Research Topics
Species | JEFFREY SALISBURYSummaryAffiliation: Mayo Clinic Country: USA Publications
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Detail Information
Publications
Centrosome amplification drives chromosomal instability in breast tumor developmentWilma L Lingle
Division of Experimental Pathology, Tumor Biology Program, Mayo Clinic, Rochester, MN 55905, USA
Proc Natl Acad Sci U S A 99:1978-83. 2002..These results further suggest that aspects of centrosome amplification may have clinical diagnostic and/or prognostic value and that the centrosome may be a potential target for cancer therapy...
Primary cilia: putting sensors togetherJeffrey L Salisbury
Tumor Biology Program, Mayo Clinic School of Medicine, Rochester, Minnesota 55905, USA
Curr Biol 14:R765-7. 2004..Recent studies reveal an intimate interplay between structural proteins of the centrosome and the formation of primary cilia, and provide new insight into the complex function of these fascinating organelles...- A mechanistic view on the evolutionary origin for centrin-based control of centriole duplicationJeffrey L Salisbury
Department of Biochemistry and Molecular Biology, Tumor Biology Program, Mayo Clinic, Rochester, Minnesota, USA
J Cell Physiol 213:420-8. 2007..This model provides an evolutionary basis for the preservation of essential features of the yeast spindle pole body (SPB) with the origin of the complex structure of the mammalian centriole... - Centrosome amplification and the origin of chromosomal instability in breast cancerJeffrey L Salisbury
Tumor Biology Program, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
J Mammary Gland Biol Neoplasia 9:275-83. 2004..This review focuses on the coordination of the centrosome, DNA, and cell cycles in normal cells and their deregulation resulting in centrosome amplification and chromosomal instability in the development and progression of breast cancer... - Centrosomes: Sfi1p and centrin unravel a structural riddleJeffrey L Salisbury
Tumor Biology Program, Mayo Clinic School of Medicine, Rochester, Minnesota 55905, USA
Curr Biol 14:R27-9. 2004..Sfi1 binds to multiple centrin molecules along a series of internal repeats, and the complex forms Ca2+-sensitive contractile fibers that function to reorient centrioles and alter centrosome structure... - Centrosome size is controlled by centriolar SAS-4Jeffrey L Salisbury
Tumor Biology Program, Mayo Clinic, Rochester, MN 55905, USA
Trends Cell Biol 13:340-3. 2003.... - Centrosomes: coiled-coils organize the cell centerJeffrey L Salisbury
Tumor Biology Program, Mayo Clinic, Rochester, MN 55905, USA
Curr Biol 13:R88-90. 2003..Recent studies on mutants of the nematode worm Caenorhabditis elegans have provided new insight into the framework to which microtubules and key regulators of centrosome behavior are anchored... - Centrin-2 is required for centriole duplication in mammalian cellsJeffrey L Salisbury
Tumor Biology Program, Mayo Clinic, Rochester, MN 55905, USA
Curr Biol 12:1287-92. 2002..However, aside from their role as an anchor point for pericentriolar material and as basal bodies of flagella and cilia, the functional attributes of centrioles remain enigmatic... - The contribution of epigenetic changes to abnormal centrosomes and genomic instability in breast cancerJ L Salisbury
Tumor Biology Program, Mayo Clinic Foundation, Rochester, Minnesota 55905, USA
J Mammary Gland Biol Neoplasia 6:203-12. 2001..Because aberrant centrosome function can result in chromosomal instability, these properties may have important implications for the origin of malignant breast tumors... - Microtubule nucleating capacity of centrosomes in tissue sectionsJ L Salisbury
Tumor Biology Program, Mayo Clinic, Rochester, Minnesota
J Histochem Cytochem 47:1265-74. 1999..These methods can be utilized to characterize MTOC activity in normal and diseased tissues and in particular tissues at different stages of development. (J Histochem Cytochem 47:1265-1273, 1999).. - GFP-centrin as a marker for centriole dynamics in the human breast cancer cell line MCF-7F Stivala
Tumor Biology Program, Mayo Clinic Foundation, Rochester, MN 55905, USA
Ital J Anat Embryol 106:103-10. 2001.... - Altered centrosome structure is associated with abnormal mitoses in human breast tumorsW L Lingle
Tumor Biology Program, Mayo Foundation, Rochester, Minnesota 55905, USA
