Elliott Richelson

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Evidence for a role of NTS2 receptors in the modulation of tonic pain sensitivity
    Geneviève Roussy
    Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Mol Pain 5:38. 2009
  2. ncbi Pharmacology of antidepressants
    E Richelson
    Department of Psychiatry and Psychology, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
    Mayo Clin Proc 76:511-27. 2001
  3. ncbi Neurotensin agonists: possible drugs for treatment of psychostimulant abuse
    Elliott Richelson
    Mayo Clinic Jacksonville, 4500 San Pablo Road, FL 32224, USA
    Life Sci 73:679-90. 2003
  4. ncbi Interactions of antidepressants with neurotransmitter transporters and receptors and their clinical relevance
    Elliott Richelson
    Department of Psychiatry, Mayo Clinic, Jacksonville, Fla, USA
    J Clin Psychiatry 64:5-12. 2003
  5. ncbi Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds
    E Richelson
    Department of Psychiatry and Psychology, and Pharmacology, Mayo Foundation for Medical Education and Research and Mayo Clinic, Jacksonville, FL 32224, USA
    Life Sci 68:29-39. 2000
  6. ncbi Receptor pharmacology of neuroleptics: relation to clinical effects
    E Richelson
    Department of Psychiatry, Mayo Clinic and Foundation, Jacksonville, Fla 32224, USA
    J Clin Psychiatry 60:5-14. 1999
  7. doi Effect of a novel neurotensin analog, NT69L, on nicotine-induced alterations in monoamine levels in rat brain
    Yanqi Liang
    Neuropsychopharmacology Laboratory and Nicotine Dependence Center, Mayo Foundation for Medical Education and Research, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Brain Res 1231:6-15. 2008
  8. pmc NT79: A novel neurotensin analog with selective behavioral effects
    Mona Boules
    Neuropsychopharmacology Laboratory, Mayo Clinic Florida, Jacksonville, FL 32224, USA
    Brain Res 1308:35-46. 2010
  9. pmc The novel neurotensin analog NT69L blocks phencyclidine (PCP)-induced increases in locomotor activity and PCP-induced increases in monoamine and amino acids levels in the medial prefrontal cortex
    Zhimin Li
    Neuropsychopharmacology Laboratory and Mayo Foundation for Medical Education and Research, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Brain Res 1311:28-36. 2010
  10. pmc Chronic NT69L potently prevents drug-induced disruption of prepulse inhibition without causing tolerance
    Siobhan Briody
    Neuropsychopharmacology Laboratory, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Behav Brain Res 207:118-24. 2010

Collaborators

Detail Information

Publications68

  1. pmc Evidence for a role of NTS2 receptors in the modulation of tonic pain sensitivity
    Geneviève Roussy
    Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Mol Pain 5:38. 2009
    ..In the present study, we therefore investigated whether activation of spinal NTS2 receptors suppressed the persistent inflammatory pain symptoms observed after intraplantar injection of formalin...
  2. ncbi Pharmacology of antidepressants
    E Richelson
    Department of Psychiatry and Psychology, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
    Mayo Clin Proc 76:511-27. 2001
    ..The information in this review will help clinicians treat acute depression with pharmacological agents...
  3. ncbi Neurotensin agonists: possible drugs for treatment of psychostimulant abuse
    Elliott Richelson
    Mayo Clinic Jacksonville, 4500 San Pablo Road, FL 32224, USA
    Life Sci 73:679-90. 2003
    ..This paper reviews the evidence for a role for neurotensin in stimulant abuse and for a neurotensin agonist for its treatment...
  4. ncbi Interactions of antidepressants with neurotransmitter transporters and receptors and their clinical relevance
    Elliott Richelson
    Department of Psychiatry, Mayo Clinic, Jacksonville, Fla, USA
    J Clin Psychiatry 64:5-12. 2003
    ..The article also reviews drugs that have dual action (effects on serotonin and norepinephrine), which may provide a therapeutic advantage in treating depressed patients...
  5. ncbi Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds
    E Richelson
    Department of Psychiatry and Psychology, and Pharmacology, Mayo Foundation for Medical Education and Research and Mayo Clinic, Jacksonville, FL 32224, USA
    Life Sci 68:29-39. 2000
    ..These data can provide guidelines for the clinician in the choice of antipsychotic drug...
