Susan L Slager

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, Bethesda, Maryland, USA
    Nat Genet 45:868-76. 2013
  2. pmc Genetic susceptibility to chronic lymphocytic leukemia
    Susan L Slager
    Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN Electronic address
    Semin Hematol 50:296-302. 2013
  3. pmc Mapping of the IRF8 gene identifies a 3'UTR variant associated with risk of chronic lymphocytic leukemia but not other common non-Hodgkin lymphoma subtypes
    Susan L Slager
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 22:461-6. 2013
  4. pmc Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non-Hodgkin lymphoma subtypes
    Susan L Slager
    Mayo Clinic College of Medicine, Rochester, MN, USA
    Br J Haematol 159:572-6. 2012
  5. pmc Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia
    Susan L Slager
    Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Blood 120:843-6. 2012
  6. ncbi request reprint Candidate-gene association studies with pedigree data: controlling for environmental covariates
    S L Slager
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905 USA
    Genet Epidemiol 24:273-83. 2003
  7. pmc Genome-wide linkage analysis of systolic blood pressure: a comparison of two approaches to phenotype definition
    Susan L Slager
    Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    BMC Genet 4:S13. 2003
  8. ncbi request reprint Susceptibility genes and B-chronic lymphocytic leukaemia
    Susan L Slager
    Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA
    Br J Haematol 139:762-71. 2007
  9. pmc Genetic susceptibility variants for chronic lymphocytic leukemia
    Susan L Slager
    Mayo Clinic College of Medicine, 200 1st Street Southwest, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 19:1098-102. 2010
  10. pmc Genome-wide association study identifies a novel susceptibility locus at 6p21.3 among familial CLL
    Susan L Slager
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Blood 117:1911-6. 2011

Research Grants

Detail Information

Publications98

  1. pmc Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, Bethesda, Maryland, USA
    Nat Genet 45:868-76. 2013
    ..3 (ODF1, P=5.40×10(-8)) and 5p15.33 (TERT, P=1.92×10(-7)). Although further studies are required, the proximity of several of these loci to genes involved in apoptosis suggests a plausible underlying biological mechanism...
  2. pmc Genetic susceptibility to chronic lymphocytic leukemia
    Susan L Slager
    Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN Electronic address
    Semin Hematol 50:296-302. 2013
    ..We review here the advances made in identifying these loci, the potential to translate these findings into clinical practice, and future directions needed to advance our understanding of the genetic susceptibility of CLL. ..
  3. pmc Mapping of the IRF8 gene identifies a 3'UTR variant associated with risk of chronic lymphocytic leukemia but not other common non-Hodgkin lymphoma subtypes
    Susan L Slager
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 22:461-6. 2013
    ..These results were further supported by a recent meta-analysis of our GWAS with two other GWAS of CLL, supporting the IRF8 gene as a strong candidate for CLL risk...
  4. pmc Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non-Hodgkin lymphoma subtypes
    Susan L Slager
    Mayo Clinic College of Medicine, Rochester, MN, USA
    Br J Haematol 159:572-6. 2012
    ..These variants also showed a trend towards association with some of the other NHL subtypes. Our results validate the prior work and support specific genetic pathways for risk among NHL subtypes...
  5. pmc Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia
    Susan L Slager
    Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Blood 120:843-6. 2012
    ..This finding provides additional support for polygenic inheritance to CLL and provides further insight into the biologic basis of disease development...
  6. ncbi request reprint Candidate-gene association studies with pedigree data: controlling for environmental covariates
    S L Slager
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905 USA
    Genet Epidemiol 24:273-83. 2003
    ..We also find GEE to fail at least 5% of the time for each simulation configuration; at times, the failure rate reaches above 80%. In summary, our robust method may be the only current regression analysis method available for MCC data...
  7. pmc Genome-wide linkage analysis of systolic blood pressure: a comparison of two approaches to phenotype definition
    Susan L Slager
    Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    BMC Genet 4:S13. 2003
    ..For each approach, multipoint linkage analysis was performed using the residuals and the SOLAR computer program. Our results show little difference between the methods based on the LOD scores...
  8. ncbi request reprint Susceptibility genes and B-chronic lymphocytic leukaemia
    Susan L Slager
    Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA
    Br J Haematol 139:762-71. 2007
    ..The challenge of future studies of this type will be overcoming study design issues, including definition of CLL, sample size limitations and multiple testing issues...
  9. pmc Genetic susceptibility variants for chronic lymphocytic leukemia
    Susan L Slager
    Mayo Clinic College of Medicine, 200 1st Street Southwest, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 19:1098-102. 2010
    ..A recent genome-wide association study of CLL identified seven genetic variants that increased the risk of CLL within a European population...
  10. pmc Genome-wide association study identifies a novel susceptibility locus at 6p21.3 among familial CLL
    Susan L Slager
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Blood 117:1911-6. 2011
    ..Our findings support the hypothesis that familial CLL cases have additional genetic variants not seen in sporadic CLL. Additional loci among familial CLL cases may be identified through larger studies...