Am J Pathol 155:1941-51. 1999..Centrosome abnormalities may confer a mutator phenotype to tumors, occasionally yielding cells with a selective advantage that emerge and thrive, thus leading the tumor to a more aggressive state... - Phosphorylation of centrin during the cell cycle and its role in centriole separation preceding centrosome duplicationW Lutz
Department of Biochemistry and Molecular Biology, Tumor Biology Program, Mayo Clinic Foundation, Rochester, Minnesota 55905, USA
J Biol Chem 276:20774-80. 2001..Taken together, these results suggest that centrin phosphorylation signals the separation of centrosomes at prophase and implicates centrin phosphorylation in centriole separation that normally precedes centrosome duplication... - Methods for the analysis of centrosome reproduction in cancer cellsW L Lingle
Experimental Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
Methods Cell Biol 67:325-36. 2001..This assay can also be used to characterize the microtubule nucleation capacity of normal tissues, during development and aging, and in disease states other than cancer where microtubule dynamics may play an important role... - Impaired p53 function leads to centrosome amplification, acquired ERalpha phenotypic heterogeneity and distant metastases in breast cancer MCF-7 xenograftsA B D'Assoro
Department of Biochemistry and Molecular Biology, Tumor Biology Program, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Oncogene 27:3901-11. 2008..Taken together, these observations indicate that abrogation of p53 function and consequent deregulation of the G1/S cell cycle transition leads to centrosome amplification responsible for breast cancer progression... - Expression of centrin isoforms in the mammalian retinaU Wolfrum
Mayo Clinic Foundation, Laboratory for Cell Biology, Rochester, Minnesota 55905, USA
Exp Cell Res 242:10-7. 1998..These observations suggest centrin 2 message may be universally expressed while centrin 1 message may be restricted to retina and testis which contain cells that have differentiated cilia or flagella, or their modifications... - Testis-specific murine centrin, Cetn1: genomic characterization and evidence for retroposition of a gene encoding a centrosome proteinP E Hart
Tumor Biology Program, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
Genomics 60:111-20. 1999..Cetn1 expression is first seen in the neonatal testis at 14 days postpartum, reaching adult levels by day 17. These observations provide new insight into the regulation, function, and evolutionary history of centrin in higher eukaryotes... - Cloning of a cDNA encoding human centrin, an EF-hand protein of centrosomes and mitotic spindle polesR Errabolu
Department of Biochemistry and Molecular Biology, Mayo Clinic Foundation, Rochester, Minnesota 55905
J Cell Sci 107:9-16. 1994.... - The structure of the human centrin 2-xeroderma pigmentosum group C protein complexJames R Thompson
Department of Physiology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
J Biol Chem 281:18746-52. 2006..The interface between centrin-2 and each peptide is predominantly nonpolar, and key hydrophobic residues of XPC have been identified that lead us to propose a novel binding motif for centrin... - Aurora a and B overexpression and centrosome amplification in early estrogen-induced tumor foci in the Syrian hamster kidney: implications for chromosomal instability, aneuploidy, and neoplasiaAdrianne E Hontz
Hormonal Carcinogenesis Laboratory, Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA
Cancer Res 67:2957-63. 2007.... - Dynamics of hydrogen-deuterium exchange in Chlamydomonas centrinMildred Ortiz
Department of Chemistry and Center for Protein Structure Function and Dynamics, University of Puerto Rico, , P.O. Box 9019, , Puerto Rico 00681-9019
Biochemistry 44:2409-18. 2005.... - Estrogen mediates Aurora-A overexpression, centrosome amplification, chromosomal instability, and breast cancer in female ACI ratsJonathan J Li
Hormonal Carcinogenesis Laboratory, Department of Pharmacology, Toxicology, and Experimental Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
Proc Natl Acad Sci U S A 101:18123-8. 2004..Thus, we report that estrogen is causally linked via estrogen receptor alpha to Aur-A overexpression, centrosome amplification, CIN, and aneuploidy leading to BC in susceptible mammary gland cells... - Breaking the ties that bind centriole numbersJeffrey L Salisbury
Nat Cell Biol 10:255-7. 2008 - Metal-binding properties of human centrin-2 determined by micro-electrospray ionization mass spectrometry and UV spectroscopyTheodore A Craig
