David I Smith

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi request reprint Transcriptional profiling develops molecular signatures for ovarian tumors
    David I Smith
    Mayo Clinic Cancer Center, Rochester, Minnesota 55905, USA
    Cytometry 47:60-2. 2002
  2. ncbi request reprint Large common fragile site genes and cancer
    David I Smith
    Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street, S W, Rochester, MN 55905, United States
    Semin Cancer Biol 17:31-41. 2007
  3. ncbi request reprint Common fragile sites, extremely large genes, neural development and cancer
    David I Smith
    Co head of the Ovarian Cancer Program, Mayo Clinic Cancer Center, Mayo Clinic College of Medicine, Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Rochester, MN 55905, USA
    Cancer Lett 232:48-57. 2006
  4. ncbi request reprint Parkin gene alterations in hepatocellular carcinoma
    Fang Wang
    Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Genes Chromosomes Cancer 40:85-96. 2004
  5. ncbi request reprint Epigenetic silencing of TCEAL7 (Bex4) in ovarian cancer
    Jeremy Chien
    Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic Foundation, 200 First Street, SW Rochester, MN 55905, USA
    Oncogene 24:5089-100. 2005
  6. ncbi request reprint HSulf-1 modulates HGF-mediated tumor cell invasion and signaling in head and neck squamous carcinoma
    Jin Ping Lai
    Division of Gastroenterology and Hepatology, Mayo Clinic Cancer Center, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Oncogene 23:1439-47. 2004
  7. ncbi request reprint Transcriptional profiling reveals that several common fragile-site genes are downregulated in ovarian cancer
    Stacy R Denison
    Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Genes Chromosomes Cancer 34:406-15. 2002
  8. ncbi request reprint Characterization of FRA6E and its potential role in autosomal recessive juvenile parkinsonism and ovarian cancer
    Stacy R Denison
    Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Foundation, Rochester, Minnesota 55905, USA
    Genes Chromosomes Cancer 38:40-52. 2003
  9. ncbi request reprint A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer
    Jeremy Chien
    Mayo Clinic Cancer Center and Department of Experimental Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Oncogene 23:1636-44. 2004
  10. doi request reprint Human papillomavirus in oropharyngeal squamous cell carcinoma: assessing virus presence in normal tissue and activity in cervical metastasis
    Rebecca R Laborde
    Department of Otorhinolaryngology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Laryngoscope 122:2707-11. 2012

Detail Information

Publications70

  1. ncbi request reprint Transcriptional profiling develops molecular signatures for ovarian tumors
    David I Smith
    Mayo Clinic Cancer Center, Rochester, Minnesota 55905, USA
    Cytometry 47:60-2. 2002
    ..Finally, we are taking top candidate genes that are consistently under-expressed in ovarian tumors and attempting to determine their functional role in the development of ovarian cancer...
  2. ncbi request reprint Large common fragile site genes and cancer
    David I Smith
    Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street, S W, Rochester, MN 55905, United States
    Semin Cancer Biol 17:31-41. 2007
    ..In this review we will discuss the large common fragile site genes that have been identified to date, and the role that these genes appear to play both in cellular responses to stress and in the development of cancer...
  3. ncbi request reprint Common fragile sites, extremely large genes, neural development and cancer
    David I Smith
    Co head of the Ovarian Cancer Program, Mayo Clinic Cancer Center, Mayo Clinic College of Medicine, Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Rochester, MN 55905, USA
    Cancer Lett 232:48-57. 2006
    ..There are also important potential linkages between normal neurological development and the development of cancer mediated by alterations in these genes...
  4. ncbi request reprint Parkin gene alterations in hepatocellular carcinoma
    Fang Wang
    Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Genes Chromosomes Cancer 40:85-96. 2004
    ..Therefore, we suggest that Parkin may be involved in tumor suppression and that the loss of Parkin contributes to the development of hepatocarcinoma...
  5. ncbi request reprint Epigenetic silencing of TCEAL7 (Bex4) in ovarian cancer
    Jeremy Chien
    Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic Foundation, 200 First Street, SW Rochester, MN 55905, USA
    Oncogene 24:5089-100. 2005
    ..These data implicate TCEAL7 as a cell death regulatory protein that is frequently inactivated in ovarian cancers, and suggest that it may function as a tumor suppressor...
