Tait Shanafelt

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi request reprint Risk factors for development of a second lymphoid malignancy in patients with chronic lymphocytic leukaemia
    Kami Maddocks-Christianson
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Br J Haematol 139:398-404. 2007
  2. ncbi request reprint Oncologist burnout: causes, consequences, and responses
    Tait Shanafelt
    Mayo Clinic, Rochester, MN 55905, USA
    J Clin Oncol 30:1235-41. 2012
  3. pmc Chronic lymphocytic leukemia in young (≤ 55 years) patients: a comprehensive analysis of prognostic factors and outcomes
    Sameer A Parikh
    Haematologica 99:140-7. 2014
  4. doi request reprint The medical marriage: a national survey of the spouses/partners of US physicians
    Tait D Shanafelt
    Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 88:216-25. 2013
  5. ncbi request reprint Overall and cancer-specific survival of patients with breast, colon, kidney, and lung cancers with and without chronic lymphocytic leukemia: a SEER population-based study
    Benjamin M Solomon
    Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Clin Oncol 31:930-7. 2013
  6. ncbi request reprint Burnout and satisfaction with work-life balance among US physicians relative to the general US population
    Tait D Shanafelt
    Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Arch Intern Med 172:1377-85. 2012
  7. pmc Phase 2 trial of daily, oral Polyphenon E in patients with asymptomatic, Rai stage 0 to II chronic lymphocytic leukemia
    Tait D Shanafelt
    Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer 119:363-70. 2013
  8. ncbi request reprint Improving treatment for patients with chronic lymphocytic leukemia
    Tait D Shanafelt
    Hematology 17:S133-6. 2012
  9. doi request reprint Avoiding burnout: the personal health habits and wellness practices of US surgeons
    Tait D Shanafelt
    Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Ann Surg 255:625-33. 2012
  10. pmc Hematologist/oncologist disease-specific expertise and survival: lessons from chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL)
    Tait D Shanafelt
    Mayo Clinic, Rochester, Minnesota 55902, USA
    Cancer 118:1827-37. 2012

Detail Information

Publications92

  1. ncbi request reprint Risk factors for development of a second lymphoid malignancy in patients with chronic lymphocytic leukaemia
    Kami Maddocks-Christianson
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Br J Haematol 139:398-404. 2007
    ..Physicians should strictly adhere to established criteria to initiate treatment for CLL patients who are not participating in clinical trials...
  2. ncbi request reprint Oncologist burnout: causes, consequences, and responses
    Tait Shanafelt
    Mayo Clinic, Rochester, MN 55905, USA
    J Clin Oncol 30:1235-41. 2012
    ..In this review, we examine the causes, consequences, and personal ramifications of oncologist burnout and explore the steps oncologists can take to promote personal well-being and professional satisfaction...
  3. pmc Chronic lymphocytic leukemia in young (≤ 55 years) patients: a comprehensive analysis of prognostic factors and outcomes
    Sameer A Parikh
    Haematologica 99:140-7. 2014
    ..Although the survival of young chronic lymphocytic leukemia patients is longer than that of those >55 years old, their survival relative to the age- and sex-matched normal population is profoundly shortened...
  4. doi request reprint The medical marriage: a national survey of the spouses/partners of US physicians
    Tait D Shanafelt
    Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 88:216-25. 2013
    ..To evaluate physician relationships from the perspective of their spouses/partners...
  5. ncbi request reprint Overall and cancer-specific survival of patients with breast, colon, kidney, and lung cancers with and without chronic lymphocytic leukemia: a SEER population-based study
    Benjamin M Solomon
    Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Clin Oncol 31:930-7. 2013
    ..Chronic lymphocytic leukemia (CLL) is associated with an increased risk of developing second cancers. However, it is unknown whether CLL alters the disease course of these cancers once they occur...
  6. ncbi request reprint Burnout and satisfaction with work-life balance among US physicians relative to the general US population
    Tait D Shanafelt
    Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Arch Intern Med 172:1377-85. 2012
    ..Despite extensive data about physician burnout, to our knowledge, no national study has evaluated rates of burnout among US physicians, explored differences by specialty, or compared physicians with US workers in other fields...
  7. pmc Phase 2 trial of daily, oral Polyphenon E in patients with asymptomatic, Rai stage 0 to II chronic lymphocytic leukemia
    Tait D Shanafelt
    Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer 119:363-70. 2013
    ..The objective of the current study was to follow up the results of phase 1 testing by evaluating the clinical efficacy of the green tea extract Polyphenon E for patients with early stage chronic lymphocytic leukemia (CLL)...
