Derek Radisky

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Microenvironmental influences that drive progression from benign breast disease to invasive breast cancer
    Magdalena A Cichon
    Department of Cancer Biology, Mayo Clinic, Jacksonville, FL 32224, USA
    J Mammary Gland Biol Neoplasia 15:389-97. 2010
  2. pmc Matrix metalloproteinase-induced epithelial-mesenchymal transition in breast cancer
    Evette S Radisky
    Mayo Clinic Cancer Center, Griffin Building, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    J Mammary Gland Biol Neoplasia 15:201-12. 2010
  3. pmc p16(INK4a) expression and breast cancer risk in women with atypical hyperplasia
    Derek C Radisky
    Division of Biochemistry Molecular Biology, Mayo Clinic in Jacksonville, Jacksonville, Florida 32224, USA
    Cancer Prev Res (Phila) 4:1953-60. 2011
  4. pmc Defining a role for the homeoprotein Six1 in EMT and mammary tumorigenesis
    Derek C Radisky
    Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida 32224, USA
    J Clin Invest 119:2528-31. 2009
  5. doi request reprint Matrix metalloproteinase-induced fibrosis and malignancy in breast and lung
    Derek C Radisky
    Mayo Clinic Cancer Center, Griffin Cancer Research Building, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Proc Am Thorac Soc 5:316-22. 2008
  6. pmc Mammary involution and breast cancer risk: transgenic models and clinical studies
    Derek C Radisky
    Department of Cancer Biology, Mayo Clinic, Jacksonville, FL 32224, USA
    J Mammary Gland Biol Neoplasia 14:181-91. 2009
  7. pmc Fibrosis and cancer: do myofibroblasts come also from epithelial cells via EMT?
    Derek C Radisky
    Department of Cancer Biology, Mayo Clinic Cancer Center, Jacksonville, FL 32224, USA
    J Cell Biochem 101:830-9. 2007
  8. pmc Matrix metalloproteinase-induced genomic instability
    Derek C Radisky
    Mayo Clinic Cancer Center, Jacksonville, FL 32225, USA
    Curr Opin Genet Dev 16:45-50. 2006
  9. ncbi request reprint Epithelial-mesenchymal transition
    Derek C Radisky
    Mayo Clinic Cancer Center, Griffin Cancer Research Building, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    J Cell Sci 118:4325-6. 2005
  10. doi request reprint Epithelial-mesenchymal transition and the stem cell phenotype
    Derek C Radisky
    Mayo Clinic Cancer Center, Jacksonville, FL 32224, USA
    Cell Stem Cell 2:511-2. 2008