  6. ncbi Receptor pharmacology of neuroleptics: relation to clinical effects
    E Richelson
    Department of Psychiatry, Mayo Clinic and Foundation, Jacksonville, Fla 32224, USA
    J Clin Psychiatry 60:5-14. 1999
    ..Several hypotheses about the molecular mechanisms that explain atypicality are considered. Finally, the in vitro receptor binding data presented for these compounds are related to the therapeutic and adverse effects of these drugs...
  7. doi Effect of a novel neurotensin analog, NT69L, on nicotine-induced alterations in monoamine levels in rat brain
    Yanqi Liang
    Neuropsychopharmacology Laboratory and Nicotine Dependence Center, Mayo Foundation for Medical Education and Research, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Brain Res 1231:6-15. 2008
    ..These data further support a role for NT69L or other neurotensin receptor agonists to treat nicotine addiction...
  8. pmc NT79: A novel neurotensin analog with selective behavioral effects
    Mona Boules
    Neuropsychopharmacology Laboratory, Mayo Clinic Florida, Jacksonville, FL 32224, USA
    Brain Res 1308:35-46. 2010
    ..NT79, with its higher selectivity to NTS2, may be potentially useful to treat visceral pain, and psychosis without concomitant side effects of hypothermia or hypotension...
  9. pmc The novel neurotensin analog NT69L blocks phencyclidine (PCP)-induced increases in locomotor activity and PCP-induced increases in monoamine and amino acids levels in the medial prefrontal cortex
    Zhimin Li
    Neuropsychopharmacology Laboratory and Mayo Foundation for Medical Education and Research, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Brain Res 1311:28-36. 2010
    ..Taken together, these data suggest that NT69L in particular and NT receptor agonists in general, will be useful as broad-spectrum antipsychotic drugs...
  10. pmc Chronic NT69L potently prevents drug-induced disruption of prepulse inhibition without causing tolerance
    Siobhan Briody
    Neuropsychopharmacology Laboratory, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Behav Brain Res 207:118-24. 2010
    ..The modulatory role of NT69L on the dopaminergic and serotonergic neurotransmission systems both of which are implicated in the pathophysiology of schizophrenia is discussed...
  11. doi Antidepressant-like pharmacological profile of a novel triple reuptake inhibitor, (1S,2S)-3-(methylamino)-2-(naphthalen-2-yl)-1-phenylpropan-1-ol (PRC200-SS)
    Yanqi Liang
    Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research and Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
    J Pharmacol Exp Ther 327:573-83. 2008
    ..Therefore, it seems that PRC200-SS may represent a novel triple reuptake inhibitor and possess antidepressant activity...
  12. pmc Hyperactivity of the dopaminergic system in NTS1 and NTS2 null mice
    Yanqi Liang
    Neuropsychopharmacology Laboratory, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
    Neuropharmacology 58:1199-205. 2010
    ..The data strengthen the hypothesis that NT receptors are involved in the pathogenesis of schizophrenia and provide a potential model for the biochemical changes of the disease...
  13. pmc Effect of amphetamine on extracellular concentrations of amino acids in striatum in neurotensin subtype 1 and 2 receptor null mice: a possible interaction between neurotensin receptors and amino acid systems for study of schizophrenia
    Zhimin Li
    Neuropsychopharmacology Laboratory, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Neuropharmacology 58:1174-8. 2010
    ..These results provide further support for the involvement of NT receptors in the pathogenesis of schizophrenia and provide a better understanding of the imbalance of amino acid systems through investigation of a DA-based animal model...
  14. doi A neurotensin analog, NT69L, attenuates intravenous nicotine self-administration in rats
    Mona Boules
    Neuropsychopharmacology Laboratory, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Neuropeptides 45:9-16. 2011
    ..These data support further study of the effects of NT analogs on attenuating the reinforcing effects of psychostimulants...