  8. ncbi request reprint Improving treatment for patients with chronic lymphocytic leukemia
    Tait D Shanafelt
    Hematology 17:S133-6. 2012
    ..In this mini-review, we summarize Mayo Clinic's recent efforts to improve CIT for patients with CLL...
  9. doi request reprint Avoiding burnout: the personal health habits and wellness practices of US surgeons
    Tait D Shanafelt
    Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Ann Surg 255:625-33. 2012
    ..To evaluate the health habits, routine medical care practices, and personal wellness strategies of American surgeons and explore associations with burnout and quality of life (QOL)...
  10. pmc Hematologist/oncologist disease-specific expertise and survival: lessons from chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL)
    Tait D Shanafelt
    Mayo Clinic, Rochester, Minnesota 55902, USA
    Cancer 118:1827-37. 2012
    ....
  11. pmc The influence of personal and environmental factors on professionalism in medical education
    Colin P West
    Division of General Internal Medicine, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
    BMC Med Educ 7:29. 2007
    ..An understanding of the factors contributing to professionalism may allow the development of more effective approaches to promoting this quality in medical education...
  12. pmc Development and preliminary psychometric properties of a well-being index for medical students
    Liselotte N Dyrbye
    Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    BMC Med Educ 10:8. 2010
    ....
  13. pmc B-cell count and survival: differentiating chronic lymphocytic leukemia from monoclonal B-cell lymphocytosis based on clinical outcome
    Tait D Shanafelt
    Mayo Clinic, Rochester, MN, USA
    Blood 113:4188-96. 2009
    ..Using clinically relevant criteria to distinguish between monoclonal B-cell lymphocytosis (MBL) and CLL could minimize patient distress caused by labeling asymptomatic people at low risk for adverse clinical consequences as having CLL...
  14. pmc The physician-patient relationship and quality of life: lessons from chronic lymphocytic leukemia
    Tait D Shanafelt
    Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, United States
    Leuk Res 33:263-70. 2009
    ..The effectiveness with which physicians help patients adjust to the physical, intellectual, and emotional challenges of CLL appears to impact patient QOL...
  15. pmc A career in surgical oncology: finding meaning, balance, and personal satisfaction
    Tait Shanafelt
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Ann Surg Oncol 15:400-6. 2008
    ..In this article, we review the literature on surgeon burnout, discuss potential personal and professional consequences, and consider steps individual surgeons can take to promote personal and professional satisfaction...
  16. ncbi request reprint Quality of life in chronic lymphocytic leukemia: an international survey of 1482 patients
    Tait D Shanafelt
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Br J Haematol 139:255-64. 2007
    ..The effects of CLL on QOL appear to differ from that of other malignancies with a more marked impact on emotional QOL. Research identifying efficacious psycho-oncologic support interventions for patients with CLL is needed...
  17. ncbi request reprint Pentostatin, cyclophosphamide, and rituximab regimen in older patients with chronic lymphocytic leukemia
    Tait D Shanafelt
    Department of Internal Medicine, Division of Hematology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Cancer 109:2291-8. 2007
    ..Although chemoimmunotherapy (CIT) has dramatically improved response rates in patients with CLL, some CIT regimens are not well tolerated by many patients >or=70 years of age...
  18. doi request reprint CD49d expression is an independent predictor of overall survival in patients with chronic lymphocytic leukaemia: a prognostic parameter with therapeutic potential
    Tait D Shanafelt
    Division of Hematology, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Br J Haematol 140:537-46. 2008
    ..Importantly, anti-CD49d antibodies are already approved for treatment of other human diseases. Clinical testing of anti-CD49d therapy in CLL appears warranted...
  19. pmc Validation of a new prognostic index for patients with chronic lymphocytic leukemia
    Tait D Shanafelt
    Department of Internal Medicine, Division of Hematology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer 115:363-72. 2009
    ..This index requires validation in an independent series of patients before widespread use can be recommended...
  20. doi request reprint Monoclonal B-cell lymphocytosis: definitions and natural history
    Tait Shanafelt
    Department of Medicine, Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA
    Leuk Lymphoma 50:493-7. 2009
    ..Additional studies are needed to determine whether the clinical outcome of patients with MBL differs from that of patients with Rai stage 0 CLL and to identify what B-cell threshold optimally distinguishes between these conditions...
