Virend Somers

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. doi request reprint Sleep apnea and cardiovascular disease: an American Heart Association/American College of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on
    Virend K Somers
    J Am Coll Cardiol 52:686-717. 2008
  2. pmc Leptin signaling in adipose tissue: role in lipid accumulation and weight gain
    Prachi Singh
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA
    Circ Res 111:599-603. 2012
  3. pmc Obstructive sleep apnea and vascular disease
    P Lanfranchi
    Mayo Clinic, Rochester, Minnesota 55905, USA
    Respir Res 2:315-9. 2001
  4. pmc Effect of weight gain on cardiac autonomic control during wakefulness and sleep
    Taro Adachi
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905
    Hypertension 57:723-30. 2011
  5. ncbi request reprint Association of atrial fibrillation and obstructive sleep apnea
    Apoor S Gami
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First St SW, Rochester, Minn 55905, USA
    Circulation 110:364-7. 2004
  6. pmc Sleep-disordered breathing in patients with the Brugada syndrome
    Paula G Macedo
    Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN, USA
    Am J Cardiol 107:709-13. 2011
  7. ncbi request reprint Obstructive sleep apnea and cardiovascular disease
    James M Parish
    Sleep Disorders Center and Division of Pulmonary Medicine and Internal Medicine, Mayo Clinic College of Medicine, Scottsdale, Ariz 85259, USA
    Mayo Clin Proc 79:1036-46. 2004
  8. ncbi request reprint Obstructive sleep apnea and the recurrence of atrial fibrillation
    Ravi Kanagala
    Mayo Clinic, 200 First St SW, Rochester, Minn 55905, USA
    Circulation 107:2589-94. 2003
  9. doi request reprint Role of smoking in the recurrence of atrial arrhythmias after cardioversion
    Masayoshi Kinoshita
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA
    Am J Cardiol 104:678-82. 2009
  10. pmc Diagnostic accuracy of split-night polysomnograms
    Imran S Khawaja
    Center for Sleep Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Clin Sleep Med 6:357-62. 2010

Research Grants

Detail Information

Publications91

  1. doi request reprint Sleep apnea and cardiovascular disease: an American Heart Association/American College of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on
    Virend K Somers
    J Am Coll Cardiol 52:686-717. 2008
  2. pmc Leptin signaling in adipose tissue: role in lipid accumulation and weight gain
    Prachi Singh
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA
    Circ Res 111:599-603. 2012
    ..Increases in leptin have been shown to impair leptin signaling via caveolin-1-dependent mechanisms. However, the role of hyperleptinemia versus impaired leptin signaling in adipose tissue is not known...
  3. pmc Obstructive sleep apnea and vascular disease
    P Lanfranchi
    Mayo Clinic, Rochester, Minnesota 55905, USA
    Respir Res 2:315-9. 2001
    ..This brief commentary will examine the evidence and mechanisms linking OSA to vascular disease...
  4. pmc Effect of weight gain on cardiac autonomic control during wakefulness and sleep
    Taro Adachi
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905
    Hypertension 57:723-30. 2011
    ..Short-term fat gain in healthy subjects is associated with increased cardiac sympathetic activation during wakefulness and sleep, but the mechanisms remain unclear...
  5. ncbi request reprint Association of atrial fibrillation and obstructive sleep apnea
    Apoor S Gami
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First St SW, Rochester, Minn 55905, USA
    Circulation 110:364-7. 2004
    ..Obstructive sleep apnea (OSA) is associated with recurrent atrial fibrillation (AF) after electrocardioversion. OSA is highly prevalent in patients who are male, obese, and/or hypertensive, but its prevalence in patients with AF is unknown...
  6. pmc Sleep-disordered breathing in patients with the Brugada syndrome
    Paula G Macedo
    Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN, USA
    Am J Cardiol 107:709-13. 2011
    ..Moreover, autonomic instability encountered in rapid eye movement sleep and arousals could potentiate the risk of arrhythmias...
  7. ncbi request reprint Obstructive sleep apnea and cardiovascular disease
    James M Parish
    Sleep Disorders Center and Division of Pulmonary Medicine and Internal Medicine, Mayo Clinic College of Medicine, Scottsdale, Ariz 85259, USA
    Mayo Clin Proc 79:1036-46. 2004
    ..Leukocyte adhesion and accumulation on endothelial cells are common in both OSA and atherosclerosis. Clinicians should be aware that OSA may be a risk factor for the development of cardiovascular disease...
