BYRON L RIGGS

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi request reprint Sex steroids and the construction and conservation of the adult skeleton
    B Lawrence Riggs
    Division of Endocrinology and Metabolism, Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, Minnesota 55905, USA
    Endocr Rev 23:279-302. 2002
  2. ncbi request reprint Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sites
    B Lawrence Riggs
    Endocrine Research Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic College of Medicine, 200 First Street SW, 5 194 Joseph, Rochester, MN 55905, USA
    J Bone Miner Res 19:1945-54. 2004
  3. ncbi request reprint Drugs used to treat osteoporosis: the critical need for a uniform nomenclature based on their action on bone remodeling
    B Lawrence Riggs
    Endocrine Research Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Bone Miner Res 20:177-84. 2005
  4. ncbi request reprint Evidence that type I osteoporosis results from enhanced responsiveness of bone to estrogen deficiency
    B Lawrence Riggs
    Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, 200 First Street SW, MN 55905, Rochester, USA
    Osteoporos Int 14:728-33. 2003
  5. ncbi request reprint Population-based analysis of the relationship of whole bone strength indices and fall-related loads to age- and sex-specific patterns of hip and wrist fractures
    B Lawrence Riggs
    Endocrine Research Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 21:315-23. 2006
  6. ncbi request reprint Effects of loss of steroid receptor coactivator-1 on the skeletal response to estrogen in mice
    Ulrike I L Modder
    Mayo Clinic, 200 First Street SW, 5 194 Joseph, Rochester, MN 55905, USA
    Endocrinology 145:913-21. 2004
  7. ncbi request reprint Mediators of the biphasic responses of bone to intermittent and continuously administered parathyroid hormone
    Rachel M Locklin
    Division of Endocrinology, Metabolism and Nutrition, Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Cell Biochem 89:180-90. 2003
  8. pmc A population-based assessment of rates of bone loss at multiple skeletal sites: evidence for substantial trabecular bone loss in young adult women and men
    B Lawrence Riggs
    Endocrine Research Unit, Division of Endocrinology and Metabolism, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    J Bone Miner Res 23:205-14. 2008
  9. pmc Role of RANK ligand in mediating increased bone resorption in early postmenopausal women
    Guitty Eghbali-Fatourechi
    Endocrine Research Unit, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    J Clin Invest 111:1221-30. 2003
  10. ncbi request reprint Estrogen receptor isoform-specific induction of progesterone receptors in human osteoblasts
    David J Rickard
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Bone Miner Res 17:580-92. 2002

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Sex steroids and the construction and conservation of the adult skeleton
    B Lawrence Riggs
    Division of Endocrinology and Metabolism, Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, Minnesota 55905, USA
    Endocr Rev 23:279-302. 2002
    ..Thus, both sex steroids are important for developing peak bone mass, but E deficiency is the major determinant of age-related bone loss in both sexes...
  2. ncbi request reprint Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sites
    B Lawrence Riggs
    Endocrine Research Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic College of Medicine, 200 First Street SW, 5 194 Joseph, Rochester, MN 55905, USA
    J Bone Miner Res 19:1945-54. 2004
    ..Over life, the cross-sectional area of the vertebrae and proximal femur increased by approximately 15% in both sexes, whereas vBMD at these sites decreased by 39-55% and 34-46%, respectively, with greater decreases in women than in men...
  3. ncbi request reprint Drugs used to treat osteoporosis: the critical need for a uniform nomenclature based on their action on bone remodeling
    B Lawrence Riggs
    Endocrine Research Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Bone Miner Res 20:177-84. 2005
    ..We hope that this classification will serve as a starting point for continued discussion on the important issue of nomenclature...
  4. ncbi request reprint Evidence that type I osteoporosis results from enhanced responsiveness of bone to estrogen deficiency
    B Lawrence Riggs
    Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, 200 First Street SW, MN 55905, Rochester, USA
    Osteoporos Int 14:728-33. 2003
    ..This is consistent with the hypothesis that the greater bone loss in type I osteoporosis is the result of impaired responsiveness of bone to low postmenopausal levels of sex steroids...
