W A Rocca

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Sex-specific risk of cardiovascular disease and cognitive decline: pregnancy and menopause
    Virginia M Miller
    Departments of Surgery and Physiology and Biomedical Engineering, 200 1st St SW, Rochester, MN 55905, USA
    Biol Sex Differ 4:6. 2013
  2. pmc History of the Rochester Epidemiology Project: half a century of medical records linkage in a US population
    Walter A Rocca
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 87:1202-13. 2012
  3. pmc Hysterectomy, oophorectomy, estrogen, and the risk of dementia
    Walter A Rocca
    Department of Neurology, College of Medicine, Mayo Clinic, Rochester, Minn 55905, USA
    Neurodegener Dis 10:175-8. 2012
  4. pmc Premature menopause or early menopause and risk of ischemic stroke
    Walter A Rocca
    Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Menopause 19:272-7. 2012
  5. pmc Long-term effects of bilateral oophorectomy on brain aging: unanswered questions from the Mayo Clinic Cohort Study of Oophorectomy and Aging
    Walter A Rocca
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Womens Health (Lond Engl) 5:39-48. 2009
  6. pmc Trends in the incidence and prevalence of Alzheimer's disease, dementia, and cognitive impairment in the United States
    Walter A Rocca
    Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN, USA
    Alzheimers Dement 7:80-93. 2011
  7. pmc Oophorectomy, menopause, estrogen treatment, and cognitive aging: clinical evidence for a window of opportunity
    Walter A Rocca
    Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN, USA
    Brain Res 1379:188-98. 2011
  8. ncbi request reprint Increased risk of essential tremor in first-degree relatives of patients with Parkinson's disease
    Walter A Rocca
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Mov Disord 22:1607-14. 2007
  9. ncbi request reprint Survival patterns after oophorectomy in premenopausal women: a population-based cohort study
    Walter A Rocca
    Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Lancet Oncol 7:821-8. 2006
  10. ncbi request reprint The Mayo Clinic cohort study of personality and aging: design and sampling, reliability and validity of instruments, and baseline description
    Walter A Rocca
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neuroepidemiology 26:119-29. 2006

Research Grants

  1. EPIDEMIOLOGY AND GENETICS OF PARKINSONS DISEASE
    Walter Rocca; Fiscal Year: 2000
  2. ROCHESTER EPIDEMIOLOGY PROJECT
    Walter Rocca; Fiscal Year: 2009
  3. ROCHESTER EPIDEMIOLOGY PROJECT
    Walter Rocca; Fiscal Year: 2007
  4. EPIDEMIOLOGY AND GENETICS OF PARKINSON'S DISEASE
    Walter Rocca; Fiscal Year: 2005
  5. ROCHESTER EPIDEMIOLOGY PROJECT
    Barbara P Yawn; Fiscal Year: 2010

Detail Information

Publications146 found, 100 shown here

  1. pmc Sex-specific risk of cardiovascular disease and cognitive decline: pregnancy and menopause
    Virginia M Miller
    Departments of Surgery and Physiology and Biomedical Engineering, 200 1st St SW, Rochester, MN 55905, USA
    Biol Sex Differ 4:6. 2013
    ..Research into specific sex differences for these disease processes with attention to an individual's sex chromosomal complement and hormonal status is important and timely...
  2. pmc History of the Rochester Epidemiology Project: half a century of medical records linkage in a US population
    Walter A Rocca
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 87:1202-13. 2012
    ..The REP can serve as a model for the development of similar research infrastructures in the United States and worldwide...
  3. pmc Hysterectomy, oophorectomy, estrogen, and the risk of dementia
    Walter A Rocca
    Department of Neurology, College of Medicine, Mayo Clinic, Rochester, Minn 55905, USA
    Neurodegener Dis 10:175-8. 2012
    ..The long-term cognitive effects of hysterectomy and oophorectomy remain controversial...
  4. pmc Premature menopause or early menopause and risk of ischemic stroke
    Walter A Rocca
    Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Menopause 19:272-7. 2012
    ..The general consensus has been that estrogen is invariably a risk factor for ischemic stroke (IS). We reviewed new observational studies that challenge this simple conclusion...
  5. pmc Long-term effects of bilateral oophorectomy on brain aging: unanswered questions from the Mayo Clinic Cohort Study of Oophorectomy and Aging
    Walter A Rocca
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Womens Health (Lond Engl) 5:39-48. 2009
    ..Results from other studies are cited as evidence for or against each possible mechanism. These putative causal mechanisms are probably intertwined, and their clarification is a research priority...
  6. pmc Trends in the incidence and prevalence of Alzheimer's disease, dementia, and cognitive impairment in the United States
    Walter A Rocca
    Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN, USA
    Alzheimers Dement 7:80-93. 2011
    ..A significant reduction in cognitive impairment measured by neuropsychological testing was identified in the national survey. Cautious optimism appears justified...