  11. ncbi request reprint Power comparisons between the TDT and two likelihood-based methods
    S L Slager
    Department of Biostatistics, University of Iowa, Iowa City, Iowa, USA
    Genet Epidemiol 20:192-209. 2001
    ..The LOD score provides the lowest power in the presence of LD for the range of GRR considered here...
  12. ncbi request reprint Case-control studies of genetic markers: power and sample size approximations for Armitage's test for trend
    S L Slager
    Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
    Hum Hered 52:149-53. 2001
    ..The formulas make no assumptions about Hardy-Weinberg equilibrium, but do assume random ascertainment of cases and controls, all of whom are independent of one another. We demonstrate the accuracy of the formulas by simulations...
  13. pmc Evaluation of candidate genes in case-control studies: a statistical method to account for related subjects
    S L Slager
    Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 55905, USA
    Am J Hum Genet 68:1457-62. 2001
    ..An application of our method, to family data from a prostate cancer study, is presented to illustrate the method's utility...
  14. ncbi request reprint Stoppage: an issue for segregation analysis
    S L Slager
    Department of Psychiatry, College of Physicians and Surgeons at Columbia University and the New York State Psychiatric Institute, New York, NY, USA
    Genet Epidemiol 20:328-39. 2001
    ..In conclusion, stoppage, a realistic scenario for some complex diseases, can represent a serious and potentially intractable problem for segregation analysis...
  15. ncbi request reprint Genome-wide linkage scan for prostate cancer aggressiveness loci using families from the University of Michigan Prostate Cancer Genetics Project
    Susan L Slager
    Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Prostate 66:173-9. 2006
    ..One measure of disease severity is the Gleason score. Using the Gleason score as a measure of tumor aggressiveness, several independent genome scans have reported evidence of linkage. As of yet, however, no genes have been implicated...
  16. pmc Associations between intake of folate and related micronutrients with molecularly defined colorectal cancer risks in the Iowa Women's Health Study
    Anthony A Razzak
    Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Nutr Cancer 64:899-910. 2012
    ..These data provide minimal support for major effects from the examined micronutrients on overall or molecularly defined CRC risks in the IWHS cohort...
  17. pmc Genetic variation in tumor necrosis factor and the nuclear factor-kappaB canonical pathway and risk of non-Hodgkin's lymphoma
    James R Cerhan
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 1st Street Southwest, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 17:3161-9. 2008
    ....
  18. pmc Postmenopausal hormone therapy and colorectal cancer risk by molecularly defined subtypes among older women
    David Limsui
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA
    Gut 61:1299-305. 2012
    ..Postmenopausal hormone (PMH) therapy may reduce colorectal cancer (CRC) risk, but existing data are inconclusive...
  19. pmc Risk of non-Hodgkin lymphoma in association with germline variation in complement genes
    James R Cerhan
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Br J Haematol 145:614-23. 2009
    ..015; OR = 0.68; 95% 0.56-0.84) remained noteworthy. Associations were similar for the common NHL subtypes. In summary, we provide evidence for a role of genetic variation in complement genes, particularly C5 and C9, and NHL risk...
  20. pmc B-cell count and survival: differentiating chronic lymphocytic leukemia from monoclonal B-cell lymphocytosis based on clinical outcome
    Tait D Shanafelt
    Mayo Clinic, Rochester, MN, USA
    Blood 113:4188-96. 2009
    ..Using clinically relevant criteria to distinguish between monoclonal B-cell lymphocytosis (MBL) and CLL could minimize patient distress caused by labeling asymptomatic people at low risk for adverse clinical consequences as having CLL...
  21. pmc Elevated pretreatment serum levels of interferon-inducible protein-10 (CXCL10) predict disease relapse and prognosis in diffuse large B-cell lymphoma patients
    Stephen M Ansell
    Division of Hematology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Am J Hematol 87:865-9. 2012
    ..99, P = 0.009, overall survival-HR 1.93, P = 0.021). Elevated pretreatment serum IP-10 levels are therefore associated with an increased likelihood of disease relapse and an inferior survival in patients with DLBCL...
  22. ncbi request reprint Investigation of polymorphisms in the CREM gene in panic disorder
    Steven P Hamilton
    Department of Psychiatry, College of Physicians and Surgeons at Columbia University and the New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Am J Med Genet B Neuropsychiatr Genet 126:111-5. 2004
    ..These findings provide little additional evidence for a susceptibility locus for panic disorder either within the CREM gene or in a nearby region of chromosome 10p11 in our sample...
  23. pmc Statin and non-steroidal anti-inflammatory drug use in relation to clinical outcome among patients with Rai stage 0 chronic lymphocytic leukemia
    Tait D Shanafelt
    Division of Hematology, Mayo Clinic, Rochester, MN, USA
    Leuk Lymphoma 51:1233-40. 2010
    ..The in vitro observation that statins reduce rituximab efficacy does not appear to have clinical significance in CLL care...
  24. pmc Trans fatty acid intake is associated with increased risk and n3 fatty acid intake with reduced risk of non-hodgkin lymphoma
    Bridget Charbonneau
    Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA
    J Nutr 143:672-81. 2013
    ..In conclusion, diets high in TFAs, processed meats, and higher fat dairy products were positively associated with NHL risk, whereas diets high in n3 fatty acids and total seafood were inversely associated with risk...