  15. pmc New model of action for mood stabilizers: phosphoproteome from rat pre-frontal cortex synaptoneurosomal preparations
    Maria Corena-McLeod
    Neuropsycopharmacology Laboratory, Mayo Clinic, Jacksonville, Florida, USA
    PLoS ONE 8:e52147. 2013
    ..We have previously reported the effects of lithium, valproate and a new antipsychotic, paliperidone on protein expression levels at the synaptic level...
  16. doi NTS1 and NTS2 mediate analgesia following neurotensin analog treatment in a mouse model for visceral pain
    Kristin E Smith
    Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Behav Brain Res 232:93-7. 2012
    ....
  17. pmc Similarities in the behavior and molecular deficits in the frontal cortex between the neurotensin receptor subtype 1 knockout mice and chronic phencyclidine-treated mice: relevance to schizophrenia
    Zhimin Li
    Department of Neuropsychopharmacology, Mayo Foundation for Medical Education and Research, Mayo Clinic, Jacksonville, FL 32224, USA
    Neurobiol Dis 40:467-77. 2010
    ..In addition, after chronic PCP administration, the DA D(1) receptor was up-regulated in NTS1(-/-) mice, results which suggest a possible interaction of NTS1/DA D(1) in mPFC contributing to chronic PCP-induced schizophrenia-like signs...
  18. pmc The role of NTS2 in the development of tolerance to NT69L in mouse models for hypothermia and thermal analgesia
    Kristin E Smith
    Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Behav Brain Res 224:344-9. 2011
    ..Additionally, we suggest potential means by which NTS2 influences these NT69L-mediated behaviors...
  19. pmc Increased ethanol consumption and preference in mice lacking neurotensin receptor type 2
    Moonnoh R Lee
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, College of Medicine, Rochester, Minnesota 55905, USA
    Alcohol Clin Exp Res 35:99-107. 2011
    ..Here, we investigated behavioral effects mediated by NTS2 in response to ethanol, which are implicated in ethanol consumption and preference, using NTS2 null mice...
  20. doi Paliperidone as a mood stabilizer: a pre-frontal cortex synaptoneurosomal proteomics comparison with lithium and valproic acid after chronic treatment reveals similarities in protein expression
    Maria del Pilar Corena-McLeod
    Neuropsychopharmacology Laboratory, Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
    Brain Res 1233:8-19. 2008
    ....
  21. ncbi The neurotensin receptor agonist NT69L suppresses sucrose-reinforced operant behavior in the rat
    Mona Boules
    Mayo Foundation for Medical Education and Research and Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Brain Res 1127:90-8. 2007
    ..The effect of NT69L on dopamine, tyrosine 3-hydroxylase, and dopamine receptor mRNA levels is discussed relative to changes occurring during extinction...
  22. ncbi Peptide nucleic acids targeted to the amyloid precursor protein
    Beth M McMahon
    Department of Psychiatry, Mayo Clinic, Jacksonville, FL 32224, USA
    J Mol Neurosci 20:261-5. 2003
    ..We report here the ongoing studies with mice and rats with PNAs targeting APP, as well as BACE...
  23. ncbi Novel neurotensin analog blocks the initiation and expression of nicotine-induced locomotor sensitization
    Paul Fredrickson
    Nicotine Dependence Center, Mayo Foundation for Medical Education and Research, and Mayo Clinic Jacksonville, 32224, Jacksonville, FL, USA
    Brain Res 979:245-8. 2003
    ..The present work demonstrates that NT69L blocks both the initiation and the expression of sensitization. In addition chronic NT69L administration blocked the acute effects of nicotine on norepinephrine and serotonin in prefrontal cortex...
  24. ncbi Selective tolerance to the hypothermic and anticataleptic effects of a neurotensin analog that crosses the blood-brain barrier
    Mona Boules
    Mayo Foundation for Medical Education and Research, and Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Brain Res 987:39-48. 2003
    ..Furthermore, due to the lack of development of tolerance, NT69L or similar analogs might be useful in modulating certain behavioral effects of psychostimulants or have potential use as an antipsychotic drug in humans...
  25. ncbi Antidepressant-like effects of novel triple reuptake inhibitors, PRC025 and PRC050
    Amanda M Shaw
    Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research and Mayo Clinic Jacksonville, Jacksonville, FL, USA
    Eur J Pharmacol 555:30-6. 2007
    ..Therefore it appears that our compounds may possess antidepressant activity and represent a new class of triple reuptake inhibitors...