  7. pmc Oophorectomy, menopause, estrogen treatment, and cognitive aging: clinical evidence for a window of opportunity
    Walter A Rocca
    Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN, USA
    Brain Res 1379:188-98. 2011
    ..Therefore, women who underwent bilateral oophorectomy before the onset of menopause or women who experienced premature or early natural menopause should be considered for hormonal treatment until approximately age 51 years...
  8. ncbi request reprint Increased risk of essential tremor in first-degree relatives of patients with Parkinson's disease
    Walter A Rocca
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Mov Disord 22:1607-14. 2007
    ..These findings suggest that PD and ET may share familial susceptibility factors...
  9. ncbi request reprint Survival patterns after oophorectomy in premenopausal women: a population-based cohort study
    Walter A Rocca
    Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Lancet Oncol 7:821-8. 2006
    ..We aimed to investigate survival patterns in a population-based sample of women who had received an oophorectomy and compare these with women who had not received an oophorectomy...
  10. ncbi request reprint The Mayo Clinic cohort study of personality and aging: design and sampling, reliability and validity of instruments, and baseline description
    Walter A Rocca
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neuroepidemiology 26:119-29. 2006
    ..68, p < 0.0001). This newly established historical cohort study provides opportunities to test hypotheses regarding the link between personality and aging, aging-related diseases, and overall mortality...
  11. pmc Anemia or low hemoglobin levels preceding Parkinson disease: a case-control study
    R Savica
    Department of Neurology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 73:1381-7. 2009
    ..Thus, we investigated the association of anemia with the subsequent risk of PD using a case-control study design...
  12. pmc Oophorectomy, menopause, estrogen, and cognitive aging: the timing hypothesis
    Walter A Rocca
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Neurodegener Dis 7:163-6. 2010
    ..The concept of neuroprotective effects of estrogen in women remains controversial...
  13. ncbi request reprint Familial aggregation of Parkinson's disease: The Mayo Clinic family study
    Walter A Rocca
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Ann Neurol 56:495-502. 2004
    ..62; 95% confidence interval, 1.66-4.15), whereas relatives of probands with later onset had no increased risk. The relative risk decreased when the incidence of all types of parkinsonism was considered...
  14. doi request reprint Long-term risk of depressive and anxiety symptoms after early bilateral oophorectomy
    Walter A Rocca
    Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Menopause 15:1050-9. 2008
    ..We studied the long-term risk of depressive and anxiety symptoms in women who underwent bilateral oophorectomy before menopause...
  15. ncbi request reprint Time trends in the incidence of parkinsonism in Olmsted County, Minnesota
    W A Rocca
    Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Neurology 57:462-7. 2001
    ..To investigate time trends in the incidence of parkinsonism and PD over a 15-year period (1976 to 1990)...
  16. ncbi request reprint Risk of cognitive impairment or dementia in relatives of patients with Parkinson disease
    Walter A Rocca
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Arch Neurol 64:1458-64. 2007
    ..The evidence for increased risk of dementia in relatives of patients with Parkinson disease (PD) remains conflicting...
  17. ncbi request reprint Increased risk of parkinsonism in women who underwent oophorectomy before menopause
    W A Rocca
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Neurology 70:200-9. 2008
    ..We studied the association of oophorectomy performed before the onset of menopause with the risk of subsequent parkinsonism...
  18. ncbi request reprint The Mayo Clinic family study of Parkinson's disease: study design, instruments, and sample characteristics
    Walter A Rocca
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minn, USA
    Neuroepidemiology 24:151-67. 2005
    ..Finally, we studied a group of 625 spouses of either cases or controls. Relatives with PD or other neurodegenerative diseases were ascertained using the family study method...
  19. ncbi request reprint Door-to-door prevalence survey of epilepsy in three Sicilian municipalities
    W A Rocca
    Department of Health Sciences Research, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Neuroepidemiology 20:237-41. 2001
    ..The age-specific prevalence figures for active epilepsy were lower than those from previous Italian surveys...
  20. ncbi request reprint Increased risk of cognitive impairment or dementia in women who underwent oophorectomy before menopause
    W A Rocca
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 69:1074-83. 2007
    ..We studied the association of oophorectomy performed before the onset of menopause with the risk of subsequent cognitive impairment or dementia...
  21. pmc The long-term effects of oophorectomy on cognitive and motor aging are age dependent
    Walter A Rocca
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Neurodegener Dis 5:257-60. 2008
    ..The evidence for a neuroprotective effect of estrogen in women remains controversial...
