B W Scheithauer

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi The pituitary in Turner syndrome
    B W Scheithauer
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Endocr Pathol 16:195-200. 2005
  2. doi Pituitary blastoma: a unique embryonal tumor
    Bernd W Scheithauer
    Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street, SW Rochester, MN 55905, USA
    Pituitary 15:365-73. 2012
  3. pmc Synovial sarcoma of the sellar region
    Bernd W Scheithauer
    Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First St, SW, Rochester, MN 55905, USA
    Neuro Oncol 9:454-9. 2007
  4. ncbi Pituitary adenoma with tumoral granulomatous reaction
    Bernd W Scheithauer
    Department of Pathology and Laboratory Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Endocr Pathol 18:86-90. 2007
  5. doi Diffuse ganglioneuromatosis and plexiform neurofibroma of the urinary bladder: report of a pediatric example and literature review
    Bernd W Scheithauer
    Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Hum Pathol 39:1708-12. 2008
  6. doi Pituitary blastoma
    Bernd W Scheithauer
    Department of Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Acta Neuropathol 116:657-66. 2008
  7. doi Ependymoma of the sella turcica: a variant of pituicytoma
    Bernd W Scheithauer
    Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Hum Pathol 40:435-40. 2009
  8. doi Immunoexpression of androgen receptor in the nontumorous pituitary and in adenomas
    Bernd W Scheithauer
    Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Endocr Pathol 19:27-33. 2008
  9. ncbi The 2007 WHO classification of tumors of the nervous system: controversies in surgical neuropathology
    Bernd W Scheithauer
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Brain Pathol 18:307-16. 2008
  10. doi Glomus tumor and glomangioma of the nerve. Report of two cases
    Bernd W Scheithauer
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Neurosurg 108:348-56. 2008

Detail Information

Publications136 found, 100 shown here

  1. ncbi The pituitary in Turner syndrome
    B W Scheithauer
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Endocr Pathol 16:195-200. 2005
    ....
  2. doi Pituitary blastoma: a unique embryonal tumor
    Bernd W Scheithauer
    Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street, SW Rochester, MN 55905, USA
    Pituitary 15:365-73. 2012
    ..Variable MGMT reactivity suggests an incomplete response to temozolomide therapy. Literature regarding similar morphologically complex, infantile, Cushing disease-associated lesions is briefly reviewed...
  3. pmc Synovial sarcoma of the sellar region
    Bernd W Scheithauer
    Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First St, SW, Rochester, MN 55905, USA
    Neuro Oncol 9:454-9. 2007
    ..Subtotal resection and radiosurgery proved to be efficacious. The spectrum of primary sellar region sarcomas is summarized...
  4. ncbi Pituitary adenoma with tumoral granulomatous reaction
    Bernd W Scheithauer
    Department of Pathology and Laboratory Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Endocr Pathol 18:86-90. 2007
    ..Histochemical and polymerase chain reaction (PCR) studies revealed neither fungi nor tubercle bacilli. We suggest that tumoral production of an as yet uncharacterized antigen may have induced the granulomatous inflammatory reaction...
  5. doi Diffuse ganglioneuromatosis and plexiform neurofibroma of the urinary bladder: report of a pediatric example and literature review
    Bernd W Scheithauer
    Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Hum Pathol 39:1708-12. 2008
    ..At present, there are no established criteria for the treatment of this rare lesion...
  6. doi Pituitary blastoma
    Bernd W Scheithauer
    Department of Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Acta Neuropathol 116:657-66. 2008
    ....
  7. doi Ependymoma of the sella turcica: a variant of pituicytoma
    Bernd W Scheithauer
    Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Hum Pathol 40:435-40. 2009
    ..The literature is reviewed and concepts of histogenesis are explored, particularly an origin in "ependymal pituicytes." The concept that sellar ependymoma is pituicyte-derived is explored...
  8. doi Immunoexpression of androgen receptor in the nontumorous pituitary and in adenomas
    Bernd W Scheithauer
    Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Endocr Pathol 19:27-33. 2008
    ..No staining of thyroid-stimulating hormone adenomas was noted. The physiologic significance of our findings remains to be explored. The literature regarding AR expression in animal and human pituitaries is reviewed...
  9. ncbi The 2007 WHO classification of tumors of the nervous system: controversies in surgical neuropathology
    Bernd W Scheithauer
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Brain Pathol 18:307-16. 2008
    ..These issues and others are the substance of this and an upcoming companion article...
