Martin Rodriguez-Porcel

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc In vivo imaging and monitoring of transplanted stem cells: clinical applications
    Martin Rodriguez-Porcel
    Stabile 4 56, Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Curr Cardiol Rep 12:51-8. 2010
  2. pmc Antioxidants improve early survival of cardiomyoblasts after transplantation to the myocardium
    Martin Rodriguez-Porcel
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
    Mol Imaging Biol 12:325-34. 2010
  3. ncbi request reprint Antioxidant intervention prevents renal neovascularization in hypercholesterolemic pigs
    Alejandro R Chade
    Department of Internal Medicine Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Soc Nephrol 15:1816-25. 2004
  4. ncbi request reprint Comparison of acute and chronic antioxidant interventions in experimental renovascular disease
    Alejandro R Chade
    Div of Hypertension, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Renal Physiol 286:F1079-86. 2004
  5. ncbi request reprint Antioxidant intervention attenuates myocardial neovascularization in hypercholesterolemia
    Xiang Yang Zhu
    Department of Internal Medicine, Division of Hypertension, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Circulation 109:2109-15. 2004
  6. ncbi request reprint Antioxidant intervention blunts renal injury in experimental renovascular disease
    Alejandro R Chade
    Department of Internal Medicine, Division of Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Am Soc Nephrol 15:958-66. 2004
  7. ncbi request reprint Beneficial effects of antioxidant vitamins on the stenotic kidney
    Alejandro R Chade
    Division of Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, Minn 55905, USA
    Hypertension 42:605-12. 2003
  8. ncbi request reprint Mechanisms of renal structural alterations in combined hypercholesterolemia and renal artery stenosis
    Alejandro R Chade
    Department of Internal Medicine, Division of Hypertension, Mayo Clinic, Rochester, Minn 55905, USA
    Arterioscler Thromb Vasc Biol 23:1295-301. 2003
  9. ncbi request reprint Hypercholesterolemia and hypertension have synergistic deleterious effects on coronary endothelial function
    Martin Rodriguez-Porcel
    Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic, 200 First St SW, Rochester, Minn 55905, USA
    Arterioscler Thromb Vasc Biol 23:885-91. 2003
  10. ncbi request reprint Distinct renal injury in early atherosclerosis and renovascular disease
    Alejandro R Chade
    Department of Internal Medicine, Division of Hypertension, Mayo Clinic, Rochester, Minn 55905, USA
    Circulation 106:1165-71. 2002

Collaborators

Detail Information

Publications39

  1. pmc In vivo imaging and monitoring of transplanted stem cells: clinical applications
    Martin Rodriguez-Porcel
    Stabile 4 56, Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Curr Cardiol Rep 12:51-8. 2010
    ..Use of these strategies will be critical as the different regenerative therapies are being tested for clinical use...
  2. pmc Antioxidants improve early survival of cardiomyoblasts after transplantation to the myocardium
    Martin Rodriguez-Porcel
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
    Mol Imaging Biol 12:325-34. 2010
    ..We tested the hypothesis that modulation of the microenvironment (using antioxidants) will increase stem cell survival in hypoxia and after transplantation to the myocardium...
  3. ncbi request reprint Antioxidant intervention prevents renal neovascularization in hypercholesterolemic pigs
    Alejandro R Chade
    Department of Internal Medicine Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Soc Nephrol 15:1816-25. 2004
    ..Chronic antioxidant supplementation may preserve the kidney in HC...
  4. ncbi request reprint Comparison of acute and chronic antioxidant interventions in experimental renovascular disease
    Alejandro R Chade
    Div of Hypertension, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Renal Physiol 286:F1079-86. 2004
    ..These suggest that chronic tissue changes play an important role in renal compromise mediated by oxidative stress in RVD...
  5. ncbi request reprint Antioxidant intervention attenuates myocardial neovascularization in hypercholesterolemia
    Xiang Yang Zhu
    Department of Internal Medicine, Division of Hypertension, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Circulation 109:2109-15. 2004
    ..We tested the hypothesis that chronic antioxidant intervention in HC would attenuate neovascularization and preserve the expression of hypoxia-inducible factor (HIF)-1alpha and vascular endothelial growth factor (VEGF)...
