Corey Raffel

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi request reprint Sporadic medulloblastomas contain PTCH mutations
    C Raffel
    Department of Neurosurgery, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Cancer Res 57:842-5. 1997
  2. pmc Medulloblastoma: molecular genetics and animal models
    Corey Raffel
    Department of Neurologic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Neoplasia 6:310-22. 2004
  3. ncbi request reprint Control of beta-catenin/Tcf-directed transcription in medulloblastoma
    C Raffel
    Mayo Clinic, Rochester, MN 55905, USA
    Acta Paediatr Suppl 93:12-6; discussion 16-7. 2004
  4. ncbi request reprint Evidence that haploinsufficiency of Ptch leads to medulloblastoma in mice
    R H Zurawel
    Department of Neurological Surgery, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Genes Chromosomes Cancer 28:77-81. 2000
  5. doi request reprint Allergic reaction to a bovine dural substitute following spinal cord untethering. Case report
    Andrew B Foy
    Department of Neurologic Surgery, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Neurosurg Pediatr 1:167-9. 2008
  6. ncbi request reprint Cortical resection for epilepsy in children with linear sebaceous nevus syndrome
    Cormac O Maher
    Department of Neurosurgery, Mayo Clinic, Rochester, Minn, USA
    Pediatr Neurosurg 39:129-35. 2003
  7. ncbi request reprint Spinal epidural hematoma in an infant as the initial presentation of severe hemophilia
    Peter Kalina
    Division of Neuroradiology, Department of Neurosurgery, Mayo Clinic, 200 First Street, Rochester, MN 55905, USA
    Emerg Radiol 15:281-4. 2008
  8. ncbi request reprint Neurosurgical treatment of brain tumors in children
    Cormac O Maher
    Department of Neurosurgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Pediatr Clin North Am 51:327-57. 2004
  9. ncbi request reprint Imaging characteristics and growth of subependymal giant cell astrocytomas
    Michelle J Clarke
    Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Neurosurg Focus 20:E5. 2006
  10. ncbi request reprint A case of infertility in a patient with a ventriculoperitoneal shunt
    J Bradley White
    Department of Neurosurgery, The Mayo Clinic, Rochester, MN 55905, USA
    Pediatr Neurosurg 43:146-8. 2007

