D Sevlever

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Glycosylphosphatidylinositol-anchor intermediates associate with triton-insoluble membranes in subcellular compartments that include the endoplasmic reticulum
    D Sevlever
    Department of Research, 4500 San Pablo Road, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
    Biochem J 343:627-35. 1999
  2. ncbi request reprint Differential effect of 1,10-phenanthroline on mammalian, yeast, and parasite glycosylphosphatidylinositol anchor synthesis
    D Sevlever
    Department of Neurosciences, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Biochem Biophys Res Commun 288:1112-8. 2001
  3. pmc Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species
    Daniel Sevlever
    Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida 32224, USA
    Biochemistry 47:9678-87. 2008
  4. pmc Matrix metalloproteinase-9 contributes to brain extravasation and edema in fulminant hepatic failure mice
    Justin H Nguyen
    Department of Transplantation, Division of Transplant Surgery, Mayo Clinic College of Medicine, 4205 Belfort Road, Suite 1100, Jacksonville, FL 32216, USA
    J Hepatol 44:1105-14. 2006
  5. ncbi request reprint Oxidative stress-induced phosphorylation, degradation and aggregation of alpha-synuclein are linked to upregulated CK2 and cathepsin D
    Makio Takahashi
    Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Eur J Neurosci 26:863-74. 2007
  6. ncbi request reprint Glycosylphosphatidylinositol-anchored proteins play an important role in the biogenesis of the Alzheimer's amyloid beta-protein
    K Sambamurti
    Mayo Clinic, Jacksonville, Florida 32224, USA
    J Biol Chem 274:26810-4. 1999
  7. pmc Altered expression of zonula occludens-2 precedes increased blood-brain barrier permeability in a murine model of fulminant hepatic failure
    Naoki Shimojima
    Department of Transplantation, Division of Transplant Surgery, Mayo Clinic College of Medicine, Jacksonville, FL 32216, USA
    J Invest Surg 21:101-8. 2008

Research Grants

  1. METABOLISM AND TRANSPORT OF MAMMALIAN GPIS
    Daniel Sevlever; Fiscal Year: 2003
  2. Role of Complement in Alzheimer's Disease
    Daniel Sevlever; Fiscal Year: 2007

Collaborators

Detail Information

Publications7

  1. pmc Glycosylphosphatidylinositol-anchor intermediates associate with triton-insoluble membranes in subcellular compartments that include the endoplasmic reticulum
    D Sevlever
    Department of Research, 4500 San Pablo Road, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
    Biochem J 343:627-35. 1999
    ..Interestingly, GlcN-PI and H7 were less enriched in ER-TIM than the other GPIs, suggesting that ER-TIMs might reflect a compartmentalization of the GPI-anchor biosynthetic pathway in the ER...
  2. ncbi request reprint Differential effect of 1,10-phenanthroline on mammalian, yeast, and parasite glycosylphosphatidylinositol anchor synthesis
    D Sevlever
    Department of Neurosciences, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Biochem Biophys Res Commun 288:1112-8. 2001
    ..In contrast to mammals and yeast, the synthesis of GPIs in T. brucei is not affected by PNT. Our results indicate that the T. brucei GPI-PET could be a potential target for antiparasitic drugs...
  3. pmc Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species
    Daniel Sevlever
    Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida 32224, USA
    Biochemistry 47:9678-87. 2008
    ..Our findings suggest that upregulation of cathepsin D could be an additional therapeutic strategy to lessen alpha-synuclein burden in synucleinopathies...
  4. pmc Matrix metalloproteinase-9 contributes to brain extravasation and edema in fulminant hepatic failure mice
    Justin H Nguyen
    Department of Transplantation, Division of Transplant Surgery, Mayo Clinic College of Medicine, 4205 Belfort Road, Suite 1100, Jacksonville, FL 32216, USA
    J Hepatol 44:1105-14. 2006
    ..Mechanisms of brain extravasation leading to brain edema remain incompletely understood. Matrix metalloproteinase (MMP)-9 is implicated in various brain injuries. We hypothesized that MMP-9 contributes to brain edema in FHF...
  5. ncbi request reprint Oxidative stress-induced phosphorylation, degradation and aggregation of alpha-synuclein are linked to upregulated CK2 and cathepsin D
    Makio Takahashi
    Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Eur J Neurosci 26:863-74. 2007
    ..Our results indicate that alpha-Syn phosphorylation caused by FeCl2 is due to CK2 upregulation, and that lysosomal proteases may have a role in producing truncated alpha-Syn for oligomer assembly...
  6. ncbi request reprint Glycosylphosphatidylinositol-anchored proteins play an important role in the biogenesis of the Alzheimer's amyloid beta-protein
    K Sambamurti
    Mayo Clinic, Jacksonville, Florida 32224, USA
    J Biol Chem 274:26810-4. 1999
    ..The cell-surface GPI-anchored protein(s) involved in Abeta biogenesis may be excellent therapeutic target(s) in Alzheimer's disease...
  7. pmc Altered expression of zonula occludens-2 precedes increased blood-brain barrier permeability in a murine model of fulminant hepatic failure
    Naoki Shimojima
    Department of Transplantation, Division of Transplant Surgery, Mayo Clinic College of Medicine, Jacksonville, FL 32216, USA
    J Invest Surg 21:101-8. 2008
    ..Significant alterations in ZO-2 expression and distribution in the tight junctions preceded the increased BBB permeability in FHF mice. These results suggest that ZO-2 may play an important role in the pathogenesis of brain edema in FHF...

Research Grants2

  1. METABOLISM AND TRANSPORT OF MAMMALIAN GPIS
    Daniel Sevlever; Fiscal Year: 2003
    ..These studies will provide a better understanding of the role played by compart-mentalization on the regulation of the GPI pathway. ..
  2. Role of Complement in Alzheimer's Disease
    Daniel Sevlever; Fiscal Year: 2007
    ..Since certain inflammation responses can be detrimental while others can be beneficial, modulation of complement activation may be one therapeutic approach for the treatment of AD. ..