  6. ncbi request reprint Antioxidant intervention blunts renal injury in experimental renovascular disease
    Alejandro R Chade
    Department of Internal Medicine, Division of Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Am Soc Nephrol 15:958-66. 2004
    ..This study supports critical pathogenic contribution of increased oxidative stress to renal injury and scarring in RVD and suggests a role for antioxidant strategies in preserving the atherosclerotic and ischemic kidney...
  7. ncbi request reprint Beneficial effects of antioxidant vitamins on the stenotic kidney
    Alejandro R Chade
    Division of Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, Minn 55905, USA
    Hypertension 42:605-12. 2003
    ..These observations underscore the involvement of oxidative stress in renal injury in RAS and support a role for antioxidant vitamins in preserving the ischemic kidney...
  8. ncbi request reprint Mechanisms of renal structural alterations in combined hypercholesterolemia and renal artery stenosis
    Alejandro R Chade
    Department of Internal Medicine, Division of Hypertension, Mayo Clinic, Rochester, Minn 55905, USA
    Arterioscler Thromb Vasc Biol 23:1295-301. 2003
    ..We tested the hypothesis that coexistence of atherosclerosis and RAS interferes with renal tissue remodeling...
  9. ncbi request reprint Hypercholesterolemia and hypertension have synergistic deleterious effects on coronary endothelial function
    Martin Rodriguez-Porcel
    Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic, 200 First St SW, Rochester, Minn 55905, USA
    Arterioscler Thromb Vasc Biol 23:885-91. 2003
    ..However, pathogenic mechanisms are poorly understood. Here we studied the effects of coexisting HC and HT on coronary endothelial function...
  10. ncbi request reprint Distinct renal injury in early atherosclerosis and renovascular disease
    Alejandro R Chade
    Department of Internal Medicine, Division of Hypertension, Mayo Clinic, Rochester, Minn 55905, USA
    Circulation 106:1165-71. 2002
    ..This study was designed to test the hypothesis that concurrent early atherosclerosis and hypoperfusion might have greater early deleterious effects on the function and structure of the stenotic kidney...
  11. ncbi request reprint Role of oxidative stress in remodeling of the myocardial microcirculation in hypertension
    Xiang Yang Zhu
    Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Arterioscler Thromb Vasc Biol 26:1746-52. 2006
    ..We tested the hypothesis that in early hypertension (HT), increased oxidative stress leads to myocardial microvascular remodeling...
  12. pmc Noninvasive monitoring of oxidative stress in transplanted mesenchymal stromal cells
    Peter J Psaltis
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    JACC Cardiovasc Imaging 6:795-802. 2013
    ..The goal of this study was to validate a pathway-specific reporter gene that could be used to noninvasively image the oxidative status of progenitor cells...
  13. ncbi request reprint Redox-sensitive myocardial remodeling and dysfunction in swine diet-induced experimental hypercholesterolemia
    Xiang Yang Zhu
    Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, MN 55905, United States
    Atherosclerosis 193:62-9. 2007
    ....
  14. ncbi request reprint Chronic antioxidant supplementation impairs coronary endothelial function and myocardial perfusion in normal pigs
    Daniele Versari
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN, USA
    Hypertension 47:475-81. 2006
    ....
  15. ncbi request reprint Long-term antioxidant intervention improves myocardial microvascular function in experimental hypertension
    Martin Rodriguez-Porcel
    Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First St SW, Rochester, Minn 55905, USA
    Hypertension 43:493-8. 2004
    ..These results support the involvement of oxidative stress in myocardial vascular dysfunction in hypertension and suggest a role for antioxidant strategies to preserve the myocardial microvasculature...
  16. ncbi request reprint Endothelin type A receptor antagonism restores myocardial perfusion response to adenosine in experimental hypercholesterolemia
    Piero O Bonetti
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Atherosclerosis 168:367-73. 2003
    ....