  10. doi Glomus tumor and glomangioma of the nerve. Report of two cases
    Bernd W Scheithauer
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Neurosurg 108:348-56. 2008
    ..An uneventful postoperative recovery was noted in both patients. Glomus tumors and glomangiomas can involve major nerves on rare occasions. They seem to follow a favorable clinical course, and conservative resection can be of benefit...
  11. ncbi Anaplastic astroblastoma-sarcoma in neurofibromatosis Type 1
    B W Scheithauer
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
    Clin Neuropathol 29:289-96. 2010
    ..The latter alterations, having been reported in astroblastoma, were noted in both tumor components, thus confirming the common origin of the glial and sarcomatous elements...
  12. doi Rosette-forming glioneuronal tumor: report of a chiasmal-optic nerve example in neurofibromatosis type 1: special pathology report
    Bernd W Scheithauer
    Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Neurosurgery 64:E771-2; discussion E772. 2009
    ..Its occurrence in the posterior fossa and association with the fourth ventricle is stereotypical and a feature of all reported cases...
  13. ncbi Pathobiology of pituitary adenomas and carcinomas
    Bernd W Scheithauer
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Neurosurgery 59:341-53; discussion 341-53. 2006
    ....
  14. ncbi Pituitary carcinoma: a clinicopathological review
    Bernd W Scheithauer
    Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, Minnesota 55901, USA
    Neurosurgery 56:1066-74; discussion 1066-74. 2005
    ..Recent studies have only begun to shed light on the probable mechanisms of tumor initiation and progression. A review of the clinicopathological and molecular genetic characteristics of pituitary carcinomas is presented...
  15. ncbi The pituitary in klinefelter syndrome
    B W Scheithauer
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Endocr Pathol 16:133-8. 2005
    ..The testes are small, blood testosterone levels are low, and blood gonadotropin levels are elevated. Pituitary changes in patients with Klinefelter syndrome have not been evaluated in detail...
  16. doi Synovial sarcoma of nerve
    Bernd W Scheithauer
    Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Hum Pathol 42:568-77. 2011
    ..Definitive recommendations regarding surgery and adjuvant therapies await additional reports and long-term follow-up. The literature is reviewed and a meta-analysis is performed with respect to clinicopathologic features versus outcome...
  17. ncbi Ganglioglioma of the neurohypophysis
    B W Scheithauer
    Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Endocr Pathol 19:112-6. 2008
    ..The morphologic and immunohistochemical features of the tumor are presented, cytogenetic considerations are discussed, and literature regarding neuronal lesions of the pituitary gland is reviewed...
  18. ncbi Malignant peripheral nerve sheath tumors of cranial nerves and intracranial contents: a clinicopathologic study of 17 cases
    Bernd W Scheithauer
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Surg Pathol 33:325-38. 2009
    ..Malignant cranial nerve sheath tumors are rare and are associated with the same poor prognosis as those of spinal nerves at other sites...
  19. doi Development of the WHO classification of tumors of the central nervous system: a historical perspective
    Bernd W Scheithauer
    Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Brain Pathol 19:551-64. 2009
    ..Four versions of its Classification of Tumours of the Central Nervous System have been published. The present work chronicles their progress, placing emphasis on the historical context of the earliest effort...
  20. doi Multiple endocrine neoplasia type 1-associated thyrotropin-producing pituitary carcinoma: report of a probable de novo example
    Bernd W Scheithauer
    Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Hum Pathol 40:270-8. 2009
    ..The literature regarding thyrotropin carcinomas is reviewed. Based on the study of several biopsies during disease progression, we believe that the carcinoma originated de novo without an intermediary adenoma phase...
  21. ncbi Clinical utility of fluorescence in situ hybridization (FISH) in morphologically ambiguous gliomas with hybrid oligodendroglial/astrocytic features
    Christine E Fuller
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri, USA
    J Neuropathol Exp Neurol 62:1118-28. 2003
    ..We conclude that 1) distinct genetic subsets are identifiable by FISH in morphologically ambiguous gliomas, and 2) both histological grading and molecular analysis yield prognostically useful information...
  22. ncbi Pituitary carcinoma: an ultrastructural study of eleven cases
    B W Scheithauer
    Department of Laboratory Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Ultrastruct Pathol 25:227-42. 2001
    ..Despite the diagnostic utility of electron microscopy in the assessment of these rare tumors, the distinction of pituitary carcinoma from pituitary adenoma cannot be firmly made on ultrastructural grounds alone...
  23. ncbi Small cell architecture--a histological equivalent of EGFR amplification in glioblastoma multiforme?
    P C Burger
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Neuropathol Exp Neurol 60:1099-104. 2001
    ..0004 with an exact test). We conclude that EGFR amplification is associated with a small cell phenotype in GBMs and that SCGBMs are an important component of "primary" GBMs...