  8. ncbi request reprint Obstructive sleep apnea and the recurrence of atrial fibrillation
    Ravi Kanagala
    Mayo Clinic, 200 First St SW, Rochester, Minn 55905, USA
    Circulation 107:2589-94. 2003
    ..We tested the hypothesis that patients with untreated obstructive sleep apnea (OSA) would be at increased risk for recurrence of atrial fibrillation (AF) after cardioversion...
  9. doi request reprint Role of smoking in the recurrence of atrial arrhythmias after cardioversion
    Masayoshi Kinoshita
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA
    Am J Cardiol 104:678-82. 2009
    ..In conclusion, smoking is an independent predictor of atrial arrhythmia recurrence after cardioversion in women; however, an increased mortality risk, but not arrhythmia recurrence risk, was seen in men...
  10. pmc Diagnostic accuracy of split-night polysomnograms
    Imran S Khawaja
    Center for Sleep Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Clin Sleep Med 6:357-62. 2010
    ..The aim of this study was to determine the diagnostic accuracy of SN-PSG, including at the lower range of AHIs...
  11. ncbi request reprint Early morning attenuation of endothelial function in healthy humans
    Maria E Otto
    Mayo Foundation, Rochester, Minn 55905, USA
    Circulation 109:2507-10. 2004
    ..We tested the hypothesis that endothelial function is reduced in the early morning, around the time of waking, compared with measurements obtained both before sleep and later in the day in healthy humans...
  12. ncbi request reprint Sleep-disordered breathing and cardiovascular disease
    Robert Wolk
    Mayo Clinic, Rochester, MN 55902, USA
    Circulation 108:9-12. 2003
  13. ncbi request reprint Plasma brain natriuretic peptide in obstructive sleep apnea
    Anna Svatikova
    Mayo Clinic Foundation, 200 First Street SW, Rochester, MH 55905, USA
    Am J Cardiol 94:529-32. 2004
    ..However, OSA did not elicit acute overnight changes in BNP, either in normal subjects or in patients with coexisting cardiovascular disease (including chronic heart failure)...
  14. ncbi request reprint Therapy Insight: interactions between atrial fibrillation and obstructive sleep apnea
    Apoor S Gami
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, MN 55905, USA
    Nat Clin Pract Cardiovasc Med 2:145-9. 2005
    ..Many data have been obtained from studies with focuses other than the direct relationship between OSA and AF. Studies carefully designed to investigate the relevant issues are now needed...
  15. doi request reprint Interactions between sleep disordered breathing and atrial fibrillation in patients with hypertrophic cardiomyopathy
    Tomas Konecny
    Mayo Clinic, Rochester, Minnesota, USA
    Am J Cardiol 105:1597-602. 2010
    ..SDB may therefore be an important and potentially modifiable cause of morbidity and mortality in this population...
  16. ncbi request reprint Update in prevention of atherosclerotic heart disease: management of major cardiovascular risk factors
    Abel Romero-Corral
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic College of Medicine, Mayo Foundation, Rochester, MN, USA
    Rev Invest Clin 58:237-44. 2006
    ..We also discuss obstructive sleep apnea (OSA) as a recently identified cardiovascular risk factor, and provide a general overview about its pathophysiology and treatment...
  17. ncbi request reprint Comparison of right and left ventricular function in obese and nonobese men
    Maria E Otto
    Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Cardiol 93:1569-72. 2004
    ..Obese subjects had increased left ventricular mass and normal left ventricular systolic and diastolic function. They also had impaired right ventricular relaxation and right ventricular filling...
  18. ncbi request reprint Relapse and mortality following cardioversion of new-onset vs. recurrent atrial fibrillation and atrial flutter in the elderly
    Ahmad A Elesber
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Eur Heart J 27:854-60. 2006
    ..Our objective was to assess the relapse rate and the effect of the relapse of new-onset atrial arrhythmias on mortality after direct-current cardioversion (DCCV)...
  19. doi request reprint Incidence of subclinical atherosclerosis as a marker of cardiovascular risk in retired professional football players
    R Todd Hurst
    Division of Cardiovascular Diseases, Mayo Clinic, Scottsdale, Arizona, USA
    Am J Cardiol 105:1107-11. 2010
    ..9%, p = 0.23). In conclusion, despite their elite athletic histories, former professional football players have a similar prevalence of advanced subclinical atherosclerosis as a clinically referred population of overweight and obese men...