Research Grants

  1. GSK-3Beta and Associated Pathways in PNET
    Corey Raffel; Fiscal Year: 2004

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Sporadic medulloblastomas contain PTCH mutations
    C Raffel
    Department of Neurosurgery, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Cancer Res 57:842-5. 1997
    ..It is interesting that all three mutations occur in exon 17 of the PTCH gene. These data suggest that inactivation of PTCH function is involved in the development of at least a subset of sporadic medulloblastomas...
  2. pmc Medulloblastoma: molecular genetics and animal models
    Corey Raffel
    Department of Neurologic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Neoplasia 6:310-22. 2004
    ..Although a great deal has been discovered about this tumor, the genetic alterations responsible for tumor development in a majority of patients have yet to be described...
  3. ncbi request reprint Control of beta-catenin/Tcf-directed transcription in medulloblastoma
    C Raffel
    Mayo Clinic, Rochester, MN 55905, USA
    Acta Paediatr Suppl 93:12-6; discussion 16-7. 2004
    ..Taken together, these data suggest that activating mutations in the beta-catenin gene may be involved in the development of a subset of medulloblastomas. The GSK-3beta gene does not appear to be a target for inactivation in this tumor...
  4. ncbi request reprint Evidence that haploinsufficiency of Ptch leads to medulloblastoma in mice
    R H Zurawel
    Department of Neurological Surgery, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Genes Chromosomes Cancer 28:77-81. 2000
    ..Expression of Gli1 was increased in tumors compared to normal cerebellum. These results suggest that deletion of one copy of Ptch may be sufficient to promote medulloblastoma development in mice...
  5. doi request reprint Allergic reaction to a bovine dural substitute following spinal cord untethering. Case report
    Andrew B Foy
    Department of Neurologic Surgery, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Neurosurg Pediatr 1:167-9. 2008
    ..Her clinical symptoms and laboratory values all improved after surgery. To the authors' knowledge this is the first reported case of an allergic reaction to bovine-based dural substitutes...
  6. ncbi request reprint Cortical resection for epilepsy in children with linear sebaceous nevus syndrome
    Cormac O Maher
    Department of Neurosurgery, Mayo Clinic, Rochester, Minn, USA
    Pediatr Neurosurg 39:129-35. 2003
    ..Our results support the utility of extensive cortical resections for children with this condition...
  7. ncbi request reprint Spinal epidural hematoma in an infant as the initial presentation of severe hemophilia
    Peter Kalina
    Division of Neuroradiology, Department of Neurosurgery, Mayo Clinic, 200 First Street, Rochester, MN 55905, USA
    Emerg Radiol 15:281-4. 2008
    ..We believe this to be the youngest reported case of a symptomatic spontaneous spinal epidural hemorrhage in an infant subsequently initially establishing a diagnosis of hemophilia...
  8. ncbi request reprint Neurosurgical treatment of brain tumors in children
    Cormac O Maher
    Department of Neurosurgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Pediatr Clin North Am 51:327-57. 2004
    ..Nevertheless, it is clear that refinements in imaging, surgical technique, and adjunctive therapies have led to longer survival and an improving quality of life in children with brain tumors...
  9. ncbi request reprint Imaging characteristics and growth of subependymal giant cell astrocytomas
    Michelle J Clarke
    Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Neurosurg Focus 20:E5. 2006
    ..In this study the authors' aim was to determine imaging characteristics of proven tumors in a single-center pediatric population...
  10. ncbi request reprint A case of infertility in a patient with a ventriculoperitoneal shunt
    J Bradley White
    Department of Neurosurgery, The Mayo Clinic, Rochester, MN 55905, USA
    Pediatr Neurosurg 43:146-8. 2007
    ..A case of infertility is presented that was thought to result from factors related to the distal end of a VP shunt residing within a patient's abdomen...
  11. ncbi request reprint Surgical treatment of fibrous dysplasia of the skull in children
    Cormac O Maher
    Department of Neurological Surgery, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA
    Pediatr Neurosurg 37:87-92. 2002
    ..We evaluate the role of surgery in the treatment of fibrous dysplasia of the skull in children...
  12. ncbi request reprint Natural history of tethered cord in patients with meningomyelocele
    Loi K Phuong
    Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Neurosurgery 50:989-93; discussion 993-5. 2002
    ..The purpose of this study was to describe the natural history of tethered cord in patients who have undergone meningomyelocele repair...
  13. ncbi request reprint Early vasculopathy following radiation in a child with medulloblastoma
    C O Maher
    Department of Neurosurgery, Mayo Clinic, Rochester, Minn, USA
    Pediatr Neurosurg 32:255-8. 2000
    ..We compare and contrast this case to similar case reports in the literature...
  14. ncbi request reprint Management of malignant pineal germ cell tumors with residual mature teratoma
    J A Friedman
    Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA
    Neurosurgery 48:518-22; discussion 522-3. 2001
    ..We reviewed our surgical experience with residual malignant pineal germ cell tumors after neoadjuvant therapy...