  26. doi NT69L blocks ethanol-induced increase of dopamine and glutamate levels in striatum of mouse
    Zhimin Li
    Neuroscience Laboratory and Mayo Foundation for Medical Education and Research, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Neurosci Lett 487:322-4. 2011
    ..These data suggest that NT69L prevents ethanol consumption through the modulation of both dopaminergic and glutamatergic systems implicated in ethanol addiction. NT agonists may provide novel treatment for alcohol addiction...
  27. pmc Sensorimotor gating in NTS1 and NTS2 null mice: effects of d-amphetamine, dizocilpine, clozapine and NT69L
    Alfredo Oliveros
    Neuropsychopharmacology Laboratory, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    J Exp Biol 213:4232-9. 2010
    ..Our results indicate that NTS1 seems essential for d-amphetamine and dizocilpine disruption of PPI. Additionally, this report provides support to the hypothesis that NT analogs could be used as novel antipsychotic drugs...
  28. ncbi Neurotensin agonists as an alternative to antipsychotics
    Mona Boules
    Neuropsychopharmacology Laboratory and Nicotine Dependence Center, Mayo Foundation for Medical Education and Research, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Expert Opin Investig Drugs 14:359-69. 2005
    ..In this review, we present the rationale for development of NT receptor agonists for treatment of certain central nervous system diseases, as well as a review of those peptide agonists that are in early stages of development...
  29. ncbi Current topics: brain penetrating neurotensin analog
    Mona Boules
    Neuropsychopharmacology Laboratory, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Life Sci 73:2785-92. 2003
    ....
  30. ncbi Bioactive analogs of neurotensin: focus on CNS effects
    Mona Boules
    Neuropsychopharmacology Laboratory, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Peptides 27:2523-33. 2006
    ....
  31. ncbi Down-regulation of amyloid precursor protein by peptide nucleic acid in vivo
    Mona Boules
    Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research, and Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
    J Mol Neurosci 24:123-8. 2004
    ..The injection of antisense PNA showed about 70% decrease in APP as measured by Western blotting. Unmodified PNA can be used in vivo to reduce the levels of APP, which plays a critical role in the development of AD...
  32. ncbi Neurotensin agonists: potential in the treatment of schizophrenia
    Mona Boules
    Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research, Mayo Clinic Jacksonville, Florida 32224, USA
    CNS Drugs 21:13-23. 2007
    ....
  33. ncbi Pharmacological profile of neuroleptics at human monoamine transporters
    M Tatsumi
    Mayo Clinic Jacksonville, FL 32224, USA
    Eur J Pharmacol 368:277-83. 1999
    ..At the human dopamine transporter, only pimozide (K(D) = 69+/-3) ziprasidone (K(D) = 76+/-5) had notable potency. These data may be useful in predicting therapeutic and adverse effects, including drug interactions of neuroleptics...
  34. ncbi Neurobiologic basis of nicotine addiction and psychostimulant abuse: a role for neurotensin?
    Paul Fredrickson
    Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Psychiatr Clin North Am 28:737-51, 746. 2005
    ....
  35. ncbi Pharmacokinetics and tissue distribution of a peptide nucleic acid after intravenous administration
    Beth M McMahon
    Laboratory of Neuropsychopharmacology, Mayo Foundation for Medical and Educational Research, Jacksonville, FL 32224, USA
    Antisense Nucleic Acid Drug Dev 12:65-70. 2002
    ..Approximately 90% of the PNA dose was recovered as unchanged parent compound in the urine 24 hours after administration...
  36. ncbi Effects of repeated injections of the neurotensin analog NT69L on dopamine release and uptake in rat striatum in vitro
    Rui Wang
    Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research, and Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Brain Res 1025:21-8. 2004
    ..These results provide further proof for the involvement of different NT receptor subtypes in mediating the effect of NT69L on dopamine release evoked by K(+) or electrical depolarization...
  37. doi Analgesic synergy of neurotensin receptor subtype 2 agonist NT79 and morphine
    Mona Boules
    Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research, Mayo Clinic, Jacksonville, Florida 32224, USA
    Behav Pharmacol 22:573-81. 2011
    ..Isobolographic analyses show analgesic synergism between NT79 and morphine in persistent pain, thus providing a promise of therapy for pain while minimizing adverse effects associated with morphine use...