  25. pmc Early life sun exposure, vitamin D-related gene variants, and risk of non-Hodgkin lymphoma
    Jennifer L Kelly
    School of Medicine and Dentistry, University of Rochester, NY, USA
    Cancer Causes Control 23:1017-29. 2012
    ....
  26. ncbi request reprint Incidence of chronic lymphocytic leukemia and high-count monoclonal B-cell lymphocytosis using the 2008 guidelines
    Timothy G Call
    Division of Hematology, Mayo Clinic, Rochester, Minnesota
    Cancer 120:2000-5. 2014
    ..The objective of the current study of Olmsted County, Minnesota, was to assess the effects of these changes on incidence rates and presentation from 2000 to 2010...
  27. pmc The association between early life and adult body mass index and physical activity with risk of non-Hodgkin lymphoma: impact of gender
    Jennifer L Kelly
    School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA
    Ann Epidemiol 22:855-62. 2012
    ..To evaluate the association of body mass index (BMI) and physical activity (PA) during adulthood and at the age of 18 years with risk of non-Hodgkin lymphoma (NHL)...
  28. pmc A two-stage evaluation of genetic variation in immune and inflammation genes with risk of non-Hodgkin lymphoma identifies new susceptibility locus in 6p21.3 region
    James R Cerhan
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Cancer Epidemiol Biomarkers Prev 21:1799-806. 2012
    ..Non-Hodgkin lymphoma (NHL) is a malignancy of lymphocytes, and there is growing evidence for a role of germline genetic variation in immune genes in NHL etiology...
  29. pmc Cigarette smoking and colorectal cancer risk by KRAS mutation status among older women
    N J Samadder
    Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Am J Gastroenterol 107:782-9. 2012
    ..In this study, we evaluated associations between cigarette smoking and CRC risk stratified by KRAS mutation status, using data and tissue resources from the Iowa Women's Health Study (IWHS)...
  30. pmc Germline variation in complement genes and event-free survival in follicular and diffuse large B-cell lymphoma
    Bridget Charbonneau
    Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Am J Hematol 87:880-5. 2012
    ..1, along with C9, were associated with FL EFS after adjusting for clinical variables, and if replicated, these findings add further support for the role of host innate immunity in FL prognosis...
  31. pmc Alcohol intake and colorectal cancer risk by molecularly defined subtypes in a prospective study of older women
    Anthony A Razzak
    Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Cancer Prev Res (Phila) 4:2035-43. 2011
    ..05 for each comparison). These data do not support an adverse effect from alcohol intake on CRC risk, overall or by specific molecularly defined subtypes, among older women...
  32. pmc Vitamin D insufficiency and prognosis in chronic lymphocytic leukemia
    Tait D Shanafelt
    Division of Hematology, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Blood 117:1492-8. 2011
    ..47; P = .07). Vitamin D insufficiency is associated with inferior TTT and OS in CLL patients. Whether normalizing vitamin D levels in deficient CLL patients would improve outcome merits clinical testing...
  33. pmc Comparison of microsatellites versus single-nucleotide polymorphisms in a genome linkage screen for prostate cancer-susceptibility Loci
    Daniel J Schaid
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Am J Hum Genet 75:948-65. 2004
    ..The strengths and weaknesses of microsatellite versus SNP markers are illustrated by the results of our genome linkage scans...
  34. ncbi request reprint Diffuse large B-cell lymphoma (Richter syndrome) in patients with chronic lymphocytic leukaemia (CLL): a cohort study of newly diagnosed patients
    Sameer A Parikh
    Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Br J Haematol 162:774-82. 2013
    ..Both underlying characteristics of the CLL clone and subsequent CLL therapy influence the risk of RS. Survival after RS remains poor and new therapies are needed...
  35. pmc Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphoma
    James R Cerhan
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Blood 110:4455-63. 2007
    ....
  36. pmc Autoimmune cytopenia in chronic lymphocytic leukemia/small lymphocytic lymphoma: changes in clinical presentation and prognosis
    Clive S Zent
    Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA
    Leuk Lymphoma 50:1261-8. 2009
    ..We propose that more sensitive and accurate diagnostic methods for CLL have decreased the perceived prevalence of AID cytopenia and that improvements in management could have increased the survival of these patients...
  37. pmc Monoclonal and polyclonal serum free light chains and clinical outcome in chronic lymphocytic leukemia
    Matthew J Maurer
    Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
    Blood 118:2821-6. 2011
    ..The FLC assay is a simple, widely available clinical test with similar prognostic utility as routinely used prognostic biomarkers for CLL. Among persons with FLC abnormalities, the type of abnormality affects prognostic significance...
  38. ncbi request reprint Evidence for genetic linkage between a polymorphism in the adenosine 2A receptor and panic disorder
    Steven P Hamilton
    Department of Psychiatry, College of Physicians and Surgeons at Columbia University and the New York State Psychiatric Institute, New York City, NY 10032, USA
    Neuropsychopharmacology 29:558-65. 2004
    ....