  21. pmc Phase I trial of daily oral Polyphenon E in patients with asymptomatic Rai stage 0 to II chronic lymphocytic leukemia
    Tait D Shanafelt
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Clin Oncol 27:3808-14. 2009
    ..To define the optimal dose of Polyphenon E for chronic daily administration and tolerability in patients with chronic lymphocytic leukemia (CLL)...
  22. pmc Pretreatment angiogenic cytokines predict response to chemoimmunotherapy in patients with chronic lymphocytic leukaemia
    Tait D Shanafelt
    Division of Hematology, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Br J Haematol 146:660-4. 2009
    ..The pretreatment VEGF:TSP ratio also correlated with overall survival (P = 0.008). A pro-angiogenic profile appears associated with diminished response and inferior survival in CLL patients receiving CIT...
  23. pmc Brief report: natural history of individuals with clinically recognized monoclonal B-cell lymphocytosis compared with patients with Rai 0 chronic lymphocytic leukemia
    Tait D Shanafelt
    Mayo Clinic, Rochester, MN 55905, USA
    J Clin Oncol 27:3959-63. 2009
    ..The natural history of clinically identified MBL is unclear. The goal of this study was to explore the outcome of patients with MBL relative to that of individuals with Rai stage 0 chronic lymphocytic leukemia (CLL)...
  24. ncbi request reprint Burnout and medical errors among American surgeons
    Tait D Shanafelt
    Department of Internal Medicine, Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA
    Ann Surg 251:995-1000. 2010
    ..To evaluate the relationship between burnout and perceived major medical errors among American surgeons...
  25. pmc Monoclonal B-cell lymphocytosis (MBL): biology, natural history and clinical management
    T D Shanafelt
    Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA
    Leukemia 24:512-20. 2010
    ..In this paper, we provide a state of the art review on the prevalence, nomenclature, biology, natural history and clinical management of MBL...
  26. pmc Statin and non-steroidal anti-inflammatory drug use in relation to clinical outcome among patients with Rai stage 0 chronic lymphocytic leukemia
    Tait D Shanafelt
    Division of Hematology, Mayo Clinic, Rochester, MN, USA
    Leuk Lymphoma 51:1233-40. 2010
    ..The in vitro observation that statins reduce rituximab efficacy does not appear to have clinical significance in CLL care...
  27. pmc Age at diagnosis and the utility of prognostic testing in patients with chronic lymphocytic leukemia
    Tait D Shanafelt
    Department of Medicine, Division of Hematology, Mayo Clinic, Rochester, Minnesota 55902, USA
    Cancer 116:4777-87. 2010
    ..A study was undertaken to analyze the survival of chronic lymphocytic leukemia (CLL) patients relative to age-matched individuals in the general population and determine the age-stratified utility of prognostic testing...
  28. pmc Phase II trials of single-agent anti-VEGF therapy for patients with chronic lymphocytic leukemia
    Tait Shanafelt
    Department of Medicine, Mayo Clinic, Rochester, MN 55902, USA
    Leuk Lymphoma 51:2222-9. 2010
    ..No complete or partial remissions were observed. Individually and collectively, these studies indicate that single-agent anti-VEGF therapy has minimal clinical activity for patients with relapsed/refractory CLL...
  29. ncbi request reprint T-cell abnormalities in patients with chronic lymphocytic leukemia
    Tait Shanafelt
    Mayo Clinic College of Medicine, Department of Internal Medicine, Division of Hematology, Rochester, MN 55905, USA
    Leuk Lymphoma 47:1197-8. 2006
  30. ncbi request reprint Shaping your career to maximize personal satisfaction in the practice of oncology
    Tait Shanafelt
    Mayo Clinic College of Medicine, Department of Internal Medicine, Division of Hematology, Rochester, MN, USA
    J Clin Oncol 24:4020-6. 2006
    ....
  31. ncbi request reprint Adaphostin-induced apoptosis in CLL B cells is associated with induction of oxidative stress and exhibits synergy with fludarabine
    Tait D Shanafelt
    Department of Medicine, Division of Hematology, Mayo Clinic, 200 First St, SW, Rochester, MN 55905, USA
    Blood 105:2099-106. 2005
    ..Further preclinical development of adaphostin as a novel agent for the treatment of CLL appears warranted...