  6. ncbi request reprint HSulf-1 modulates HGF-mediated tumor cell invasion and signaling in head and neck squamous carcinoma
    Jin Ping Lai
    Division of Gastroenterology and Hepatology, Mayo Clinic Cancer Center, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Oncogene 23:1439-47. 2004
    ....
  7. ncbi request reprint Transcriptional profiling reveals that several common fragile-site genes are downregulated in ovarian cancer
    Stacy R Denison
    Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Genes Chromosomes Cancer 34:406-15. 2002
    ..We identified portions of seven uncloned CFSs and provide data to suggest that several of the genes mapping within CFSs may be inactivated in ovarian cancer...
  8. ncbi request reprint Characterization of FRA6E and its potential role in autosomal recessive juvenile parkinsonism and ovarian cancer
    Stacy R Denison
    Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Foundation, Rochester, Minnesota 55905, USA
    Genes Chromosomes Cancer 38:40-52. 2003
    ..2) and FRA16D (16q23.2) in representing a large region of genomic instability and containing an extremely large gene that may play a role in the development of ovarian and many other cancers...
  9. ncbi request reprint A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer
    Jeremy Chien
    Mayo Clinic Cancer Center and Department of Experimental Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Oncogene 23:1636-44. 2004
    ..These observations raise the possibility of HtrA1 as a candidate tumor suppressor involved in promoting serine-protease-mediated cell death and that downregulation of HtrA1 in ovarian cancer may contribute to malignant phenotype...
  10. doi request reprint Human papillomavirus in oropharyngeal squamous cell carcinoma: assessing virus presence in normal tissue and activity in cervical metastasis
    Rebecca R Laborde
    Department of Otorhinolaryngology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Laryngoscope 122:2707-11. 2012
    ..Although much research has focused on HPV's oncogenic behavior in primary OPSCC, minimal information exists about HPV in adjacent normal and metastatic tissue...
  11. pmc Transcriptional profiling by sequencing of oropharyngeal cancer
    Rebecca R Laborde
    Division of Experimental Pathology and Laboratory Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Mayo Clin Proc 87:226-32. 2012
    ..To compare full transcriptome expression levels of matched tumor and normal samples from patients with oropharyngeal carcinoma stratified by known tumor etiologic factors...
  12. ncbi request reprint Transcriptional repression of WEE1 by Kruppel-like factor 2 is involved in DNA damage-induced apoptosis
    Fang Wang
    Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Oncogene 24:3875-85. 2005
    ..Thus, the level of WEE1 is regulated by KLF2 and enhanced KLF2 expression sensitizes cells to DNA damage-induced apoptosis...
  13. doi request reprint Identification of long stress-induced non-coding transcripts that have altered expression in cancer
    Jessica M Silva
    Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Genomics 95:355-62. 2010
    ..LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer...
  14. ncbi request reprint Long, abundantly expressed non-coding transcripts are altered in cancer
    Damon S Perez
    Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, 200 First Street, S W, Rochester, MN 55905, USA
    Hum Mol Genet 17:642-55. 2008
    ..Although the function of these NCTs is currently unknown, our study indicates that they may play an important function in both normal cells and in cancer development...
  15. ncbi request reprint Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer
    Jinping Lai
    Mayo Clinic Cancer Center, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Biol Chem 278:23107-17. 2003
    ..Collectively, these observations provide evidence that HSulf-1 modulates signaling by heparin-binding growth factors, and HSulf-1 down-regulation represents a novel mechanism by which cancer cells can enhance growth factor signaling...
  16. ncbi request reprint Common fragile sites are preferential targets for HPV16 integrations in cervical tumors
    Erik C Thorland
    Department of Biochemistry and Molecular Biology Mayo Clinic, Rochester, MN 55905, USA
    Oncogene 22:1225-37. 2003
    ..2), and FRA17B (17q23). Finally, our data suggest that cellular genes, such as Notch 1, are disrupted by the HPV16 integrations, which may contribute to the malignant phenotype...
  17. ncbi request reprint Characterization of the common fragile site FRA9E and its potential role in ovarian cancer
    Gwen Callahan
    Tumor Biology Program, Mayo Graduate School, Mayo Foundation, Rochester, MN 55905, USA
    Oncogene 22:590-601. 2003
    ..This study provides evidence to suggest that instability within FRA9E may play an important role in the development of ovarian cancer and lends further support for the hypothesis that CFSs may be causally related to cancer...