  22. pmc The incidence of MCI differs by subtype and is higher in men: the Mayo Clinic Study of Aging
    R O Roberts
    Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN, USA
    Neurology 78:342-51. 2012
    ..We estimated the incidence of amnestic MCI (aMCI) and nonamnestic MCI (naMCI) in men and women separately...
  23. ncbi request reprint Incident dementia in women is preceded by weight loss by at least a decade
    D S Knopman
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurology 69:739-46. 2007
    ..Although several studies reported weight loss preceding the onset of dementia, other studies suggested that obesity in midlife or even later in life may be a risk factor for dementia...
  24. ncbi request reprint Hysterectomy, menopause, and estrogen use preceding Parkinson's disease: an exploratory case-control study
    M D Benedetti
    Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Mov Disord 16:830-7. 2001
    ..Despite the limited sample size of this exploratory study, we hypothesize that there is an increased risk of PD in conditions causing an early reduction in endogenous estrogen. This hypothesis needs to be confirmed in a larger study...
  25. ncbi request reprint Education and occupations preceding Parkinson disease: a population-based case-control study
    R Frigerio
    Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Neurology 65:1575-83. 2005
    ..To investigate the association of Parkinson disease (PD) with education and occupations using a case-control study design...
  26. ncbi request reprint Coronary artery bypass grafting is not a risk factor for dementia or Alzheimer disease
    D S Knopman
    The Mayo Alzheimer Disease Research Center, Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA
    Neurology 65:986-90. 2005
    ..To study coronary artery bypass grafting (CABG) as a risk factor for dementia and Alzheimer disease (AD) using a case-control design...
  27. pmc Medical records documentation of constipation preceding Parkinson disease: A case-control study
    R Savica
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 73:1752-8. 2009
    ..We investigated constipation preceding PD using a case-control study design in a population-based sample...
  28. ncbi request reprint Head trauma preceding PD: a case-control study
    J H Bower
    Department of Neurology, Mayo Foundation, Rochester, MN 55905, USA
    Neurology 60:1610-5. 2003
    ..To investigate the association of PD with preceding head trauma using a case-control study design...
  29. ncbi request reprint A limited role for DJ1 in Parkinson disease susceptibility
    D M Maraganore
    Department of Neurology, Mayo Clinic Rochester, MN 55905, USA
    Neurology 63:550-3. 2004
    ..None of the four haplotype tagging single-nucleotide polymorphisms (SNPs) was associated with PD overall, but SNP1 (position 4,345 bp) and SNP3 (position 16,491 bp) were associated with PD in women (p = 0.03 and p = 0.002)...
  30. pmc Novelty seeking and introversion do not predict the long-term risk of Parkinson disease
    G Arabia
    Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Neurology 75:349-57. 2010
    ..It has been suggested that people who develop Parkinson disease (PD) may have a characteristic premorbid personality. We tested this hypothesis using a large historical cohort study with long follow-up...
  31. pmc Prevalence of mild cognitive impairment is higher in men. The Mayo Clinic Study of Aging
    R C Petersen
    Department of Neurology, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Neurology 75:889-97. 2010
    ..We investigated the prevalence of mild cognitive impairment (MCI) in Olmsted County, MN, using in-person evaluations and published criteria...
  32. ncbi request reprint Validity of family history data on PD: evidence for a family information bias
    A Elbaz
    Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Neurology 61:11-7. 2003
    ..To study the validity of information provided by case and control subjects (or their proxies) about PD among their first-degree relatives...
  33. doi request reprint Alpha-synuclein, pesticides, and Parkinson disease: a case-control study
    L Brighina
    Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Neurology 70:1461-9. 2008
    ..Pesticide exposures may also confer susceptibility to PD. Our objective was to test possible joint effects of SNCA REP1 genotypes and pesticide exposures on the risk of PD...
  34. ncbi request reprint Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease
    D M Maraganore
    Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Neurology 53:1858-60. 1999
    ..However, S18Y polymorphism carriers had significantly lower risk of PD (odds ratio = 0.53; p = 0.03), and the risk reduction was greater for younger onset cases...
  35. ncbi request reprint Interaction of alpha-synuclein and tau genotypes in Parkinson's disease
    Catherine E Mamah
    Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Ann Neurol 57:439-43. 2005
    ..These findings are consistent with in vitro experiments that revealed tau-mediated fibrillization of alpha-synuclein protein at low concentrations (dose threshold effect)...
  36. ncbi request reprint Complex segregation analysis of Parkinson's disease: The Mayo Clinic Family Study
    Shannon K McDonnell
    Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Ann Neurol 59:788-95. 2006
    ..To conduct complex segregation analyses of Parkinson's disease (PD)...
  37. ncbi request reprint Risk of cancer after the diagnosis of Parkinson's disease: a historical cohort study
    Alexis Elbaz
    Departments of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Mov Disord 20:719-25. 2005
    ..Among PD patients, there was no relation between the risk of cancer and the cumulative dose of levodopa received or the use of other PD medications...
