STEVEN SINE

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. doi request reprint Inter-residue coupling contributes to high-affinity subtype-selective binding of α-bungarotoxin to nicotinic receptors
    Steven M Sine
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55902, USA
    Biochem J 454:311-21. 2013
  2. pmc End-plate acetylcholine receptor: structure, mechanism, pharmacology, and disease
    Steven M Sine
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Physiol Rev 92:1189-234. 2012
  3. pmc Naturally occurring mutations at the acetylcholine receptor binding site independently alter ACh binding and channel gating
    Steven M Sine
    Receptor Biology Laboratory, Department of Physiology and Biophysics, and Mayo Foundation, Rochester, MN 55905, USA
    J Gen Physiol 120:483-96. 2002
  4. ncbi request reprint Recent advances in Cys-loop receptor structure and function
    Steven M Sine
    Department of Physiology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Nature 440:448-55. 2006
  5. ncbi request reprint Toward atomic-scale understanding of ligand recognition in the muscle nicotinic receptor
    Steven M Sine
    Receptor Biology Laboratory, Department of Physiology and Biophysics, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Curr Med Chem 11:559-67. 2004
  6. ncbi request reprint Mechanistic diversity underlying fast channel congenital myasthenic syndromes
    Steven M Sine
    Receptor Biology Laboratory, Department of Physiology and Biophysics, Mayo Medical School, Rochester, Minnesota 55905, USA
    Ann N Y Acad Sci 998:128-37. 2003
  7. pmc Recent structural and mechanistic insights into endplate acetylcholine receptors
    Steven M Sine
    Receptor Biology Laboratory, Departments of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Ann N Y Acad Sci 1132:53-60. 2008
  8. ncbi request reprint The nicotinic receptor ligand binding domain
    Steven M Sine
    Department of Physiology and Biophysics, Mayo Foundation, Rochester, Minnesota 55905, USA
    J Neurobiol 53:431-46. 2002
  9. ncbi request reprint Lysine scanning mutagenesis delineates structural model of the nicotinic receptor ligand binding domain
    Steven M Sine
    Receptor Biology Laboratory, Department of Physiology and Biophysics, Mayo Foundation, Rochester, Minnesota 55905, USA
    J Biol Chem 277:29210-23. 2002
  10. pmc On the origin of ion selectivity in the Cys-loop receptor family
    Steven M Sine
    Receptor Biology Laboratory, Departments of Physiology and Biomedical Engineering and Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Mol Neurosci 40:70-6. 2010

Collaborators

Detail Information

Publications52

  1. doi request reprint Inter-residue coupling contributes to high-affinity subtype-selective binding of α-bungarotoxin to nicotinic receptors
    Steven M Sine
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55902, USA
    Biochem J 454:311-21. 2013
    ..Thus interaction between Tyr¹⁸⁴ and local residues contributes to high-affinity subtype-selective α-btx binding...
  2. pmc End-plate acetylcholine receptor: structure, mechanism, pharmacology, and disease
    Steven M Sine
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Physiol Rev 92:1189-234. 2012
    ..Recent studies provide an increasingly detailed picture of the structure of the AChR and the symphony of molecular motions that underpin its remarkably fast and efficient chemoelectrical transduction...
  3. pmc Naturally occurring mutations at the acetylcholine receptor binding site independently alter ACh binding and channel gating
    Steven M Sine
    Receptor Biology Laboratory, Department of Physiology and Biophysics, and Mayo Foundation, Rochester, MN 55905, USA
    J Gen Physiol 120:483-96. 2002
    ..The overall results show that key residues at the ACh binding site differentially stabilize the agonist bound to closed, open and desensitized states, and provide a set point for gating of the channel...
  4. ncbi request reprint Recent advances in Cys-loop receptor structure and function
    Steven M Sine
    Department of Physiology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Nature 440:448-55. 2006
    ..Namely, analyses of disease-causing mutations have clarified receptor structure-function relationships as well as mechanisms governing the postsynaptic response...
