MARGARET REDFIELD

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi request reprint Trends in prevalence and outcome of heart failure with preserved ejection fraction
    Theophilus E Owan
    Cardiorenal Research Laboratory, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    N Engl J Med 355:251-9. 2006
  2. ncbi request reprint Systolic and diastolic heart failure in the community
    Francesca Bursi
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    JAMA 296:2209-16. 2006
  3. pmc Anti-remodeling effects of rapamycin in experimental heart failure: dose response and interaction with Angiotensin receptor blockade
    Kalkidan Bishu
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 8:e81325. 2013
  4. pmc Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial
    Margaret M Redfield
    Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    JAMA 309:1268-77. 2013
  5. doi request reprint Strategies to screen for stage B as a heart failure prevention intervention
    Margaret M Redfield
    Cardiovascular Division, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    Heart Fail Clin 8:285-96. 2012
  6. ncbi request reprint Diastolic heart failure in the community
    C Y Hart
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, 200 First Street, Southwest, Rochester, MN 55905, USA
    Curr Cardiol Rep 2:461-9. 2000
  7. ncbi request reprint Age- and gender-related ventricular-vascular stiffening: a community-based study
    Margaret M Redfield
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN, USA
    Circulation 112:2254-62. 2005
  8. ncbi request reprint Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic
    Margaret M Redfield
    Division of Cardiovascular Diseases, Department of Internal Medicine, Guggenheim 9, Mayo Clinic and Foundation, 200 First St SW, Rochester, MN 55905, USA
    JAMA 289:194-202. 2003
  9. pmc Sildenafil and B-type natriuretic peptide acutely phosphorylate titin and improve diastolic distensibility in vivo
    Kalkidan Bishu
    Mayo Clinic Cardiovascular Division, 200 First St SW, Rochester, MN 55905, USA
    Circulation 124:2882-91. 2011
  10. ncbi request reprint Plasma brain natriuretic peptide concentration: impact of age and gender
    Margaret M Redfield
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 40:976-82. 2002

Research Grants

  1. Cyclic GMP And Ventricular Function In Heart Failure
    MARGARET REDFIELD; Fiscal Year: 2001
  2. Mayo Heart Failure Regional Clinical Center
    MARGARET REDFIELD; Fiscal Year: 2007
  3. ISOLATED DIASTOLIC DYSFUNCTION
    MARGARET REDFIELD; Fiscal Year: 2007
  4. ISOLATED DIASTOLIC DYSFUNCTION
    MARGARET REDFIELD; Fiscal Year: 2006
  5. ISOLATED DIASTOLIC DYSFUNCTION
    MARGARET REDFIELD; Fiscal Year: 2005
  6. Cyclic GMP And Ventricular Function In Heart Failure
    MARGARET REDFIELD; Fiscal Year: 2003
  7. ISOLATED DIASTOLIC DYSFUNCTION
    MARGARET REDFIELD; Fiscal Year: 2003
  8. Cyclic GMP And Ventricular Function In Heart Failure
    MARGARET REDFIELD; Fiscal Year: 2002
  9. ISOLATED DIASTOLIC DYSFUNCTION
    MARGARET REDFIELD; Fiscal Year: 2002
  10. ISOLATED DIASTOLIC DYSFUNCTION
    MARGARET REDFIELD; Fiscal Year: 2001

Detail Information

Publications68

  1. ncbi request reprint Trends in prevalence and outcome of heart failure with preserved ejection fraction
    Theophilus E Owan
    Cardiorenal Research Laboratory, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    N Engl J Med 355:251-9. 2006
    ..We performed a study to define secular trends in the prevalence of heart failure with preserved ejection fraction among patients at a single institution over a 15-year period...
  2. ncbi request reprint Systolic and diastolic heart failure in the community
    Francesca Bursi
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    JAMA 296:2209-16. 2006
    ..Further, diastolic function is seldom systematically assessed based on standardized techniques...