  38. ncbi request reprint A longitudinal study of the prevalence of asthma in a community population of school-age children
    Barbara P Yawn
    Department of Research, Olmsted Medical Center, Rochester, Minnesota 55904, USA
    J Pediatr 140:576-81. 2002
    ..To describe the age and sex rates and temporal trends in new asthma diagnoses and associations with race and socio-economic status...
  39. ncbi request reprint Autopsy patterns for Parkinson's disease and related disorders in Olmsted County, Minnesota
    D M Maraganore
    Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Neurology 53:1342-4. 1999
    ..The overall autopsy rate was low (23%). Diagnostic certainty (for PD), diagnostic type (PD versus other parkinsonism), sex, age at death, and location at death were important selection factors for autopsy...
  40. ncbi request reprint Immunologic diseases, anti-inflammatory drugs, and Parkinson disease: a case-control study
    J H Bower
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurology 67:494-6. 2006
    ..In addition, cases used anti-inflammatory agents less frequently than controls (nonsignificant trend). The results may support the hypothesis that there is an inflammatory component in the pathogenesis of PD...
  41. ncbi request reprint Medical services utilization and prognosis in Parkinson disease: a population-based study
    Sotirios A Parashos
    Department of Neurology, Mayo Clinic, Rochester, Minn 55905, USA
    Mayo Clin Proc 77:918-25. 2002
    ..To investigate prognostic outcomes and utilization of medical services by patients with Parkinson disease (PD) and to identify predictors of such use...
  42. ncbi request reprint UCHL1 is associated with Parkinson's disease: a case-unaffected sibling and case-unrelated control study
    Maurizio Facheris
    Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Neurosci Lett 381:131-4. 2005
    ..Analyses confirmed a significant inverse association of the UCHL1 S18Y polymorphism with PD overall (OR=0.18, 95% CI=0.05-0.64, p=0.002, recessive model) and in several strata...
  43. pmc Increased cardiovascular mortality after early bilateral oophorectomy
    Cathleen M Rivera
    Division of Preventive and Occupational Medicine, Department of Internal Medicine, College of Medicine, Mayo Clinic, Rochester, MN, USA
    Menopause 16:15-23. 2009
    ..To investigate the mortality associated with cardiovascular diseases and the effect of estrogen treatment in women who underwent unilateral or bilateral oophorectomy before menopause...
  44. pmc Pessimistic, anxious, and depressive personality traits predict all-cause mortality: the Mayo Clinic cohort study of personality and aging
    Brandon R Grossardt
    Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Psychosom Med 71:491-500. 2009
    ..To study the association between several personality traits and all-cause mortality...
  45. ncbi request reprint Case-control study of dopamine transporter-1, monoamine oxidase-B, and catechol-O-methyl transferase polymorphisms in Parkinson's disease
    John L Goudreau
    Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Mov Disord 17:1305-11. 2002
    ..These significant differences at the two-tailed alpha level of 0.05 and restricted to subgroup analyses may have a biological basis or may be chance findings...
  46. ncbi request reprint Incidence of medically recognized migraine: A 1989-1990 study in Olmsted County, Minnesota
    T D Rozen
    Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Headache 40:216-23. 2000
    ..CONCLUSIONS: Although our incidence rates were restricted to medically recognized cases of migraine, we confirmed previously reported epidemiological patterns...
  47. ncbi request reprint Case-Control study of the extended tau gene haplotype in Parkinson's disease
    D M Maraganore
    Department of Neurology Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Ann Neurol 50:658-61. 2001
    ....
  48. ncbi request reprint The incidence of frontotemporal lobar degeneration in Rochester, Minnesota, 1990 through 1994
    D S Knopman
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurology 62:506-8. 2004
    ..The incidence rates (new cases per 100,000 person-years) were 2.2 for ages 40 to 49, 3.3 for ages 50 to 59, and 8.9 for ages 60 to 69. For comparison, the corresponding rates for Alzheimer disease were 0.0, 3.3, and 88.9...
  49. pmc Beta-synuclein gene variants and Parkinson's disease: a preliminary case-control study
    Laura Brighina
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurosci Lett 420:229-34. 2007
    ..The results of this preliminary study suggest that the SNCB locus, though not a susceptibility gene for PD, might modify the age at onset of PD...
  50. ncbi request reprint Fracture risk after the diagnosis of Parkinson's disease: Influence of concomitant dementia
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Mov Disord 21:1361-7. 2006
    ..1). The increased fracture risk in patients with PD is not entirely explained by concomitant dementia, and additional study is needed to determine the relative contributions to fracture risk of falls versus bone loss in these patients...