  5. ncbi request reprint Population-based analysis of the relationship of whole bone strength indices and fall-related loads to age- and sex-specific patterns of hip and wrist fractures
    B Lawrence Riggs
    Endocrine Research Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 21:315-23. 2006
    ..These load/strength ratios more closely simulated patterns of wrist and hip fractures occurring in the same population than did measurement of vBMD...
  6. ncbi request reprint Effects of loss of steroid receptor coactivator-1 on the skeletal response to estrogen in mice
    Ulrike I L Modder
    Mayo Clinic, 200 First Street SW, 5 194 Joseph, Rochester, MN 55905, USA
    Endocrinology 145:913-21. 2004
    ..These findings establish that, in mice, loss of SRC-1 leads to skeletal resistance to E predominantly in cancellous bone...
  7. ncbi request reprint Mediators of the biphasic responses of bone to intermittent and continuously administered parathyroid hormone
    Rachel M Locklin
    Division of Endocrinology, Metabolism and Nutrition, Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Cell Biochem 89:180-90. 2003
    ....
  8. pmc A population-based assessment of rates of bone loss at multiple skeletal sites: evidence for substantial trabecular bone loss in young adult women and men
    B Lawrence Riggs
    Endocrine Research Unit, Division of Endocrinology and Metabolism, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    J Bone Miner Res 23:205-14. 2008
    ..Cortical bone loss began in perimenopause in women and later in life in men. In contrast, trabecular bone loss began in young adulthood in both sexes...
  9. pmc Role of RANK ligand in mediating increased bone resorption in early postmenopausal women
    Guitty Eghbali-Fatourechi
    Endocrine Research Unit, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    J Clin Invest 111:1221-30. 2003
    ..The data suggest that upregulation of RANKL on bone marrow cells is an important determinant of increased bone resorption induced by estrogen deficiency...
  10. ncbi request reprint Estrogen receptor isoform-specific induction of progesterone receptors in human osteoblasts
    David J Rickard
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Bone Miner Res 17:580-92. 2002
    ..Together, these results show that although estrogen can up-regulate endogenous PR gene expression in osteoblasts via both ER isoforms, ER-alpha is the predominant inducer...
  11. ncbi request reprint Role of low levels of endogenous estrogen in regulation of bone resorption in late postmenopausal women
    Hassan M Heshmati
    Division of Endocrinology and Metabolism, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Bone Miner Res 17:172-8. 2002
    ....
  12. ncbi request reprint Circulating osteoblast-lineage cells in humans
    Guiti Z Eghbali-Fatourechi
    Endocrine Research Unit, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    N Engl J Med 352:1959-66. 2005
    ..We further reasoned that the concentration of these cells is elevated during times of increased bone formation, such as during pubertal growth...
  13. ncbi request reprint Evaluation of a prediction model for long-term fracture risk
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 20:551-6. 2005
    ..The NOF cost-effectiveness model, based on clinical risk factors and femoral neck aBMD, predicted overall fracture risk in a cohort of postmenopausal women followed for up to 22 years...
  14. ncbi request reprint Relative contributions of bone density, bone turnover, and clinical risk factors to long-term fracture prediction
    L Joseph Melton
    Division of Epidemiology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Bone Miner Res 18:312-8. 2003
    ..Identifying patients at increased long-term risk of fracture is challenging, but it is reassuring that femoral neck bone mineral density can predict osteoporotic fractures up to 20 years later...
  15. ncbi request reprint Role of parathyroid hormone in mediating age-related changes in bone resorption in men
    Kurt A Kennel
    Endocrine Research Unit, Division of Endocrinology, Metabolism and Nutrition, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    Osteoporos Int 14:631-6. 2003
    ..Since both estrogen and testosterone can attenuate the bone resorbing effects of PTH, it is possible that this difference may be due to the much milder degree of sex steroid deficiency in elderly men as compared to postmenopausal women...