  24. ncbi Coexisting corticotroph and lactotroph adenomas: case report with reference to the relationship of corticotropin and prolactin excess
    A G Wynne
    Division of Endocrinology, Mayo Clinic, Rochester, Minnesota
    Neurosurgery 30:919-23. 1992
    ..The mechanisms underlying simultaneous adrenocorticotropic hormone and prolactin excess are discussed...
  25. ncbi PS6K amplification characterizes a small subset of anaplastic meningiomas
    D X Cai
    Department of Pathology, Washington University School of Medicine, 660 S Euclid Ave, Box 8118, St Louis, MO 63110, USA
    Am J Clin Pathol 115:213-8. 2001
    ..Further studies are needed to map the 17q23 amplicon to determine whether additional genes in this region are amplified in high-grade meningiomas...
  26. ncbi Analysis of beta-catenin mutations and alpha-, beta-, and gamma-catenin expression in normal and neoplastic human pituitary tissues
    V Tziortzioti
    Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN, USA
    Endocr Pathol 12:125-36. 2001
    ....
  27. ncbi Results of treatment of pituitary disease in multiple endocrine neoplasia, type I
    T O'BRIEN
    Division of Endocrinology Metabolism and Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Neurosurgery 39:273-8; discussion 278-9. 1996
    ..The aim of the present study was to examine the clinical and pathological features of pituitary disease in patients with multiple endocrine neoplasia, Type I (MEN I) and to assess the prognosis...
  28. ncbi A retrospective analysis of pituitary apoplexy
    D C Bills
    Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota
    Neurosurgery 33:602-8; discussion 608-9. 1993
    ..In the stable, conscious patient with residual vision in each eye, surgical decompression should be performed as soon as possible, because delays beyond 1 week may retard the return of visual function...
  29. ncbi Pituitary adenoma in Carney complex: an immunohistochemical, ultrastructural, and immunoelectron microscopic study
    O Kurtkaya-Yapicier
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ultrastruct Pathol 26:345-53. 2002
    ..The lack of morphologic similarity between the 2 adenomas indicatesthat pituitary tumors in patients with Carney complex may not exhibit the same phenotype...
  30. ncbi Pituitary adenoma: a DNA flow cytometric study of 192 clinicopathologically characterized tumors
    T A Gaffey
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Clin Neuropathol 24:56-63. 2005
    ..When compared to long-term follow-up, neither this parameter nor ploidy correlated with tumor size or invasiveness. Lastly, long-term follow-up showed ploidy to be an unreliable predictor of tumor persistence or recurrence...
  31. ncbi Surgical outcome and predictive factors in adult patients with intractable epilepsy and focal cortical dysplasia
    A M Siegel
    Division of Epilepsy, Mayo Clinic, Rochester, MN 55905, USA
    Acta Neurol Scand 113:65-71. 2006
    ..To determine the surgical outcome and prognostic factors in adult patients with intractable epilepsy and focal cortical dysplasia (FCD)...
  32. pmc Transforming growth factor-beta, transforming growth factor-beta receptor II, and p27Kip1 expression in nontumorous and neoplastic human pituitaries
    L Jin
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Pathol 151:509-19. 1997
    ....
  33. pmc p27kip1: a multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers
    R V Lloyd
    Department of Laboratory Medicine and Pathology, Mayo Foundation and Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Pathol 154:313-23. 1999
    ..We also review studies indicating the increasingly important roles of p27, other CDKIs, and cyclins in endocrine cell hyperplasia and tumor development...
  34. ncbi A phase III study of radiation therapy plus carmustine with or without recombinant interferon-alpha in the treatment of patients with newly diagnosed high-grade glioma
    J C Buckner
    Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Cancer 92:420-33. 2001
    ....
  35. ncbi Gliosarcoma arising in oligodendroglial tumors ("oligosarcoma"): a clinicopathologic study
    Fausto J Rodriguez
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Surg Pathol 31:351-62. 2007
    ....
  36. ncbi Oligodendrogliomas: the Mayo Clinic experience
    E G Shaw
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota
    J Neurosurg 76:428-34. 1992
    ..9 years, 62%, and 31% for the 29 patients receiving surgery and high-dose radiation therapy (greater than or equal to 5000 cGy), respectively...
  37. ncbi Inactivation of the p16 gene in human pituitary nonfunctioning tumors by hypermethylation is more common in null cell adenomas
    K H Ruebel
    Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Endocr Pathol 12:281-9. 2001
    ....
