Vijay H Shah

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. Kostallari E, Shah V. Pericytes in the Liver. Adv Exp Med Biol. 2019;1122:153-167 pubmed publisher
    ..In this chapter, we will discuss HSC quiescence and activation in the context of healthy liver and diseases, such as fibrosis, steatohepatitis, and hepatocellular carcinoma. ..
  2. Thursz M, Kamath P, Mathurin P, Szabo G, Shah V. Alcohol-related liver disease: Areas of consensus, unmet needs and opportunities for further study. J Hepatol. 2019;70:521-530 pubmed publisher
  3. Martin Mateos R, de Assuncao T, Arab J, Jalan Sakrikar N, Yaqoob U, Greuter T, et al. Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis. Cell Mol Gastroenterol Hepatol. 2019;7:197-209 pubmed publisher
    ..The data discussed in this publication have been deposited in NCBI's Gene Expression Omnibus and are accessible through GEO Series accession number GSE119606 (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE119606). ..
  4. request reprint
    Shah V, Kamath P. Nitric oxide in liver transplantation: pathobiology and clinical implications. Liver Transpl. 2003;9:1-11 pubmed
    ..This review article focuses on new advances relating to the role of nitric oxide in these syndromes with an emphasis on pathobiology and potential clinical implications. ..
  5. Dou C, Liu Z, Tu K, Zhang H, Chen C, Yaqoob U, et al. P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-Promoting Myofibroblasts. Gastroenterology. 2018;154:2209-2221.e14 pubmed publisher
    ..In studies of mice, we found liver stiffness to activate HSC differentiation into myofibroblasts, which required nuclear accumulation of p300. p300 increases HSC expression of genes that promote metastasis. ..
  6. Verma V, Li H, Wang R, Hirsova P, Mushref M, Liu Y, et al. Alcohol stimulates macrophage activation through caspase-dependent hepatocyte derived release of CD40L containing extracellular vesicles. J Hepatol. 2016;64:651-60 pubmed publisher
    ..In conclusion, hepatocytes release CD40L containing EV in a caspase-dependent manner in response to alcohol exposure which promotes macrophage activation, contributing to inflammation in ALD. ..
  7. Bi Y, Venkatesh S, Shah V. Detecting fibrosis without a liver biopsy: getting to the fat of the issue. Hepatol Int. 2013;7:792-4 pubmed publisher
  8. Wang R, Ding Q, Yaqoob U, de Assuncao T, Verma V, Hirsova P, et al. Exosome Adherence and Internalization by Hepatic Stellate Cells Triggers Sphingosine 1-Phosphate-dependent Migration. J Biol Chem. 2015;290:30684-96 pubmed publisher
    ..These findings advance our understanding of EC/HSC cross-talk and identify exosomes as a potential target to attenuate pathobiology signals. ..
  9. Nagy L, Ding W, Cresci G, Saikia P, Shah V. Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes. Gastroenterology. 2016;150:1756-68 pubmed publisher
    ..We also discuss how recent insights into the pathogenesis of ALD will affect the treatment and management of patients. ..