  39. pmc Pretreatment circulating serum cytokines associated with follicular and diffuse large B-cell lymphoma: a clinic-based case-control study
    Bridget Charbonneau
    Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
    Cytokine 60:882-9. 2012
    ..Abnormal immune function is a key factor in predisposition to non-Hodgkin lymphoma (NHL). We evaluated the association of 30 cytokines individually and as a profile with diffuse large B-cell (DLBCL) and follicular (FL) lymphomas...
  40. pmc Treatment of autoimmune cytopenia complicating progressive chronic lymphocytic leukemia/small lymphocytic lymphoma with rituximab, cyclophosphamide, vincristine, and prednisone
    Deborah A Bowen
    Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA
    Leuk Lymphoma 51:620-7. 2010
    ..No patient required blood cell transfusions after cycle 1 of therapy. We conclude that R-CVP is effective and tolerable therapy for autoimmune cytopenia complicating progressive CLL, but the duration of response is suboptimal...
  41. pmc Age at diagnosis and the utility of prognostic testing in patients with chronic lymphocytic leukemia
    Tait D Shanafelt
    Department of Medicine, Division of Hematology, Mayo Clinic, Rochester, Minnesota 55902, USA
    Cancer 116:4777-87. 2010
    ..A study was undertaken to analyze the survival of chronic lymphocytic leukemia (CLL) patients relative to age-matched individuals in the general population and determine the age-stratified utility of prognostic testing...
  42. pmc Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma
    Jennifer L Kelly
    School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA
    Cancer Epidemiol Biomarkers Prev 19:2847-58. 2010
    ..In addition, germline variation in both BCL2L11 (BIM) and CASP9, known regulators of apoptosis, has recently been linked to NHL risk. We conducted a comprehensive evaluation of 36 apoptosis pathway genes with risk of NHL...
  43. pmc CXCR5 polymorphisms in non-Hodgkin lymphoma risk and prognosis
    Bridget Charbonneau
    Department of Health Sciences Research, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, USA
    Cancer Immunol Immunother 62:1475-84. 2013
    ..64; 95% CI 0.47-0.87; p = 0.004). These results provide additional evidence for a role of host genetic variation in CXCR5 in lymphomagenesis, particularly for FL...
  44. pmc Rates and outcomes of follicular lymphoma transformation in the immunochemotherapy era: a report from the University of Iowa/MayoClinic Specialized Program of Research Excellence Molecular Epidemiology Resource
    Brian K Link
    Brian K Link, Sergei I Syrbu, University of Iowa College of Medicine, Iowa City, IA and Matthew J Maurer, Grzegorz S Nowakowski, Stephen M Ansell, William R Macon, Susan L Slager, Carrie A Thompson, David J Inwards, Patrick B Johnston, Joseph P Colgan, Thomas E Witzig, Thomas M Habermann, and James R Cerhan, Mayo Clinic College of Medicine and Mayo Foundation, Rochester, MN
    J Clin Oncol 31:3272-8. 2013
    ..This study sought to characterize transformation incidence and outcome for patients with follicular lymphoma (FL) in a prospective observational series begun after diffusion of rituximab use...
  45. pmc Hematologist/oncologist disease-specific expertise and survival: lessons from chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL)
    Tait D Shanafelt
    Mayo Clinic, Rochester, Minnesota 55902, USA
    Cancer 118:1827-37. 2012
    ....
  46. pmc The physician-patient relationship and quality of life: lessons from chronic lymphocytic leukemia
    Tait D Shanafelt
    Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, United States
    Leuk Res 33:263-70. 2009
    ..The effectiveness with which physicians help patients adjust to the physical, intellectual, and emotional challenges of CLL appears to impact patient QOL...
  47. pmc Vitamin D insufficiency and prognosis in non-Hodgkin's lymphoma
    Matthew T Drake
    College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Clin Oncol 28:4191-8. 2010
    ..Recent data also suggest that vitamin D insufficiency is related to inferior prognosis in some cancers, although there are no data for NHL...
  48. pmc Associations between cigarette smoking, hormone therapy, and folate intake with incident colorectal cancer by TP53 protein expression level in a population-based cohort of older women
    Lori S Tillmans
    Authors Affiliations Departments of Laboratory Medicine and Pathology and Health Sciences Research Division of Epidemiology Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester Department of Epidemiology, University of Minnesota, Minneapolis, Minnesota Department of Medicine Gastroenterology, Huntsman Cancer Institute and University of Utah, Salt Lake City, Utah Department of Epidemiology, University of Iowa, Iowa City, Iowa Department of Preventive Medicine, Keck School of Medicine of University of Southern California, Los Angeles, California and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington
    Cancer Epidemiol Biomarkers Prev 23:350-5. 2014
    ..50; 95% CI, 0.27-0.94). No other statistically significant associations were observed. These data support possible heterogeneous effects from HT on TP53-related pathways of colorectal carcinogenesis in older women...