  3. pmc Anti-remodeling effects of rapamycin in experimental heart failure: dose response and interaction with Angiotensin receptor blockade
    Kalkidan Bishu
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 8:e81325. 2013
    ..Losartan monotherapy did not attenuate remodeling, whereas Losartan added to rapamycin provided no incremental benefit over rapamycin alone. These data lend support to investigation of low dose rapamycin as a novel therapy in human HF. ..
  4. pmc Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial
    Margaret M Redfield
    Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    JAMA 309:1268-77. 2013
    ..Studies in experimental and human heart failure suggest that phosphodiesterase-5 inhibitors may enhance cardiovascular function and thus exercise capacity in heart failure with preserved ejection fraction (HFPEF)...
  5. doi request reprint Strategies to screen for stage B as a heart failure prevention intervention
    Margaret M Redfield
    Cardiovascular Division, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    Heart Fail Clin 8:285-96. 2012
    ..Targeting Stage B HF represents one such potential strategy...
  6. ncbi request reprint Diastolic heart failure in the community
    C Y Hart
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, 200 First Street, Southwest, Rochester, MN 55905, USA
    Curr Cardiol Rep 2:461-9. 2000
    ..This review focuses on the emerging data regarding the prevalence and natural history of diastolic heart failure in the community...
  7. ncbi request reprint Age- and gender-related ventricular-vascular stiffening: a community-based study
    Margaret M Redfield
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN, USA
    Circulation 112:2254-62. 2005
    ..The prevalence of HFnlEF increases strikingly with age, particularly in women. We hypothesized that ventricular-vascular stiffening may occur with age and be more pronounced in women in the general community...
  8. ncbi request reprint Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic
    Margaret M Redfield
    Division of Cardiovascular Diseases, Department of Internal Medicine, Guggenheim 9, Mayo Clinic and Foundation, 200 First St SW, Rochester, MN 55905, USA
    JAMA 289:194-202. 2003
    ..Yet, the prevalence of diastolic dysfunction and its relation to systolic dysfunction and CHF in the community remain undefined...
  9. pmc Sildenafil and B-type natriuretic peptide acutely phosphorylate titin and improve diastolic distensibility in vivo
    Kalkidan Bishu
    Mayo Clinic Cardiovascular Division, 200 First St SW, Rochester, MN 55905, USA
    Circulation 124:2882-91. 2011
    ..We hypothesized that a phosphodiesterase-5A inhibitor (sildenafil) alone or in combination with BNP would increase left ventricular diastolic distensibility by phosphorylating titin...
  10. ncbi request reprint Plasma brain natriuretic peptide concentration: impact of age and gender
    Margaret M Redfield
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 40:976-82. 2002
    ..We wished to examine the effects of age and gender on plasma brain natriuretic peptide (BNP) concentration in a population-based study...
  11. ncbi request reprint The natriuretic peptides in cardiovascular medicine
    Vijaya K Munagala
    Mayo Clinic, Rochester, Minnesota 55905, USA
    Curr Probl Cardiol 29:707-69. 2004
    ..The clinical literature regarding the use of recombinant BNP for the treatment of HF is reviewed, underscoring current gaps in our knowledge regarding the indications for and benefits of this novel agent...
  12. ncbi request reprint Plasma brain natriuretic peptide to detect preclinical ventricular systolic or diastolic dysfunction: a community-based study
    Margaret M Redfield
    Guggenheim 9, Mayo Clinic, 200 First St, Southwest, Rochester, MN 55905, USA
    Circulation 109:3176-81. 2004
    ..We postulated that plasma brain natriuretic peptide (BNP) might serve as a biomarker for preclinical ventricular dysfunction (PCVD) but that the discriminatory values for BNP may vary with age and sex...
  13. pmc Haploinsufficiency of target of rapamycin attenuates cardiomyopathies in adult zebrafish
    Yonghe Ding
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Circ Res 109:658-69. 2011
    ..We explored adult zebrafish as a novel vertebrate model for dissecting signaling pathways in cardiomyopathy...
  14. ncbi request reprint Prevalence and prognostic significance of heart failure stages: application of the American College of Cardiology/American Heart Association heart failure staging criteria in the community
    Khawaja Afzal Ammar
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Circulation 115:1563-70. 2007
    ..The prevalence of HF stages and their association with mortality are unknown. We sought to estimate HF stage prevalence in the community and to measure the association of HF stages with mortality...