  38. ncbi Sex- and age-related differences in ceramide dihexosides of primary human brain tumors
    A J Yates
    Department of Pathology, The Ohio State University, Columbus 43210, USA
    Lipids 34:1-4. 1999
    ....
  39. ncbi Identification and consequences of galectin-3 expression in pituitary tumors
    A Righi
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
    Mol Cell Endocrinol 326:8-14. 2010
    ..Given its role in pituitary tumor cell proliferation and in apoptosis, galectin-3 may be a target for the treatment of aggressive pituitary tumors...
  40. ncbi Congenital gigantism due to growth hormone-releasing hormone excess and pituitary hyperplasia with adenomatous transformation
    D Zimmerman
    Department of Pediatrics, Mayo Clinic, Rochester, Minnesota 55905
    J Clin Endocrinol Metab 76:216-22. 1993
    ..The peripheral plasma immunoreactive GHRH concentration remained unaffected by pharmacological and surgical interventions. We suspect that a congenital hypothalamic regulatory defect may be responsible for the GHRH excess in this case...
  41. ncbi Tumefactive demyelination and glioblastoma: a rare collision lesion
    S F Roemer
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    Clin Neuropathol 30:186-91. 2011
    ..Termed "tumefactive demyelination" it often prompts a brain biopsy...
  42. ncbi Leptin and leptin receptor in anterior pituitary function
    R V Lloyd
    Department of Laboratory Medicine and Pathology, Mayo Foundation, Rochester, MN 55905, USA
    Pituitary 4:33-47. 2001
    ..These proteins are activated by tyrosine-phosphorylation in anterior pituitary cells. The various steps in pituitary leptin signal transduction remain to be elucidated...
  43. pmc Myosin XVA expression in the pituitary and in other neuroendocrine tissues and tumors
    R V Lloyd
    Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Am J Pathol 159:1375-82. 2001
    ..These data suggest that in neuroendocrine cells myosin XVA may have a role in secretory granule movement and/or secretion...
  44. doi Expression of diagnostic neuronal markers and outcome in glioblastoma
    K Donev
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Neuropathol Appl Neurobiol 36:411-21. 2010
    ..High-grade gliomas featuring giant cells, often demonstrate immunoreactivity for neuronal markers, a finding prognostically significant according to some studies. We investigated this event in glioblastomas (GBM)...
  45. ncbi Infiltrative astrocytomas with granular cell features (granular cell astrocytomas): a study of histopathologic features, grading, and outcome
    Daniel J Brat
    Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Surg Pathol 26:750-7. 2002
    ..6 months). Two patients died postoperatively, and one was alive at 51 months. Granular cell astrocytoma is an uncommon morphologic variant that appears to be rapidly progressive and usually fatal...
  46. ncbi The spectrum of malignancy in craniopharyngioma
    Fausto J Rodriguez
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Surg Pathol 31:1020-8. 2007
    ..De novo malignancy in odontogenic tumors of the sella is even more unusual, but also has an ominous prognosis...
  47. ncbi Diagnostic and prognostic value of glycosyltransferase mRNA in glioblastoma multiforme patients
    J L Oblinger
    Department of Pathology, The Ohio State University, Columbia, OH, USA
    Neuropathol Appl Neurobiol 32:410-8. 2006
    ..In summary, the data indicate that measuring glycosyltransferase mRNA levels by real-time PCR may be clinically useful for determining both diagnosis and prognosis in GBM patients...
  48. ncbi Oligodendrogliomas: reproducibility and prognostic value of histologic diagnosis and grading
    C Giannini
    Department of Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Neuropathol Exp Neurol 60:248-62. 2001
    ..Our study found few factors independently associated with cause specific-survival among morphological parameters. These findings are consistent with the present WHO stratification of oligodendrogliomas into low- and high-grade variants...
  49. ncbi Extraventricular neurocytomas: pathologic features and clinical outcome
    D J Brat
    Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Surg Pathol 25:1252-60. 2001
    ..Thus, the majority of EVNs are well differentiated and appear unlikely to recur after gross total resection. Subtotal resection, atypical histologic features, and high cell proliferation rates correlate with recurrence...
  50. ncbi "Rhabdoid" meningioma: an aggressive variant
    A Perry
    Department of Laboratory Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Surg Pathol 22:1482-90. 1998
    ..Report of four cases. Am J Surg Pathol 1998;22:231-8). They further suggest that rhabdoid meningiomas are highly aggressive tumors and that the rhabdoid phenotype represents a marker of malignant transformation in meningiomas...