  38. ncbi Using peptide nucleic acids as gene-expression modifiers to reduce beta-amyloid levels
    Beth M McMahon
    Departments of Neuroscience and Pharmacology, Mayo Clinic, Jacksonville, FL 32224, USA
    J Mol Neurosci 19:71-6. 2002
    ..In spite of this, we have identified one PNA sequence that specifically lowers mouse brain A beta(1-40) A beta(1-42) by 37% and 47%, respectively...
  39. ncbi Synthesis and biological studies of novel neurotensin(8-13) mimetics
    Feng Hong
    Neuropsychopharmarcology Research, Mayo Clinic Jacksonville, 4500 San Pablo Road, FL 32224, USA
    Bioorg Med Chem 10:3849-58. 2002
    ..As a comparison, compounds 5 and 6 were also synthesized. The binding difference between 3, 4 and 5, 6 argues the importance of the carboxylic group in achieving higher potency NT(8-13) mimetics...
  40. ncbi Blockade of nicotine-induced locomotor sensitization by a novel neurotensin analog in rats
    Paul Fredrickson
    Nicotine Dependence Center, Mayo Foundation for Medical Education and Research, and Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Eur J Pharmacol 458:111-8. 2003
    ....
  41. ncbi A single amino acid of the human and rat neurotensin receptors (subtype 1) determining the pharmacological profile of a species-selective neurotensin agonist
    B Cusack
    Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research and Mayo Clinic Jacksonville, FL 32224, USA
    Biochem Pharmacol 60:793-801. 2000
    ....
  42. ncbi Highly potent neurotensin analog that causes hypothermia and antinociception
    B M Tyler-McMahon
    Laboratories of Neuropsychopharmacology, Mayo Foundation for Medical and Educational Research, Jacksonville, FL 32224, USA
    Eur J Pharmacol 390:107-11. 2000
    ..NT69L was overall the most potent and longest lasting neurotensin analog that has been reported. These studies provide the background for further testing of a stable, potent and long lasting neurotensin analog as a potential neuroleptic...
  43. ncbi Neurotensin: peptide for the next millennium
    B M Tyler-McMahon
    Laboratory of Neuropharmacology, Mayo Foundation for Medical and Educational Research, 4500 San Pablo Rd, 32224, Jacksonville, FL, USA
    Regul Pept 93:125-36. 2000
    ..Special emphasis is placed on the behavioral studies, particularly with reference to agonists, antagonists, and antisense studies, as well as, the interaction of neurotensin with other neurotransmitters...
  44. ncbi Analysis of binding sites and efficacy of a species-specific peptide at rat and human neurotensin receptors
    B Cusack
    Neuropsychopharmacology Research, Mayo Foundation for Medical Education and Research, Jacksonville, FL 32224, USA
    J Pept Res 55:72-80. 2000
    ..Finally, we compared the relative efficacies of both compounds and found that NT34 was about 2-fold and 4-fold more efficacious than NT in stimulating phosphatidylinositol turnover in rat and human NT receptors, respectively...
  45. ncbi Detection of peptide nucleic acids in tissue extracts of treated animals by gel mobility shift assay
    K Jansen
    Laboratory of Neuropsychopharmacology, Mayo Foundation for Medical and Educational Research, Jacksonville, FL 32224, USA
    J Biochem Biophys Methods 42:31-4. 2000
    ..This detection method is useful for detecting PNAs in many different tissues, including brain, heart, kidney, liver, spleen, and serum, as well as cells in culture...
  46. ncbi A novel neurotensin analog blocks cocaine- and D-amphetamine-induced hyperactivity
    M Boules
    Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research, and Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Eur J Pharmacol 426:73-6. 2001
    ....
  47. ncbi In vitro binding and CNS effects of novel neurotensin agonists that cross the blood-brain barrier
    B M Tyler
    Neuropsychopharmacology, Mayo Clinic, Jacksonville, FL 32224, USA
    Neuropharmacology 38:1027-34. 1999
    ..p. administration. These results in animals suggest that NT66L has agonist properties at NTR-1 in vivo after extracranial administration and provide support for its further study in behavioral tests predictive of neuroleptic activity...