  20. pmc Independent association between obstructive sleep apnea and subclinical coronary artery disease
    Dan Sorajja
    Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Chest 133:927-33. 2008
    ..We evaluated the association between OSA and the presence of subclinical coronary disease assessed by coronary artery calcification (CAC)...
  21. doi request reprint New insights into the predictors of left atrial stunning after successful direct-current cardioversion of atrial fibrillation and flutter
    Rowlens M Melduni
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Soc Echocardiogr 21:848-54. 2008
    ..Direct-current cardioversion (DCCV) of atrial fibrillation and atrial flutter commonly causes post-DCCV left atrial (LA) stunning (LAS), which may potentiate thromboembolic complications. Data on LAS determinants are inconclusive...
  22. ncbi request reprint Association between plasma adiponectin levels and unstable coronary syndromes
    Robert Wolk
    Division of Cardiovascular Diseases, Mayo Clinic, 1216 Second Street SW, Rochester, MN 55902, USA
    Eur Heart J 28:292-8. 2007
    ..This study evaluated the association between adiponectin and ACS...
  23. doi request reprint Implications of obstructive sleep apnea for atrial fibrillation and sudden cardiac death
    Apoor S Gami
    Heart Rhythm Services, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Cardiovasc Electrophysiol 19:997-1003. 2008
    ..Currently, few data exist to support the efficacy of OSA therapy, namely continuous positive airway pressure, as an adjunct for arrhythmia prevention or management...
  24. pmc Exercise oscillatory ventilation: instability of breathing control associated with advanced heart failure
    Lyle J Olson
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Chest 133:474-81. 2008
    ..40. The aim of this study was to compare clinical characteristics including ventilatory responses of subjects with EOV to those of control subjects with HF matched for LVEF...
  25. ncbi request reprint Sleep-disordered breathing and cardiovascular risk
    Sean M Caples
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Sleep 30:291-303. 2007
    ..Available evidence regarding the implications of CSA in the context of heart failure is discussed...
  26. ncbi request reprint Comparison of cardiac structural and functional changes in obese otherwise healthy adults with versus without obstructive sleep apnea
    Maria E Otto
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Am J Cardiol 99:1298-302. 2007
    ..1 +/- 0.5 cm/s in those with OSA, p = 0.1) beyond that seen in obesity alone. In conclusion, OSA independent of obesity may induce cardiac changes that could predispose to atrial fibrillation and heart failure...
  27. ncbi request reprint Sleep apnea: implications for heart failure
    Lyle J Olson
    Department of Internal Medicine, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Curr Heart Fail Rep 4:63-9. 2007
    ..There is no consensus regarding treatment for central sleep apnea. Studies which evaluate cardiovascular endpoints will be necessary to define management strategies for patients with CHF and either obstructive or central sleep apnea...
  28. ncbi request reprint Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies
    Apoor S Gami
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 49:403-14. 2007
    ..The purpose of this research was to assess the association between the metabolic syndrome (MetSyn) and cardiovascular events and mortality by meta-analyses of longitudinal studies...
  29. ncbi request reprint The scoring of cardiac events during sleep
    Sean M Caples
    Mayo Clinic College of Medicine, Rochester, MN, USA
    J Clin Sleep Med 3:147-54. 2007
    ..In the future, expansion to multiple ECG leads and the use of alternative tools may provide better definition of heart rates and cardiac events during sleep...
  30. ncbi request reprint Adipose tissue of atrial septum as a marker of coronary artery disease
    Nithima Chaowalit
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, 200 First St, Rochester, MN 55905, USA
    Chest 132:817-22. 2007
    ..Adipose tissue is the main determinant of atrial septum thickness. The association between atrial septum thickness and coronary artery disease (CAD) has never been studied...
  31. pmc Weight change after myocardial infarction--the Enhancing Recovery in Coronary Heart Disease patients (ENRICHD) experience
    Francisco Lopez-Jimenez
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine and Mayo Clinic Foundation, Rochester, MN, USA
    Am Heart J 155:478-84. 2008
    ..The relationship of changes in weight to outcomes in patients after myocardial infarction (MI) is controversial...
  32. ncbi request reprint Diagnostic performance of body mass index to detect obesity in patients with coronary artery disease
    Abel Romero-Corral
    Division of Cardiovascular Diseases, Department of Internal Medicine, Gonda 5 368, 200 First Street SW, Rochester, MN 55905, USA
    Eur Heart J 28:2087-93. 2007
    ..We hypothesize that these results are related to the poor diagnostic performance of BMI to detect adiposity, especially in the intermediate BMI ranges...