  17. ncbi request reprint Hypertension exacerbates the effect of hypercholesterolemia on the myocardial microvasculature
    Martin Rodriguez-Porcel
    Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA
    Cardiovasc Res 58:213-21. 2003
    ..HC and HT are individually associated with abnormal myocardial vascular function, but whether HT exacerbates the HC-induced myocardial vascular dysfunction remains unclear...
  18. ncbi request reprint Endothelin-1 receptor blockade prevents renal injury in experimental hypercholesterolemia
    Alejandro R Chade
    Department of Internal Medicine, Division of Hypertension, Mayo Clinic, Rochester, Minnesota, USA
    Kidney Int 64:962-9. 2003
    ..However, the involvement of endothelin (ET) in this disease process is yet unknown...
  19. ncbi request reprint Pathways of renal fibrosis and modulation of matrix turnover in experimental hypercholesterolemia
    Alejandro R Chade
    Division of Nephrology, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
    Hypertension 46:772-9. 2005
    ..Notably, many of these pathways may be reversible in hypercholesterolemia, and crucial targets could potentially be identified for early interventions to preserve the kidney...
  20. ncbi request reprint Dietary reversal of experimental hypercholesterolemia improves endothelial dysfunction of epicardial arteries but not of small coronary vessels in pigs
    Katherine J E Sattler
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN, USA
    Atherosclerosis 188:301-8. 2006
    ..Hence, dietary normalization of serum lipid levels alone may not be synonymous to normalization of the components of endothelial dysfunction...
  21. pmc Functional and structural remodeling of the myocardial microvasculature in early experimental hypertension
    Martin Rodriguez-Porcel
    Department of Internal Medicine, Division of Cardiovascular Disease, Mayo Clinic College of Medicine, 200 First St SW, Rochester, Minnesota 55905, USA
    Am J Physiol Heart Circ Physiol 290:H978-84. 2006
    ..These observations underscore the direct and early effects of HT on the myocardial vasculature...
  22. ncbi request reprint Cortical microvascular remodeling in the stenotic kidney: role of increased oxidative stress
    Xiang Yang Zhu
    Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Arterioscler Thromb Vasc Biol 24:1854-9. 2004
    ..Mechanisms of renal injury distal to renal artery stenosis (RAS) remain unclear. We tested the hypothesis that it involves microvascular remodeling consequent to increased oxidative stress...
  23. ncbi request reprint Angiotensin II AT1 receptor blockade improves renal perfusion in hypercholesterolemia
    Alejandro R Chade
    Department of Internal Medicine, Division of Hypertension, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Hypertens 16:111-5. 2003
    ..This study tested the hypothesis that AT1 receptor blockade improved renal perfusion and functional responses in hypercholesterolemic pigs...
  24. ncbi request reprint Oxidative stress-related increase in ubiquitination in early coronary atherogenesis
    Joerg Hermann
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    FASEB J 17:1730-2. 2003
    ..These results demonstrate that the UPS is functionally active in early atherogenesis despite increase in oxidative stress with important repercussions in the pathophysiology and therapy of cardiovascular diseases...
  25. pmc Polycystic kidneys have decreased vascular density: a micro-CT study
    Rende Xu
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Microcirculation 20:183-9. 2013
    ..It remains unclear whether PKD is associated with abnormal microvascular structure. Thus, this study examined the renovascular structure in PKD...
  26. ncbi request reprint Image-guided cardiac cell delivery using high-resolution small-animal ultrasound
    Martin Rodriguez-Porcel
    Department of Internal Medicine, Divisions of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Mol Ther 12:1142-7. 2005
    ..We are confident that the use of these technologies will play a significant role in the future of gene and cell therapy...
  27. ncbi request reprint Simvastatin preserves myocardial perfusion and coronary microvascular permeability in experimental hypercholesterolemia independent of lipid lowering
    Piero O Bonetti
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 40:546-54. 2002
    ....
  28. pmc Endothelial dysfunction occurs prior to clinical evidence of polycystic kidney disease
    Karen M Peterson
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minn, USA
    Am J Nephrol 38:233-40. 2013
    ..Whether vascular endothelial dysfunction is also present in ARPKD, and its relationship with renal dysfunction remain to be determined...