Department of Medicine, Mayo Clinic College of Medicine and Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
J Am Soc Mass Spectrom 17:1158-71. 2006..We conclude that HsCen-2 binds calcium and magnesium and that calcium modulates HsCen-2 structure and function by increasing its stability without undergoing significant changes in secondary or tertiary structure... - Centrin gene disruption impairs stage-specific basal body duplication and cell cycle progression in LeishmaniaAngamuthu Selvapandiyan
Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Food and Drug Administration, Bethesda, MD 20892, USA
J Biol Chem 279:25703-10. 2004..The centrin null mutant defective in amastigote growth could be useful as a vaccine candidate against leishmaniasis... - Centrin: its secondary structure in the presence and absence of cationsBelinda Pastrana-Rios
Department of Chemistry, University of Puerto Rico Mayagüez Campus, Mayaguez, Puerto Rico 00681 9019, USA
Biochemistry 41:6911-9. 2002..Thermal dependence revealed reversible conformational transition temperatures for apocentrin at 37 degrees C and holocentrin at 45 degrees C, suggesting greater stability for holocentrin... - Centrosome amplification and the development of cancerWilma L Lingle
Tumor Biology Program, Mayo Clinic, Rochester, Minnesota, MN 55905, USA
Oncogene 21:6146-53. 2002 - Deregulation of the centrosome cycle and the origin of chromosomal instability in cancerWilma L Lingle
Mayo Clinic College of Medicine, Mayo Clinic Foundation, Mayo Clinic Cancer Center, Rochester, Minnesota 55905, USA
Adv Exp Med Biol 570:393-421. 2005..Centrosome amplification, therefore, can serve to exacerbate and/or generate genetic instabilities associated with cancers... - Amplified centrosomes in breast cancer: a potential indicator of tumor aggressivenessSusan L Barrett
Tumor Biology Program, Mayo Clinic Foundation, Rochester, MN 55905, USA
Breast Cancer Res Treat 75:25-34. 2002..Centrosome amplification is associated with mitotic spindle abnormalities in breast carcinomas and thus may contribute to genomic instability and the development of more aggressive phenotypes during tumor progression... - A novel vitamin D-regulated immediate-early gene, IEX-1, alters cellular growth and apoptosisRajiv Kumar
Department of Medicine, Mayo Clinic and Foundation, 911A Guggenheim Building, 200 First Street S W, Rochester, MN 55905, USA
Recent Results Cancer Res 164:123-34. 2003..1alpha,25(OH)2D3 alters the subcellular localization of IEX-1 by causing an efflux of IEX-1 from the nucleus, and the sterol decreases the expression of IEX-1 messenger RNA in cells via a novel DR3 repeat-type DNA response element... - Genotoxic stress leads to centrosome amplification in breast cancer cell lines that have an inactive G1/S cell cycle checkpointRobert Busby
Tumor Biology Program, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
Oncogene 23:4068-75. 2004.... - Asymmetric distribution of nuclear pore complexes and the cytoplasmic localization of beta2-tubulin mRNA in Chlamydomonas reinhardtiiDANIEL A COLON-RAMOS
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
Dev Cell 4:941-52. 2003.... 
Expression of selected Aurora A kinase substrates in solely estrogen-induced ectopic uterine stem cell tumors in the Syrian hamster kidneyAdrianne E Hontz
Department of Pharmacology, University of Kansas University Medical Center, Kansas City, KS, USA
Adv Exp Med Biol 617:411-8. 2008..Collectively, these data indicate that over-expression of AurA/B is under estrogen control and that the deregulation of Aur kinase protein substrates is implicated in eliciting the alterations observed during oncogenesis...- Centrin1 is required for organelle segregation and cytokinesis in Trypanosoma bruceiAngamuthu Selvapandiyan
Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
Mol Biol Cell 18:3290-301. 2007..brucei...
Research Grants
- Centrosome Amplification in Human Breast CancerJEFFREY SALISBURY; Fiscal Year: 2006..The study of centrosome behavior is of fundamental importance to our understanding of the origin of malignant tumors and may reveal new targets for intervention or prevention of the development of breast cancer. ..
- MULTIDISCIPLINARY BASIC RESEARCH TRAINING IN CANCERJEFFREY SALISBURY; Fiscal Year: 2002..Separate facilities are available for animal housing, engineering, and classroom and lecture space. ..
- CENTROSOME HYPERTROPHY IN HUMAN BREAST TUMORSJEFFREY SALISBURY; Fiscal Year: 2001....