  51. ncbi request reprint Number of children and risk of Parkinson's disease
    Roberta Frigerio
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Mov Disord 22:632-9. 2007
    ..The independent replication in two distinct populations and using different epidemiologic study designs may suggest a link between the number of children and PD restricted to men...
  52. ncbi request reprint Increased risk of depressive and anxiety disorders in relatives of patients with Parkinson disease
    Gennarina Arabia
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Arch Gen Psychiatry 64:1385-92. 2007
    ..Relatives of patients with Parkinson disease (PD) have an increased risk of PD and other neurologic disorders; however, their risk of psychiatric disorders remains uncertain...
  53. ncbi request reprint Risk tables for parkinsonism and Parkinson's disease
    Alexis Elbaz
    Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA
    J Clin Epidemiol 55:25-31. 2002
    ..Lifetime risk estimates are useful in clinical practice, epidemiologic research, and public health...
  54. ncbi request reprint Chemical exposures and Parkinson's disease: a population-based case-control study
    Roberta Frigerio
    Division of Epidemiology, Department of Health Sciences Research, Mayo College of Medicine, Rochester, Minnesota 55905, USA
    Mov Disord 21:1688-92. 2006
    ..This population-based study suggests a link between pesticides use and PD that is restricted to men. Pesticides may interact with other genetic or nongenetic factors that are different in men and women...
  55. ncbi request reprint A population-based study of the incidence and complication rates of herpes zoster before zoster vaccine introduction
    Barbara P Yawn
    Department of Research, Olmsted Medical Center, 210 Ninth St SE, Rochester, MN, USA
    Mayo Clin Proc 82:1341-9. 2007
    ..To establish accurate, up-to-date, baseline epidemiological data for herpes zoster (HZ) before the introduction of the recently licensed HZ vaccine...
  56. pmc Increased risk of serious pneumococcal disease in patients with atopic conditions other than asthma
    Ji A Jung
    Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Allergy Clin Immunol 125:217-21. 2010
    ..We reported an increased risk of serious pneumococcal disease (SPD) among patients with asthma. It is not known whether this is true for patients with other atopic conditions...
  57. ncbi request reprint Trends in the incidence and survival of patients with hospitalized myocardial infarction, Olmsted County, Minnesota, 1979 to 1994
    Veronique L Roger
    From the Mayo Clinic, Mayo Foundation, and Olmsted Medical Group, Rochester, Minnesota 55905, USA
    Ann Intern Med 136:341-8. 2002
    ..Evidence indicates that deaths from coronary disease are decreasing less in elderly persons and women. Understanding the determinants of these trends is important for prevention...
  58. doi request reprint The diabetes mellitus medication choice decision aid: a randomized trial
    Rebecca J Mullan
    Knowledge and Encounter Research Unit, Mayo Center for Translational Science Activities, Mayo Clinic, Rochester, MN 55905, USA
    Arch Intern Med 169:1560-8. 2009
    ..Patient involvement in the choice of antihyperglycemic agents could improve adherence and optimize glycemic control in patients with type 2 diabetes mellitus...
  59. pmc The gender specific frequency of risk factor and CHD diagnoses prior to incident MI: a community study
    Barbara P Yawn
    Department of Research, Olmsted Medical Center, Rochester, MN, USA
    BMC Fam Pract 8:18. 2007
    ..Earlier recognition of CHD may be associated with higher levels of recognition and treatment of CHD risk factors that may delay incident AMI. To assess timing of CHD and CHD risk factor diagnoses prior to incident AMI...
  60. ncbi request reprint Incidence of heart failure after myocardial infarction: is it changing over time?
    Jens P Hellermann
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Am J Epidemiol 157:1101-7. 2003
    ..This suggests that improved survival after MI is unlikely to be a major contributor to the heart failure epidemic...
  61. ncbi request reprint Exclusion of genetic linkage to 4q21-23 and 17q21 in a family with Lewy body parkinsonism
    J Hardy
    Mayo Clinic Jacksonville, Florida 32224, USA
    Am J Med Genet 81:166-71. 1998
    ..A brief clinical comparison of this family with families showing linkage to these loci is presented. The data suggest that at least one other major genetic determinant for Lewy body parkinsonism remains to be identified...
  62. pmc Increased mortality for neurological and mental diseases following early bilateral oophorectomy
    Cathleen M Rivera
    Division of Preventive and Occupational Medicine, Department of Internal Medicine, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Neuroepidemiology 33:32-40. 2009
    ..The effects of oophorectomy on brain aging remain uncertain...
  63. pmc The Mayo Clinic Study of Aging: design and sampling, participation, baseline measures and sample characteristics
    Rosebud O Roberts
    Division of Epidemiology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Neuroepidemiology 30:58-69. 2008
    ..The objective of this study was to establish a prospective population-based cohort to investigate the prevalence, incidence and risk factors for mild cognitive impairment (MCI) and dementia...