  18. doi request reprint Genome-wide analysis reveals recurrent structural abnormalities of TP63 and other p53-related genes in peripheral T-cell lymphomas
    George Vasmatzis
    Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Blood 120:2280-9. 2012
    ..As TP53 mutations are rare in PTCL compared with other malignancies, our findings suggest that a constellation of alternate genetic abnormalities may contribute to disruption of p53-associated tumor suppressor function in PTCL...
  19. doi request reprint Linking expression of FOXM1, CEP55 and HELLS to tumorigenesis in oropharyngeal squamous cell carcinoma
    Jeffrey R Janus
    Department of Otorhinolaryngology, Division of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Laryngoscope 121:2598-603. 2011
    ..To investigate the relationship between the expression of FOXM1, CEP55, and HELLS in oropharyngeal squamous cell carcinoma to human papillomavirus (HPV), smoking, and tumor stage...
  20. ncbi request reprint Disabled-1 is a large common fragile site gene, inactivated in multiple cancers
    Sarah McAvoy
    Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN 55902, USA
    Genes Chromosomes Cancer 47:165-74. 2008
    ..In summary, DAB1 is another gene that resides within an unstable CFS region and might play a role in human tumorigenesis. These data may provide further linkage between neurological development and cancer...
  21. ncbi request reprint Evidence that instability within the FRA3B region extends four megabases
    Nicole A Becker
    Department of Experimental Pathology, Mayo Foundation, Rochester, Minnesota, MN 55905, USA
    Oncogene 21:8713-22. 2002
    ..These data provide additional support that regions of instability associated with CFSs and the genes contained within them, may play an important role in cancer development...
  22. ncbi request reprint hSulf1 Sulfatase promotes apoptosis of hepatocellular cancer cells by decreasing heparin-binding growth factor signaling
    Jin Ping Lai
    Division of Gastroenterology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Gastroenterology 126:231-48. 2004
    ..Heparin-binding growth factor signaling is regulated by sulfation of cell-surface heparan sulfate proteoglycans (HSPGs). We hypothesized that hSulf1, a recently described sulfatase, regulates growth signaling in HCCs...
  23. ncbi request reprint Biallelic methylation and silencing of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines
    Sean C Dowdy
    Department of Obstetrics and Gynecology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Gynecol Oncol 99:126-34. 2005
    ..To measure mRNA expression levels of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines and to determine if DNA methylation is involved in the control of PEG3 expression...
  24. ncbi request reprint Positioning of cervical carcinoma and Burkitt lymphoma translocation breakpoints with respect to the human papillomavirus integration cluster in FRA8C at 8q24.13
    Matthew J Ferber
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA
    Cancer Genet Cytogenet 154:1-9. 2004
    ..In the context of the familial nature of cervical cancer, FRA8C may be considered a candidate susceptibility region for cervical carcinoma...
  25. doi request reprint Search for chromosome rearrangements: new approaches toward discovery of novel translocations in head and neck squamous cell carcinoma
    Vivian W Wang
    Department of Experimental Pathology, Division of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA
    Head Neck 35:831-5. 2013
    ..The purpose of this study was to discover novel translocations that could result in gene fusions in oropharyngeal squamous cell carcinomas (OPSCCs)...
  26. doi request reprint Molecular characterization of endometrial cancer: a correlative study assessing microsatellite instability, MLH1 hypermethylation, DNA mismatch repair protein expression, and PTEN, PIK3CA, KRAS, and BRAF mutation analysis
    Lisa M Peterson
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
    Int J Gynecol Pathol 31:195-205. 2012
    ..No BRAF V600E mutations were indentified. This study provides a comprehensive molecular genetic analysis of commonly analyzed targets in a large cohort of endometrial cancers...
  27. pmc Human TopBP1 ensures genome integrity during normal S phase
    Ja Eun Kim
    Department of Oncology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Mol Cell Biol 25:10907-15. 2005
    ..By ensuring proper DNA replication, TopBP1 plays a critical role in the maintenance of genomic stability during normal S phase as well as following genotoxic stress...