  15. ncbi request reprint Impaired functional status and echocardiographic abnormalities signifying global dysfunction enhance the prognostic significance of previously unrecognized myocardial infarction detected by electrocardiography
    Khawaja Afzal Ammar
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Ann Noninvasive Electrocardiol 12:27-37. 2007
    ..The relationship between electrocardiographic unrecognized myocardial infarction (UMI), abnormal functional status, echocardiographic abnormalities, and mortality has not been evaluated...
  16. ncbi request reprint Use of BNP and CRP as biomarkers in assessing cardiovascular disease: diagnosis versus risk
    Virginia M Miller
    Departments of Surgery, Physiology and Biomedical Engineering, Mayo Clinic Rochester, Rochester, MN 55905, USA
    Curr Vasc Pharmacol 5:15-25. 2007
    ....
  17. ncbi request reprint Unexplained pulmonary hypertension in elderly patients
    Brian P Shapiro
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
    Chest 131:94-100. 2007
    ..However, a subset of patients with IPAH is elderly. Our objective was to compare elderly (age >/= 65 years) vs younger persons with unexplained pulmonary hypertension (PH) and a presumptive diagnosis of IPAH...
  18. ncbi request reprint BNP-induced activation of cGMP in human cardiac fibroblasts: interactions with fibronectin and natriuretic peptide receptors
    Brenda K Huntley
    Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55904, USA
    J Cell Physiol 209:943-9. 2006
    ..Lastly, the NPR-C may also have a role in mediating anti-proliferative actions of BNP in CFs...
  19. ncbi request reprint Use of ejection fraction tests and coronary angiography in patients with heart failure
    Christopher E Kurtz
    Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 81:906-13. 2006
    ..To examine the use of tests that measure ejection fraction (EF) and the use of coronary angiography among patients with an initial diagnosis of heart failure (HF)...
  20. ncbi request reprint Diabetes in heart failure: prevalence and impact on outcome in the population
    Aaron M From
    The Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Med 119:591-9. 2006
    ..Little is known on the prevalence and prognostic importance of diabetes mellitus (DM) among individuals with heart failure (HF) in community-based cohorts...
  21. pmc Membrane guanylyl cyclase receptors: an update
    David L Garbers
    Cecil H and Ida Green Center for Reproductive Biology Sciences, and Department of Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390 9051, USA
    Trends Endocrinol Metab 17:251-8. 2006
    ..Some of these receptors also mediate important communication between the heart and intestine, and the kidney to regulate blood volume and Na+ balance...
  22. ncbi request reprint Association of obesity with left ventricular remodeling and diastolic dysfunction in patients without coronary artery disease
    Brian D Powell
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA
    Am J Cardiol 98:116-20. 2006
    ..In conclusion, ventricular remodeling, LV diastolic dysfunction, and elevated filling pressures may contribute to the prevalence of heart failure in obese patients...
  23. ncbi request reprint Alternate circulating pro-B-type natriuretic peptide and B-type natriuretic peptide forms in the general population
    Carolyn S P Lam
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 49:1193-202. 2007
    ..This study was designed to determine whether alternate pro-B-type natriuretic peptide (proBNP) and BNP forms circulate in the general population...
  24. ncbi request reprint Immunoreactivity and guanosine 3',5'-cyclic monophosphate activating actions of various molecular forms of human B-type natriuretic peptide
    Denise M Heublein
    Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hypertension 49:1114-9. 2007
    ..These findings also demonstrate differential cGMP activating properties of BNP forms and, importantly, that pro-BNP 1-108 and NT-pro-BNP 1-76 have reduced cGMP activity in vitro that may have biological relevance to human heart failure...
  25. ncbi request reprint Natriuretic peptides as regulators of myocardial structure and function: pathophysiologic and therapeutic implications
    Alessandro Cataliotti
    Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55904, USA
    Heart Fail Clin 2:269-76. 2006
  26. pmc Advanced glycation end products accumulate in vascular smooth muscle and modify vascular but not ventricular properties in elderly hypertensive canines
    Brian P Shapiro
    Cardiorenal Research Laboratory, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Circulation 118:1002-10. 2008
    ..We determined whether and where AGEs were increased in elderly hypertensive nondiabetic dogs and whether an AGE cross-link breaker (ALT-711) improved vascular or ventricular function...