  32. ncbi request reprint The clinical and biologic importance of neovascularization and angiogenic signaling pathways in chronic lymphocytic leukemia
    Tait D Shanafelt
    Division of Hematology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Semin Oncol 33:174-85. 2006
    ....
  33. ncbi request reprint Are chemotherapy response rates related to treatment-induced survival prolongations in patients with advanced cancer?
    Tait D Shanafelt
    Departmentof Ocology, Mayo Clinic, Rochester, MN 55905, USA
    J Clin Oncol 22:1966-74. 2004
    ..The average prolongation in survival with chemotherapy compared with best supportive care has not been well described...
  34. ncbi request reprint Current approach to diagnosis and management of chronic lymphocytic leukemia
    Tait D Shanafelt
    Division of Hematology and Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 79:388-98. 2004
    ....
  35. ncbi request reprint The well-being and personal wellness promotion strategies of medical oncologists in the North Central Cancer Treatment Group
    Tait D Shanafelt
    Department of Oncology, Mayo Clinic, Rochester, Minn, USA
    Oncology 68:23-32. 2005
    ..While much is known about oncologist distress, little is known about oncologist well-being. We set out to evaluate oncologist well-being and the personal wellness promotion strategies used by oncologists...
  36. ncbi request reprint Finding meaning, balance, and personal satisfaction in the practice of oncology
    Tait D Shanafelt
    Mayo Clinic, Departments of Oncology and Hematology Oncology, Rochester, Minnesota 55905, USA
    J Support Oncol 3:157-62, 164. 2005
  37. doi request reprint Special report: suicidal ideation among American surgeons
    Tait D Shanafelt
    Mayo Clinic, Rochester, MN 55905, USA
    Arch Surg 146:54-62. 2011
    ..Suicide is a disproportionate cause of death for US physicians. The prevalence of suicidal ideation (SI) among surgeons and their use of mental health resources are unknown...
  38. ncbi request reprint Rituximab for immune cytopenia in adults: idiopathic thrombocytopenic purpura, autoimmune hemolytic anemia, and Evans syndrome
    Tait D Shanafelt
    Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, Minn 55905, USA
    Mayo Clin Proc 78:1340-6. 2003
    ..To evaluate the efficacy of rituximab for the treatment of adult patients with immune cytopenia, including idiopathic thrombocytopenic purpura (ITP), autoimmune hemolytic anemia, and Evans syndrome...
  39. pmc Relationship between increased personal well-being and enhanced empathy among internal medicine residents
    Tait D Shanafelt
    Department of Internal Medicine, Mayo Clinic, Rochester, Minn, USA
    J Gen Intern Med 20:559-64. 2005
    ..While resident distress and its potential to negatively effect patient care have been well documented, little is known bout resident well-being or its potential to enhance care...
  40. ncbi request reprint Clinical effects of oral green tea extracts in four patients with low grade B-cell malignancies
    T D Shanafelt
    Mayo Clinic College of Medicine, Division of Hematology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Leuk Res 30:707-12. 2006
    ..An NCI sponsored phase I/II trial of de-caffeinated green tea extracts for patients with asymptomatic, early stage CLL opened at Mayo Clinic in August 2005...
  41. ncbi request reprint Pathophysiology and treatment of hot flashes
    Tait D Shanafelt
    Department of Oncology, Mayo Clinic, Rochester, Minn 55905, USA
    Mayo Clin Proc 77:1207-18. 2002
    ..The use of clonidine, methyldopa, and belladonna should be discouraged because of their modest efficacy and adverse effects...
  42. pmc Ofatumumab-based chemoimmunotherapy is effective and well tolerated in patients with previously untreated chronic lymphocytic leukemia (CLL)
    Tait Shanafelt
    Mayo Clinic, Rochester, Minnesota
    Cancer 119:3788-96. 2013
    ..There remains interest in identifying new approaches to improve the effectiveness of CIT. Ofatumumab is a fully human anti-CD20 monoclonal antibody with greater apparent single-agent activity than rituximab in CLL patients...
  43. doi request reprint Comorbid conditions and survival in unselected, newly diagnosed patients with chronic lymphocytic leukemia
    Paul Thurmes
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Leuk Lymphoma 49:49-56. 2008
    ..Clinical trials evaluating treatments that are designed to be tolerated by patients who do not meet traditional clinical trial eligibility criteria are needed...