  64. pmc Physical exercise, aging, and mild cognitive impairment: a population-based study
    Yonas E Geda
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905
    Arch Neurol 67:80-6. 2010
    ..Physical exercise is associated with decreased risk of dementia and Alzheimer disease...
  65. ncbi request reprint Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease
    Demetrius M Maraganore
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    JAMA 296:661-70. 2006
    ..Alpha-synuclein (SNCA) has been one of the most promising susceptibility genes, but large-scale studies have been lacking...
  66. ncbi request reprint Postmenopausal estrogen therapy and Alzheimer disease: overall negative findings
    Rosebud O Roberts
    Divisions of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA
    Alzheimer Dis Assoc Disord 20:141-6. 2006
    ..68 (95% CI=0.35-1.32) among never-smokers (P for interaction=0.01). Our findings do not confirm a significant association between ET and AD overall; however, the possible interaction with smoking deserves further study...
  67. pmc Anxious personality predicts an increased risk of Parkinson's disease
    James H Bower
    Department of Neurology, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Mov Disord 25:2105-13. 2010
    ..Our long-term historical cohort study suggests that an anxious personality trait may predict an increased risk of PD developing many years later...
  68. ncbi request reprint Direct medical costs associated with Parkinson's disease: a population-based study
    Cynthia L Leibson
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Mov Disord 21:1864-71. 2006
    ..99, for those with tremor). These population-based estimates of PD-associated direct medical costs from onset forward can uniquely inform policy decisions and cost-effectiveness research...
  69. pmc Validation of the telephone interview for cognitive status-modified in subjects with normal cognition, mild cognitive impairment, or dementia
    David S Knopman
    Department of Neurology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Neuroepidemiology 34:34-42. 2010
    ..The telephone assessment of cognitive functions may reduce the cost and burden of epidemiological studies...
  70. pmc Association of duration and severity of diabetes mellitus with mild cognitive impairment
    Rosebud O Roberts
    Department of Health Sciences Research, Division of Epidemiology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Arch Neurol 65:1066-73. 2008
    ..It remains unknown whether diabetes mellitus (DM) is a risk factor for mild cognitive impairment (MCI)...
  71. ncbi request reprint Risk of cancer among relatives of patients with glioma
    Brian P O'Neill
    Department of Neurology, and the Mayo Clinic Cancer Center, Rochester Minnesota 55905, USA
    Cancer Epidemiol Biomarkers Prev 11:921-4. 2002
    ..Our results do not support the hypothesis of a familial aggregation of glioma indicative of a glioma susceptibility gene...
  72. pmc Prophylactic oophorectomy in premenopausal women and long-term health
    Lynne T Shuster
    Department of Internal Medicine, Women s Health Clinic, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Menopause Int 14:111-6. 2008
    ..To review the data on long-term outcomes in women who underwent prophylactic bilateral oophorectomy, a common surgical procedure that has more than doubled in frequency since the 1960s...
  73. pmc Prevalence of neuropsychiatric symptoms in mild cognitive impairment and normal cognitive aging: population-based study
    Yonas E Geda
    Department of Psychiatry and Psychology, College of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Arch Gen Psychiatry 65:1193-8. 2008
    ..Little is known about the population-based prevalence of neuropsychiatric symptoms in mild cognitive impairment (MCI)...
  74. ncbi request reprint Parkinson's disease in Africa: A systematic review of epidemiologic and genetic studies
    Njideka U Okubadejo
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
    Mov Disord 21:2150-6. 2006
    ..There are no case-control or cohort studies of PD reported from Africa. This review provides a summary of PD research in Africa over the past 60 years and highlights the information gaps and potential areas for future research...
  75. ncbi request reprint UCHL1 is a Parkinson's disease susceptibility gene
    Demetrius M Maraganore
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    Ann Neurol 55:512-21. 2004
    ..These findings confirm that UCHL1 is a susceptibility gene for PD and a potential target for disease-modifying therapies...
  76. pmc High-resolution whole-genome association study of Parkinson disease
    Demetrius M Maraganore
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA
    Am J Hum Genet 77:685-93. 2005
    ..07 x 10(-6); P=2.96 x 10(-5)) tagged the PARK10 late-onset PD susceptibility locus. Independent replication across populations will clarify the role of the genomic loci tagged by these SNPs in conferring PD susceptibility...
  77. ncbi request reprint Comorbid conditions associated with Parkinson's disease: a population-based study
    Cynthia L Leibson
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Mov Disord 21:446-55. 2006
    ..quot; The excess morbidity and mortality observed for persons with PD are consistent with recognized PD sequelae...