  33. ncbi request reprint Differentiating between body fat and lean mass-how should we measure obesity?
    Abel Romero-Corral
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Nat Clin Pract Endocrinol Metab 4:322-3. 2008
  34. doi request reprint Short-term effects of cardiac resynchronization therapy on sleep-disordered breathing in patients with systolic heart failure
    Tomas Kara
    International Clinical Research Center Brno, St Anne s University Hospital Brno, Pekarska 53, 65691 Brno, Czech Republic
    Chest 134:87-93. 2008
    ..We evaluated the short-term effect of cardiac resynchronization therapy (CRT) on sleep apnea in patients with systolic heart failure...
  35. ncbi request reprint Body mass index: a risk factor for unstable angina and myocardial infarction in patients with angiographically confirmed coronary artery disease
    Robert Wolk
    Division of Cardiovascular Diseases, Mayo Clinic, 1216 Second St SW, Rochester, Minn 55902, USA
    Circulation 108:2206-11. 2003
    ..We hypothesized that body mass index (BMI) might be an independent predictor of an acute coronary syndrome in patients with established coronary atherosclerosis...
  36. ncbi request reprint Leptin and the ventilatory response to exercise in heart failure
    Robert Wolk
    Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 42:1644-9. 2003
    ..The aim of the study was to test the hypothesis that leptin is involved in the regulation of ventilatory responses to exercise in chronic heart failure (CHF)...
  37. ncbi request reprint Cardiovascular consequences of obstructive sleep apnoea
    Fatima H Sert Kuniyoshi
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN, USA
    Indian J Med Res 131:196-205. 2010
    ..Randomized intervention studies are needed to establish whether early identification and treatment of OSA patients reduces cardiovascular morbidity...
  38. ncbi request reprint Plasma adrenomedullin and obstructive sleep apnea
    Robert Wolk
    Mayo Clinic, Rochester, Minnesota, USA
    Am J Hypertens 17:74-6. 2004
    ..Obstructive sleep apnea (OSA) is associated with hypertension. The vasorelaxing peptide adrenomedullin (ADM) may counteract effects of OSA-induced release of vasopressor substances...
  39. ncbi request reprint Cardiac troponin T in obstructive sleep apnea
    Apoor S Gami
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Chest 125:2097-100. 2004
    ..We tested the hypothesis that severe nocturnal hypoxia in patients with OSA causes myocyte necrosis as evidenced by increases in cardiac troponin T...
  40. ncbi request reprint Elevated C-reactive protein in patients with obstructive sleep apnea
    Abu S M Shamsuzzaman
    Mayo Clinic Rochester, Rochester, MN 59905, USA
    Circulation 105:2462-4. 2002
    ..Inflammatory processes associated with OSA may contribute to cardiovascular morbidity in these patients. We tested the hypothesis that OSA patients have increased plasma C-reactive protein (CRP)...
  41. pmc Trends in 10-year predicted risk of cardiovascular disease in the United States, 1976 to 2004
    Francisco Lopez-Jimenez
    Divisions of Cardiovascular Diseases, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Circ Cardiovasc Qual Outcomes 2:443-50. 2009
    ..We assessed these trends by applying the Framingham Heart Study prediction model to national data...
  42. pmc The effects of sildenafil and acetazolamide on breathing efficiency and ventilatory control during hypoxic exercise
    Sophie Lalande
    Division of Cardiovascular Diseases, Mayo Clinic, College of Medicine, Rochester, MN 55905, USA
    Eur J Appl Physiol 106:509-15. 2009
    ....
  43. ncbi request reprint Safety and efficacy of bariatric surgery in patients with coronary artery disease
    Francisco Lopez-Jimenez
    Department of Internal Medicine and Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Mayo Clin Proc 80:1157-62. 2005
    ..To determine the safety and efficacy of bariatric surgery in obese patients with documented coronary artery disease (CAD)...
  44. pmc Major weight loss prevents long-term left atrial enlargement in patients with morbid and extreme obesity
    Carolina A Garza
    Division of Cardiovascular Diseases, Department of Medicine, 200 First St SW, Rochester 55905, MN, USA
    Eur J Echocardiogr 9:587-93. 2008
    ....