  49. pmc Patients with chronic lymphocytic leukaemia and clonal deletion of both 17p13.1 and 11q22.3 have a very poor prognosis
    Patricia T Greipp
    Department of Laboratory Medicine and Pathology, Cytogenetics Laboratory, Mayo Clinic College of Medicine, Rochester, MN, USA
    Br J Haematol 163:326-33. 2013
    ..Use of an ATM/TP53 combination FISH probe set could identify these very-high risk patients. ..
  50. pmc Postmenopausal hormone therapy and colorectal cancer risk in relation to somatic KRAS mutation status among older women
    Paul J Limburg
    Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 21:681-4. 2012
    ....
  51. pmc Linkage analysis using principal components of gene expression data
    Elizabeth J Atkinson
    Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 1st Street SW, Rochester, Minnesota 55905, USA
    BMC Proc 1:S79. 2007
    ....
  52. pmc A comprehensive evaluation of the prognostic significance of 13q deletions in patients with B-chronic lymphocytic leukaemia
    Daniel L Van Dyke
    Division of Laboratory Genetics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Br J Haematol 148:544-50. 2010
    ..019). The clinical implications of 13q- in CLL appear more complex than originally appreciated...
  53. pmc Mutations in CHEK2 associated with prostate cancer risk
    Xiangyang Dong
    Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic Mayo Medical School, Rochester, MN 55905, USA
    Am J Hum Genet 72:270-80. 2003
    ..Overall, our data suggest that mutations in CHEK2 may contribute to prostate cancer risk and that the DNA-damage-signaling pathway may play an important role in the development of prostate cancer...
  54. pmc Evaluating the influence of quality control decisions and software algorithms on SNP calling for the affymetrix 6.0 SNP array platform
    Mariza de Andrade
    Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minn, USA mandrade mayo edu
    Hum Hered 71:221-33. 2011
    ..Our goal was to evaluate the influence of quality control (QC) decisions using two genotype calling algorithms, CRLMM and Birdseed, designed for the Affymetrix SNP Array 6.0...
  55. pmc Genetic variation in B-cell-activating factor is associated with an increased risk of developing B-cell non-Hodgkin lymphoma
    Anne J Novak
    Division of Hematology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Cancer Res 69:4217-24. 2009
    ..3 ng/mL in those with the high-risk alleles (P = 0.02). Taken together, our data suggest that genetic variation in the TNFSF13B gene is significantly associated with NHL risk and elevated serum BAFF levels...
  56. pmc CD5-positive chronic B-cell lymphoproliferative disorders: diagnosis and prognosis of a heterogeneous disease entity
    Roxana S Dronca
    Division of Hematology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cytometry B Clin Cytom 78:S35-41. 2010
    ..e. CD5+B-CLPD) are poorly defined...
  57. pmc Event-free survival at 24 months is a robust end point for disease-related outcome in diffuse large B-cell lymphoma treated with immunochemotherapy
    Matthew J Maurer
    Matthew J Maurer, Hervé Ghesquières, Thomas E Witzig, Carrie A Thompson, Ivana N Micallef, William R Macon, Paul J Kurtin, Cristine Allmer, Susan L Slager, Thomas M Habermann, and James R Cerhan, Mayo Clinic, Rochester, MN Hervé Ghesquières and Emmanuelle Nicolas Virelizier, Centre Léon Bérard Hervé Ghesquières and Gilles Salles, Universite Claude Bernard, Unité Mixte de Recherche UMR, Centre National de la Recherche Scientifique 5239, Lyon Jean Philippe Jais, Institut National de la Santé et de la Recherche Médicale INSERM UMR S 872, Necker Hospital, Assistance Publique Hopitaux de Paris Richard Delarue, Necker Hospital Thierry Jo Molina, Paris Descartes University, Paris Centre University Hospital, Paris Corinne Haioun, Henri Mondor Hospital, Universite Paris Est, Créteil Frédéric Peyrade, Centre Antoine Lacassagne, Nice Olivier Fitoussi, Polyclinique Bordeaux Nord, Bordeaux Gilles Salles, Hospices Civils de Lyon
    J Clin Oncol 32:1066-73. 2014
    ..We evaluated the timing and type of events in newly diagnosed DLBCL and compared patient outcome with reference population data...
  58. pmc Prognostic significance of pretreatment serum cytokines in classical Hodgkin lymphoma
    Preethi Reddy Marri
    Authors Affiliations Divisions of Hematology and Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota and Department of Internal Medicine, College of Medicine, University of Iowa, Iowa City, Iowa
    Clin Cancer Res 19:6812-9. 2013
    ..As cytokines are critically involved in driving cHL, we tested whether pretreatment serum cytokine levels could provide additional prognostic information...
  59. pmc The Functional Assessment of Cancer Therapy - General (FACT-G) is valid for monitoring quality of life in patients with non-Hodgkin lymphoma
    Kathleen J Yost
    Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
    Leuk Lymphoma 54:290-7. 2013
    ..Overall, the FACT-G was a valid measure for monitoring QoL over time in patients with NHL. However, sensitivity analyses based on subscale scoring that excludes potentially problematic items may be warranted...