More Information

Publications25

  1. Yang L, Kwon J, Popov Y, Gajdos G, ORDOG T, Brekken R, et al. Vascular endothelial growth factor promotes fibrosis resolution and repair in mice. Gastroenterology. 2014;146:1339-50.e1 pubmed publisher
    ..We observed that VEGF regulates vascular permeability, monocyte infiltration, and scar-associated macrophages function. ..
  2. de Assuncao T, Lomberk G, Cao S, Yaqoob U, Mathison A, Simonetto D, et al. New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids. J Biol Chem. 2014;289:15798-809 pubmed publisher
    ..Thus, this is the first description of the activity and mechanisms underlying the function of KLF14 as an activator protein and novel regulator of lipid signaling. ..
  3. Greuter T, Shah V. Hepatic sinusoids in liver injury, inflammation, and fibrosis: new pathophysiological insights. J Gastroenterol. 2016;51:511-9 pubmed publisher
    ..This article builds upon a seminar given at the recent 3rd JSGE International Topic Conference in Sendai, Japan, and reviews the areas outlined above. ..
  4. Baig M, Yaqoob U, Cao S, Saqib U, Shah V. Non-canonical role of matrix metalloprotease (MMP) in activation and migration of hepatic stellate cells (HSCs). Life Sci. 2016;155:155-60 pubmed publisher
    ..These findings suggest that macrophage MMP-8 promotes HSC activation and might have a role in liver disease progression. MMP-8 targeting in the liver may have therapeutic potential in alcoholic liver disease (ALD). ..
  5. Kostallari E, Shah V. Angiocrine signaling in the hepatic sinusoids in health and disease. Am J Physiol Gastrointest Liver Physiol. 2016;311:G246-51 pubmed publisher
    ..Therapeutic strategies to target angiocrine signaling are in progress but are in the early stages. Here, we offer a short synthesis of recent studies on angiocrine signaling in liver homeostasis, regeneration, and fibrogenesis. ..
  6. Dunn W, Shah V. Pathogenesis of Alcoholic Liver Disease. Clin Liver Dis. 2016;20:445-56 pubmed publisher
    ..New pathophysiology-based therapies are under study, including antibiotics, caspase inhibition, interleukin-22, anakinra, FXR agonist and others. These studies provide hope for better future outcomes for this difficult disease. ..
  7. Arab J, Martín Mateos R, Shah V. Gut-liver axis, cirrhosis and portal hypertension: the chicken and the egg. Hepatol Int. 2018;12:24-33 pubmed publisher
    ..This review summarizes the current knowledge about the role of gut microbiota in the pathogenesis of chronic liver diseases and portal hypertension. ..
  8. Seo Y, Kwon J, Yaqoob U, Yang L, de Assuncao T, Simonetto D, et al. HMGB1 recruits hepatic stellate cells and liver endothelial cells to sites of ethanol-induced parenchymal cell injury. Am J Physiol Gastrointest Liver Physiol. 2013;305:G838-48 pubmed publisher
    ..Hepatocytes release HMGB1 in response to ethanol with subsequent recruitment of HSC and LEC. This pathway has implications for HSC and LEC recruitment to sites of ethanol-induced liver injury. ..
  9. Lee J, Kang Decker N, Chatterjee S, Yao J, Friedman S, Shah V. Mechanisms of nitric oxide interplay with Rho GTPase family members in modulation of actin membrane dynamics in pericytes and fibroblasts. Am J Pathol. 2005;166:1861-70 pubmed
    ..In conclusion, these studies identify novel crosstalk between small GTPases, cytoskeletal structures, and NO in pericyte-specific pathways, providing counterbalances in the chemotactic responses to growth factors. ..
  10. Bi Y, Li J, Ji B, Kang N, Yang L, Simonetto D, et al. Sphingosine-1-phosphate mediates a reciprocal signaling pathway between stellate cells and cancer cells that promotes pancreatic cancer growth. Am J Pathol. 2014;184:2791-802 pubmed publisher
    ..Pancreatic cancer cell-derived S1P activates PSCs to release paracrine factors, including matrix metalloproteinase-9, which reciprocally promotes tumor cell migration and invasion in vitro and cancer growth in vivo. ..
  11. Bi Y, Mukhopadhyay D, Drinane M, Ji B, Li X, Cao S, et al. Endocytosis of collagen by hepatic stellate cells regulates extracellular matrix dynamics. Am J Physiol Cell Physiol. 2014;307:C622-33 pubmed publisher
    ..Interaction with extracellular matrix regulates matrix dynamics through modulating multiple gene expressions including MMP-9. ..
  12. Wang R, Ding Q, de Assuncao T, Mounajjed T, Maiers J, Dou C, et al. Hepatic Stellate Cell Selective Disruption of Dynamin-2 GTPase Increases Murine Fibrogenesis through Up-Regulation of Sphingosine-1 Phosphate-Induced Cell Migration. Am J Pathol. 2017;187:134-145 pubmed publisher
    ..Genetic disruption of Dyn2 GTPase activity selectively in HSC enhances fibrogenesis, driven at least in part through up-regulation of the SK1 pathway and cell migration in HSCs. ..
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    Shah V, Chen A, Cao S, Hendrickson H, Weiler D, Smith L, et al. Gene transfer of recombinant endothelial nitric oxide synthase to liver in vivo and in vitro. Am J Physiol Gastrointest Liver Physiol. 2000;279:G1023-30 pubmed
    ..These events were associated with increased ionomycin-stimulated NO release. In summary, this is the first study to demonstrate successful delivery of the recombinant eNOS gene to liver in vivo and in vitro with ensuing NO production...
  14. Liu Y, Verma V, Malhi H, Gores G, Kamath P, Sanyal A, et al. Lipopolysaccharide downregulates macrophage-derived IL-22 to modulate alcohol-induced hepatocyte cell death. Am J Physiol Cell Physiol. 2017;313:C305-C313 pubmed publisher
    ..Macrophage-derived IL-22 protects hepatocytes from ethanol-induced cell death. IL-22 downregulation is a new regulatory target of LPS in the pathogenesis of AH. ..
  15. Vargas J, Arrese M, Shah V, Arab J. Use of Statins in Patients with Chronic Liver Disease and Cirrhosis: Current Views and Prospects. Curr Gastroenterol Rep. 2017;19:43 pubmed publisher
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    Shah V, Cao S, Hendrickson H, Yao J, Katusic Z. Regulation of hepatic eNOS by caveolin and calmodulin after bile duct ligation in rats. Am J Physiol Gastrointest Liver Physiol. 2001;280:G1209-16 pubmed
    ..We conclude that, in cholestatic portal hypertension, caveolin may negatively regulate NOS activity in a manner that is reversible by excess calmodulin...