  45. pmc Effect of bariatric surgery on the metabolic syndrome: a population-based, long-term controlled study
    John A Batsis
    Division of Primary Care Internal Medicine, Mayo Clinic, Rochester, MN, USA
    Mayo Clin Proc 83:897-907. 2008
    ..To assess the effect of weight loss by bariatric surgery on the prevalence of the metabolic syndrome (MetS) and to examine predictors of MetS resolution...
  46. pmc Dynamic changes of left ventricular performance and left atrial volume induced by the mueller maneuver in healthy young adults and implications for obstructive sleep apnea, atrial fibrillation, and heart failure
    Marek Orban
    Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA
    Am J Cardiol 102:1557-61. 2008
    ..These changes reflected an increase in LV afterload. Repeated swings in afterload burden and chamber volumes may have implications for the future development of atrial fibrillation and heart failure...
  47. ncbi request reprint Prevalence and management of central sleep apnea in heart failure patients
    Farouk Mookadam
    Mayo Clinic College of Medicine, Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA
    Curr Heart Fail Rep 5:233-7. 2008
    ..Currently, CSA treatment involves standard optimal HF therapies, although growing evidence indicates that newer ventilation modes and cardiac resynchronization therapy may prove to be useful...
  48. ncbi request reprint Plasma levels of adiponectin, a novel adipocyte-derived hormone, in sleep apnea
    Robert Wolk
    Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Mayo Foundation, St Mary s Hospital, DO 4 350, 1216 Second Street SW, Rochester, MN 55902, USA
    Obes Res 13:186-90. 2005
    ..The purpose of the study was to investigate whether OSA affected plasma levels of adiponectin, which might help explain OSA-associated cardiovascular morbidity...
  49. ncbi request reprint Evidence for liver injury in the setting of obstructive sleep apnea
    Thomas J Byrne
    Division of Hepatology, Department of Internal Medicine, Mayo Clinic, Phoenix, Arizona, USA
    Ann Hepatol 11:228-31. 2012
    ..Obstructive sleep apnea (OSA) and non-alcoholic fatty liver disease (NAFLD) are both strongly associated with obesity. Whether OSA is an independent risk factor for liver injury is uncertain...
  50. pmc Interactions between obesity and obstructive sleep apnea: implications for treatment
    Abel Romero-Corral
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Mayo Foundation, Rochester, MN 55905, USA
    Chest 137:711-9. 2010
    ..Rather, a multidisciplinary and integrated strategy is required to achieve effective and long-lasting therapeutic success...
  51. ncbi request reprint Decreased right and left ventricular myocardial performance in obstructive sleep apnea
    Abel Romero-Corral
    Division of Cardiovascular Diseases, Gonda 5 368, Mayo Clinic College of Medicine, Mayo Foundation, 200 First St SW, Rochester MN 55905, USA
    Chest 132:1863-70. 2007
    ..Obstructive sleep apnea (OSA) may predispose patients to congestive heart failure (CHF), suggesting a deleterious effect of OSA on myocardial contractility...
  52. ncbi request reprint Effect of weight loss on predicted cardiovascular risk: change in cardiac risk after bariatric surgery
    John A Batsis
    Division of Primary Care Internal Medicine, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Obesity (Silver Spring) 15:772-84. 2007
    ..Our goal was to assess the effect of bariatric surgery on cardiovascular risk estimations of preventable, long-term adverse outcomes...
  53. ncbi request reprint Plasma leptin and prognosis in patients with established coronary atherosclerosis
    Robert Wolk
    Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA
    J Am Coll Cardiol 44:1819-24. 2004
    ..This study was designed to evaluate the relationship between plasma leptin and prognosis in patients with angiographically confirmed coronary atherosclerosis...
  54. ncbi request reprint Independent association between plasma leptin and C-reactive protein in healthy humans
    Abu S M Shamsuzzaman
    Division of Cardiovascular Diseases, Mayo Clinic Rochester, Rochester, Minn 55905, USA
    Circulation 109:2181-5. 2004
    ..We tested the hypothesis that leptin is associated with CRP levels independently of the influences of gender, body mass index (BMI), waist-to-hip ratio, and other variables...
  55. ncbi request reprint Cardiopulmonary consequences of obstructive sleep apnea
    Sean M Caples
    Department of Medicine, Divisions of Pulmonary and Critical Care Medicine, Mayo Clinic, 200 First Street SW, Rochester, NY 10001, USA
    Semin Respir Crit Care Med 26:25-32. 2005
    ..This review discusses some of the physiological mechanisms associated with disordered breathing during sleep and explores putative cardiopulmonary disease associations...