  60. ncbi request reprint Overall and cancer-specific survival of patients with breast, colon, kidney, and lung cancers with and without chronic lymphocytic leukemia: a SEER population-based study
    Benjamin M Solomon
    Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Clin Oncol 31:930-7. 2013
    ..Chronic lymphocytic leukemia (CLL) is associated with an increased risk of developing second cancers. However, it is unknown whether CLL alters the disease course of these cancers once they occur...
  61. pmc Food-frequency questionnaire-based estimates of total antioxidant capacity and risk of non-Hodgkin lymphoma
    Shernan G Holtan
    Division of Hematology, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Int J Cancer 131:1158-68. 2012
    ....
  62. pmc The genetics of gene expression: comparison of linkage scans using two phenotype normalization methods
    Mariza de Andrade
    Division of Biostatistics, Mayo Clinic College of Medicine, 200 First Street Southwest, Harwick 7, Rochester, Minnesota 55905, USA
    BMC Proc 1:S151. 2007
    ..In summary, we conclude, as have other published reports, that normalization methods play an important role in the linkage results, and that some significant linkage signals might be due to a specific normalization method...
  63. ncbi request reprint No association of germline alteration of MSR1 with prostate cancer risk
    Liang Wang
    Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, 920 Hilton Building, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Nat Genet 35:128-9. 2003
    ..Our results do not support MSR1 as a risk factor for prostate cancer...
  64. pmc Cigarette smoking and colorectal cancer risk by molecularly defined subtypes
    David Limsui
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Natl Cancer Inst 102:1012-22. 2010
    ..Because colorectal carcinogenesis is a heterogeneous process, we investigated whether cigarette smoking is differentially associated with molecularly defined subtypes of colorectal cancer...
  65. pmc LIM domain only 2 protein expression, LMO2 germline genetic variation, and overall survival in diffuse large B-cell lymphoma in the pre-rituximab era
    James R Cerhan
    College of Medicine, Mayo Clinic, Rochester, MN, USA
    Leuk Lymphoma 53:1105-12. 2012
    ..In conclusion, germline genetic variation in LMO2 was associated with DLBCL prognosis and provided slightly stronger predictive ability relative to LMO2 IHC status...
  66. pmc Functional and clinical significance of variants localized to 8q24 in colon cancer
    Mine S Cicek
    Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street Southwest, 920 Hilton Building, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 18:2492-500. 2009
    ..Finally, these risk alleles do not seem to be associated with survival...
  67. pmc Comparison of tagging single-nucleotide polymorphism methods in association analyses
    Ellen L Goode
    Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    BMC Proc 1:S6. 2007
    ..e., whether a SNP or haplotype is responsible); unfortunately, this is often unknown at the time of SNP selection. Additional evaluations using empirical and simulated data are needed...
  68. pmc Statin use and prognosis in patients with diffuse large B-cell lymphoma and follicular lymphoma in the rituximab era
    Grzegorz S Nowakowski
    Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Clin Oncol 28:412-7. 2010
    ..The clinical impact of statin use on the outcome of lymphoma patients treated with a rituximab-containing regimen is unknown...
  69. pmc Association of mu-opioid receptor variants and response to citalopram treatment in major depressive disorder
    Holly A Garriock
    Department of Psychiatry, University of California, San Francisco, CA 94143 0984, USA
    Am J Psychiatry 167:565-73. 2010
    ....
  70. pmc Analysis of the RNASEL gene in familial and sporadic prostate cancer
    Liang Wang
    Department of Laboratory Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Am J Hum Genet 71:116-23. 2002
    ..82; P=.03), as well as in the subset analyses. These results suggest that polymorphic changes within the RNASEL gene may be associated with increased risk of familial but not sporadic PC...
  71. pmc Brief report: natural history of individuals with clinically recognized monoclonal B-cell lymphocytosis compared with patients with Rai 0 chronic lymphocytic leukemia
    Tait D Shanafelt
    Mayo Clinic, Rochester, MN 55905, USA
    J Clin Oncol 27:3959-63. 2009
    ..The natural history of clinically identified MBL is unclear. The goal of this study was to explore the outcome of patients with MBL relative to that of individuals with Rai stage 0 chronic lymphocytic leukemia (CLL)...
  72. pmc Identification of genes involved in alcohol consumption and cigarettes smoking
    Mariza de Andrade
    Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA
    BMC Genet 6:S112. 2005
    ....
  73. pmc Familial chronic lymphocytic leukemia: what does it mean to me?
    Susan L Slager
    Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN 55905, USA
    Clin Lymphoma Myeloma 9:S194-7. 2009
    ..At present it is best to indicate to concerned CLL patients that their relatives are at relatively low risk of developing CLL or other LPDs...
  74. pmc LEF-1 is a prosurvival factor in chronic lymphocytic leukemia and is expressed in the preleukemic state of monoclonal B-cell lymphocytosis
    Albert Gutierrez
    Department of Immunology, Mayo Clinic, College of Medicine, Rochester, MN 55905, USA
    Blood 116:2975-83. 2010
    ..This study has identified the constitutive activation and prosurvival function of LEF-1 and the Wnt pathway in CLL and uncovered a possible role for these factors in the preleukemic state of monoclonal B-cell lymphocytosis...
