ROSEBUD ROBERTS

..Nonamnestic mild cognitive impairment, a putative precursor of vascular and other non-Alzheimer dementias, is hypothesized to have a vascular etiology...

..52-1.20]; p for trend = 0.03) in the fully adjusted models. A dietary pattern with relatively high caloric intake from carbohydrates and low caloric intake from fat and proteins may increase the risk of MCI or dementia in elderly persons...

..We estimated the incidence of amnestic MCI (aMCI) and nonamnestic MCI (naMCI) in men and women separately...

..Factors associated with dropout were evaluated in a twelve-year community-based, prospective cohort study of urologic disease in men...

..The objective of this study was to establish a prospective population-based cohort to investigate the prevalence, incidence and risk factors for mild cognitive impairment (MCI) and dementia...

..It remains unknown whether diabetes mellitus (DM) is a risk factor for mild cognitive impairment (MCI)...

..Despite biologic plausibility, the associations between sex hormones and measures of benign prostatic hyperplasia (BPH) have not been consistently reported...

..The objective of the study was to examine associations between SRD5A2 polymorphisms and measures of benign prostatic hyperplasia (BPH)...

..75; 95% CI=1.28-2.41), but not with na-MCI (OR=1.17; 95% CI=0.69-2.00). The association of CHD with prevalent na-MCI but not with a-MCI suggests that CHD and na-MCI may have similar underlying etiologies...

..This study examined the association of inflammatory markers in serum or plasma with prevalent MCI and MCI subtypes in a population-based sample...

..This study investigates associations between polymorphisms in genes involved in sex hormone metabolism and measures of benign prostatic hyperplasia (BPH)...

..The association of infection or inflammation of the prostate with prostate cancer has been suggested but not established. This study was undertaken to investigate this association...

..We evaluate the agreement between self-reported physician diagnosed prostatitis and pain questions from the National Institutes of Health Chronic Prostatitis Symptom Index (CPSI)...

..In this study, higher intake of PUFA and MUFA was associated with a reduced likelihood of MCI among elderly persons in the population-based setting...

..To investigate the association of type 2 diabetes with subcortical infarctions...

..To obtain community-based information about the incidence of interstitial cystitis, a chronic disabling condition of the bladder where knowledge is limited because there are no definitive diagnostic criteria...

..Nonetheless, these studies suggest hypotheses that should be tested in well-designed population-based studies...

..68 (95% CI=0.35-1.32) among never-smokers (P for interaction=0.01). Our findings do not confirm a significant association between ET and AD overall; however, the possible interaction with smoking deserves further study...

..6, 4.7), a peak flow rate <12 ml/second (HR = 1.9, 95% CI: 1.1, 3.4), and an AUASI >7 (HR = 1.6, 95% CI: 1.0, 2.7). Androgen receptor gene polymorphisms may have a potential role in the pathogenesis of benign prostatic hyperplasia...

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..22 (95% CI=0.38, 3.87). These findings do not demonstrate a significant association between T levels and dementia. However, they suggest a need for further investigation of these potential associations...

..While pain measures may be useful in distinguishing between men with and without prostatitis-like symptoms, the urinary symptom and quality of life impact scores could partly reflect benign prostatic hyperplasia...

..The stronger effect among older men suggests that NSAIDs may prevent the progression of prostate cancer from latent to clinical disease...

..The telephone assessment of cognitive functions may reduce the cost and burden of epidemiological studies...

..Little is known about the population-based prevalence of neuropsychiatric symptoms in mild cognitive impairment (MCI)...

..Physical exercise is associated with decreased risk of dementia and Alzheimer disease...

..To investigate associations of the Mediterranean diet (MeDi) components and the MeDi score with mild cognitive impairment (MCI)...

..This review summarizes the progress that has been made while also recognizing the challenges that remain...

..Defining the nature of the contribution of stroke to cognitive impairment remains challenging...

..72, 95% CI: 1.05, 2.82), after simultaneous adjustment for IGF-I and age, but not with other urologic measures. These data do not provide evidence for an association between benign prostatic hyperplasia and serum IGF-I...

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..The role of vascular risk factors in midlife should be the focus of public health efforts to reduce the burden of late-life cognitive impairment...

..Specific strategies may be needed to reduce the incidence of postbiopsy infection in men with a recent urogenital infection before biopsy...

..64 (0.82-8.47) in men with a family history of prostate cancer (P = 0.006). These findings suggest an association between prostate cancer and daily use of calcium channel blockers that varies by family history of prostate cancer...

..00, 2.02), and there was a dose response. Although the causal pathway underlying this association is not clear, this study contributes to the growing literature describing an association between smoking and erectile dysfunction...

..31; 95% CI=1.07, 5.00), but not with a-MCI (OR=0.96; 95% CI=0.59, 1.54). The combined presence of MetS and high levels of inflammation is associated with na-MCI in this elderly cohort, and suggests etiologic differences in MCI subtypes...

..These findings also indicate that assessing the incidence of regional-distant prostate cancer only at the initial diagnosis underestimates the full impact of the benefits of early detection and treatment...

..Extrapolation of findings from the placebo arm of clinical trials to describe the natural history of disease in community-dwelling men should be done with caution and appropriate recognition of limitations...

..We examined the association of diabetes and domains of sexual dysfunction in a population based sample of men residing in Olmsted County, Minnesota...

..81). CONCLUSION: There was a cross-sectional association between signs and symptoms of bladder outlet obstruction and chronic kidney disease in community-dwelling men. Prostatic enlargement was not associated with chronic kidney disease...

..To investigate the associations between benign prostatic hyperplasia (BPH) and polymorphisms in genes that encode growth factors, cytokines, and vitamin D and their receptors...

..Furthermore, men with impaired mental health may be less likely to report pain associated impairment of sexual function, while the reverse may be true in the presence of comorbidity...

..In an earlier case-control study, we found that DRE might reduce PCa mortality. The present case-control study assessed the association between PSA and DRE testing and PCa mortality...

..CONCLUSIONS: The cross-sectional data suggest that sexual function is inversely associated with LUTS severity and that this association is only partially attributable to the confounding effects of age...

..CONCLUSIONS: The results of this study suggest that the presence of diabetes may be more closely associated with the dynamic components of lower urinary tract function than with benign prostatic hyperplasia progression, per se...

..Animal studies suggest that hypothyroidism can directly cause liver cell damage and might be a risk factor for HCC. We conducted a case-control study to evaluate the relationship between hypothyroidism and HCC...

..We evaluated the utility of AFP-L3% for diagnosis of HCC in a US referral population...

..These data provide no evidence of a consistent significant relation between anthropometric measures and BPH...

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..However, there remain some men with increases in frequency who do not report similar increases in bother, possibly representing some component of adaptation or acceptance of worsening symptom severity with age...

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..This community-based cohort study should provide insights that should improve our understanding of the genetic control of hormonal mechanisms in the pathogenesis of BPH. ..

..The K01 award will culminate in an R01 application that will pave the way for the candidate to become an independent investigator in MCI and AD research. ..