  27. pmc K(ATP) channel polymorphism is associated with left ventricular size in hypertensive individuals: a large-scale community-based study
    Santiago Reyes
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN, USA
    Hum Genet 123:665-7. 2008
    ..These findings implicate Kir6.2 K23 as a risk factor for adverse subclinical myocardial remodeling, and underscore the significance of cardiac K(ATP) channels within the population...
  28. doi request reprint Comparison of echocardiographic dyssynchrony assessment by tissue velocity and strain imaging in subjects with or without systolic dysfunction and with or without left bundle-branch block
    Chinami Miyazaki
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Circulation 117:2617-25. 2008
    ..The present study aimed to compare tissue velocity-derived and strain-derived dyssynchrony indexes in patients with or without systolic dysfunction and left bundle-branch block...
  29. pmc The effects of nesiritide on renal function and diuretic responsiveness in acutely decompensated heart failure patients with renal dysfunction
    Theophilus E Owan
    Mayo Clinic College of Medicine, Division of Cardiovascular Diseases, Rochester, Minneosta 55905
    J Card Fail 14:267-75. 2008
    ..We hypothesized that brain natriuretic peptide (nesiritide) added to standard HF therapy would preserve renal function and enhance diuretic responsiveness...
  30. ncbi request reprint Mineralocorticoid signaling in transition to heart failure with normal ejection fraction
    Brian P Shapiro
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN, USA
    Hypertension 51:289-95. 2008
    ....
  31. ncbi request reprint Impact of arterial load and loading sequence on left ventricular tissue velocities in humans
    Barry A Borlaug
    Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 50:1570-7. 2007
    ..The aim of this study was to examine the relationship between individual components of left ventricular (LV) afterload and tissue Doppler echocardiography (TDE) velocities in humans...
  32. ncbi request reprint Response to cardiac resynchronization therapy predicts survival in heart failure: a single-center experience
    Yong Mei Cha
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Cardiovasc Electrophysiol 18:1015-9. 2007
    ..To determine whether survival after cardiac resynchronization therapy (CRT) is related to improvement in clinical or echocardiographic parameters...
  33. ncbi request reprint Revisiting methods for assessing and comparing left ventricular diastolic stiffness: impact of relaxation, external forces, hypertrophy, and comparators
    Wissam A Jaber
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 293:H2738-46. 2007
    ..The concordance between these two methods was poorly reflected by comparing the derived alpha and beta but apparent when using EDV(10-30), which provides information regarding the position of the PVR in a single number...
  34. ncbi request reprint Mineralocorticoid escape by the kidney but not the heart in experimental asymptomatic left ventricular dysfunction
    Lisa C Costello-Boerrigter
    Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic and Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Hypertension 50:481-8. 2007
    ..Despite renal escape, increased left ventricular collagen deposition suggests that the heart but not the kidney failed to escape the tissue effects of DOCA...
  35. ncbi request reprint Acute and chronic ventricular-arterial coupling in systole and diastole: insights from an elderly hypertensive model
    Brian P Shapiro
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Hypertension 50:503-11. 2007
    ..These observations provide insight into the mechanisms whereby arterial remodeling and acute and chronic VA coupling in both systole and diastole may predispose to and interact with increases in load to cause HFnlEF...
  36. pmc Cardiac structure and ventricular-vascular function in persons with heart failure and preserved ejection fraction from Olmsted County, Minnesota
    Carolyn S P Lam
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, 200 First St SW, Rochester, MN 55905, USA
    Circulation 115:1982-90. 2007
    ....
  37. ncbi request reprint Nonhypotensive low-dose nesiritide has differential renal effects compared with standard-dose nesiritide in patients with acute decompensated heart failure and renal dysfunction
    Henry G Riter
    J Am Coll Cardiol 47:2334-5. 2006
  38. ncbi request reprint Secular trends in renal dysfunction and outcomes in hospitalized heart failure patients
    Theophilus E Owan
    Cardiorenal Research Laboratory, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Card Fail 12:257-62. 2006
    ..We determined whether the severity of renal dysfunction, the incidence of WRF or outcomes have changed over time (secular trends) in patients hospitalized for HF therapy...