  75. pmc The prognostic significance of cytopenia in chronic lymphocytic leukaemia/small lymphocytic lymphoma
    Clive S Zent
    Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA
    Br J Haematol 141:615-21. 2008
    ..Revisions of the National Cancer Institute Working Group 96 criteria should consider the aetiology of cytopenia in staging CLL patients...
  76. ncbi request reprint Risk factors for development of a second lymphoid malignancy in patients with chronic lymphocytic leukaemia
    Kami Maddocks-Christianson
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Br J Haematol 139:398-404. 2007
    ..Physicians should strictly adhere to established criteria to initiate treatment for CLL patients who are not participating in clinical trials...
  77. ncbi request reprint Evidence for a susceptibility locus for panic disorder near the catechol-O-methyltransferase gene on chromosome 22
    Steven P Hamilton
    Department of Psychiatry, College of Physicians and Surgeons at Columbia University, New York, NY, USA
    Biol Psychiatry 51:591-601. 2002
    ....
  78. ncbi request reprint Genome scan for linkage to asthma using a linkage disequilibrium-lod score test
    Y Jiang
    Department of Statistics and Actuarial Science, 241 Schaeffer Hall, University of Iowa, Iowa City, IA 52242, USA
    Genet Epidemiol 21:S303-7. 2001
    ....
  79. pmc Associations between variants in the cyclooxygenase 2 enzyme gene (PTGS2) and development of benign prostate enlargement
    Jennifer L St Sauver
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
    BJU Int 108:1610-5. 2011
    ....
  80. ncbi request reprint Markov chain Monte Carlo linkage analysis: effect of bin width on the probability of linkage
    S L Slager
    New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Genet Epidemiol 21:S700-5. 2001
    ..We found that bin width, as expected, does affect the max PL and the location estimate, and we recommend that users of Loki explore how their results vary with different bin widths...
  81. pmc Analysis of variation in NF-kappaB genes and expression levels of NF-kappaB-regulated molecules
    Wen Liu Mares
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, Minnesota 55905, USA
    BMC Proc 1:S126. 2007
    ..We conclude that variation in the genes encoding p50 and c-Rel may play a role in NF-kappaB-related transcription of FAS, IRF1, and CD40...
  82. pmc A BAFF-R mutation associated with non-Hodgkin lymphoma alters TRAF recruitment and reveals new insights into BAFF-R signaling
    Joanne M Hildebrand
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Exp Med 207:2569-79. 2010
    ..Together, these data identify a novel lymphoma-associated mutation in human BAFF-R that results in NF-κB activation and reveals TRAF6 as a necessary component of normal BAFF-R signaling...
  83. ncbi request reprint Quality of life in chronic lymphocytic leukemia: an international survey of 1482 patients
    Tait D Shanafelt
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Br J Haematol 139:255-64. 2007
    ..The effects of CLL on QOL appear to differ from that of other malignancies with a more marked impact on emotional QOL. Research identifying efficacious psycho-oncologic support interventions for patients with CLL is needed...
  84. ncbi request reprint Role of HPC2/ELAC2 in hereditary prostate cancer
    L Wang
    Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Cancer Res 61:6494-9. 2001
    ..Cumulatively, these results suggest that alterations within the HPC2/ELAC2 gene play a limited role in genetic susceptibility to HPC...
  85. ncbi request reprint Effect of allelic heterogeneity on the power of the transmission disequilibrium test
    S L Slager
    Department of Preventive Medicine and Environmental Health, Division of Biostatistics, University of Iowa, Iowa City 52242, USA
    Genet Epidemiol 18:143-56. 2000
    ..Thus, the TDT may not be an optimal test in the context of genomic screens under more biologically realistic assumptions...
  86. pmc Confirmation of linkage of prostate cancer aggressiveness with chromosome 19q
    S L Slager
    Department of Health Sciences Research, Mayo Clinic Foundation, Rochester, MN 55905, USA
    Am J Hum Genet 72:759-62. 2003
    ..In addition, we report suggestive evidence for linkage on chromosome 4 (D4S403, P=.00012). The results of previous findings, together with our results, provide strong evidence that chromosome 19 harbors a gene for tumor aggressiveness...
  87. pmc Increased prevalence of light chain monoclonal gammopathy of undetermined significance (LC-MGUS) in first-degree relatives of individuals with multiple myeloma
    Alexandra J Greenberg
    Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN, USA
    Br J Haematol 157:472-5. 2012
    ..We saw no increased risk in relatives of HC-MGUS probands. We conclude that the prevalence of LC-MGUS is significantly higher among 1° relatives of MM probands compared to the reference population...
  88. ncbi request reprint Investigation of serotonin-related genes in antidepressant response
    E J Peters
    Department of Psychiatry, University of California, San Francisco, CA 94143 0984, USA
    Mol Psychiatry 9:879-89. 2004
    ..Intriguingly, we observe that a number of the less frequent alleles of many of the SNP markers were associated with the nonresponse and nonspecific phenotypes...