  51. ncbi Cushing's disease due to plurihormonal adrenocorticotropic hormone and gonadotropin-producing pituitary adenoma
    R Egensperger
    Department of Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Acta Neuropathol 102:398-403. 2001
    ..This represents the second report of a plurihormonal gonadotroph adenoma producing sufficient ACTH to result in pituitary-dependent Cushing's disease...
  52. ncbi Transformation of low grade glioma and correlation with outcome: an NCCTG database analysis
    K A Jaeckle
    Mayo Clinic, Cannaday 2 E, Jacksonville, FL 32224, USA
    J Neurooncol 104:253-9. 2011
    ..From time of recurrence, OS was not significantly different for those with primary versus secondary GBM, and it may thus be reasonable include patients with secondary GBM in clinical therapeutic trials for recurrent disease...
  53. ncbi Newly codified glial neoplasms of the 2007 WHO Classification of Tumours of the Central Nervous System: angiocentric glioma, pilomyxoid astrocytoma and pituicytoma
    Daniel J Brat
    Department of Pathology and Laboratory Medicine, 1364 Clifton Road NE, Atlanta, GA 30322, USA
    Brain Pathol 17:319-24. 2007
    ..It is solid in architecture, composed of spindle cells and presumably derived from pituicytes. Pituicytomas are indolent tumours, and are designated WHO grade I...
  54. ncbi Concurrent solitary fibrous tumor and low-grade fibrillary astrocytoma of the cerebellum
    J I Lopez
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Mayo Clinic College of Medicine, Rochester, MN, USA
    Clin Neuropathol 29:301-6. 2010
    ..We report the clinicopathologic features of a solitary fibrous tumor (SFT) having undergone malignant transformation and being intimately associated with a WHO Grade II astrocytoma...
  55. ncbi Fibrous meningioma with tyrosine-rich crystals
    M E Couce
    Department of Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ultrastruct Pathol 23:341-5. 1999
    ..By morphology, histochemistry, and ultrastructure, the crystals resembled tyrosine-rich crystals occurring in salivary gland tumors. This is the first report of a fibrous meningioma containing tyrosine-rich crystals...
  56. ncbi Analysis of p53 mutation and expression in pleomorphic xanthoastrocytoma
    C Giannini
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Neurogenetics 3:159-62. 2001
    ..Consequently, our findings suggest that the genetic events that underlie PXA formation differ from those involved in diffuse astrocytoma...
  57. ncbi PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme
    J S Smith
    Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Natl Cancer Inst 93:1246-56. 2001
    ....
  58. ncbi Mixed conventional and desmoplastic infantile ganglioglioma: an autopsied case with 6-year follow-up
    T Komori
    Department of Pathology and Laboratory MedicineMayo Clinic, Rochester, Minnesota, USA
    Mod Pathol 14:720-6. 2001
    ..If so, their derivation may be from multipotential cells of the neural plate...
  59. ncbi Chromosome 1p and 14q FISH analysis in clinicopathologic subsets of meningioma: diagnostic and prognostic implications
    D X Cai
    Department of Pathology, MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    J Neuropathol Exp Neurol 60:628-36. 2001
    ..Furthermore, 14q FISH analysis may aid in assessing recurrence risk in histologically benign meningiomas...
  60. ncbi Benign metastasizing leiomyomatosis with massive brachial plexus involvement mimicking neurofibromatosis type 1
    G C W de Ruiter
    Department of Neurologic Surgery, Mayo Clinic, Rochester, MN 55905, USA
    Clin Neuropathol 25:282-7. 2006
    ..Although a rare condition, BML should be considered in the differential diagnosis of NF and in patients having a history of uterine leiomyoma. The remarkable, selective involvement of the brachial plexus in this case is unexplained...
  61. ncbi A rosette-forming glioneuronal tumor of the fourth ventricle: infratentorial form of dysembryoplastic neuroepithelial tumor?
    Takashi Komori
    Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Surg Pathol 26:582-91. 2002
    ....
  62. ncbi Galectin-3 Expression in Functioning and Silent ACTH-Producing Adenomas
    Long Jin
    Department of Pathology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Endocr Pathol 16:107-14. 2005
    ..The use of ACTH and Gal-3 immunostaining should help in the diagnosis of silent ACTH adenomas...
  63. ncbi Congenital and childhood plexiform (multinodular) cellular schwannoma: a troublesome mimic of malignant peripheral nerve sheath tumor
    James M Woodruff
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Am J Surg Pathol 27:1321-9. 2003
    ..These features may lead to a misdiagnosis of malignancy, which could result in harmful overtreatment...