  39. ncbi request reprint Trends in heart failure incidence and survival in a community-based population
    Veronique L Roger
    Division of Cardiovascular Diseases and Internal Medicine, Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, Minn 55095, USA
    JAMA 292:344-50. 2004
    ..The epidemic of heart failure has yet to be fully investigated, and data on incidence, survival, and sex-specific temporal trends in community-based populations are limited...
  40. ncbi request reprint Atrial fibrillation and ventricular dysfunction: a vicious electromechanical cycle
    Yong Mei Cha
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minn 55905, USA
    Circulation 109:2839-43. 2004
  41. ncbi request reprint Triphasic mitral inflow velocity with middiastolic filling: clinical implications and associated echocardiographic findings
    Jong Won Ha
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Am Soc Echocardiogr 17:428-31. 2004
    ..Triphasic mitral inflow with middiastolic flow is related to elevated filling pressure, delayed myocardial relaxation, and slow heart rate, indicating advanced diastolic dysfunction...
  42. ncbi request reprint The role of brain natriuretic peptide in population screening
    Liselotte N Dyrbye
    Department of Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Heart Fail Rev 8:349-54. 2003
    ..Here we review available population-based studies assessing the predictive characteristics of BNP for the detection of pre-clinical structural heart disease (Stage B Heart Failure)...
  43. ncbi request reprint Association of newer diastolic function parameters with age in healthy subjects: a population-based study
    Vijaya K Munagala
    Department of Health Science Research, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    J Am Soc Echocardiogr 16:1049-56. 2003
    ..We sought to determine if newer Doppler diastolic function parameters are associated with age and to define age-stratified reference ranges for these parameters in a population-based setting...
  44. ncbi request reprint Incidence of heart failure after myocardial infarction: is it changing over time?
    Jens P Hellermann
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Am J Epidemiol 157:1101-7. 2003
    ..This suggests that improved survival after MI is unlikely to be a major contributor to the heart failure epidemic...
  45. ncbi request reprint Angiotensin II AT1 receptor antagonism prevents detrimental renal actions of acute diuretic therapy in human heart failure
    Horng H Chen
    Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Physiol Renal Physiol 284:F1115-9. 2003
    ..These findings support the use of AT(1) receptor blockade for human CHF requiring acute diuretics to improve renal hemodynamic and tubular function and to suppress aldosterone...
  46. ncbi request reprint Left atrial volume as an index of left atrial size: a population-based study
    Allison M Pritchett
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    J Am Coll Cardiol 41:1036-43. 2003
    ..We studied left atrial volume (LAV) as an index of atrial size...
  47. ncbi request reprint Failing atrial myocardium: energetic deficits accompany structural remodeling and electrical instability
    Yong Mei Cha
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Physiol Heart Circ Physiol 284:H1313-20. 2003
    ..Myocardial bioenergetic deficits are a conserved feature of dysfunctional atrial and ventricular myocardium in CHF and may constitute a component of the substrate for AF in CHF...
  48. ncbi request reprint Diastolic heart failure in the community: clinical profile, natural history, therapy, and impact of proposed diagnostic criteria
    Horng H Chen
    Division of Cardiovascular Diseases and the Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Card Fail 8:279-87. 2002
    ..The frequency with which patients met recently proposed standardized criteria for diagnosis of DHF was assessed...
  49. ncbi request reprint Hemodynamic and humoral effects of vasopeptidase inhibition in canine hypertension
    Calin V Maniu
    Division of Cardiovascular Diseases, Mayo Clinic and Mayo Foundation, Rochester, Minn 55905, USA
    Hypertension 40:528-34. 2002
    ..Synergistic effects on humoral and probably endothelial vasodilatory factors appear to be important in mediating the unique hemodynamic profile of vasopeptidase inhibition in this form of experimental hypertension...
