Affiliation: Mayo Clinic
- Sporadic medulloblastomas contain PTCH mutationsC Raffel
Department of Neurosurgery, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
Cancer Res 57:842-5. 1997..It is interesting that all three mutations occur in exon 17 of the PTCH gene. These data suggest that inactivation of PTCH function is involved in the development of at least a subset of sporadic medulloblastomas...
- Medulloblastoma: molecular genetics and animal modelsCorey Raffel
Department of Neurologic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Neoplasia 6:310-22. 2004..Although a great deal has been discovered about this tumor, the genetic alterations responsible for tumor development in a majority of patients have yet to be described...
- Control of beta-catenin/Tcf-directed transcription in medulloblastomaC Raffel
Mayo Clinic, Rochester, MN 55905, USA
Acta Paediatr Suppl 93:12-6; discussion 16-7. 2004..Taken together, these data suggest that activating mutations in the beta-catenin gene may be involved in the development of a subset of medulloblastomas. The GSK-3beta gene does not appear to be a target for inactivation in this tumor...
- Evidence that haploinsufficiency of Ptch leads to medulloblastoma in miceR H Zurawel
Department of Neurological Surgery, Mayo Clinic and Foundation, Rochester, Minnesota, USA
Genes Chromosomes Cancer 28:77-81. 2000..Expression of Gli1 was increased in tumors compared to normal cerebellum. These results suggest that deletion of one copy of Ptch may be sufficient to promote medulloblastoma development in mice...
- Allergic reaction to a bovine dural substitute following spinal cord untethering. Case reportAndrew B Foy
Department of Neurologic Surgery, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
J Neurosurg Pediatr 1:167-9. 2008..Her clinical symptoms and laboratory values all improved after surgery. To the authors' knowledge this is the first reported case of an allergic reaction to bovine-based dural substitutes...
- Cortical resection for epilepsy in children with linear sebaceous nevus syndromeCormac O Maher
Department of Neurosurgery, Mayo Clinic, Rochester, Minn, USA
Pediatr Neurosurg 39:129-35. 2003..Our results support the utility of extensive cortical resections for children with this condition...
- Spinal epidural hematoma in an infant as the initial presentation of severe hemophiliaPeter Kalina
Division of Neuroradiology, Department of Neurosurgery, Mayo Clinic, 200 First Street, Rochester, MN 55905, USA
Emerg Radiol 15:281-4. 2008..We believe this to be the youngest reported case of a symptomatic spontaneous spinal epidural hemorrhage in an infant subsequently initially establishing a diagnosis of hemophilia...
- Neurosurgical treatment of brain tumors in childrenCormac O Maher
Department of Neurosurgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Pediatr Clin North Am 51:327-57. 2004..Nevertheless, it is clear that refinements in imaging, surgical technique, and adjunctive therapies have led to longer survival and an improving quality of life in children with brain tumors...
- Imaging characteristics and growth of subependymal giant cell astrocytomasMichelle J Clarke
Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
Neurosurg Focus 20:E5. 2006..In this study the authors' aim was to determine imaging characteristics of proven tumors in a single-center pediatric population...
- A case of infertility in a patient with a ventriculoperitoneal shuntJ Bradley White
Department of Neurosurgery, The Mayo Clinic, Rochester, MN 55905, USA
Pediatr Neurosurg 43:146-8. 2007..A case of infertility is presented that was thought to result from factors related to the distal end of a VP shunt residing within a patient's abdomen...
- Surgical treatment of fibrous dysplasia of the skull in childrenCormac O Maher
Department of Neurological Surgery, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA
Pediatr Neurosurg 37:87-92. 2002..We evaluate the role of surgery in the treatment of fibrous dysplasia of the skull in children...
- Natural history of tethered cord in patients with meningomyeloceleLoi K Phuong
Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota 55905, USA
Neurosurgery 50:989-93; discussion 993-5. 2002..The purpose of this study was to describe the natural history of tethered cord in patients who have undergone meningomyelocele repair...
- Early vasculopathy following radiation in a child with medulloblastomaC O Maher
Department of Neurosurgery, Mayo Clinic, Rochester, Minn, USA
Pediatr Neurosurg 32:255-8. 2000..We compare and contrast this case to similar case reports in the literature...
- Management of malignant pineal germ cell tumors with residual mature teratomaJ A Friedman
Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA
Neurosurgery 48:518-22; discussion 522-3. 2001..We reviewed our surgical experience with residual malignant pineal germ cell tumors after neoadjuvant therapy...