  16. ncbi request reprint Pathophysiology of age-related bone loss and osteoporosis
    Sundeep Khosla
    Division of Endocrinology, Metabolism, and Nutrition, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Endocrinol Metab Clin North Am 34:1015-30, xi. 2005
  17. ncbi request reprint Hormonal and biochemical determinants of trabecular microstructure at the ultradistal radius in women and men
    Sundeep Khosla
    Mayo Clinic, Endocrine Research Unit, 200 First Street SW, 5 194 Joseph, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 91:885-91. 2006
    ....
  18. ncbi request reprint Osteoporosis assessment by whole body region vs. site-specific DXA
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street S W, Rochester, MN 55905, USA
    Osteoporos Int 16:1558-64. 2005
    ....
  19. ncbi request reprint Relationship of volumetric BMD and structural parameters at different skeletal sites to sex steroid levels in men
    Sundeep Khosla
    Endocrine Research Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 20:730-40. 2005
    ..Associations between these bone mass/structural parameters and sex steroid levels were progressively stronger with age. Our previously postulated "threshold" for skeletal estrogen deficiency was most evident at cortical sites...
  20. ncbi request reprint Native osteoprotegerin gene transfer inhibits the development of murine osteolytic bone disease induced by tumor xenografts
    Patrick M Doran
    Molecular Medicine Program, Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minn 55905, USA
    Exp Hematol 32:351-9. 2004
    ..In order to overcome these limitations, the therapeutic effects of native OPG gene transfer are examined...
  21. pmc Effects of sex and age on bone microstructure at the ultradistal radius: a population-based noninvasive in vivo assessment
    Sundeep Khosla
    Endocrine Research Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 21:124-31. 2006
    ..Compared with women, men had thicker trabeculae in young adulthood and had less microstructural damage with aging. These findings may contribute to the virtual immunity of men to age-related increases in wrist fractures...
  22. ncbi request reprint High serum IGFBP-2 is predictive of increased bone turnover in aging men and women
    Shreyasee Amin
    Division of Rheumatology, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 22:799-807. 2007
    ..Studying an age-stratified community-based sample of 344 men and 276 women, IGFBP-2 was the strongest predictor of increased bone resorption among the IGF/IGFBPs studied...
  23. pmc Relationship of volumetric bone density and structural parameters at different skeletal sites to sex steroid levels in women
    Sundeep Khosla
    Mayo Clinic, Endocrine Research Unit, 200 First Street SW, 5 194 Joseph, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 90:5096-103. 2005
    ..There are no data testing this in women...
  24. ncbi request reprint The role of the immune system in the pathophysiology of osteoporosis
    Jackie A Clowes
    Mayo Clinic College of Medicine, Endocrine Research Unit, St Mary s Hospital, Rochester, MN 55905, USA
    Immunol Rev 208:207-27. 2005
    ..Although significant progress has been made, there remains much to be done in unraveling this complex interaction between the immune system and bone...
  25. ncbi request reprint Does reduced skeletal loading account for age-related bone loss?
    L Joseph Melton
    Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 21:1847-55. 2006
    ..However, in a population-based study of 375 women and 325 men (age, 21-97 years), we failed to find a close correspondence between these variables and changes in bone strength with aging...
  26. ncbi request reprint Contributions of bone density and structure to fracture risk assessment in men and women
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Osteoporos Int 16:460-7. 2005
    ..Because of the strong correlations, however, some judgment can be used in selecting the variables easiest to measure...
  27. ncbi request reprint A potentially deleterious role of IGFBP-2 on bone density in aging men and women
    Shreyasee Amin
    Division of Rheumatology, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 19:1075-83. 2004
    ..IGFBP-2, which increases with age in both men and women, was the strongest, most consistent predictor of BMD among the IGF/IGFBPs studied...
  28. pmc Relation of vertebral deformities to bone density, structure, and strength
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Bone Miner Res 25:1922-30. 2010
    ..Thus significantly impaired bone density, structure, and strength compared with controls indicate that many grade 1 deformities do represent early osteoporotic fractures, with corresponding implications for clinical decision making...