  50. ncbi request reprint The potential of brain natriuretic peptide as a biomarker for New York Heart Association class during the outpatient treatment of heart failure
    Shang Chiun Lee
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Card Fail 8:149-54. 2002
    ..Their relative value in monitoring symptom status during the chronic treatment of congestive heart failure (CHF) remains undefined...
  51. ncbi request reprint The Breathing Not Proper trial: enough evidence to change heart failure guidelines?
    Margaret M Redfield
    Cardiorenal Laboratory, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Card Fail 8:120-3. 2002
  52. ncbi request reprint Mitral regurgitation in patients with advanced systolic heart failure
    Jeetendra B Patel
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Card Fail 10:285-91. 2004
    ..Our objective was to define the prevalence, clinical correlates, and prognostic implications of functional MR and the use of mitral annuloplasty in patients with advanced systolic CHF evaluated in a heart failure clinic...
  53. ncbi request reprint Participation bias in a population-based echocardiography study
    Steven J Jacobsen
    Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Ann Epidemiol 14:579-84. 2004
    ..To compare the characteristics of participants and non-participants in a population-based study of cardiac ventricular function...
  54. ncbi request reprint Acute and chronic reduction of functional mitral regurgitation in experimental heart failure by percutaneous mitral annuloplasty
    Calin V Maniu
    Division of Cardiovascular Disease, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    J Am Coll Cardiol 44:1652-61. 2004
    ..Further, we evaluated the potential for adverse effects on left ventricular (LV) function and coronary perfusion...
  55. pmc Amino-terminal pro-B-type natriuretic peptide and B-type natriuretic peptide: biomarkers for mortality in a large community-based cohort free of heart failure
    Paul M McKie
    Cardiorenal Research Laboratory, Mayo Clinic and Foundation, Rochester, MN, USA
    Hypertension 47:874-80. 2006
    ....
  56. ncbi request reprint Unrecognized myocardial infarction: the association with cardiopulmonary symptoms and mortality is mediated via echocardiographic abnormalities of global dysfunction instead of regional dysfunction: the Olmsted County Heart Function Study
    Khawaja Afzal Ammar
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN, USA
    Am Heart J 151:799-805. 2006
    ..There are very few data describing the association of electrocardiogram-based unrecognized myocardial infarction (ECG-UMI) with nonanginal cardiopulmonary symptoms, echocardiographic abnormalities, and mortality in the community...
  57. pmc Amino-terminal pro-B-type natriuretic peptide and B-type natriuretic peptide in the general community: determinants and detection of left ventricular dysfunction
    Lisa C Costello-Boerrigter
    Cardiorenal Research Laboratory, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 47:345-53. 2006
    ..This study sought to characterize factors influencing amino-terminal pro-B-type natriuretic peptide (NT-proBNP) and to evaluate the ability of NT-proBNP to detect left ventricular (LV) dysfunction in a large community sample...
  58. ncbi request reprint Bioenergetic protection of failing atrial and ventricular myocardium by vasopeptidase inhibitor omapatrilat
    Yong Mei Cha
    Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 290:H1686-92. 2006
    ..Thus therapy with omapatrilat demonstrates the benefit in protecting phosphotransfer enzyme activities and in preventing impairment of atrial and ventricular bioenergetics in heart failure...
  59. ncbi request reprint Echocardiographic characteristics of electrocardiographically unrecognized myocardial infarctions in a community population
    Khawaja Afzal Ammar
    Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Am J Cardiol 96:1069-75. 2005
    ..The similar prognosis after UMI and RMI cannot be explained by comparable degrees of ventricular damage...
  60. ncbi request reprint Effects of omapatrilat on cardiac nerve sprouting and structural remodeling in experimental congestive heart failure
    Yong Mei Cha
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
    Heart Rhythm 2:984-90. 2005
    ..Congestive heart failure (CHF) results in decreased cardiac sympathetic innervation...
  61. ncbi request reprint Elevated blood pressure and cardiac hypertrophy after ablation of the gly96/IEX-1 gene
    Stacy L Sommer
    Department of Internal Medicine, MS 1 120, Mayo Clinic Rochester, Mayo College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    J Appl Physiol (1985) 100:707-16. 2006
    ..Ablation of the gly96/IEX-1 gene results in hypertension and cardiac hypertrophy, suggesting a novel role for this gene in cardiovascular physiology...