  28. ncbi request reprint The role of viral integration in the development of cervical cancer
    Tingxi Yu
    Division of Experimental Pathology and Mayo Clinic Cancer Center, Mayo Clinic College of Medicine, 800C Hilton, 200 First Street, S W, Rochester, MN 55905, USA
    Cancer Genet Cytogenet 158:27-34. 2005
    ....
  29. ncbi request reprint Preferential integration of human papillomavirus type 18 near the c-myc locus in cervical carcinoma
    Matthew J Ferber
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA
    Oncogene 22:7233-42. 2003
    ..Our results suggest that the sites of HPV18 integration are nonrandom and may play an important role in the development of cervical tumors...
  30. ncbi request reprint Alterations in the common fragile site gene Parkin in ovarian and other cancers
    Stacy R Denison
    Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic Cancer Center, Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Oncogene 22:8370-8. 2003
    ..While functional analyses have not yet been performed for Parkin, these data suggest that like FHIT and WWOX, Parkin may represent a tumor suppressor gene...
  31. ncbi request reprint Gene expression profiles predict early relapse in ovarian cancer after platinum-paclitaxel chemotherapy
    Lynn C Hartmann
    Mayo Clinic Cancer Center, 200 First Street Southwest, Rochester, MN 55905, USA
    Clin Cancer Res 11:2149-55. 2005
    ..We hypothesized that differences in gene expression before treatment could distinguish patients with short versus long time to recurrence after administration of platinum-paclitaxel combination chemotherapy...
  32. doi request reprint Expression profiles of viral responsive genes in oral and oropharyngeal cancers
    Rebecca R Laborde
    Department of Experimental Pathology, Division of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Eur J Cancer 46:1153-8. 2010
    ..This would suggest that either an as of yet unidentified virus present in the oral tumour samples is not eliciting a typical immune response, or that there are no novel viral sequences or viruses present in the oral tumours examined...
  33. ncbi request reprint The common fragile site FRA16D and its associated gene WWOX are highly conserved in the mouse at Fra8E1
    Kurt A Krummel
    Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic Cancer Center, Rochester, Minnesota 55905, USA
    Genes Chromosomes Cancer 34:154-67. 2002
    ..This evolutionary conservation suggests that the two most active CFSs share many features, and that CFSs and their associated genes may be necessary for cell survival...
  34. ncbi request reprint LSINCT5 is over expressed in breast and ovarian cancer and affects cellular proliferation
    Jessica M Silva
    Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, MN, USA
    RNA Biol 8:496-505. 2011
    ..We have therefore characterized a novel lncRNA that is overexpressed in breast and ovarian cancers, enhances cellular proliferation and may play a significant role in multiple processes...
  35. ncbi request reprint AGR2, an androgen-inducible secretory protein overexpressed in prostate cancer
    Jin San Zhang
    Department of Urology, Mayo Clinic College of Medicine, Mayo Clinic Foundation, Rochester, MN 55905, USA
    Genes Chromosomes Cancer 43:249-59. 2005
    ..Therefore, the androgen-induced secretory protein AGR2 may serve as a potential therapeutic target and/or molecular marker for prostate cancer...
  36. pmc 3' tag digital gene expression profiling of human brain and universal reference RNA using Illumina Genome Analyzer
    Yan W Asmann
    Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
    BMC Genomics 10:531. 2009
    ..In this preliminary effort, we evaluated the 3' DGE approach using two reference RNA samples from the MicroArray Quality Control Consortium (MAQC)...
  37. pmc Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss
    Christopher J Klein
    Mayo Clinic, Department of Neurology, Division of Peripheral Nerve Diseases, Rochester, Minnesota, USA
    Nat Genet 43:595-600. 2011
    ..Our study shows that DNMT1 mutations cause the aberrant methylation implicated in complex pathogenesis. The discovered DNMT1 mutations provide a new framework for the study of neurodegenerative diseases...
  38. pmc Tetratricopeptide repeat cochaperones in steroid receptor complexes
    David F Smith
    S C Johnson Research Center, Mayo Clinic Scottsdale, Scottsdale, AZ 85259, USA
    Cell Stress Chaperones 9:109-21. 2004
    ..To provide a coherent, representative minireview of TPR protein function, the scope of this article has been narrowed down primarily to functions of steroid receptor-associated TPR cochaperones...