  48. pmc Peptide nucleic acids targeted to the neurotensin receptor and administered i.p. cross the blood-brain barrier and specifically reduce gene expression
    B M Tyler
    Laboratory of Neuropsychopharmacology, Mayo Foundation for Medical and Educational Research, Jacksonville, FL 32224, USA
    Proc Natl Acad Sci U S A 96:7053-8. 1999
    ..p. delivery by crossing the normal blood-brain barrier. Equally important was that an antigene strategy, the sense PNA, was shown in vivo to be a potentially effective therapeutic treatment...
  49. ncbi Evidence for additional neurotensin receptor subtypes: neurotensin analogs that distinguish between neurotensin-mediated hypothermia and antinociception
    B M Tyler
    Neuropsychopharmacology Research, Mayo Foundation for Medical and Educational Research, Jacksonville, FL 32224, USA
    Brain Res 792:246-52. 1998
    ..6 nmol). Equally intriguing, was that NT24, a sterioisomer of NT27, with a much higher affinity (KD=0. 5 nM) at NTR-1, did not selectively induce hypothermia in mice, but did selectively induce hypothermia in rats...
  50. ncbi In vivo studies with low doses of levocabastine and diphenhydramine, but not pyrilamine, antagonize neurotensin-mediated antinociception
    B M Tyler
    Neuropsychopharmacology Research, Mayo Foundation for Medical and Educational Research, Jacksonville, FL 32224, USA
    Brain Res 787:78-84. 1998
    ..Therefore, these data may suggest the presence of yet unidentified NTR subtypes responsible for NT-mediated hypothermia and antinociception...
  51. ncbi Specific gene blockade shows that peptide nucleic acids readily enter neuronal cells in vivo
    B M Tyler
    Neuropsychopharmacology, Mayo Clinic, Jacksonville, FL 32224, USA
    FEBS Lett 421:280-4. 1998
    ..Binding studies confirmed a large reduction in receptor sites. The loss of behavioral responses was long lasting but did fully recover. The implications of specifically and readily turning off gene expression in vivo are profound...
  52. ncbi Intraperitoneal injection of antisense peptide nucleic acids targeted to the mu receptor decreases response to morphine and receptor protein levels in rat brain
    B M McMahon
    Neuropsychopharmacology, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
    Brain Res 904:345-9. 2001
    ..Lastly, the AS-MOR rats continued to show a normal antinociceptive response to neurotensin. This study, therefore, provides additional support for the use of PNAs to target proteins within brain by systemically administered PNAs...
  53. doi NT69L, a novel analgesic, shows synergy with morphine
    M Boules
    Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research, Jacksonville, Florida, USA
    Brain Res 1294:22-8. 2009
    ....
  54. ncbi Neurotensin analog selective for hypothermia over antinociception and exhibiting atypical neuroleptic-like properties
    M Boules
    Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research, and Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Brain Res 919:1-11. 2001
    ..Thus, NT77L selectively caused hypothermia, over antinociception, while exhibiting atypical neuroleptic-like effects...
  55. ncbi The effects of systemic NT69L, a neurotensin agonist, on baseline and drug-disrupted prepulse inhibition
    P D Shilling
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Behav Brain Res 143:7-14. 2003
    ....
  56. ncbi Altering behavioral responses and dopamine transporter protein with antisense peptide nucleic acids
    B M Tyler-McMahon
    Neuropsychopharmacology, Mayo Clinic, Birdsall Medical Research Building, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
    Biochem Pharmacol 62:929-32. 2001
    ..Additionally, these results suggest some novel approaches for the treatment of diseases dependent upon the function of the dopamine transporter...
  57. ncbi Antiparkinson-like effects of a novel neurotensin analog in unilaterally 6-hydroxydopamine lesioned rats
    M Boules
    Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research, and Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Eur J Pharmacol 428:227-33. 2001
    ..After three daily injections of NT69L, its effects on this rotational behavior were unchanged, suggesting that no tolerance develops to this effect of NT69L...