  56. ncbi request reprint High sensitivity C-reactive protein: a novel predictor for recurrence of atrial fibrillation after successful cardioversion
    Joseph F Malouf
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 46:1284-7. 2005
    ..We sought to test the hypothesis that C-reactive protein (CRP) can predict the recurrence of atrial fibrillation (AF) after successful electrical cardioversion (CV)...
  57. ncbi request reprint Interactions between obstructive sleep apnea and the metabolic syndrome
    Anna Svatikova
    Mayo Clinic College of Medicine, 200 First Street, SW, Rochester, MN 55905, USA
    Curr Diab Rep 5:53-8. 2005
    ....
  58. ncbi request reprint Sleep apnea and cardiovascular disease. Implications for understanding erectile dysfunction
    Adelaide M Arruda-Olson
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Herz 28:298-303. 2003
    ..This review will examine the evidence and potential mechanisms, including abnormalities of neural, endothelial and hormonal function, linking OSA to erectile dysfunction...
  59. ncbi request reprint Obstructive sleep apnea, obesity, and the risk of incident atrial fibrillation
    Apoor S Gami
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    J Am Coll Cardiol 49:565-71. 2007
    ..This study sought to identify whether obesity and obstructive sleep apnea (OSA) independently predict incident atrial fibrillation/flutter (AF)...
  60. ncbi request reprint Sex-selective QT prolongation during rapid eye movement sleep
    Paola A Lanfranchi
    Department of Internal Medicine, Mayo Clinic, Rochester, Minn 55905, USA
    Circulation 106:1488-92. 2002
    ..We examined the effects of the various sleep stages on RR and QT intervals in healthy subjects and tested the hypothesis that there is a differential effect of sleep stage on QT interval in women compared with men...
  61. ncbi request reprint Influence of cardiac function and failure on sleep-disordered breathing: evidence for a causative role
    Sean M Caples
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Appl Physiol 99:2433-9. 2005
    ..This review will examine experimental and observational data that explore possible pathophysiological mechanisms and potential targets for therapy in heart failure and sleep-disordered breathing...
  62. ncbi request reprint Oxidative stress in obstructive sleep apnoea
    Anna Svatikova
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Eur Heart J 26:2435-9. 2005
    ..We tested the hypothesis that measures of oxidative stress are increased in otherwise healthy subjects with OSA when compared to closely matched OSA-free control subjects...
  63. ncbi request reprint Obesity, sleep apnea, and hypertension
    Robert Wolk
    Mayo Clinic, Rochester, Minn, USA
    Hypertension 42:1067-74. 2003
    ....
  64. ncbi request reprint Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: a systematic review of cohort studies
    Abel Romero-Corral
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Mayo Foundation, Rochester, MN 55905, USA
    Lancet 368:666-78. 2006
    ..We undertook a systematic review to determine the extent and nature of this association...
  65. ncbi request reprint Effects of beta-blocker therapy on ventilatory responses to exercise in patients with heart failure
    Robert Wolk
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Card Fail 11:333-9. 2005
    ..We hypothesized beta-blockers increase ventilatory efficiency in patients with CHF...
  66. ncbi request reprint Sleep-disordered breathing: implications for the pathophysiology and management of cardiovascular disease
    Christy A Nelson
    Division of Hypertension and Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55906, USA
    Compr Ther 31:21-7. 2005
    ..Diagnosis and treatment of sleep apnea and the implications for cardiovascular disease are discussed...
  67. ncbi request reprint Sleep and cardiovascular disease
    Robert Wolk
    Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Curr Probl Cardiol 30:625-62. 2005
    ..Further understanding of specific pathophysiological pathways linking sleep disorders to cardiovascular disease is important for developing therapeutic strategies and may have important implications for cardiovascular chronotherapeutics...
  68. pmc Obstructive sleep apnea, inflammation, and the metabolic syndrome
    Andrew D Calvin
    Mayo School of Graduate Medical Education, Mayo Clinic, Rochester, Minnesota 55905, USA
    Metab Syndr Relat Disord 7:271-8. 2009
    ..Whether some or all of these metabolic alterations mechanistically link OSA to metabolic syndrome remains to be proven, but it is an area of intense scientific interest...
  69. ncbi request reprint Serum amyloid a in obstructive sleep apnea
    Anna Svatikova
    Mayo Foundation, Rochester, Minn, USA
    Circulation 108:1451-4. 2003
    ..Serum amyloid A (SAA) protein has recently been linked to the development of atherosclerosis, stroke, diabetes, and dementia. We tested the hypothesis that plasma SAA levels are increased in otherwise healthy subjects with OSA...