  29. pmc Cell tracking and the development of cell-based therapies: a view from the Cardiovascular Cell Therapy Research Network
    Martin Rodriguez-Porcel
    Mayo Clinic, Rochester, Minnesota, USA
    JACC Cardiovasc Imaging 5:559-65. 2012
    ..In this review, different imaging methods and technologies are discussed within the framework of the physiological answers that the imaging strategies can provide, with a special focus on the inherent regulatory issues...
  30. pmc Improved survival of mesenchymal stromal cell after hypoxia preconditioning: role of oxidative stress
    Karen M Peterson
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA
    Life Sci 88:65-73. 2011
    ....
  31. doi request reprint Non-invasive assessment of cardiac function in a mouse model of renovascular hypertension
    Federico Franchi
    Department of Internal Medicine, Divisions of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Hypertens Res 36:770-5. 2013
    ..Non-invasive high-resolution ultrasonography allowed assessment of the diastolic function profile in a small animal model of renovascular hypertension. ..
  32. ncbi request reprint Vascular responses in vivo to 8-epi PGF(2alpha) in normal and hypercholesterolemic pigs
    James D Krier
    Department of Internal Medicine, Division of Hypertension, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Physiol Regul Integr Comp Physiol 283:R303-8. 2002
    ....
  33. doi request reprint Molecular imaging of cell therapy for gastroenterologic applications
    Vanessa M Dimayuga
    Mayo Medical School, Mayo Clinic, Rochester, MN, USA
    Pancreatology 11:414-27. 2011
    ..In this review, we will discuss the potential imaging strategies and how they can be utilized, depending on the questions that need to be answered...
  34. pmc Humanin, a cytoprotective peptide, is expressed in carotid atherosclerotic [corrected] plaques in humans
    David G Zacharias
    Division of Cardiovascular Diseases, Department of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
    PLoS ONE 7:e31065. 2012
    ..Humanin (HN) is a newly emerging endogenously expressed cytoprotective peptide. Our goal was to determine the presence and localization of HN in carotid atherosclerotic plaques...
  35. ncbi request reprint Chronic antioxidant supplementation attenuates nuclear factor-kappa B activation and preserves endothelial function in hypercholesterolemic pigs
    Martin Rodriguez-Porcel
    Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Cardiovasc Res 53:1010-8. 2002
    ..The physiological significance of in vivo chronic antioxidant intervention on HC-induced NF-kappa B activation and coronary endothelial function remains unclear...
  36. doi request reprint Safety and efficacy of extracorporeal shock wave myocardial revascularization therapy for refractory angina pectoris
    Andrew Cassar
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN
    Mayo Clin Proc 89:346-54. 2014
    ..To assess the safety and efficacy of extracorporeal shockwave myocardial revascularization (ESMR) therapy in treating patients with refractory angina pectoris...
  37. pmc Emerging roles for integrated imaging modalities in cardiovascular cell-based therapeutics: a clinical perspective
    Peter J Psaltis
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Eur J Nucl Med Mol Imaging 39:165-81. 2012
    ....
  38. pmc Role of oxidative stress in hypoxia preconditioning of cells transplanted to the myocardium: a molecular imaging study
    A Aly
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA
    J Cardiovasc Surg (Torino) 52:579-85. 2011
    ..We hypothesize that the beneficial effect of HPC on stem cell survival is in part due to preservation of oxidant status, an effect that will be monitored using state-of-the-art molecular imaging...
  39. ncbi request reprint Differential effect of experimental hypertension and hypercholesterolemia on adventitial remodeling
    Joerg Herrmann
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic Rochester, MN 55905, USA
    Arterioscler Thromb Vasc Biol 25:447-53. 2005
    ..Intima-media remodeling, as frequently assessed by changes in the external elastic lamina-to-lumen area (EELLA), is well-described in coronary artery disease in contrast to adventitial remodeling, especially in the early disease stage...