Genomes and Genes




Affiliation: Mayo Clinic
Country: USA


  1. Redfield M, Chen H, Borlaug B, Semigran M, Lee K, Lewis G, et al. Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial. JAMA. 2013;309:1268-77 pubmed publisher Identifier: NCT00763867. ..
  2. Abouezzeddine O, Haines P, Stevens S, Nativi Nicolau J, Felker G, Borlaug B, et al. Galectin-3 in heart failure with preserved ejection fraction. A RELAX trial substudy (Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Diastolic Heart Failure). JACC Heart Fail. 2015;3:245-52 pubmed publisher
    ..These findings underscore the need to adjust for renal function when interpreting Gal-3 levels, and call into question the value of Gal-3 to quantify disease severity in overt HFpEF. ..
  3. Moulay G, Ohtani T, Ogut O, Guenzel A, Behfar A, Zakeri R, et al. Cardiac AAV9 Gene Delivery Strategies in Adult Canines: Assessment by Long-term Serial SPECT Imaging of Sodium Iodide Symporter Expression. Mol Ther. 2015;23:1211-1221 pubmed publisher
    ..These data are relevant to efforts to develop cardiac gene delivery as heart failure therapy. ..
  4. Mohammed S, Mirzoyev S, Edwards W, Dogan A, Grogan D, Dunlay S, et al. Left ventricular amyloid deposition in patients with heart failure and preserved ejection fraction. JACC Heart Fail. 2014;2:113-22 pubmed publisher
  5. Hussain I, Mohammed S, Forfia P, Lewis G, Borlaug B, Gallup D, et al. Impaired Right Ventricular-Pulmonary Arterial Coupling and Effect of Sildenafil in Heart Failure With Preserved Ejection Fraction: An Ancillary Analysis From the Phosphodiesterase-5 Inhibition to Improve Clinical Status And Exercise Capacity in Diast. Circ Heart Fail. 2016;9:e002729 pubmed publisher
    ..In RELAX patients with RVD and impaired RV-PA coupling, sildenafil did not improve RV function, exercise capacity, or ventilatory efficiency. URL: Unique identifier: NCT00763867. ..
  6. Saiki H, Eidem B, Ohtani T, Grogan M, Redfield M. Ventricular-Arterial Function and Coupling in the Adult Fontan Circulation. J Am Heart Assoc. 2016;5: pubmed
    ..Maintenance of CI is dependent on lower afterload, eccentric remodeling, and relative preservation of diastolic function. These data contribute to our understanding of circulatory physiology in adult Fontan patients. ..
  7. Abouezzeddine O, McKie P, Scott C, Rodeheffer R, Chen H, Michael Felker G, et al. Biomarker-based risk prediction in the community. Eur J Heart Fail. 2016;18:1342-1350 pubmed publisher
    ..This data provides a framework for biomarker selection which may inform design of biomarker-guided preventative intervention trials. ..
  8. Saiki H, Petersen I, Scott C, Bailey K, Dunlay S, Finley R, et al. Risk of Heart Failure With Preserved Ejection Fraction in Older Women After Contemporary Radiotherapy for Breast Cancer. Circulation. 2017;135:1388-1396 pubmed publisher
    ..Moreover, these data provide further support for the importance of coronary microvascular compromise in the pathophysiology of HFpEF. ..
  9. Saiki H, Moulay G, Guenzel A, Liu W, Decklever T, Classic K, et al. Experimental cardiac radiation exposure induces ventricular diastolic dysfunction with preserved ejection fraction. Am J Physiol Heart Circ Physiol. 2017;313:H392-H407 pubmed publisher

More Information


  1. Chaanine A, Sreekumaran Nair K, Bergen R, Klaus K, Guenzel A, Hajjar R, et al. Mitochondrial Integrity and Function in the Progression of Early Pressure Overload-Induced Left Ventricular Remodeling. J Am Heart Assoc. 2017;6: pubmed publisher
  2. Abouezzeddine O, French B, Mirzoyev S, Jaffe A, Levy W, Fang J, et al. From statistical significance to clinical relevance: A simple algorithm to integrate brain natriuretic peptide and the Seattle Heart Failure Model for risk stratification in heart failure. J Heart Lung Transplant. 2016;35:714-21 pubmed publisher
    ..The simple SHFM+BNP algorithm displays stable performance across diverse HFrEF cohorts and may enhance risk stratification to enable appropriate decision-making regarding HF therapeutic or palliative strategies. ..
  3. Abouezzeddine O, McKie P, Dunlay S, Stevens S, Felker G, Borlaug B, et al. Suppression of Tumorigenicity 2 in Heart Failure With Preserved Ejection Fraction. J Am Heart Assoc. 2017;6: pubmed publisher
    ..These data suggest that ST2 may be a marker of systemic inflammation in HFpEF and potentially of extracardiac origin. URL: Unique identifier: NCT00763867. ..
  4. Snipelisky D, Kelly J, Levine J, Koepp G, Anstrom K, McNulty S, et al. Accelerometer-Measured Daily Activity in Heart Failure With Preserved Ejection Fraction: Clinical Correlates and Association With Standard Heart Failure Severity Indices. Circ Heart Fail. 2017;10:e003878 pubmed publisher
    ..URL: Unique identifier: NCT02053493. ..
  5. Chaanine A, Kohlbrenner E, Gamb S, Guenzel A, Klaus K, Fayyaz A, et al. FOXO3a regulates BNIP3 and modulates mitochondrial calcium, dynamics, and function in cardiac stress. Am J Physiol Heart Circ Physiol. 2016;311:H1540-H1559 pubmed publisher
    ..Our results suggest an important role of FOXO3a in HF, making it an attractive potential therapeutic target. ..
  6. Win S, Hussain I, Hebl V, Dunlay S, Redfield M. Inpatient Mortality Risk Scores and Postdischarge Events in Hospitalized Heart Failure Patients: A Community-Based Study. Circ Heart Fail. 2017;10: pubmed publisher
    ..0001 for all). The simple ADHERE and GWTG scores stratify hospitalized HF patients for both inpatient and early postdischarge mortality risk, allowing comprehensive risk assessment on admission. ..
  7. Fayyaz A, Edwards W, Maleszewski J, Konik E, DuBrock H, Borlaug B, et al. Global Pulmonary Vascular Remodeling in Pulmonary Hypertension Associated With Heart Failure and Preserved or Reduced Ejection Fraction. Circulation. 2018;137:1796-1810 pubmed publisher
    ..These findings expand our understanding of the pathobiology of PH in HF. ..