  44. ncbi request reprint Pilot evaluation of citalopram for the relief of hot flashes
    Debra L Barton
    Mayo Clinic, Rochester, Minnesota 55905, USA
    J Support Oncol 1:47-51. 2003
    ..This pilot trial suggests that citalopram may be an effective non-hormonal treatment for hot flashes in women who can tolerate it...
  45. pmc A survey of U.S. physicians and their partners regarding the impact of work-home conflict
    Liselotte N Dyrbye
    Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA
    J Gen Intern Med 29:155-61. 2014
    ..Work-home conflicts (WHC) threaten work-life balance among physicians, especially those in dual career relationships. In this study, we analyzed factors associated with WHC for physicians and their employed partners...
  46. ncbi request reprint Elevated serum B-lymphocyte stimulator levels in patients with familial lymphoproliferative disorders
    Anne J Novak
    Division of Hematology and Internal Medicine, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Clin Oncol 24:983-7. 2006
    ..Therefore, we sought to establish whether BLyS levels were elevated in patients with B-cell lymphoproliferative disorders and to determine whether elevated BLyS levels correlated with clinical characteristics of the disease...
  47. ncbi request reprint Phase II Evaluation of Desipramine for the Treatment of Hot Flashes
    Debra L Barton
    Comprehensive Cancer Center, Mayo Clinic College of Medicine, Rochester, MN
    Support Cancer Ther 4:219-24. 2007
    ..It is of physiologic interest that this older antidepressant, classified as a tricyclic, did not achieve a clinically significant reduction in hot flash scores in this pilot trial...
  48. ncbi request reprint Serum-free light chain-a new biomarker for patients with B-cell non-Hodgkin lymphoma and chronic lymphocytic leukemia
    William Martin
    Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA
    Transl Res 149:231-5. 2007
    ..Future studies are warranted to elucidate the role of serum FLC as biomarkers of disease, for monitoring of minimal residual disease, and as a prognostic factor for response and survival...
  49. ncbi request reprint When your favorite patient relapses: physician grief and well-being in the practice of oncology
    Tait Shanafelt
    Department of Oncology, Mayo Clinic, Rochester, MN, USA
    J Clin Oncol 21:2616-9. 2003
  50. ncbi request reprint VEGF receptors on chronic lymphocytic leukemia (CLL) B cells interact with STAT 1 and 3: implication for apoptosis resistance
    Y K Lee
    Department of Internal Medicine, Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA
    Leukemia 19:513-23. 2005
    ..Thus, a VEGF-VEGF receptor pathway in CLL B cells can be linked to activation of STAT proteins that are able to enhance their apoptotic resistance...
  51. ncbi request reprint Systematic review of depression, anxiety, and other indicators of psychological distress among U.S. and Canadian medical students
    Liselotte N Dyrbye
    Mayo Clinic, 200 First Street SW, Rochester, MN 55906, USA
    Acad Med 81:354-73. 2006
    ..To systematically review articles reporting on depression, anxiety, and burnout among U.S. and Canadian medical students...
  52. doi request reprint Road map for maintaining career satisfaction and balance in surgical oncology
    Henry M Kuerer
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Am Coll Surg 207:435-42. 2008
  53. pmc Early treatment of high-risk chronic lymphocytic leukemia with alemtuzumab and rituximab
    Clive S Zent
    Division of Hematology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer 113:2110-8. 2008
    ..In this phase 2 study, the authors tested the safety and efficacy of early treatment for patients with high-risk CLL using alemtuzumab and rituximab...
  54. ncbi request reprint Burnout and suicidal ideation among U.S. medical students
    Liselotte N Dyrbye
    Mayo Clinic, Rochester, Minnesota, USA
    Ann Intern Med 149:334-41. 2008
    ..Little is known about the prevalence of suicidal ideation among U.S. medical students or how it relates to burnout...
  55. ncbi request reprint VEGF receptor phosphorylation status and apoptosis is modulated by a green tea component, epigallocatechin-3-gallate (EGCG), in B-cell chronic lymphocytic leukemia
    Yean K Lee
    Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Blood 104:788-94. 2004
    ..Thus, these results suggest that VEGF signaling regulates survival signals in CLL cells and that interruption of this autocrine pathway results in caspase activation and subsequent leukemic cell death...