  62. ncbi request reprint Epidemiology of diastolic heart failure
    Theophilius E Owan
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Prog Cardiovasc Dis 47:320-32. 2005
    ....
  63. ncbi request reprint Natriuretic and antialdosterone actions of chronic oral NEP inhibition during progressive congestive heart failure
    Fernando L Martin
    Cardiorenal Research Laboratory, The Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Kidney Int 67:1723-30. 2005
    ..We also hypothesized that chronic NEPI during progressive CHF (PCHF) would improve the natriuretic response to acute volume expansion...
  64. ncbi request reprint Cardiac-specific attenuation of natriuretic peptide A receptor activity accentuates adverse cardiac remodeling and mortality in response to pressure overload
    Jeetendra B Patel
    Cardiorenal Research Laboratory, Guggenheim 9, Mayo Clinic, 200 First St, Southwest, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 289:H777-84. 2005
    ....
  65. pmc Ventricular structure and function in aged dogs with renal hypertension: a model of experimental diastolic heart failure
    Vijaya K Munagala
    Cardiorenal Research Laboratory, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    Circulation 111:1128-35. 2005
    ..Our objective was to develop a clinically relevant large-animal model to better understand the pathophysiology of DHF...
  66. ncbi request reprint Heart failure after myocardial infarction: clinical presentation and survival
    Jens P Hellermann
    Division of Cardiovascular Diseases and Internal Medicine, Rochester, MN, USA
    Eur J Heart Fail 7:119-25. 2005
    ....
  67. ncbi request reprint Atrial BNP endocrine function during chronic unloading of the normal canine heart
    Ondrej Lisy
    Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, 200 First St, SW, Rochester, MN 55905, USA
    Am J Physiol Regul Integr Comp Physiol 288:R158-62. 2005
    ....
  68. ncbi request reprint Actions of a novel synthetic natriuretic peptide on hemodynamics and ventricular function in the dog
    John G Lainchbury
    Cardiorenal Research Laboratory, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Physiol Regul Integr Comp Physiol 282:R993-8. 2002
    ..05), and Tau decreased (31 +/- 2 to 27 +/- 1 ms, P < 0.05). The effects on hemodynamics, LV function, and second messenger generation suggest synthetic DNP may have a role as a cardiac unloading and lusitropic peptide...

Research Grants12

  1. Cyclic GMP And Ventricular Function In Heart Failure
    MARGARET REDFIELD; Fiscal Year: 2001
    ..abstract_text> ..
  2. Mayo Heart Failure Regional Clinical Center
    MARGARET REDFIELD; Fiscal Year: 2007
    ..Specific Aim 4. Establish a Clinical HF Research Skills Development Core The objective is to train future investigators in clinical HF research facilitating their ability to attain independent status. (End of Abstract) ..
  3. ISOLATED DIASTOLIC DYSFUNCTION
    MARGARET REDFIELD; Fiscal Year: 2007
    ....
  4. ISOLATED DIASTOLIC DYSFUNCTION
    MARGARET REDFIELD; Fiscal Year: 2006
    ....
  5. ISOLATED DIASTOLIC DYSFUNCTION
    MARGARET REDFIELD; Fiscal Year: 2005
    ....
  6. Cyclic GMP And Ventricular Function In Heart Failure
    MARGARET REDFIELD; Fiscal Year: 2003
    ..abstract_text> ..
  7. ISOLATED DIASTOLIC DYSFUNCTION
    MARGARET REDFIELD; Fiscal Year: 2003
    ....
  8. Cyclic GMP And Ventricular Function In Heart Failure
    MARGARET REDFIELD; Fiscal Year: 2002
    ..abstract_text> ..
  9. ISOLATED DIASTOLIC DYSFUNCTION
    MARGARET REDFIELD; Fiscal Year: 2002
    ....
  10. ISOLATED DIASTOLIC DYSFUNCTION
    MARGARET REDFIELD; Fiscal Year: 2001
    ....