  39. pmc Genome-wide characterization of transcriptional patterns in high and low antibody responders to rubella vaccination
    Iana H Haralambieva
    Vaccine Research Group, Mayo Clinic, Rochester, Minnesota, USA
    PLoS ONE 8:e62149. 2013
    ..Such information may provide new scientific insights into vaccine-induced immunity useful in rational vaccine development and immune response monitoring...
  40. pmc Mutations in CHEK2 associated with prostate cancer risk
    Xiangyang Dong
    Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic Mayo Medical School, Rochester, MN 55905, USA
    Am J Hum Genet 72:270-80. 2003
    ..Overall, our data suggest that mutations in CHEK2 may contribute to prostate cancer risk and that the DNA-damage-signaling pathway may play an important role in the development of prostate cancer...
  41. pmc Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation
    Haojie Huang
    Department of Biochemistry, and Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Proc Natl Acad Sci U S A 102:1649-54. 2005
    ..Furthermore, expression of the FOXO1 protein is lost in a mouse lymphoma model, where Skp2 is overexpressed. These data suggest that the Skp2-promoted proteolysis of FOXO1 plays a key role in tumorigenesis...
  42. pmc Discovery of recurrent t(6;7)(p25.3;q32.3) translocations in ALK-negative anaplastic large cell lymphomas by massively parallel genomic sequencing
    Andrew L Feldman
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
    Blood 117:915-9. 2011
    ..3. These findings represent the first recurrent translocation reported in ALK-negative ALCL and highlight the utility of massively parallel genomic sequencing to discover novel translocations in lymphoma and other cancers...
  43. ncbi request reprint Human papillomavirus-associated oropharyngeal squamous cell carcinomas: primary tumor burden and survival in surgical patients
    Odey C Ukpo
    Department of Otorhinolaryngology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Otol Rhinol Laryngol 118:368-73. 2009
    ..We sought to determine whether the primary tumor burden in oropharyngeal squamous cell carcinoma is lower in tumors positive for human papillomavirus (HPV) or in tumors with a smoking- or alcohol-related cause...
  44. doi request reprint High detection rates of colorectal neoplasia by stool DNA testing with a novel digital melt curve assay
    Hongzhi Zou
    Miles and Shirley Fiterman Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Gastroenterology 136:459-70. 2009
    ..We developed a digital melt curve (DMC) assay to quantify low-abundance mutations in stool samples for detection of colorectal neoplasms and compared this test with other approaches...
  45. ncbi request reprint Identification of underexpressed genes in early- and late-stage primary ovarian tumors by suppression subtraction hybridization
    Viji Shridhar
    Department of Experimental Pathology, Division of Laboratory Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Res 62:262-70. 2002
    ..In conclusion, our analysis has identified down-regulated genes, which map to known as well as novel regions of deletions and may represent potential candidate tumor suppressor genes involved in ovarian cancer...
  46. ncbi request reprint Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas
    Ken Taniguchi
    Division of Experimental Pathology, Mayo Clinic, Rochester, Minnesota, MN 55905, USA
    Oncogene 21:4863-71. 2002
    ....
  47. pmc Domain:domain interactions within Hop, the Hsp70/Hsp90 organizing protein, are required for protein stability and structure
    Patricia E Carrigan
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Scottsdale, AZ 85259, USA
    Protein Sci 15:522-32. 2006
    ....
  48. ncbi request reprint Host genetic polymorphism analysis in cervical cancer
    Eric S Calhoun
    Mayo Foundation for Medical Education and Research, Rochester, MN 55905, USA
    Clin Chem 48:1218-24. 2002
    ..Identifying host determinants of viral persistence may help to better understand the mechanisms of tolerance and may lead to the development of tests that can allow more focused follow-up of high-risk individuals...
  49. pmc Comparison of the carboxy-terminal DP-repeat region in the co-chaperones Hop and Hip
    Gregory M Nelson
    Samuel C Johnson Research Center, Mayo Clinic Scottsdale, Scottsdale, AZ 85259, USA
    Cell Stress Chaperones 8:125-33. 2003
    ..We conclude that the DP repeats are important structural elements within a C-terminal domain, which is important for Hop and Hip function...