  64. ncbi Differential expression of galectin-3 in pituitary tumors
    Dominik Riss
    Department of Pathology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Cancer Res 63:2251-5. 2003
    ..Inhibition of Gal-3 gene expression by RNA interference decreased HP75 cell proliferation and increased apoptosis. These results indicate that Gal-3 has an important role in pituitary cell proliferation and tumor progression...
  65. ncbi Primary melanocytic tumor of the cerebellopontine angle mimicking a vestibular schwannoma: case report
    Mark P Piedra
    Department of Neurological Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota 55901, USA
    Neurosurgery 59:E206; discussion E206. 2006
    ..We report the case of a primary malignant melanoma of the CPA that mimicked a vestibular schwannoma (acoustic neuroma). We discuss the differential diagnosis and prognosis of melanotic lesions at this location...
  66. ncbi MGMT immunoexpression in silent subtype 3 pituitary adenomas: possible therapeutic implications
    Michael E Fealey
    Mayo Work Study Program, Mayo Clinic, Rochester, MN 55905, USA
    Endocr Pathol 21:161-5. 2010
    ..The observed lack of or low-level expression of MGMT by this distinctive, clinically aggressive form of pituitary adenoma suggests potential efficacy of treatment with the alkylating agent temozolomide...
  67. ncbi Solitary fibrous tumor of the cerebellopontine angle with salivary gland heterotopia: a unique presentation
    Fausto Rodriguez
    Department of Pathology, Mayo Foundation, Rochester, Minnesota 55902, USA
    Am J Surg Pathol 28:139-42. 2004
    ..The presence of a myoepithelial cell layer, surrounding some of the acini and highlighted by the smooth muscle actin immunostain, strengthened this interpretation...
  68. ncbi Central neurocytoma: management recommendations based on a 35-year experience
    James L Leenstra
    Department of Radiation Oncology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Int J Radiat Oncol Biol Phys 67:1145-54. 2007
    ..METHODS AND MATErials: The data from 45 patients with central neurocytomas diagnosed between 1971 and 2003 were retrospectively evaluated. Various combinations of surgery, radiotherapy (RT), and chemotherapy had been used for treatment...
  69. pmc Clinical and radiographic spectrum of pathologically confirmed tumefactive multiple sclerosis
    C F Lucchinetti
    Department of Neurology, College of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Brain 131:1759-75. 2008
    ..Although increased awareness of this broad spectrum may obviate need for biopsy in many circumstances, an important role for diagnostic brain biopsy may be required in some cases...
  70. ncbi Schwannoma with rhabdomyoblastic differentiation: a unique variant of malignant triton tumor
    O Kurtkaya-Yapicier
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Surg Pathol 27:848-53. 2003
    ..It supports the contention that the Schwann cell is the source of a variety of heterologous elements in nerve sheath tumors...
  71. ncbi Dysembryoplastic neuroepithelial tumor and calcifying pseudoneoplasms of the neuraxis: a collision of two seizure-associated lesions
    X Yan
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
    Clin Neuropathol 30:197-202. 2011
    ..The association of DNET and CPNA has not been previously reported. The literature relevant to these two seizure-associated lesions is reviewed...
  72. ncbi Management of malignant pineal germ cell tumors with residual mature teratoma
    J A Friedman
    Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA
    Neurosurgery 48:518-22; discussion 522-3. 2001
    ..We reviewed our surgical experience with residual malignant pineal germ cell tumors after neoadjuvant therapy...
  73. ncbi The treatable dementia of Sjögren's syndrome
    R J Caselli
    Department of Neurology, Mayo Clinic, Rochester, MN
    Ann Neurol 30:98-101. 1991
    ..Treatment with high-dose corticosteroids produced rapid and nearly complete resolution of the dementia...
  74. ncbi The results of radiotherapy for brainstem tumors
    S E Schild
    Mayo Clinic Scottsdale, Department of Radiation Oncology, AZ 85259, USA
    J Neurooncol 40:171-7. 1998
    ..This analysis was performed to examine the outcome of adult and pediatric patients with brainstem tumors...
  75. ncbi The results of radiotherapy for ependymomas: the Mayo Clinic experience
    S E Schild
    Mayo Clinic Arizona, Department of Radiation Oncology, Scottsdale 85259, USA
    Int J Radiat Oncol Biol Phys 42:953-8. 1998
    ..This analysis was performed to examine the outcome of patients with histologically confirmed ependymomas of the brain or spinal cord who received postoperative radiotherapy...