- Phase II trial of primary chemotherapy followed by reduced-dose radiation for CNS germ cell tumorsJ C Buckner
Division of Medical Oncology, Mayo Clinic, Rochester, MN 55905, USA
J Clin Oncol 17:933-40. 1999....
- Peri-ictal SPECT and surgical treatment for intractable epilepsy related to schizencephalyG D Cascino
Mayo Clinic, 200 First Street SW, Rochester, MN 55905
Neurology 63:2426-8. 2004..The patient with an indeterminate SISCOM had an unfavorable outcome. SISCOM is useful in evaluating patients with schizencephaly for epilepsy surgery...
- Acute cerebellitis presenting as tumor. Report of two casesNelly Amador
Departments of Neurological Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
J Neurosurg 107:57-61. 2007..The literature is reviewed and therapy considerations are emphasized...
- Frequency and significance of acute postoperative seizures following epilepsy surgery in children and adolescentsKristen Park
Mayo Medical School, Mayo Clinic, Rochester, Minnesota, USA
Epilepsia 43:874-81. 2002..To determine the frequency and prognostic features of acute postoperative seizures (APOSs), within the first postoperative week, in a group of children undergoing surgery for the treatment of medically refractory epilepsy...
- Toxicology study of repeat intracerebral administration of a measles virus derivative producing carcinoembryonic antigen in rhesus macaques in support of a phase I/II clinical trial for patients with recurrent gliomasRae Myers
Molecular Medicine Program, Mayo Clinic, Rochester, MN 55905, USA
Hum Gene Ther 19:690-8. 2008..Our results support the safety of CNS administration of MV-CEA in glioma patients. A clinical trial of intratumoral and resection cavity administration of MV-CEA in patients with recurrent glioblastoma multiforme is currently ongoing...
- Cloning of a human ortholog (RPH3AL) of (RNO)Rph3al from a candidate 17p13.3 medulloblastoma tumor suppressor locusJ S Smith
Division of Laboratory Genetics, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
Genomics 59:97-101. 1999..No mutations were identified. Thus, despite its location in a homozygously deleted 17p13.3 locus, it is unlikely that RPH3AL is a gene involved in the oncogenesis of medulloblastoma, FTC, or ovarian cancer...
- Recurrence of dysembryoplastic neuroepithelial tumor following resectionCormac O Maher
Department of Neurosurgery, University of Michigan, Ann Arbor, Mich 48109 0338, USA
Pediatr Neurosurg 44:333-6. 2008..Although recurrence of DNT following resection is rare, this case suggests that surveillance imaging may have a role in patients with DNT, even following resections that are thought to be complete...
- Pediatric neurosurgeryCormac O Maher
Department of Neurosurgery, Children s Hospital Boston, Boston, MA, USA
Prog Neurol Surg 19:97-106. 2006..This chapter will attempt to summarize the recent progress that has been made in this area...
- Developmental outcomes for neonatal dural arteriovenous fistulasJonathan N Johnson
Department of Pediatrics, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
J Neurosurg Pediatr 3:105-9. 2009..The patient did not require placement of a ventriculoperitoneal shunt. At 21 months of age, the child had near normal development without any focal neurological deficits...
- Neurostimulation therapy for epilepsy: current modalities and future directionsAaron A Cohen-Gadol
Department of Neurologic Surgery, Mayo Clinic, Rochester, Minn 55905, USA
Mayo Clin Proc 78:238-48. 2003..We review the history, proposed mechanisms of action, clinical trials, adverse effects, and future direction of VNS and other modalities of neurostimulation therapy for epilepsy...
- Oligodendrogliomas with neurocytic differentiation. A report of 4 cases with diagnostic and histogenetic implicationsArie Perry
Division of Neuropathology, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
J Neuropathol Exp Neurol 61:947-55. 2002..In any case, their occurrence suggests a histogenetic overlap between oligodendroglioma and extraventricular neurocytoma not previously recognized...
- Mutations in SUFU predispose to medulloblastomaMichael D Taylor
Division of Neurosurgery, The Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Canada
Nat Genet 31:306-10. 2002..SUFU is a newly identified tumor-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway through a newly identified mechanism...
- Congenital and childhood plexiform (multinodular) cellular schwannoma: a troublesome mimic of malignant peripheral nerve sheath tumorJames M Woodruff
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Am J Surg Pathol 27:1321-9. 2003..These features may lead to a misdiagnosis of malignancy, which could result in harmful overtreatment...
- GSK-3Beta and Associated Pathways in PNETCorey Raffel; Fiscal Year: 2004..As phosphorylation of Beta-catenin is critical for protein degradation, control of GSK-3Beta activity in PNET will be investigated. ..