  56. ncbi request reprint Methylprednisolone-rituximab is an effective salvage therapy for patients with relapsed chronic lymphocytic leukemia including those with unfavorable cytogenetic features
    Deborah A Bowen
    Mayo Clinic College of Medicine, Rochester, Minnesota 55902, USA
    Leuk Lymphoma 48:2412-7. 2007
    ..Three-year survival was 41% (95% CI: 26 - 66%). HDMP-rituximab is an active regimen in patients with relapsed, refractory, and cytogenetically high-risk CLL. Further evaluation of this regimen in controlled trials appears warranted...
  57. ncbi request reprint The effects of work-hour limitations on resident well-being, patient care, and education in an internal medicine residency program
    Lara Goitein
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Box 359762, University of Washington Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98104, USA
    Arch Intern Med 165:2601-6. 2005
    ..The Accreditation Council for Graduate Medical Education work-hour limitations (WHLs) were implemented in July 2003. Effects on resident well-being, patient care, and education are not well understood. We investigated these effects of WHLs...
  58. ncbi request reprint Medical student distress: causes, consequences, and proposed solutions
    Liselotte N Dyrbye
    Department of Internal Medicine and Division of Primary Care Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 80:1613-22. 2005
    ..In this article, we review the manifestations and causes of student distress, its potential adverse personal and professional consequences, and proposed institutional approaches to decrease student distress...
  59. ncbi request reprint Burnout and self-reported patient care in an internal medicine residency program
    Tait D Shanafelt
    University of Washington, Veterans Affairs Northwest Health Services Research and Development Center of Excellence, and Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Ann Intern Med 136:358-67. 2002
    ..Burnout is a syndrome of depersonalization, emotional exhaustion, and a sense of low personal accomplishment. Little is known about burnout in residents or its relationship to patient care...
  60. ncbi request reprint The well-being of physicians
    Tait D Shanafelt
    Mayo Clinic, Rochester, Minnesota, USA
    Am J Med 114:513-9. 2003
  61. ncbi request reprint Pilot evaluation of citalopram for the treatment of hot flashes in women with inadequate benefit from venlafaxine
    Charles L Loprinzi
    Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Palliat Med 8:924-30. 2005
    ....
  62. pmc How do distress and well-being relate to medical student empathy? A multicenter study
    Matthew R Thomas
    Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Gen Intern Med 22:177-83. 2007
    ....
  63. ncbi request reprint Fluorescent-labeled DNA probes applied to novel biological aspects of B-cell chronic lymphocytic leukemia
    Stephanie R Fink
    Division of Laboratory Genetics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Leuk Res 29:253-62. 2005
    ..Deletions in IGHv occurred in 25% of patients and correlated with IGHv gene expression. Probes for 6q23 detected more deletions in 6q than probes for 6q21...
  64. doi request reprint Predictive value of blood and bone marrow flow cytometry in B-cell lymphoma classification: comparative analysis of flow cytometry and tissue biopsy in 252 patients
    William G Morice
    Division of Hematopathology, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 83:776-85. 2008
    ..To study the effectiveness of peripheral blood (PB) and bone marrow flow cytometric immunophenotyping (FCIP) in predicting the histologic B-cell lymphoma type...
  65. pmc Effects of resident work hour limitations on faculty professional lives
    Lara Goitein
    Department of Radiology, University of Washington Medical Center, Seattle, WA, USA
    J Gen Intern Med 23:1077-83. 2008
    ..The Accreditation Council for Graduate Medical Education resident work hour limitations were implemented in July, 2003. Effects on faculty are not well understood...
  66. ncbi request reprint Career satisfaction, practice patterns and burnout among surgical oncologists: report on the quality of life of members of the Society of Surgical Oncology
    Henry M Kuerer
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Ann Surg Oncol 14:3043-53. 2007
    ..Studies show that 30-50% of medical oncologists experience burnout, but little is known about burnout among surgical oncologists. We hypothesized that wide variation in burnout and career satisfaction exist among surgical oncologists...
  67. ncbi request reprint Association of perceived medical errors with resident distress and empathy: a prospective longitudinal study
    Colin P West
    Division of General Internal Medicine, Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    JAMA 296:1071-8. 2006
    ..Medical errors are associated with feelings of distress in physicians, but little is known about the magnitude and direction of these associations...
  68. pmc Expression of TCL-1 as a potential prognostic factor for treatment outcome in B-cell chronic lymphocytic leukemia
    Rebekah L Browning
    Ohio State University, Columbus, OH, United States
    Leuk Res 31:1737-40. 2007
    ..199) were noted with lower TCL-1 expression. These data suggest TCL-1 expression may help predict treatment outcome in CLL patients following chemoimmunotherapy, and examination in larger studies is warranted...