  58. ncbi Neurotensin analogs indications for use as potential antipsychotic compounds
    Beth M McMahon
    Laboratory of Neuropharmacology, Mayo Foundation for Medical and Educational Research, Jacksonville, FL 32224, USA
    Life Sci 70:1101-19. 2002
    ....
  59. pmc Neurotensin receptor type 1 regulates ethanol intoxication and consumption in mice
    Moonnoh R Lee
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, College of Medicine, Rochester, MN 55905, USA
    Pharmacol Biochem Behav 95:235-41. 2010
    ..Our study also demonstrates NTS1-mediated behavioral effects of NT69L. Therefore, our findings will be useful for understanding some aspects of alcoholism as well as to develop novel pharmacological therapeutic options for humans...
  60. pmc Matrix metalloproteinase-9 contributes to brain extravasation and edema in fulminant hepatic failure mice
    Justin H Nguyen
    Department of Transplantation, Division of Transplant Surgery, Mayo Clinic College of Medicine, 4205 Belfort Road, Suite 1100, Jacksonville, FL 32216, USA
    J Hepatol 44:1105-14. 2006
    ..Mechanisms of brain extravasation leading to brain edema remain incompletely understood. Matrix metalloproteinase (MMP)-9 is implicated in various brain injuries. We hypothesized that MMP-9 contributes to brain edema in FHF...
  61. ncbi Neurotensin agonists block the prepulse inhibition deficits produced by a 5-HT2A and an alpha1 agonist
    P D Shilling
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA
    Psychopharmacology (Berl) 175:353-9. 2004
    ..This suggested that NT agonists could inhibit 5-HT2A modulation of neurotransmission...
  62. ncbi Peptide nucleic acids specifically cause antigene effects in vivo by systemic injection
    Beth M McMahon
    Laboratory of Neuropsychopharmacology, Mayo Foundation for Medical and Educational Research, Jacksonville, FL 32224, USA
    Life Sci 71:325-37. 2002
    ..Thus, these results demonstrate on the molecular, protein, and physiological levels that antigene PNAs are effective in vivo upon systemic administration...
  63. doi Daily left prefrontal repetitive transcranial magnetic stimulation in the acute treatment of major depression: clinical predictors of outcome in a multisite, randomized controlled clinical trial
    Sarah H Lisanby
    Division of Brain Stimulation and Therapeutic Modulation, Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 34:522-34. 2009
    ..Shorter duration of current illness and lack of anxiety comorbidity may also confer an increased likelihood of good antidepressant response to TMS...
  64. ncbi Characterization of the genomic structure, promoter region, and a tetranucleotide repeat polymorphism of the human neurotensin receptor gene
    F Le
    Laboratory of Neuropsychopharmacology, Mayo Clinic, Jacksonville, Florida 32224, USA
    J Biol Chem 272:1315-22. 1997
    ..The tetranucleotide repeat polymorphism is highly informative with at least 23 alleles and might serve as a very useful marker for genetic study of the relationship between the NTR and neuropsychiatric disorders...
  65. ncbi Effects of 5 daily injections of the neurotensin-mimetic NT69L on the expression of neurotensin receptors in rat brain
    Rui Wang
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031, PR China
    Brain Res Mol Brain Res 138:24-34. 2005
    ..The present results suggest that distinct NT receptors involved in the effects exerted by NT69L may contribute to the interactions of NT69L with both neural networks and cellular proteins...
  66. ncbi Neurotensin receptor agonists and antagonists for schizophrenia
    Elliott Richelson
    Am J Psychiatry 162:633-4; author reply 635. 2005
  67. ncbi Neurotensin analog NT77 induces regulated hypothermia in the rat
    Christopher J Gordon
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Life Sci 73:2611-23. 2003
    ..Inducing a regulated hypothermic response with drugs such as NT77 may be an important therapy for ischemic disease and other insults...
  68. doi Spinal NTS1 receptors regulate nociceptive signaling in a rat formalin tonic pain model
    Geneviève Roussy
    Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Quebec, Canada
    J Neurochem 105:1100-14. 2008
    ..These results demonstrate that NTS1 receptors play a key role in the mediation of the analgesic effects of NT in persistent pain and suggest that NTS1-selective agonists may represent a new line of analgesic compounds...