  70. doi request reprint Changes in left and right ventricular mechanics during the Mueller maneuver in healthy adults: a possible mechanism for abnormal cardiac function in patients with obstructive sleep apnea
    Yuki Koshino
    Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Circ Cardiovasc Imaging 3:282-9. 2010
    ..In this research, the changes in strain (S) and strain rate (SR) during the performance of the Mueller maneuver (MM) in an effort to better understand how negative intrathoracic pressures affect ventricular mechanics...
  71. pmc Day-night variation of acute myocardial infarction in obstructive sleep apnea
    Fatima H Sert Kuniyoshi
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 52:343-6. 2008
    ..This study sought to evaluate the day-night variation of acute myocardial infarction (MI) in patients with obstructive sleep apnea (OSA)...
  72. ncbi request reprint Pathophysiological characteristics of heart rate recovery in heart failure
    Robert Wolk
    Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Med Sci Sports Exerc 38:1367-73. 2006
    ..Heart failure (HF) is associated with blunted HR recovery after exercise. The determinants of altered HR recovery in HF are unknown. The aim of this study was to investigate clinical correlates of HR recovery in HF patients...
  73. pmc Obstructive sleep apnea, cardiovascular disease, and pulmonary hypertension
    Jason M Golbin
    Division of Pulmonary, Mayo Clinic, Rochester, MN 55905, USA
    Proc Am Thorac Soc 5:200-6. 2008
    ..This review examines pathophysiologic mechanisms and explores current concepts regarding the impact of OSA and its treatment on selected clinical disease states...
  74. ncbi request reprint Relationship between age-related macular degeneration-associated variants of complement factor H and LOC387715 with coronary artery disease
    Jose S Pulido
    Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 82:301-7. 2007
    ..To determine whether either of the gene variants associated with age-related macular degeneration is associated with coronary artery disease (CAD)...
  75. pmc Diagnostic accuracy of the Berlin Questionnaire in detecting sleep-disordered breathing in patients with a recent myocardial infarction
    Fatima H Sert Kuniyoshi
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN, USA
    Chest 140:1192-7. 2011
    ..However, there are no data regarding the validity of the BQ in detecting the presence of SDB in patients after myocardial infarction (MI). The aim of this study was to determine the performance of the BQ in patients after MI...
  76. pmc Patients with obstructive sleep apnea exhibit impaired endothelial function after myocardial infarction
    Fatima H Sert Kuniyoshi
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Chest 140:62-7. 2011
    ..These patients often have obstructive sleep apnea (OSA). We tested the hypothesis that patients with OSA post MI will exhibit more severe impairment in FMD...
  77. ncbi request reprint Sleep disordered breathing and risk factors for cardiovascular disease
    Bradley G Phillips
    College of Pharmacy, University of Iowa, Iowa City 52242, USA
    Curr Opin Pulm Med 8:516-20. 2002
    ....
  78. ncbi request reprint Central sleep apnea in left ventricular dysfunction: prevalence and implications for arrhythmic risk
    Paola A Lanfranchi
    Division of Cardiology, Fondazione Salvatore Maugeri IRCCS, Veruno, Italy
    Circulation 107:727-32. 2003
    ....
  79. ncbi request reprint Hypertension and obstructive sleep apnea
    Bradley G Phillips
    College of Pharmacy, University of Iowa, Iowa City, IA 52242, USA
    Curr Hypertens Rep 5:380-5. 2003
    ..Patients with sleep apnea are often obese and may be predisposed to weight gain. Hence, obesity may further contribute to hypertension in this patient population...
  80. doi request reprint Prevalence of metabolic syndrome in retired National Football League players
    Marc A Miller
    The Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai Medical Center, New York, New York, USA
    Am J Cardiol 101:1281-4. 2008
    ....
  81. ncbi request reprint Erythropoietin and obstructive sleep apnea
    Mikolaj Winnicki
    Medical University of Gdansk, Gdansk, Poland
    Am J Hypertens 17:783-6. 2004
    ..We tested the hypothesis that repetitive severe hypoxemia resulting from obstructive sleep apnea would increase serum erythropoietin, and that this increase would be attenuated by effective treatment of obstructive sleep apnea...