  29. pmc A bone structural basis for fracture risk in diabetes
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street Southwest, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 93:4804-9. 2008
    ..Elevated areal bone mineral density (aBMD) in type 2 diabetes mellitus is inconsistent with increased fracture risk at some skeletal sites...
  30. ncbi request reprint A fragment of the hypophosphatemic factor, MEPE, requires inducible cyclooxygenase-2 to exert potent anabolic effects on normal human marrow osteoblast precursors
    D E Nagel
    Endocrine Research Unit, Division of Endocrinology, Metabolism and Nutrition, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Cell Biochem 93:1107-14. 2004
    ..Thus, AC-100 has potent anabolic activity on osteoblast precursor cells in vitro and these effects require the induction of COX-2...
  31. ncbi request reprint A genetic basis for the "Adonis" phenotype of low adiposity and strong bones
    Geoffrey B Johnson
    Transplantation Biology, Mayo Clinic College of Medicine, 200 First St SW, 2 66 Medical Sciences Building, Rochester, Minnesota, MN 55905, USA p
    FASEB J 18:1282-4. 2004
    ..Thus, defects in TLR4/CD14 complex generate an "Adonis" phenotype, characterized by this ideal body type, and this function could potentially be exploited for the treatment of osteoporosis and obesity...
  32. ncbi request reprint Clinical review 144: Estrogen and the male skeleton
    Sundeep Khosla
    Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 87:1443-50. 2002
    ....
  33. ncbi request reprint Relationship of estrogen receptor genotypes to bone mineral density and to rates of bone loss in men
    Sundeep Khosla
    Endocrine Research Unit, Division of Endocrinology, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 89:1808-16. 2004
    ....
  34. ncbi request reprint Estrogen receptor isoform-specific regulation of endogenous gene expression in human osteoblastic cell lines expressing either ERalpha or ERbeta
    David G Monroe
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Cell Biochem 90:315-26. 2003
    ....
  35. ncbi request reprint Effect of blockade of TNF-alpha and interleukin-1 action on bone resorption in early postmenopausal women
    Natthinee Charatcharoenwitthaya
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Bone Miner Res 22:724-9. 2007
    ..This is consistent with an important role for these immune cytokines in mediating the effect of estrogen deficiency on bone...
  36. ncbi request reprint Structural determinants of vertebral fracture risk
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Bone Miner Res 22:1885-92. 2007
    ..Vertebral fractures are more strongly associated with specific bone density, structure, and strength parameters than with areal BMD, but all of these variables are correlated...
  37. ncbi request reprint Role of the vitamin D-endocrine system in the pathophysiology of postmenopausal osteoporosis
    B Lawrence Riggs
    Endocrine Research Unit, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Cell Biochem 88:209-15. 2003
    ..Nonetheless, a minority of them, especially nutritional vitamin D deficiency and impaired 25(OH)D 1alpha-hydroxylase activity late in life, appear to be primary and are independent of estrogen deficiency...
  38. pmc Relation of serum serotonin levels to bone density and structural parameters in women
    Ulrike I Mödder
    Endocrine Research Unit, College of Medicine, Mayo Clinic, Rochester, MN, USA
    J Bone Miner Res 25:415-22. 2010
    ..Collectively, our data provide support for a physiologic role for circulating serotonin in regulating bone mass in humans...
  39. ncbi request reprint Selective estrogen-receptor modulators -- mechanisms of action and application to clinical practice
    B Lawrence Riggs
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    N Engl J Med 348:618-29. 2003
  40. ncbi request reprint Changes in Runx2/Cbfa1 expression and activity during osteoblastic differentiation of human bone marrow stromal cells
    Chaoxiang Shui
    Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Bone Miner Res 18:213-21. 2003
    ..Our findings also show that the increase in Runx2/Cbfa1 activity occurs through a posttranslational mechanism involving phosphorylation of key residues...
  41. ncbi request reprint Fracture risk after bilateral oophorectomy in elderly women
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Bone Miner Res 18:900-5. 2003
    ....
  42. pmc Bone structure at the distal radius during adolescent growth
    Salman Kirmani
    College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Bone Miner Res 24:1033-42. 2009
    ..Whether these deficits are more severe in children who sustain forearm fractures or persist into later life warrants further study...