  76. doi Immunoglobulin derived depositions in the nervous system: novel mass spectrometry application for protein characterization in formalin-fixed tissues
    Fausto J Rodriguez
    Department of Laboratory Medicine and Pathology, Research Center, Mayo Clinic, Rochester, MN 55905, USA
    Lab Invest 88:1024-37. 2008
    ..LC-MS/MS represents a novel application for characterization of these deposits and is of diagnostic utility in addition to standard immunohistochemical analyses...
  77. ncbi Immunophenotype of pleomorphic xanthoastrocytoma
    Caterina Giannini
    Department of Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Surg Pathol 26:479-85. 2002
    ..We found no evidence that the former is a precursor of the latter...
  78. doi Rate of spontaneous hemorrhage in histologically proven cases of pilocytic astrocytoma
    J Bradley White
    Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Neurosurg 108:223-6. 2008
    ..Hemorrhage associated with pilocytic astrocytomas (PAs) is only sporadically reported. The authors report on a series of patients in whom PAs presenting as hemorrhages prompted them to examine the incidence of bleeding in these tumors...
  79. ncbi Spinal meningiomas in patients younger than 50 years of age: a 21-year experience
    Aaron A Cohen-Gadol
    Department of Neurologic Surgery, Mayo Medical School, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
    J Neurosurg 98:258-63. 2003
    ..Spinal meningiomas occurring in younger patients may be more aggressive, with a worse prognosis. The authors present their 21-year experience with spinal meningiomas in patients younger than 50 years of age...
  80. ncbi Granular cell tumor of the sellar and suprasellar region: clinicopathologic study of 11 cases and literature review
    Aaron A Cohen-Gadol
    Department of Neurologic Surgery, Mayo Clinic, Rochester, Minn 55905, USA
    Mayo Clin Proc 78:567-73. 2003
    ..To report a series of cases of surgically resected granular cell tumors in an attempt to better characterize their clinical presentation, imaging features, and treatment outcomes with attention to previously published literature...
  81. ncbi Ependymoma and intraparenchymal calcifying pseudoneoplasm of the neural axis: incidental collision or unique reactive phenomenon?
    Fausto J Rodriguez
    Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA
    Acta Neuropathol 115:363-6. 2008
    ..The unique combination of an ependymoma with marked reactive gliosis and a calcifying pseudoneoplasm supports the reactive nature of the latter...
  82. ncbi Hemangiopericytoma in the central nervous system: treatment, pathological features, and long-term follow up in 38 patients
    Robert D Ecker
    Department of Neurologic Surgery, The Mayo Clinic and Foundation, Rochester, Minnesota, USA
    J Neurosurg 98:1182-7. 2003
    ..The authors reviewed the Mayo Clinic experience with the treatment of hemangiopericytoma in the primary central nervous system (CNS)...
  83. ncbi Colocalized cellular schwannoma and plexiform neurofibroma in the absence of neurofibromatosis. Case report
    Robert J Spinner
    Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Neurosurg 107:435-9. 2007
    ..The latter finding supports the suggestion that these were two different clonal neoplasms, and is consistent with a collision tumor pattern...
  84. ncbi Peroneal intraneural ganglia: the importance of the articular branch. Clinical series
    Robert J Spinner
    Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Neurosurg 99:319-29. 2003
    ....
  85. ncbi Ependymal tumors with sarcomatous change ("ependymosarcoma"): a clinicopathologic and molecular cytogenetic study
    Fausto J Rodriguez
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Surg Pathol 32:699-709. 2008
    ..Although rare, ependymal neoplasms must be included among the gliomas prone to undergo sarcomatous change and we propose the term "ependymosarcoma" for these tumors...
  86. ncbi Effects of TGFbeta1 on gene expression in the HP75 human pituitary tumor cell line identified by gene expression profiling
    Katharina H Ruebel
    Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street, SW, Rochester, MN, 55905, USA
    Endocrine 33:62-76. 2008
    ..These findings highlight the diverse gene networks and pathways through which TGFbeta operates in its effects on pituitary tumor cells...
  87. pmc Interphase cytogenetics for 1p19q and t(1;19)(q10;p10) may distinguish prognostically relevant subgroups in extraventricular neurocytoma
    Fausto J Rodriguez
    Department of Laboratory Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Brain Pathol 19:623-9. 2009
    ..5 to 5.5 years after first resection. These results suggest that 1p19q loss and t(1;19) occur in a subset of EVN, and may be associated with aggressive histology in these tumors...
  88. doi Prognosis and treatment of spinal cord astrocytoma
    Kiernan J Minehan
    Department of Radiation Oncology, Mayo Clinic, Rochester, MN 55905, USA
    Int J Radiat Oncol Biol Phys 73:727-33. 2009
    ..To identify the prognostic factors for spinal cord astrocytoma and determine the effects of surgery and radiotherapy on outcome...