  50. ncbi request reprint Physiological role for the cochaperone FKBP52 in androgen receptor signaling
    Joyce Cheung-Flynn
    Department of Biochemistry and Molecular Biology, Johnson Research Building, Mayo Clinic Scottsdale, 13400 East Shea Boulevard, Scottsdale, Arizona 85259, USA
    Mol Endocrinol 19:1654-66. 2005
    ..We conclude that FKBP52 is an AR folding factor that has critically important physiological roles in some male reproductive tissues...
  51. ncbi request reprint Multiple domains of the co-chaperone Hop are important for Hsp70 binding
    Patricia E Carrigan
    Samuel C Johnson Research Center, Mayo Clinic Scottsdale, Scottsdale, Arizona 85259, USA
    J Biol Chem 279:16185-93. 2004
    ..All point mutants retained an ability to dimerize, and none appeared to be grossly misfolded. These results raise questions about current models for Hop/Hsp70 interaction...
  52. pmc The "old" Euonymus europaeus agglutinin represents a novel family of ubiquitous plant proteins
    Elke Fouquaert
    Laboratory of Biochemistry and Glycobiology, Department of Molecular Biotechnology, Ghent University, 9000 Ghent, Belgium
    Plant Physiol 147:1316-24. 2008
    ....
  53. pmc The Hsp90-binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo
    Daniel L Riggs
    Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, Scottsdale, AZ 85259, USA
    EMBO J 22:1158-67. 2003
    ..The mechanism for potentiation is an increase in GR hormone-binding affinity that requires both the Hsp90-binding ability and the prolyl isomerase activity of FKBP52...
  54. ncbi request reprint Overexpression of FKBP51 in idiopathic myelofibrosis regulates the growth factor independence of megakaryocyte progenitors
    Stephane Giraudier
    INSERM U362, Pavillon de Recherche 1, Institut Gustave Roussy, Villejuif Cedex, France Laboratoire d Hématologie and Laboratoire de Toxicologie, Hopital Henri Mondor, Creteil, France
    Blood 100:2932-40. 2002
    ..In conclusion, FKBP51 is overexpressed in IMF megakaryocytes and this overexpression could be, in part, responsible for the megakaryocytic accumulation observed in this disorder by regulating their apoptotic program...
  55. pmc Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes
    Cindy R Sinars
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853 1301, USA
    Proc Natl Acad Sci U S A 100:868-73. 2003
    ..The two FKBP domains differ by an insertion in the second that affects the formation of the progesterone receptor complex...
  56. pmc Characterization of a streptococcal cholesterol-dependent cytolysin with a lewis y and b specific lectin domain
    Stephen Farrand
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Biochemistry 47:7097-107. 2008
    ..Hence, LLY represents a new class of CDC whose pore-forming mechanism is modulated by a glycan-binding domain...
  57. ncbi request reprint Functional comparison of human and Drosophila Hop reveals novel role in steroid receptor maturation
    Patricia E Carrigan
    Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, Scottsdale, Arizona 85259, USA
    J Biol Chem 280:8906-11. 2005
    ..Chimeric Hop constructs combining human and Drosophila domains demonstrate that the C-terminal domain DP2 is critical for this previously unrecognized role in steroid receptor function...
  58. ncbi request reprint The heat shock protein 70 cochaperone hip enhances functional maturation of glucocorticoid receptor
    Gregory M Nelson
    S C Johnson Research Center, Mayo Clinic Scottsdale, Arizona 85259, USA
    Mol Endocrinol 18:1620-30. 2004
    ..Unexpectedly, Hip binding to Hsp70 is not critical for boosting GR responsiveness to hormone. In conclusion, Hip functions by a previously unrecognized mechanism to promote the efficiency of GR maturation in cells...
  59. ncbi request reprint Progesterone receptor deficient in chromatin binding has an altered cellular state
    Jeannine Botos
    Laboratory of Receptor Biology and Gene Expression, NCI, National Institutes of Health, Bethesda, Maryland 20892 5055, USA
    J Biol Chem 279:15231-9. 2004
    ..These findings also reveal that transiently expressed steroid receptors may not always be processed like their endogenous counterparts...
  60. ncbi request reprint Structure-function analysis of squirrel monkey FK506-binding protein 51, a potent inhibitor of glucocorticoid receptor activity
    Wesley B Denny
    Department of Pharmacology, University of South Alabama, Mobile, Alabama 36688, USA
    Endocrinology 146:3194-201. 2005
    ..Thus, the potent inhibitory activity of squirrel monkey FKBP51 involves both FK domains and the heat shock protein 90-binding TPR domain...