  5. ncbi request reprint Toward atomic-scale understanding of ligand recognition in the muscle nicotinic receptor
    Steven M Sine
    Receptor Biology Laboratory, Department of Physiology and Biophysics, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Curr Med Chem 11:559-67. 2004
    ..The results have important implications for design of drugs targeting nicotinic receptors and members of the superfamily of pentameric ligand-gated ion channels...
  6. ncbi request reprint Mechanistic diversity underlying fast channel congenital myasthenic syndromes
    Steven M Sine
    Receptor Biology Laboratory, Department of Physiology and Biophysics, Mayo Medical School, Rochester, Minnesota 55905, USA
    Ann N Y Acad Sci 998:128-37. 2003
    ..This review focuses on new mechanisms underlying the FCCMS...
  7. pmc Recent structural and mechanistic insights into endplate acetylcholine receptors
    Steven M Sine
    Receptor Biology Laboratory, Departments of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Ann N Y Acad Sci 1132:53-60. 2008
    ..Structural models of the human AChR enable precise mapping of disease-causing mutations, while studies of the speed with which single AChR channels open and close cast light on pathogenic mechanisms...
  8. ncbi request reprint The nicotinic receptor ligand binding domain
    Steven M Sine
    Department of Physiology and Biophysics, Mayo Foundation, Rochester, Minnesota 55905, USA
    J Neurobiol 53:431-46. 2002
    ....
  9. ncbi request reprint Lysine scanning mutagenesis delineates structural model of the nicotinic receptor ligand binding domain
    Steven M Sine
    Receptor Biology Laboratory, Department of Physiology and Biophysics, Mayo Foundation, Rochester, Minnesota 55905, USA
    J Biol Chem 277:29210-23. 2002
    ..The overall results suggest that lysine scanning can provide the basis for structural modeling of other members of the AChR superfamily as well as of other proteins with repeating structures delimiting a hydrophobic core...
  10. pmc On the origin of ion selectivity in the Cys-loop receptor family
    Steven M Sine
    Receptor Biology Laboratory, Departments of Physiology and Biomedical Engineering and Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Mol Neurosci 40:70-6. 2010
    ....
  11. pmc Invariant aspartic Acid in muscle nicotinic receptor contributes selectively to the kinetics of agonist binding
    Won Yong Lee
    Department of Physiology and Biophysics, Mayo Clinic College of Medicine, 200 First St, SW, MSB 1 35, Rochester, MN 55905, USA
    J Gen Physiol 124:555-67. 2004
    ..The specific effect of alphaD89N on ACh association suggests that interdomain hydrogen bonding positions alphaW149 for optimal interaction with ACh...
  12. pmc Curariform antagonists bind in different orientations to acetylcholine-binding protein
    Fan Gao
    Receptor Biology Laboratory, Department of Physiology and Biophysics, Mayo Clinic Department of Pharmacology, Mayo Graduate School, Rochester, Minnesota 55905, USA
    J Biol Chem 278:23020-6. 2003
    ..Thus structurally similar ligands can adopt distinct orientations at receptor binding sites, posing challenges for interpreting structure-activity relationships for many drugs...
  13. pmc Initial coupling of binding to gating mediated by conserved residues in the muscle nicotinic receptor
    Nuriya Mukhtasimova
    Receptor Biology Laboratory, Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Gen Physiol 126:23-39. 2005
    ..Thus, interplay between these three conserved residues relays the initial conformational change from the ACh binding site toward the ion channel...
  14. pmc Detection and trapping of intermediate states priming nicotinic receptor channel opening
    Nuriya Mukhtasimova
    Receptor Biology Laboratory, Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Nature 459:451-4. 2009
    ..Thus, a change in binding-site conformation primes the AChR for channel opening in a process that enables selective activation by ACh while maximizing the speed and efficiency of the biological response...