  43. ncbi request reprint Contribution of in vivo structural measurements and load/strength ratios to the determination of forearm fracture risk in postmenopausal women
    L Joseph Melton
    Division of Epidemology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 22:1442-8. 2007
    ..Bone structure, strength and load-strength ratios contribute to forearm fracture risk independently of areal BMD...
  44. pmc Circulating osteogenic cells: characterization and relationship to rates of bone loss in postmenopausal women
    Anita Undale
    Endocrine Research Unit, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Bone 47:83-92. 2010
    ..Our study also provides "proof-of-concept" for the use of PB lin-/AP+ cells in clinical-investigative studies, and identifies several pathways that could potentially regulate rates of bone loss in postmenopausal women...
  45. pmc Effects of parathyroid hormone treatment on circulating sclerostin levels in postmenopausal women
    Matthew T Drake
    Division of Endocrinology and Metabolism, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 95:5056-62. 2010
    ..Intermittent PTH treatment stimulates bone formation, but the mechanism(s) of this effect remain unclear. Sclerostin is an inhibitor of Wnt signaling, and animal studies have demonstrated that PTH suppresses sclerostin production...
  46. ncbi request reprint Costs and strategies in minority recruitment for osteoporosis research
    Miriam A Marquez
    Office of Diversity in Clinical Research, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Bone Miner Res 18:3-8. 2003
    ..These results should contribute to more realistic budgets for recruiting minority subjects into clinical research studies...
  47. ncbi request reprint Dose-response of estrogen on bone versus the uterus in ovariectomized mice
    Ulrike I L Modder
    Endocrine Research Unit, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Eur J Endocrinol 151:503-10. 2004
    ..Estrogen is known to have important effects on both reproductive and non-reproductive tissues. Moreover, there is increasing interest in developing compounds that may have selective effects on bone versus reproductive tissues...
  48. ncbi request reprint Incidence of childhood distal forearm fractures over 30 years: a population-based study
    Sundeep Khosla
    Endocrine Research Unit, Division of Endocrinology, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minn 55905, USA
    JAMA 290:1479-85. 2003
    ..Changes in physical activity or diet may therefore influence risk of forearm fracture...
  49. ncbi request reprint Effect of estrogen replacement therapy on parathyroid hormone secretion in elderly postmenopausal women
    Ann Vincent
    Endocrine Research Unit, Division of Endocrinology, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Menopause 10:165-71. 2003
    ..The goal of the present study was to test for these possible direct effects of estrogen on PTH secretion...
  50. ncbi request reprint Endocrine causes of age-related bone loss and osteoporosis
    B Lawrence Riggs
    Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Novartis Found Symp 242:247-59; discussion 260-4. 2002
    ..Other changes in endocrine secretion, although present in the elderly, seem less important in the pathophysiology of age-related bone loss and osteoporosis...
  51. ncbi request reprint Bone turnover matters: the raloxifene treatment paradox of dramatic decreases in vertebral fractures without commensurate increases in bone density
    B Lawrence Riggs
    J Bone Miner Res 17:11-4. 2002
  52. ncbi request reprint Age- and sex-specific differences in the factor of risk for vertebral fracture: a population-based study using QCT
    Mary L Bouxsein
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Bone Miner Res 21:1475-82. 2006
    ..With age, vertebral strength declined and Phi(vert) increased significantly more in women than men. Age- and sex-specific differences in Phi(vert) closely resembled previously reported vertebral fracture incidence...

Research Grants7

  1. EPIDEMIOLOGY OF AGE-RELATED BONE LOSS AND FRACTURES
    B Riggs; Fiscal Year: 1990
    ....
  2. EPIDEMIOLOGY OF AGE RELATED BONE LOSS AND FRACTURES
    B Riggs; Fiscal Year: 2001
    ..The new bone structure measurements should take us to a new level of understanding of the causes of age-related bone loss and fractures and improve substantially the assessment of risk for osteoporosis. ..