  89. ncbi request reprint No association or linkage between polymorphisms in the genes encoding cholecystokinin and the cholecystokinin B receptor and panic disorder
    S P Hamilton
    Department of Psychiatry, College of Physicians and Surgeons at Columbia University and the New York State Psychiatric Institute, USA
    Mol Psychiatry 6:59-65. 2001
    ..The results reported here provide little support for the role of these polymorphisms in panic disorder...
  90. ncbi request reprint The IDDM13 region containing the insulin-like growth factor binding protein-5 (IGFBP5) gene on chromosome 2q33-q36 and the genetic susceptibility to rheumatoid arthritis
    S L Slager
    New York Psychiatric Institute, Department of Psychiatry adn Department of Biostatistics, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Genes Immun 3:110-3. 2002
    ..These results suggest that, despite the involvement of the 2q33-q36 chromosomal region in another organ-specific autoimmune disease, it is unlikely that this region harbors a RA susceptibility locus...
  91. pmc Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene
    Z Deng
    Department of Psychiatry, College of Physicians and Surgeons at Columbia University and the New York State Psychiatric Institute, New York, NY, USA
    Am J Hum Genet 67:737-44. 2000
    ..These findings indicate that the bone morphogenetic protein-signaling pathway is defective in patients with primary pulmonary hypertension and may implicate the pathway in the nonfamilial forms of the disease...
  92. pmc A high-density SNP genome-wide linkage search of 206 families identifies susceptibility loci for chronic lymphocytic leukemia
    Gabrielle S Sellick
    Section of Cancer Genetics, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, UK
    Blood 110:3326-33. 2007
    ..002). None of the regions coincided with areas of common chromosomal abnormalities frequently observed in CLL. These findings provide direct evidence for Mendelian predisposition to CLL and evidence for the location of disease loci...
  93. pmc Pharmacokinetic genes do not influence response or tolerance to citalopram in the STAR*D sample
    Eric J Peters
    Department of Psychiatry and Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 3:e1872. 2008
    ..We sought to determine whether clinical response or tolerance to the Selective Serotonin Reuptake Inhibitor (SSRI) citalopram is associated with genetic polymorphisms in potentially relevant pharmacokinetic enzymes...
  94. pmc Family history of hematopoietic malignancies and risk of non-Hodgkin lymphoma (NHL): a pooled analysis of 10 211 cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph)
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, MD 20892, USA
    Blood 109:3479-88. 2007
    ..0; 95% CI = 1.6-5.6). The pattern of NHL heritability appeared to be uniform across NHL subtypes, but risk patterns differed by specific hematopoietic malignancies and the sex of the relative, revealing critical clues to disease etiology...
  95. ncbi request reprint Analysis of association between the serotonin transporter and antidepressant response in a large clinical sample
    Jeffrey B Kraft
    Department of Psychiatry and Center for Human Genetics, University of California, San Francisco, California 94143 0984, USA
    Biol Psychiatry 61:734-42. 2007
    ..We sought to replicate our previous findings that SLC6A4 is associated with response to a selective serotonin reuptake inhibitor (SSRI) in a large case-control study...
  96. pmc Non-Hodgkin lymphoma and obesity: a pooled analysis from the InterLymph Consortium
    Eleanor V Willett
    Epidemiology and Genetics Unit, Department of Health Sciences, University of York, Heslington, York YO10 5DD, United Kingdom
    Int J Cancer 122:2062-70. 2008
    ....
  97. ncbi request reprint Sequence analysis of the serotonin transporter and associations with antidepressant response
    Jeffrey B Kraft
    Department of Psychiatry and Center for Human Genetics, University of California San Francisco, 401 Parnassus Avenue, San Francisco, CA 94143 0984, USA
    Biol Psychiatry 58:374-81. 2005
    ..We sought to test further the hypothesis that SLC6A4 is associated with SSRI response by resequencing this gene in subjects with major depression...
  98. ncbi request reprint Associations of pacifier use, digit sucking, and child care attendance with cessation of breastfeeding
    Steven M Levy
    Universit of Iowa, Iowa City 52242, USA
    J Fam Pract 51:465. 2002
    ..This study assessed the associations between pacifier use, digit sucking, childcare attendance, and breastfeeding cessation among 1387 infants in the Iowa Fluoride Study...

Research Grants4

  1. Statistical Genetic Methods for Cancer Gene Studies
    Susan Slager; Fiscal Year: 2006
    ..abstract_text> ..
  2. Genetic Epidemiology of Chronic Lymphocytic Leukemia
    Susan Slager; Fiscal Year: 2007
    ..We expect to identify at least one significant chromosomal region through the linkage analysis conducted in Aim 3. We will then fine map these regions by genotyping additional markers within the regions. ..
  3. Pooling and expansion of Chronic Lymphocytic Leukemia GWA data
    Susan L Slager; Fiscal Year: 2010
    ..Identifying and understanding these genes will inform our limited biology of CLL, as well as improve risk prediction and stratification, and may enable identification of patients who will benefit from early prevention strategies. ..