  15. ncbi request reprint Agonist-mediated conformational changes in acetylcholine-binding protein revealed by simulation and intrinsic tryptophan fluorescence
    Fan Gao
    Receptor Biology Laboratory, Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Biol Chem 280:8443-51. 2005
    ..The collective findings showed that ACh initially establishes close register of conserved Trps from adjacent subunits and then draws the C-loop inward to occlude the entrance to the binding cavity...
  16. pmc Mutation causing severe myasthenia reveals functional asymmetry of AChR signature cystine loops in agonist binding and gating
    Xin Ming Shen
    Department of Neurology and Neuromuscular Research Laboratory, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Invest 111:497-505. 2003
    ..The overall findings reveal functional asymmetry between cys-loops of the different AChR subunits in contributing to ACh binding and channel gating...
  17. ncbi request reprint Slow-channel mutation in acetylcholine receptor alphaM4 domain and its efficient knockdown
    Xin Ming Shen
    Neuromuscular Research Laboratory and Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Ann Neurol 60:128-36. 2006
    ..To identify the genetic basis of a slow-channel myasthenic syndrome, characterize functional properties of the mutant receptor, and selectively silence the mutant allele...
  18. ncbi request reprint An intersubunit trigger of channel gating in the muscle nicotinic receptor
    Nuriya Mukhtasimova
    Department of Physiology and Biomedical Engineering, Receptor Biology Laboratory, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Neurosci 27:4110-9. 2007
    ..Thus, the Tyr-Asn pair is an intersubunit trigger of rapid and efficient gating of muscle nicotinic receptors...
  19. ncbi request reprint Subunit-specific contribution to agonist binding and channel gating revealed by inherited mutation in muscle acetylcholine receptor M3-M4 linker
    Xin Ming Shen
    Department of Neurology and Neuromuscular Research Laboratory, Mayo Clinic, Rochester, MN 55905, USA
    Brain 128:345-55. 2005
    ..The overall studies reveal subunit asymmetry in the contributions of the M3-M4 loops in optimizing AChR activation through allosteric links to the channel and the agonist binding site...
  20. ncbi request reprint Principal pathway coupling agonist binding to channel gating in nicotinic receptors
    Won Yong Lee
    Receptor Biology Laboratory, Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Nature 438:243-7. 2005
    ..The series of interresidue couplings identified here constitutes a primary allosteric pathway that links neurotransmitter binding to channel gating...
  21. pmc Congenital myasthenia-related AChR delta subunit mutation interferes with intersubunit communication essential for channel gating
    Xin Ming Shen
    Muscle Research Laboratory, Department of Neurology, Receptor Biology Laboratory, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Invest 118:1867-76. 2008
    ..Thus, deltaL42 is part of an intersubunit network that enables ACh binding to rapidly open the AChR channel, which may be compromised in patients with CM...
  22. pmc Control of cation permeation through the nicotinic receptor channel
    Hai Long Wang
    Receptor Biology Laboratory, Department of Physiology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    PLoS Comput Biol 4:e41. 2008
    ....
  23. pmc Further observations in congenital myasthenic syndromes
    Andrew G Engel
    Department of Neurology and Muscle Research Laboratory, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Ann N Y Acad Sci 1132:104-13. 2008
    ..4, MuSK, and Dok-7. Moreover, emerging genotype-phenotype correlations are providing clues for targeted mutation analysis. This review focuses on the recent observations in selected CMS...
  24. pmc What have we learned from the congenital myasthenic syndromes
    Andrew G Engel
    Department of Neurology and Muscle Research Laboratory, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Mol Neurosci 40:143-53. 2010
    ..Mutations in EP-specific proteins also prompted expression studies that proved pathogenicity, highlighted important functional domains of the abnormal proteins, and pointed to rational therapy...
  25. pmc Single-channel current through nicotinic receptor produced by closure of binding site C-loop
    Hai Long Wang
    Receptor Biology Laboratory, Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Biophys J 96:3582-90. 2009
    ..This approach of applying Biology Boltzmann transport Monte Carlo simulation can be used to further investigate the binding to gating transduction mechanism and the structural bases for ion selection and translocation...