  69. ncbi request reprint Combination therapies for previously untreated CLL
    Tait D Shanafelt
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Lancet 370:197-8. 2007
  70. ncbi request reprint Medical education research and IRB review: an analysis and comparison of the IRB review process at six institutions
    Liselotte N Dyrbye
    Mayo Clinic Department of Internal Medicine, Rochester, Minnesota, USA
    Acad Med 82:654-60. 2007
    ..To compare how different institutional review boards (IRBs) process and evaluate the same multiinstitutional educational research proposal of medical students' quality of life...
  71. ncbi request reprint A prospective study of the relationship between medical knowledge and professionalism among internal medicine residents
    Colin P West
    Division of General Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55095, USA
    Acad Med 82:587-92. 2007
    ..To explore residents' competency in medical knowledge and in empathy, one element of professionalism, and to evaluate the relationship between competencies in these domains...
  72. ncbi request reprint Using smudge cells on routine blood smears to predict clinical outcome in chronic lymphocytic leukemia: a universally available prognostic test
    Grzegorz S Nowakowski
    Division of Hematology, College of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 82:449-53. 2007
    ..001). The percentage of smudge cells as a continuous variable correlated with overall survival (P=.04). The estimation of smudge cells on a blood smear could be a universally available prognostic test in early-stage CLL...
  73. ncbi request reprint A multicenter study of burnout, depression, and quality of life in minority and nonminority US medical students
    Liselotte N Dyrbye
    Division of Primary Care Internal Medicine, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 81:1435-42. 2006
    ..To determine the well-being of minority medical students in a multicenter sample of US medical students...
  74. ncbi request reprint Update on risk-stratified management for chronic lymphocytic leukemia
    Clive S Zent
    Division of Hematology, Mayo Clinic College of Medicine, 200 1st Street SW, Rochester, MN 55905, USA
    Leuk Lymphoma 47:1738-46. 2006
    ..The management of CLL is in a dynamic phase of rapid evolution. Risk stratification using biological prognostic markers can improve current patient care and direct future clinical research...
  75. pmc Combination chemoimmunotherapy with pentostatin, cyclophosphamide, and rituximab shows significant clinical activity with low accompanying toxicity in previously untreated B chronic lymphocytic leukemia
    Neil E Kay
    Mayo Clinic, Stabile 628, 200 First St SW, Rochester, MN 55905, and The Ohio State University, Columbus, USA
    Blood 109:405-11. 2007
    ....
  76. ncbi request reprint Physician well-being and professionalism
    Colin P West
    Mayo Clinic College of Medicine, USA
    Minn Med 90:44-6. 2007
    ....
  77. pmc Karyotype evolution on fluorescent in situ hybridization analysis is associated with short survival in patients with chronic lymphocytic leukemia and is related to CD49d expression
    Tait D Shanafelt
    J Clin Oncol 26:e5-6. 2008
  78. pmc Prognostic importance of T and NK-cells in a consecutive series of newly diagnosed patients with chronic lymphocytic leukaemia
    Shanique Palmer
    Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Br J Haematol 141:607-14. 2008
    ..These characteristics can be modified and continued evaluation of immunomodulatory drugs, vaccination strategies and cellular therapies to delay/prevent disease progression are warranted...
  79. pmc The prognostic significance of cytopenia in chronic lymphocytic leukaemia/small lymphocytic lymphoma
    Clive S Zent
    Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA
    Br J Haematol 141:615-21. 2008
    ..Revisions of the National Cancer Institute Working Group 96 criteria should consider the aetiology of cytopenia in staging CLL patients...
  80. pmc Bone biopsy derived marrow stromal elements rescue chronic lymphocytic leukemia B-cells from spontaneous and drug induced cell death and facilitates an "angiogenic switch"
    Neil E Kay
    Mayo Clinic, Stabile 628, 200 First Street SW, Rochester, MN 55905, USA
    Leuk Res 31:899-906. 2007
    ..These results indicate the interaction between CLL B-cells and marrow stromal elements regulates angiogenic switching and may be linked to disease progression...
  81. doi request reprint Controversies in the front-line management of chronic lymphocytic leukemia
    Chadi Nabhan
    Oncology Specialists, S C, Lutheran General Hospital, Department of Medicine, Division of Hematology and Medical Oncology, Park Ridge, IL 60068, USA
    Leuk Res 32:679-88. 2008
    ..The review is intended to discuss and simplify first-line therapy selection for patients with CLL in the era of new prognostic indicators and the better understanding of disease biology...