  82. ncbi request reprint Treating central sleep apnea in heart failure: outcomes revisited
    Lyle J Olson
    Circulation 115:3140-2. 2007
  83. ncbi request reprint The effect of patient sex on recurrence of atrial fibrillation following successful direct current cardioversion
    Osnat T Gurevitz
    Division of Electrophysiology and Pacing, Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Israel
    Am Heart J 152:155.e9-13. 2006
    ..The effect of patient sex on recurrence of atrial fibrillation after a successful direct current cardioversion is unknown...
  84. ncbi request reprint Activity-adjusted 24-hour ambulatory blood pressure and cardiac remodeling in children with sleep disordered breathing
    Raouf Amin
    Cincinnati Children s Hospital Medical Center, Ohio, USA
    Hypertension 51:84-91. 2008
    ..The association between left ventricular remodeling and 24-hour blood pressure highlights the role of sleep disordered breathing in increasing cardiovascular morbidity...
  85. ncbi request reprint Stress measures linking sleep apnea, hypertension and diabetes--AHI vs arousals vs hypoxemia
    Francisco Lopez-Jimenez
    Sleep 29:743-4. 2006
  86. ncbi request reprint Sleep apnea in hypertension: when, how, and why should we treat?
    Fatima H Sert Kuniyoshi
    Hypertension 47:818-9. 2006
  87. ncbi request reprint Modulation of cardiovascular risk factors by obstructive sleep apnea
    Lyle J Olson
    Chest 129:218-20. 2006
  88. ncbi request reprint Atrial fibrillation, sleep apnea and obesity
    Mina K Chung
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk F 15, Cleveland, OH 44195, USA
    Nat Clin Pract Cardiovasc Med 1:56-9, quiz 1 p following 59. 2004
    ..He was scheduled for catheter ablation targeting pulmonary vein antral isolation. He embarked on a weight-loss program, which successfully reduced AF burden...
  89. ncbi request reprint Menopause, hormone replacement and RR and QT modulation during sleep
    Paola A Lanfranchi
    Centre de Recherche, Hopital du Sacre Coeur de Montreal, 5400 Boul Gouin Ouest, Montreal, Que, Canada H4J 1C5
    Sleep Med 6:561-6. 2005
    ..The aim of the present study was to evaluate sleep-related RR and QT changes: (1) with the physiological decline in female hormones occurring with menopause, and (2) after hormone replacement therapy with estrogen and progesterone (HRT)...
  90. ncbi request reprint Sleep and the metabolic syndrome
    Robert Wolk
    Cardiovascular Metabolic Diseases, Pfizer Global Research and Development, Eastern Point Road, MS 8260 2506, Groton, CT 06340, USA
    Exp Physiol 92:67-78. 2007
    ....
  91. ncbi request reprint The scoring of respiratory events in sleep: reliability and validity
    Susan Redline
    Department of Pediatrics, Case Western Reserve University, Cleveland, OH, WA 44106 6033, USA
    J Clin Sleep Med 3:169-200. 2007
    ....

Research Grants27

  1. Neural Circulatory Control in the Long QT Syndrome
    Virend Somers; Fiscal Year: 2006
    ..We believe that these studies will provide important and clinically relevant insights into the interaction between the genetics of ion channel dysfunction and associated neural control phenotypes. ..
  2. CARDIOVASCULAR DISEASE MECHANISMS IN SLEEP APNEA
    Virend Somers; Fiscal Year: 2007
    ..Identification of the mechanisms mediating vascular disease in OSA will enhance our understanding of disease pathophysiology, and may provide opportunities for new therapeutic strategies. ..
  3. Fat Gain and Cardiovascular Disease Mechanisms
    Virend Somers; Fiscal Year: 2007
    ..Jensen. This integrated state-of-the-art approach will enable important and novel insights into interactions between fat gain and neural, vascular, and inflammatory cardiovascular disease mechanisms. ..
  4. CARDIOVASCULAR DISEASE MECHANISMS IN SLEEP APNEA
    Virend Somers; Fiscal Year: 2002
    ..abstract_text> ..
  5. MECHANISMS MEDIATING CARDIOVASCULAR RESPONSES TO SMOKING
    Virend Somers; Fiscal Year: 2003
    ..These studies build on our broad experience in investigating both smoking and neural circulatory control, and should contribute significantly to understanding the mechanisms linking cigarette smoking to acute cardiovascular events. ..
  6. Adipokines and Cardiovascular Disease in Diabetes
    Virend K Somers; Fiscal Year: 2010
    ..abstract_text> ..