  26. pmc Nicotinic receptor interloop proline anchors beta1-beta2 and Cys loops in coupling agonist binding to channel gating
    Won Yong Lee
    Receptor Biology Laboratory, Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Gen Physiol 132:265-78. 2008
    ..The overall results indicate that alphaPro 272 functionally couples to flanking Val residues extending from the beta1-beta2 and Cys loops within the ACh binding to channel opening transduction pathway...
  27. pmc Binding to gating transduction in nicotinic receptors: Cys-loop energetically couples to pre-M1 and M2-M3 regions
    Won Yong Lee
    Receptor Biology Laboratory and Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Neurosci 29:3189-99. 2009
    ..Thus, the extracellular beta1-beta2 and Cys-loops bridge the pre-M1 domain and M2-M3 linker to transduce agonist binding into channel gating...
  28. ncbi request reprint Sleuthing molecular targets for neurological diseases at the neuromuscular junction
    Andrew G Engel
    Department of Neurology and Neuromuscular Research Laboratory, Mayo Clinic, Rochester, Minnesota 55905, USA
    Nat Rev Neurosci 4:339-52. 2003
  29. ncbi request reprint Congenital myasthenic syndromes: progress over the past decade
    Andrew G Engel
    Department of Neurology and Neuromuscular Research Laboratory, Mayo Clinic, Rochester, Minnesota 55905, USA
    Muscle Nerve 27:4-25. 2003
    ..In a subset of CMS patients, endplate AChR deficiency is caused by mutations in rapsyn, a molecule that plays a critical role in concentrating AChR in the postsynaptic membrane...
  30. ncbi request reprint Congenital myasthenic syndromes: multiple molecular targets at the neuromuscular junction
    Andrew G Engel
    Neuromuscular Disease Research Laboratory, Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann N Y Acad Sci 998:138-60. 2003
    ..In a subset of CMS patients, endplate AChR deficiency is caused by mutations in rapsyn, a molecule that plays a critical role in concentrating AChR in the postsynaptic membrane...
  31. ncbi request reprint Congenital myasthenic syndromes: A diverse array of molecular targets
    Andrew G Engel
    Department of Neurology and Neuromuscular Research Laboratory, Mayo Clinic, Rochester, MN 55905
    J Neurocytol 32:1017-37. 2003
    ....
  32. ncbi request reprint Current understanding of congenital myasthenic syndromes
    Andrew G Engel
    Department of Neurology and Neuromuscular Research Laboratory, Mayo Clinic, Rochester, Minnesota 55905, USA
    Curr Opin Pharmacol 5:308-21. 2005
    ..Recent crystallography studies of choline acetyltransferase and homology structural models of the acetylcholine receptor are providing further clues to how point mutations alter protein function...
  33. ncbi request reprint The spectrum of congenital myasthenic syndromes
    Andrew G Engel
    Department of Neurology and Neuromuscular Research Laboratory, Mayo Clinic, Rochester, MN 55905, USA
    Mol Neurobiol 26:347-67. 2002
    ..Future studies will likely uncover new types of CMS that reside in molecules governing quantal release, organization of the synaptic basal lamina, and expression and aggregation of AChR on the postsynaptic junctional folds...
  34. ncbi request reprint Solution NMR of acetylcholine binding protein reveals agonist-mediated conformational change of the C-loop
    Fan Gao
    Receptor Biology Laboratory, Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester MN 55905, USA
    Mol Pharmacol 70:1230-5. 2006
    ..The collective findings suggest a structural mechanism for agonist recognition in AChBP and related Cys-loop receptors...
  35. ncbi request reprint Curariform antagonists bind in different orientations to the nicotinic receptor ligand binding domain
    Hai Long Wang
    Receptor Biology Laboratory, Department of Physiology and Biophysics, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 278:32284-91. 2003
    ..The overall mutagenesis and computational results show that despite their similar structures, d-TC and metocurine bind in distinctly different orientations to the adult human AChR...