  89. ncbi Choristoma of the optic nerve: case report
    Caterina Giannini
    Department of Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Neurosurgery 50:1125-8. 2002
    ..Optic nerve choristoma is a rare lesion composed of adipose tissue and smooth muscle involving the optic nerve. Few cases have been reported...
  90. ncbi Phase II trial of procarbazine, lomustine, and vincristine as initial therapy for patients with low-grade oligodendroglioma or oligoastrocytoma: efficacy and associations with chromosomal abnormalities
    Jan C Buckner
    Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    J Clin Oncol 21:251-5. 2003
    ....
  91. ncbi Risk of cancer among relatives of patients with glioma
    Brian P O'Neill
    Department of Neurology, and the Mayo Clinic Cancer Center, Rochester Minnesota 55905, USA
    Cancer Epidemiol Biomarkers Prev 11:921-4. 2002
    ..Our results do not support the hypothesis of a familial aggregation of glioma indicative of a glioma susceptibility gene...
  92. pmc Gene expression profiling of NF-1-associated and sporadic pilocytic astrocytoma identifies aldehyde dehydrogenase 1 family member L1 (ALDH1L1) as an underexpressed candidate biomarker in aggressive subtypes
    Fausto J Rodriguez
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Neuropathol Exp Neurol 67:1194-204. 2008
    ..In summary, we have identified a molecular signature that distinguishes NF1-PA from S-PA and found that ALDH1L1 underexpression is associated with aggressive histology and/or biologic behavior...
  93. doi Intraneural ganglion cyst: a 200-year-old mystery solved
    Robert J Spinner
    Mayo Clinic, Department of Neurologic Surgery, Rochester, MN 55905, USA
    Clin Anat 21:611-8. 2008
    ..The purpose of this report is to clarify historical misconceptions regarding the pathogenesis of this controversial entity...
  94. doi The unifying articular (synovial) origin of intraneural ganglia: evolution-revelation-revolution
    Robert J Spinner
    Departments of Neurologic Surgery, Orthopedics, and Anatomy, Mayo Clinic, Rochester, Minnesota 55905, USA
    Neurosurgery 65:A115-24. 2009
    ..This article describes the ongoing process of critically analyzing and challenging previous observations and evidence in an effort to prove a concept and a theory...
  95. ncbi Anaplasia in pilocytic astrocytoma predicts aggressive behavior
    Fausto J Rodriguez
    Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Am J Surg Pathol 34:147-60. 2010
    ..In summary, PA with anaplastic features exhibits a spectrum of morphologies and is associated with decreased survival when compared with typical PA...
  96. ncbi Epineurial compartments and their role in intraneural ganglion cyst propagation: an experimental study
    Robert J Spinner
    Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Clin Anat 20:826-33. 2007
    ..Additional work is needed to be done to correlate these anatomic findings with magnetic resonance imaging and surgical pathology...
  97. ncbi Phase I/II trial of pyrazoloacridine and carboplatin in patients with recurrent glioma: a North Central Cancer Treatment Group trial
    Evanthia Galanis
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Invest New Drugs 23:495-503. 2005
    ....
  98. ncbi Deep Sylvian fissure chordoid meningioma: case report
    Jon I McIver
    Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Neurosurgery 57:E1064; discussion E1064. 2005
    ..A case of chordoid meningioma originating in the right sylvian fissure is reported. Chordoid meningiomas are uncommon tumors. This is the first reported case of a chordoid meningioma without dural attachment arising in the sylvian fissure...
  99. ncbi Neurocytoma of the VIIIth cranial nerve: case report
    Onder Onguru
    Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Neurosurgery 57:E1065; discussion E1065. 2005
    ..We described the clinicopathological features of an example arising in the cochlear-vestibular portion of the VIIIth nerve with extension into the cerebellopontine angle...
  100. doi Inflammatory pseudotumor of nerve: clinicopathological characteristics and a potential therapy
    Michelle L Mauermann
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    J Peripher Nerv Syst 15:216-26. 2010
    ..The primary pathophysiology is unknown but the inflammation and response to treatment suggests that there may be an immune component...
  101. ncbi Coexisting secondary intraneural and vascular adventitial ganglion cysts of joint origin: a causal rather than a coincidental relationship supporting an articular theory
    Robert J Spinner
    Department of Neurologic Surgery, Mayo Clinic, Rochester, MN 5590, USA
    Skeletal Radiol 35:734-44. 2006
    ..To introduce the clinical entity of an intraneural ganglion cyst coexisting with a vascular adventitial cyst arising from the same joint...