports the application of this technique to longitudinal studies of CAN...
  71. ncbi request reprint Decline in native renal function early after bladder-drained pancreas transplantation alone
    Marek J Mazur
    Department of Internal Medicine, Division of Nephrology, Mayo Clinic, Rochester, MN 55905, USA
    Transplantation 77:844-9. 2004
    ..This study examines trends in native renal function during the first posttransplant year in PTA recipients with a spectrum of pretransplant glomerular filtration rates (GFR)...
  72. doi request reprint Inter and intra laboratory concordance of HLA antibody results obtained by single antigen bead based assay
    Manish J Gandhi
    Division of Transfusion Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Hum Immunol 74:310-7. 2013
    ..991-0.997, while within laboratory it was 0.997-0.999. There is good correlation between laboratories and within laboratory using the same manufacturer, same lot and same protocol while performing SAB...
  73. ncbi request reprint Blood pressure evaluation among older living kidney donors
    Stephen C Textor
    Department of Internal Medicine, Divisions of Hypertension and Nephrology, Mayo Clinic, Rochester, Minnesota, USA
    J Am Soc Nephrol 14:2159-67. 2003
    ..Detailed evaluations of ABPM findings, GFR, and urinary protein levels are warranted for Caucasian subjects with high clinic BP readings who are otherwise suitable potential donors...
  74. doi request reprint Epidemiology of infections requiring hospitalization during long-term follow-up of pancreas transplantation
    Nassir Rostambeigi
    Division of Endocrinology, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
    Transplantation 89:1126-33. 2010
    ..Bladder drainage increases infection risk and low ALC partially predicts episodes. Limitations include retrospective design, unequal composition of PT groups, and lack of data between kidney and PT for PAK...
  75. ncbi request reprint Conquering absolute contraindications to transplantation: positive-crossmatch and ABO-incompatible kidney transplantation
    Patrick G Dean
    Division of Transplantation Surgery, Department of Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Surgery 137:269-73. 2005
  76. doi request reprint Pulmonary hypertension is associated with reduced patient survival after kidney transplantation
    Naim Issa
    Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Transplantation 86:1384-8. 2008
    ..Pulmonary hypertension (PH) is common in patients on dialysis where it is associated with reduced survival. The possible association between PH and kidney transplant recipient survival has not been previously evaluated...
  77. ncbi request reprint Differences between early and late posttransplant lymphoproliferative disorders in solid organ transplant patients: are they two different diseases?
    Irene M Ghobrial
    Division of Hematology, Department of Internal Medicine, Mayo Clinic, 200 First Street, Rochester, MN 55905, USA
    Transplantation 79:244-7. 2005
    ....
  78. doi request reprint Relationship between FKBP5 polymorphisms and depression symptoms among kidney transplant recipients
    Gen Shinozaki
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Depress Anxiety 28:1111-8. 2011
    ....
  79. ncbi request reprint Prospective, randomized, multi-center trial of antibody induction therapy in simultaneous pancreas-kidney transplantation
    Dixon B Kaufman
    Feinberg School of Medicine at Northwestern University, Chicago, IL, USA
    Am J Transplant 3:855-64. 2003
    ..Decisions regarding the routine use of induction therapy in SPK transplantation must take into consideration its differential effects on risk of rejection and infection...
  80. ncbi request reprint Should we be performing pancreas transplants?
    Herwig Ulf Meier-Kriesche
    Am J Transplant 4:1935-6. 2004
  81. ncbi request reprint The development of kidney allocation policy
    Mark D Stegall
    Am J Kidney Dis 46:974-5. 2005
  82. ncbi request reprint Prognostic analysis for survival in adult solid organ transplant recipients with post-transplantation lymphoproliferative disorders
    Irene M Ghobrial
    Division of Hematology, Department of Internal Medicine, Mayo Clinic and Mayo Foundation, 200 First St, SW, Rochester, MN 55905, USA
    J Clin Oncol 23:7574-82. 2005
    ..The objective of this study was to determine prognostic factors for overall survival in patients with post-transplantation lymphoproliferative disorders (PTLDs)...
  83. ncbi request reprint Prospective, randomized evaluation of a cuffed expanded polytetrafluoroethylene graft for hemodialysis vascular access
    Abraham J Sorom
    Division of Transplantation, Mayo Medical School, Mayo Clinic, Rochester, Minn 55905, USA
    Surgery 132:135-40. 2002
    ..The purpose of this study was to compare graft patency and blood flow rates of cuffed and noncuffed (standard) ePTFE grafts placed for hemodialysis access...
  84. ncbi request reprint A novel model of allograft rejection: immune reconstitution of Rag-1 recipients with 2C transgenic T-cell receptor lymphocytes
    Dora Ninova
    The Transplant Immunology Laboratory, Division of Transplant Surgery, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Transpl Int 18:101-10. 2005
    ..This model of allorejection may be useful to study the activation and homing of allospecific cells in vivo...
  85. ncbi request reprint Forskolin suppresses insulin gene transcription in islet beta-cells through a protein kinase A-independent pathway
    Wei Qun Ding
    Department of Medicine, Center for Basic Research in Digestive Diseases, Mayo Clinic and Foundation, Guggenheim 17, Rochester, MN 55905, USA
    Cell Signal 15:27-35. 2003
    ..These results demonstrate that forskolin suppresses insulin transcription in INS-1 cells through a PKA-independent mechanism that probably involves MAP kinase signalling...

Research Grants4

  1. VLA4 IN CTL MEDIATED ISLET ALLOGRAFT REJECTION
    Mark Stegall; Fiscal Year: 2001
    ..The approach may lead to novel forms of immune suppression that may benefit not only islet transplantation, but also other types of organ allografts. ..
  2. Chronic Antibody-Mediated Injury in Renal Allografts
    Mark D Stegall; Fiscal Year: 2010
    ..This study aims to understand how these antibodies destroy the kidney and also will test if a new drug can prevent this destruction by blocking the immune system's ability to make these antibodies. ..