  36. pmc New horizons for congenital myasthenic syndromes
    Andrew G Engel
    Neuromuscular Research Laboratory, Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
    Ann N Y Acad Sci 1275:54-62. 2012
    ....
  37. pmc Mechanism of tacrine block at adult human muscle nicotinic acetylcholine receptors
    Richard J Prince
    School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Gen Physiol 120:369-93. 2002
    ..Overall, the best description of our data was obtained with a model that combined two binding sites in the open channel with a single site in the closed state of the receptor...
  38. ncbi request reprint Residues in the epsilon subunit of the nicotinic acetylcholine receptor interact to confer selectivity of waglerin-1 for the alpha-epsilon subunit interface site
    Brian E Molles
    Department of Pharmacology, Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, CA92093 0636, USA
    Biochemistry 41:7895-906. 2002
    ..We use the binding and interaction energies for Wtx-1 to generate structural models of the alpha-epsilon, alpha-gamma, and alpha-delta binding sites containing the nonhomologous insertion...
  39. pmc The interface between extracellular and transmembrane domains of homomeric Cys-loop receptors governs open-channel lifetime and rate of desensitization
    Cecilia Bouzat
    Instituto de Investigaciones Bioquimicas, Universidad Nacional del Sur Consejo Nacional de Investigaciones Científicas y Técnicas, Bahia Blanca 8000, Argentina
    J Neurosci 28:7808-19. 2008
    ....
  40. pmc Subunit-selective contribution to channel gating of the M4 domain of the nicotinic receptor
    Cecilia Bouzat
    Instituto de Investigaciones Bioquimicas, UNS CONICET, Bahia Blanca, Argentina
    Biophys J 82:1920-9. 2002
    ..Thus, we identify subunit-specific contributions to channel gating of equivalent residues in M4 and elucidate the underlying mechanistic and structural bases...
  41. ncbi request reprint Novel modulation of neuronal nicotinic acetylcholine receptors by association with the endogenous prototoxin lynx1
    Ines Ibanez-Tallon
    Laboratory of Molecular Biology, Howard Hughes Medical Institute, New York, NY 10021, USA
    Neuron 33:893-903. 2002
    ....
  42. ncbi request reprint Identification of residues at the alpha and epsilon subunit interfaces mediating species selectivity of Waglerin-1 for nicotinic acetylcholine receptors
    Brian E Molles
    Department of Pharmacology, University of California, San Diego, La Jolla, California 92093 0636, USA
    J Biol Chem 277:5433-40. 2002
    ..The overall results show that non-conserved residues at the nAChR binding site, although not crucial for activation by ACh, govern the potency of neuromuscular toxins...
  43. pmc Asymmetric structural motions of the homomeric alpha7 nicotinic receptor ligand binding domain revealed by molecular dynamics simulation
    Richard H Henchman
    Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California 92093, USA
    Biophys J 85:3007-18. 2003
    ..Furthermore, the shape of the asymmetry with binding sites of differing affinity for acetylcholine, characteristic of other nicotinic receptors, may be a natural property of the relaxed, activatable state of alpha7...
  44. ncbi request reprint Single-channel kinetic analysis of chimeric alpha7-5HT3A receptors
    Diego Rayes
    Instituto de Investigaciones Bioquimicas, Camino La Carrindanga Km 7, 8000 Bahia Blanca, Argentina
    Mol Pharmacol 68:1475-83. 2005
    ..Channel closing and desensitization occur at similar rates and account for the invariant open and closed time distributions...
  45. pmc Ligand-induced conformational change in the alpha7 nicotinic receptor ligand binding domain
    Richard H Henchman
    Howard Hughes Medical Institute, NSF Center for Theoretical Biophysics, Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA
    Biophys J 88:2564-76. 2005
    ....