  61. ncbi request reprint Functional specificity of co-chaperone interactions with Hsp90 client proteins
    Daniel L Riggs
    Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, Scottsdale, AZ 85259, USA
    Crit Rev Biochem Mol Biol 39:279-95. 2004
    ..This review focuses on the differential effects of Hsp90 co-chaperones toward client protein function and on the specificity that allows co-chaperones to discriminate between even closely related clients...
  62. pmc Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation
    Susanne Tranguch
    Departments of Pediatrics, Cell and Developmental Biology, Cancer Biology, and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 102:14326-31. 2005
    ..Collectively, the present investigation provides evidence for an in vivo role for this cochaperone in regulating tissue-specific hormone action and its critical role in uterine receptivity for implantation...
  63. ncbi request reprint Deficiency of co-chaperone immunophilin FKBP52 compromises sperm fertilizing capacity
    Jiyoung Hong
    Pediatrics, Cell and Developmental Biology, Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Reproduction 133:395-403. 2007
    ..This study is clinically relevant because unraveling the role of immunophilin signaling in male fertility will help identify new targets for male contraceptives and/or alleviate male infertility...
  64. ncbi request reprint FK506-binding protein 52 phosphorylation: a potential mechanism for regulating steroid hormone receptor activity
    Marc B Cox
    Mayo Clinic Arizona, S C Johnson Research Building, Scottsdale, Arizona 85259, USA
    Mol Endocrinol 21:2956-67. 2007
    ..However, phosphorylation of the FK linker appears to be an important regulatory determinant of FKBP52-mediated potentiation of steroid receptor activity...
  65. pmc Noncatalytic role of the FKBP52 peptidyl-prolyl isomerase domain in the regulation of steroid hormone signaling
    Daniel L Riggs
    Mayo Clinic Arizona, 13400 E Shea Blvd, Scottsdale, AZ 85259, USA
    Mol Cell Biol 27:8658-69. 2007
    ..These results suggest that the FK1 domain, and in particular the loop overhanging the catalytic pocket, is critically involved in receptor interactions and receptor activity...
  66. pmc A novel mechanism for LSECtin binding to Ebola virus surface glycoprotein through truncated glycans
    Alex S Powlesland
    Division of Molecular Biosciences, Imperial College, London, United Kingdom
    J Biol Chem 283:593-602. 2008
    ..Thus, multiple receptors interact with surface glycoproteins of enveloped viruses that bear different types of relatively poorly processed glycans...
  67. ncbi request reprint The FK506-binding immunophilin FKBP51 is transcriptionally regulated by progestin and attenuates progestin responsiveness
    Tina R Hubler
    Department of Pharmacology, University of South Alabama College of Medicine, Mobile, Alabama 36688, USA
    Endocrinology 144:2380-7. 2003
    ..Furthermore, overexpression of FKBP51 in the squirrel monkey may be a contributing cause of progesterone resistance in this species...
  68. ncbi request reprint C-terminal sequences outside the tetratricopeptide repeat domain of FKBP51 and FKBP52 cause differential binding to Hsp90
    Joyce Cheung-Flynn
    S C Johnson Research Center, Mayo Clinic Scottsdale, Scottsdale, Arizona 85259, USA
    J Biol Chem 278:17388-94. 2003
    ..Taking into account the x-ray crystal structure for FKBP51, we conclude that the C-terminal regions of FKBP51 and FKBP52 outside the core TPR domains are likely to assume alternative conformations that significantly impact Hsp90 binding...
  69. pmc Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions
    David F Smith
    Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, Arizona 85259, USA
    Mol Endocrinol 22:2229-40. 2008
    ..Here, we point out several areas in need of investigation to encourage new ideas and participants in this burgeoning field...
  70. ncbi request reprint Proteomic analysis identifies immunophilin FK506 binding protein 4 (FKBP52) as a downstream target of Hoxa10 in the periimplantation mouse uterus
    Takiko Daikoku
    Department of Pediatrics and Cancer Biology, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Mol Endocrinol 19:683-97. 2005
    ..Collectively, these results and the female infertility phenotype of FKBP52 suggest that a Hoxa10-FKBP52 signaling axis is critical to uterine receptivity and implantation...