  78. ncbi request reprint Clinical correlates of the pathology underlying parkinsonism: a population perspective
    James H Bower
    Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Mov Disord 17:910-6. 2002
    ..Despite this selection bias, the retrospective data collection, and the small sample size, we made several observations that illustrate the difficulty in achieving an accurate antemortem diagnosis of parkinsonism...
  79. ncbi request reprint Incidence of vascular dementia in Rochester, Minn, 1985-1989
    David S Knopman
    Department of Neurology, Mayo Clinic, 200 First St SW, Rochester MN 55905, USA
    Arch Neurol 59:1605-10. 2002
    ..To examine the contribution of cerebrovascular disease to dementia...
  80. ncbi request reprint Survival study of vascular dementia in Rochester, Minnesota
    David S Knopman
    Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Arch Neurol 60:85-90. 2003
    ..To investigate the relationship between features and definitions of vascular dementia (VaD) and survival...
  81. ncbi request reprint Nonfatal cancer preceding Parkinson's disease: a case-control study
    Alexis Elbaz
    Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Epidemiology 13:157-64. 2002
    ..We conducted a population-based case-control study to investigate the association of Parkinson's disease (PD) with preceding nonfatal cancer...
  82. ncbi request reprint Vascular dementia in a population-based autopsy study
    David S Knopman
    Department of Neurology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Arch Neurol 60:569-75. 2003
    ..The validity of the clinical diagnosis of vascular dementia (VaD) remains suboptimal...
  83. ncbi request reprint Complex interactions in Parkinson's disease: a two-phased approach
    Demetrius M Maraganore
    Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Mov Disord 18:631-6. 2003
    ..42; P = 0.003). Our findings are consistent with the hypothesis that PD is a multigenic disorder of the UPS...
  84. ncbi request reprint Case-control study of the alpha-synuclein interacting protein gene and Parkinson's disease
    Demetrius M Maraganore
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Mov Disord 18:1233-9. 2003
    ..0001). Recursive partitioning showed no interactions between variants of the SNCAIP gene and variants of the alpha-synuclein gene (SNCA) or the parkin (PARK2) gene...
  85. ncbi request reprint Heart disease and dementia: a population-based study
    Francesca Bursi
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN55905, USA
    Am J Epidemiol 163:135-41. 2006
    ..82, 95% CI: 0.70, 0.95; p = 0.010). There was no evidence of a positive association between dementia and preceding myocardial infarction, while there was a decreased risk of myocardial infarction and cardiac death following dementia...
  86. ncbi request reprint Depression, apolipoprotein E genotype, and the incidence of mild cognitive impairment: a prospective cohort study
    Yonas E Geda
    Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn, USA
    Arch Neurol 63:435-40. 2006
    ..It remains unknown whether depression and apolipoprotein E genotype are risk factors for incident mild cognitive impairment (MCI)...
  87. ncbi request reprint Population-based study of the relationship between atherosclerotic aortic debris and cerebrovascular ischemic events
    George W Petty
    Division of Cerebrovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Mayo Clin Proc 81:609-14. 2006
    ..To assess the validity of the suggestion that protruding atheromatous material in the thoracic aorta is an important cause of cerebrovascular ischemic events (CIEs) (ie, transient ischemic attack or ischemic stroke)...
  88. ncbi request reprint Population-based study of the relationship between patent foramen ovale and cerebrovascular ischemic events
    George W Petty
    Division of Cerebrovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Mayo Clin Proc 81:602-8. 2006
    ..To determine whether patent foramen ovale (PFO) is a risk factor for a cryptogenic cerebrovascular ischemic event (CIE)...
  89. ncbi request reprint Dementia and Alzheimer disease incidence rates do not vary by sex in Rochester, Minn
    Steven D Edland
    Department of Health Sciences Research, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Arch Neurol 59:1589-93. 2002
    ..Cohort studies in the United States, on the other hand, have consistently reported no difference in incidence across sex...
  90. ncbi request reprint Case-control study of estrogen receptor gene polymorphisms in Parkinson's disease
    Demetrius M Maraganore
    Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Mov Disord 17:509-12. 2002
    ..While exogenous and endogenous estrogen may modify the risk of PD in women, the two estrogen receptor gene polymorphisms considered here do not seem to contribute to PD susceptibility...
  91. ncbi request reprint Incidence and causes of nondegenerative nonvascular dementia: a population-based study
    David S Knopman
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Arch Neurol 63:218-21. 2006
    ..Information on the incidence of nondegenerative and nonvascular dementia is limited...
  92. pmc Passive case-finding for Alzheimer's disease and dementia in two U.S. communities
    David S Knopman
    Department of Neurology, College of Medicine, Mayo Clinic, Rochester, MN, USA
    Alzheimers Dement 7:53-60. 2011
    ..In this article, the advantages and disadvantages of passive case-finding were discussed, and the following conclusion was drawn: the purpose of the study being conducted should determine the case-finding approach that is to be used...