  46. ncbi request reprint Alpha-conotoxins ImI and ImII target distinct regions of the human alpha7 nicotinic acetylcholine receptor and distinguish human nicotinic receptor subtypes
    Michael Ellison
    Department of Biology and Psychiatry, University of Utah, Salt Lake City, Utah 84112, USA
    Biochemistry 43:16019-26. 2004
    ..Collectively, the data show that while alpha-ImI targets the classical competitive ligand binding site in a subtype selective manner, alpha-ImII is a probe of a novel inhibitory site in homomeric alpha7 nAChRs...
  47. ncbi request reprint Structural basis for epibatidine selectivity at desensitized nicotinic receptors
    Richard A Pennington
    School of Biological Sciences, University of Manchester, G38 Stopford Bldg, Oxford Rd, Manchester M13 9PT, United Kingdom
    Mol Pharmacol 67:123-31. 2005
    ..The structural basis for epibatidine selectivity is explained by computational docking of epibatidine to a homology model of the alpha-gamma binding site...
  48. pmc Targeted molecular dynamics study of C-loop closure and channel gating in nicotinic receptors
    Xiaolin Cheng
    Howard Hughes Medical Institute, University of California San Diego, La Jolla, California, United States of America
    PLoS Comput Biol 2:e134. 2006
    ....
  49. ncbi request reprint Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel
    Cecilia Bouzat
    Instituto de Investigaciones Bioquimicas, UNS CONICET, Bahia Blanca 8000, Argentina
    Nature 430:896-900. 2004
    ..Structural modelling reveals a network of interacting loops between binding and pore domains that mediates this allosteric coupling process...
  50. ncbi request reprint Barriers to ion translocation in cationic and anionic receptors from the Cys-loop family
    Ivaylo Ivanov
    Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093 0365, USA
    J Am Chem Soc 129:8217-24. 2007
    ..Thus, the overall electrostatics and the presence of rings of charged residues at the entrance and exit of the channels were sufficient to explain the experimentally observed anion and cation selectivity...
  51. pmc Nanosecond-timescale conformational dynamics of the human alpha7 nicotinic acetylcholine receptor
    Xiaolin Cheng
    Howard Hughes Medical Institute, National Science Foundation Center for Theoretical Biophysics, Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA
    Biophys J 93:2622-34. 2007
    ..The resulting concerted motion causes a downward shift of the M2 helices that disrupts a hydrophobic girdle formed by 9' and 13' residues...
  52. pmc Morantel allosterically enhances channel gating of neuronal nicotinic acetylcholine alpha 3 beta 2 receptors
    Tse Yu Wu
    Department of Chemistry, Grinnell College, Grinnell, Iowa 50112, USA
    Mol Pharmacol 74:466-75. 2008
    ....

Research Grants13

  1. Allosteric Coupling in Homomeric Cys-loop Receptors
    STEVEN SINE; Fiscal Year: 2009
    ..Knowledge of how Cys-loop receptors operate at the molecular level is essential to developing therapeutic strategies and drugs with fewer side effects. ..
  2. Allosteric Coupling in Homomeric Cys-loop Receptors
    STEVEN SINE; Fiscal Year: 2007
    ..Knowledge of how Cys-loop receptors operate at the molecular level is essential to developing therapeutic strategies and drugs with fewer side effects. ..
  3. STRUCTURE AND FUNCTION OF THE ACETYLCHOLINE RECEPTOR
    STEVEN SINE; Fiscal Year: 2000
    ....
  4. STRUCTURE AND BIOPHYSICS OF THE ACETYLCHOLINE RECEPTOR
    STEVEN SINE; Fiscal Year: 1993
    ..The insights gained may provide similar insights for the entire superfamily of neurotransmitter-gated ion channels...
  5. Structure and Function of Acetylcholine Receptors
    Steven M Sine; Fiscal Year: 2010
    ..Understanding both structures and molecular mechanisms of post-synaptic receptors would enable design of more specific drugs. ..