  15. ncbi request reprint Phase II trial of primary chemotherapy followed by reduced-dose radiation for CNS germ cell tumors
    J C Buckner
    Division of Medical Oncology, Mayo Clinic, Rochester, MN 55905, USA
    J Clin Oncol 17:933-40. 1999
    ....
  16. ncbi request reprint Peri-ictal SPECT and surgical treatment for intractable epilepsy related to schizencephaly
    G D Cascino
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905
    Neurology 63:2426-8. 2004
    ..The patient with an indeterminate SISCOM had an unfavorable outcome. SISCOM is useful in evaluating patients with schizencephaly for epilepsy surgery...
  17. ncbi request reprint Acute cerebellitis presenting as tumor. Report of two cases
    Nelly Amador
    Departments of Neurological Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Neurosurg 107:57-61. 2007
    ..The literature is reviewed and therapy considerations are emphasized...
  18. ncbi request reprint Frequency and significance of acute postoperative seizures following epilepsy surgery in children and adolescents
    Kristen Park
    Mayo Medical School, Mayo Clinic, Rochester, Minnesota, USA
    Epilepsia 43:874-81. 2002
    ..To determine the frequency and prognostic features of acute postoperative seizures (APOSs), within the first postoperative week, in a group of children undergoing surgery for the treatment of medically refractory epilepsy...
  19. pmc Toxicology study of repeat intracerebral administration of a measles virus derivative producing carcinoembryonic antigen in rhesus macaques in support of a phase I/II clinical trial for patients with recurrent gliomas
    Rae Myers
    Molecular Medicine Program, Mayo Clinic, Rochester, MN 55905, USA
    Hum Gene Ther 19:690-8. 2008
    ..Our results support the safety of CNS administration of MV-CEA in glioma patients. A clinical trial of intratumoral and resection cavity administration of MV-CEA in patients with recurrent glioblastoma multiforme is currently ongoing...
  20. ncbi request reprint Cloning of a human ortholog (RPH3AL) of (RNO)Rph3al from a candidate 17p13.3 medulloblastoma tumor suppressor locus
    J S Smith
    Division of Laboratory Genetics, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Genomics 59:97-101. 1999
    ..No mutations were identified. Thus, despite its location in a homozygously deleted 17p13.3 locus, it is unlikely that RPH3AL is a gene involved in the oncogenesis of medulloblastoma, FTC, or ovarian cancer...
  21. doi request reprint Recurrence of dysembryoplastic neuroepithelial tumor following resection
    Cormac O Maher
    Department of Neurosurgery, University of Michigan, Ann Arbor, Mich 48109 0338, USA
    Pediatr Neurosurg 44:333-6. 2008
    ..Although recurrence of DNT following resection is rare, this case suggests that surveillance imaging may have a role in patients with DNT, even following resections that are thought to be complete...
  22. ncbi request reprint Pediatric neurosurgery
    Cormac O Maher
    Department of Neurosurgery, Children s Hospital Boston, Boston, MA, USA
    Prog Neurol Surg 19:97-106. 2006
    ..This chapter will attempt to summarize the recent progress that has been made in this area...
  23. doi request reprint Developmental outcomes for neonatal dural arteriovenous fistulas
    Jonathan N Johnson
    Department of Pediatrics, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Neurosurg Pediatr 3:105-9. 2009
    ..The patient did not require placement of a ventriculoperitoneal shunt. At 21 months of age, the child had near normal development without any focal neurological deficits...
  24. ncbi request reprint Neurostimulation therapy for epilepsy: current modalities and future directions
    Aaron A Cohen-Gadol
    Department of Neurologic Surgery, Mayo Clinic, Rochester, Minn 55905, USA
    Mayo Clin Proc 78:238-48. 2003
    ..We review the history, proposed mechanisms of action, clinical trials, adverse effects, and future direction of VNS and other modalities of neurostimulation therapy for epilepsy...
  25. ncbi request reprint Oligodendrogliomas with neurocytic differentiation. A report of 4 cases with diagnostic and histogenetic implications
    Arie Perry
    Division of Neuropathology, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    J Neuropathol Exp Neurol 61:947-55. 2002
    ..In any case, their occurrence suggests a histogenetic overlap between oligodendroglioma and extraventricular neurocytoma not previously recognized...
  26. ncbi request reprint Mutations in SUFU predispose to medulloblastoma
    Michael D Taylor
    Division of Neurosurgery, The Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Canada
    Nat Genet 31:306-10. 2002
    ..SUFU is a newly identified tumor-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway through a newly identified mechanism...
  27. ncbi request reprint Congenital and childhood plexiform (multinodular) cellular schwannoma: a troublesome mimic of malignant peripheral nerve sheath tumor
    James M Woodruff
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Am J Surg Pathol 27:1321-9. 2003
    ..These features may lead to a misdiagnosis of malignancy, which could result in harmful overtreatment...

Research Grants1

  1. GSK-3Beta and Associated Pathways in PNET
    Corey Raffel; Fiscal Year: 2004
    ..As phosphorylation of Beta-catenin is critical for protein degradation, control of GSK-3Beta activity in PNET will be investigated. ..