  82. pmc MBL or CLL: which classification best categorizes the clinical course of patients with an absolute lymphocyte count >or= 5 x 10(9) L(-1) but a B-cell lymphocyte count <5 x 10(9) L(-1)?
    Tait D Shanafelt
    Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, United States
    Leuk Res 32:1458-61. 2008
    ..In contrast, CD38 predicted TTT (p=0.02) regardless of the proposed new classification. Molecular characteristics of the leukemic clone are a better predictor of progression than an arbitrary ALC or B lymphocyte count threshold...
  83. ncbi request reprint Race, ethnicity, and medical student well-being in the United States
    Liselotte N Dyrbye
    Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55906, USA
    Arch Intern Med 167:2103-9. 2007
    ..We explore differences in the prevalence of burnout, depressive symptoms, and quality of life (QOL) among minority and nonminority medical students as well as the role race/ethnicity plays in students' experiences...
  84. ncbi request reprint Community-based phase II trial of PCR for CLL/SLL patients
    Neil E Kay
    Cancer Biother Radiopharm 22:713-4; author reply 715-7. 2007
  85. pmc Immunoglobulin diversity gene usage predicts unfavorable outcome in a subset of chronic lymphocytic leukemia patients
    Renee C Tschumper
    Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Invest 118:306-15. 2008
    ..In addition, these data support the concept that antigen-driven selection of specific Ig receptors plays a role in the clinical course of B-CLL...
  86. ncbi request reprint Personal life events and medical student burnout: a multicenter study
    Liselotte N Dyrbye
    Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55906, USA
    Acad Med 81:374-84. 2006
    ..The authors sought to identify the prevalence of burnout, variation of its prevalence during medical school, and the impact of personal life events on burnout and other types of student distress...
  87. ncbi request reprint Andropause: symptom management for prostate cancer patients treated with hormonal ablation
    Carrie A Thompson
    Mayo Clinic, Rochester, Minnesota 55905, USA
    Oncologist 8:474-87. 2003
    ..In this article, we review the current literature on the symptoms, signs, and possible therapies available to men who cannot take replacement testosterone...
  88. ncbi request reprint Cytogenetic abnormalities can change during the course of the disease process in chronic lymphocytic leukemia
    Tait D Shanafelt
    J Clin Oncol 24:3218-9; author reply 3219-20. 2006
  89. ncbi request reprint Prospective evaluation of clonal evolution during long-term follow-up of patients with untreated early-stage chronic lymphocytic leukemia
    Tait D Shanafelt
    Mayo Clinic College of Medicine, Department of Internal Medicine, Division of Hematology, Rochester, MN 55905, USA
    J Clin Oncol 24:4634-41. 2006
    ..There are minimal prospective data on the clinical utility of the widely used hierarchical FISH prognostic categories in patients with newly diagnosed early-stage CLL or the frequency of clonal evolution as determined by interphase FISH...
  90. ncbi request reprint Loss of TP53 is due to rearrangements involving chromosome region 17p10 approximately p12 in chronic lymphocytic leukemia
    Stephanie R Fink
    Cytogenetics Laboratory, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Cancer Genet Cytogenet 167:177-81. 2006
    ..Translocations or isochromosome formations at sites of low-copy DNA repeats in 17p10 to 17p12 appear to be the mechanism for the loss of TP53 in B-CLL...
  91. ncbi request reprint Narrative review: initial management of newly diagnosed, early-stage chronic lymphocytic leukemia
    Tait D Shanafelt
    Department of Internal Medicine, Division of Hematology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Ann Intern Med 145:435-47. 2006
    ..Recommendations for patient counseling, follow-up, supportive care, and initial treatment are presented for each risk category...
  92. ncbi request reprint Metaphase cells with normal G-bands have cryptic interstitial deletions in 13q14 detectable by fluorescence in situ hybridization in B-cell chronic lymphocytic leukemia
    Kimberly J Stockero
    Cytogenetics Laboratory, Mayo Clinic, Rochester, MN 55905, USA
    Cancer Genet Cytogenet 166:152-6. 2006
    ..As a result of this study, we report evidence that B-CLL metaphases with 13q- are not detected because these deletions are often cryptic and not visible by standard G-banding...