  93. doi request reprint Translating comparative effectiveness into practice: the case of diabetes medications
    Nilay D Shah
    Division of Health Care Policy and Research, Mayo Clinic, Rochester, MN 55905, USA
    Med Care 48:S153-8. 2010
    ..However, little is known about translating the findings from CER into routine practice such that it provides value to the patients, clinicians, and the healthcare system...
  94. ncbi request reprint Impact of case ascertainment on recent trends in diabetes incidence in Rochester, Minnesota
    James P Burke
    Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
    Am J Epidemiol 155:859-65. 2002
    ..181) from 1987 to 1994, while the incidence of diabetes increased (p = 0.033). Thus, the authors conclude that the increase in diabetes incidence accelerated over the last quinquennium and was not due to increased surveillance...
  95. ncbi request reprint Incidence and characterization of diagnosed endometriosis in a geographically defined population
    Cynthia L Leibson
    Health Sciences Research, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Fertil Steril 82:314-21. 2004
    ..We examined whether widespread use of laparoscopy was accompanied by increased diagnosis of asymptomatic endometriosis, inflated rates of diagnosis, or changes in the clinical spectrum of disease...
  96. ncbi request reprint Trends in heart failure incidence and survival in a community-based population
    Veronique L Roger
    Division of Cardiovascular Diseases and Internal Medicine, Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, Minn 55095, USA
    JAMA 292:344-50. 2004
    ..The epidemic of heart failure has yet to be fully investigated, and data on incidence, survival, and sex-specific temporal trends in community-based populations are limited...
  97. ncbi request reprint Impaired functional status and echocardiographic abnormalities signifying global dysfunction enhance the prognostic significance of previously unrecognized myocardial infarction detected by electrocardiography
    Khawaja Afzal Ammar
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Ann Noninvasive Electrocardiol 12:27-37. 2007
    ..The relationship between electrocardiographic unrecognized myocardial infarction (UMI), abnormal functional status, echocardiographic abnormalities, and mortality has not been evaluated...
  98. ncbi request reprint Provider satisfaction in clinical encounters with ethnic immigrant patients
    Celia C Kamath
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minn 55905, USA
    Mayo Clin Proc 78:1353-60. 2003
    ..To determine whether physicians' satisfaction in clinical encounters with ethnic immigrant patients differs from satisfaction in clinical encounters with white patients in the local community...
  99. pmc Increased risk of serious pneumococcal disease in patients with asthma
    Young J Juhn
    Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Allergy Clin Immunol 122:719-23. 2008
    ..Individuals with asthma have been reported to be at increased risk of invasive pneumococcal disease (IPD). These findings need to be confirmed in a different population-based study setting...
  100. ncbi request reprint Changing epidemiology of hepatitis B in a U.S. community
    W Ray Kim
    Division of Gastroenterology and Hepatology Mayo 16E, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Hepatology 39:811-6. 2004
    ..69) and age greater than 40 years (OR = 2.32 per decade). In conclusion, in this Midwestern community, chronic HBV infection was predominantly seen in immigrants from endemic parts of the world...
  101. doi request reprint Relationship between parenting stress and concerns identified by developmental screening and their effects on parental medical care-seeking behavior
    Robert G Voigt
    Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Clin Pediatr (Phila) 48:362-8. 2009
    ..Primary pediatric health care providers who routinely perform developmental screening need to consider this relationship when interpreting developmental screening results and offer supportive and referral services to families as needed...

Research Grants15

  1. EPIDEMIOLOGY AND GENETICS OF PARKINSONS DISEASE
    Walter Rocca; Fiscal Year: 2000
    ..These studies will contribute greatly to understanding the causes and possible prevention of PD. ..
  2. ROCHESTER EPIDEMIOLOGY PROJECT
    Walter Rocca; Fiscal Year: 2009
    ..abstract_text> ..
  3. ROCHESTER EPIDEMIOLOGY PROJECT
    Walter Rocca; Fiscal Year: 2007
    ..abstract_text> ..
  4. EPIDEMIOLOGY AND GENETICS OF PARKINSON'S DISEASE
    Walter Rocca; Fiscal Year: 2005
    ..These three studies will contribute greatly to understanding the causes and possible prevention of PD by exploring novel hypotheses and by using innovative methods. ..
  5. ROCHESTER EPIDEMIOLOGY PROJECT
    Barbara P Yawn; Fiscal Year: 2010
    ..S. The ultimate goal is to continue to facilitate population-based research of disease etiology, preventive interventions, improved medical practice, and better health for the population, as outlined in the NIH Roadmap. ..