Research Grants

Collaborators

Detail Information

Publications40

  1. pmc Microenvironmental influences that drive progression from benign breast disease to invasive breast cancer
    Magdalena A Cichon
    Department of Cancer Biology, Mayo Clinic, Jacksonville, FL 32224, USA
    J Mammary Gland Biol Neoplasia 15:389-97. 2010
    ..We also suggest approaches to identify processes that control earlier stages of disease progression...
  2. pmc Matrix metalloproteinase-induced epithelial-mesenchymal transition in breast cancer
    Evette S Radisky
    Mayo Clinic Cancer Center, Griffin Building, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    J Mammary Gland Biol Neoplasia 15:201-12. 2010
    ..We also suggest approaches to inhibit these MMP-mediated malignant processes for therapeutic benefit...
  3. pmc p16(INK4a) expression and breast cancer risk in women with atypical hyperplasia
    Derek C Radisky
    Division of Biochemistry Molecular Biology, Mayo Clinic in Jacksonville, Jacksonville, Florida 32224, USA
    Cancer Prev Res (Phila) 4:1953-60. 2011
    ..01). However, the addition of p16 levels did not strengthen this association. p16 overexpression, either alone or in combination with COX-2 and Ki-67, does not significantly stratify breast cancer risk in women with AH...
  4. pmc Defining a role for the homeoprotein Six1 in EMT and mammary tumorigenesis
    Derek C Radisky
    Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida 32224, USA
    J Clin Invest 119:2528-31. 2009
    ..Their findings implicate Six1 as a central mediator of breast cancer development...
  5. doi request reprint Matrix metalloproteinase-induced fibrosis and malignancy in breast and lung
    Derek C Radisky
    Mayo Clinic Cancer Center, Griffin Cancer Research Building, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Proc Am Thorac Soc 5:316-22. 2008
    ....
  6. pmc Mammary involution and breast cancer risk: transgenic models and clinical studies
    Derek C Radisky
    Department of Cancer Biology, Mayo Clinic, Jacksonville, FL 32224, USA
    J Mammary Gland Biol Neoplasia 14:181-91. 2009
    ..By contrast, new human studies show that completion of lobular involution protects against subsequent breast cancer incidence...
  7. pmc Fibrosis and cancer: do myofibroblasts come also from epithelial cells via EMT?
    Derek C Radisky
    Department of Cancer Biology, Mayo Clinic Cancer Center, Jacksonville, FL 32224, USA
    J Cell Biochem 101:830-9. 2007
    ..This connection provides a new perspective on the development of the fibrosis and tumor microenvironments...
  8. pmc Matrix metalloproteinase-induced genomic instability
    Derek C Radisky
    Mayo Clinic Cancer Center, Jacksonville, FL 32225, USA
    Curr Opin Genet Dev 16:45-50. 2006
    ..Delineating the mechanisms involved in these processes and identifying how they are coordinated in vivo could aid identification of the crucial contribution of MMPs to tumorigenesis...
  9. ncbi request reprint Epithelial-mesenchymal transition
    Derek C Radisky
    Mayo Clinic Cancer Center, Griffin Cancer Research Building, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    J Cell Sci 118:4325-6. 2005
  10. doi request reprint Epithelial-mesenchymal transition and the stem cell phenotype
    Derek C Radisky
    Mayo Clinic Cancer Center, Jacksonville, FL 32224, USA
    Cell Stem Cell 2:511-2. 2008
    ..In a recent issue of Cell, Mani et al. (2008) show that induction of EMT stimulates cultured breast cells to adopt characteristics of stem cells...
  11. pmc miR-200c at the nexus of epithelial-mesenchymal transition, resistance to apoptosis, and the breast cancer stem cell phenotype
    Derek C Radisky
    Department of Cancer Biology, Mayo Clinic, Jacksonville, FL 32224, USA
    Breast Cancer Res 13:110. 2011
    ..An article in the previous issue of Breast Cancer Research identifies additional targets of miR-200c that link increased cancer cell invasiveness, resistance to apoptosis, and induction of breast cancer stem cell characteristics...
  12. pmc Lobular involution: localized phenomenon or field effect?
    Robert A Vierkant
    Mayo Clinic Cancer Center, Rochester, MN, USA
    Breast Cancer Res Treat 117:193-6. 2009
    ..75, 95% CI 0.59, 0.89). Our study suggests that lobular involution is a homogeneous process, supporting the use of involution measures from a single benign biopsy as a component in breast cancer risk assessment paradigms...
  13. ncbi request reprint Matrix metalloproteinase-induced malignancy in mammary epithelial cells
    Melody Stallings-Mann
    Mayo Clinic Comprehensive Cancer Center, Jacksonville, Fla 32224, USA
    Cells Tissues Organs 185:104-10. 2007
    ....
  14. pmc Immune promotion of epithelial-mesenchymal transition and generation of breast cancer stem cells
    Jennifer M Reiman
    Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA
    Cancer Res 70:3005-8. 2010
    ..These studies provide a window to understanding how BCSC arise and are maintained within tumors, and how to best target these processes for therapeutic benefit...
  15. pmc Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells
    Marta Santisteban
    Department of Oncology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Res 69:2887-95. 2009
    ..These findings have several important implications related to disease progression and relapse...
  16. doi request reprint Matrix metalloproteinases stimulate epithelial-mesenchymal transition during tumor development
    Lidiya S Orlichenko
    Mayo Clinic Cancer Center, Jacksonville, FL 32224, USA
    Clin Exp Metastasis 25:593-600. 2008
    ..Here, we provide an overview of recent findings of MMP action in tumors and the mechanisms by which MMPs induce both phenotypic and genotypic alterations that facilitate tumor progression...
  17. ncbi request reprint Stromal induction of breast cancer: inflammation and invasion
    Evette S Radisky
    Mayo Clinic Cancer Center, Jacksonville, FL 32224, USA
    Rev Endocr Metab Disord 8:279-87. 2007
    ....
  18. ncbi request reprint Matrix metalloproteinase-induced epithelial-mesenchymal transition: tumor progression at Snail's pace
    Jennifer A Przybylo
    Mayo Clinic Cancer, 4500 San Pablo Avenue, Jacksonville, FL 32225, USA
    Int J Biochem Cell Biol 39:1082-8. 2007
    ..In this review, we examine how MMPs and Snail function in tumor progression and how identification of an MMP-Snail signaling axis provides insight into new anticancer therapeutic strategies...
  19. pmc Estrogen receptor expression in atypical hyperplasia: lack of association with breast cancer
    Fritcher Emily G Barr
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
    Cancer Prev Res (Phila) 4:435-44. 2011
    ..We found increasing ER expression in AH with increasing age. ER expression in AH does not further discriminate breast cancer risk in women with atypia...
  20. pmc Pseudoangiomatous stromal hyperplasia and breast cancer risk
    Amy C Degnim
    Department of Surgery, Mayo Clinic, Rochester, MN, USA
    Ann Surg Oncol 17:3269-77. 2010
    ..Pseudoangiomatous stromal hyperplasia (PASH) is a benign localized fibrotic lesion in which clusters of spindle cells form cleftlike spaces, resembling ectatic vessels. Its relationship to breast cancer risk has not been characterized...
  21. doi request reprint Separation anxiety: detachment from the extracellular matrix induces metabolic changes that can stimulate tumorigenesis
    Magdalena A Cichon
    Mayo Clinic Cancer Center, Jacksonville, FL 32225, USA
    J Mol Cell Biol 2:113-5. 2010
    ..New research using a physiologically relevant breast cancer model reveals how separation from the ECM stimulates metabolic changes characteristic of developing tumors...
  22. doi request reprint Neuropilin-1 upholds dedifferentiation and propagation phenotypes of renal cell carcinoma cells by activating Akt and sonic hedgehog axes
    Ying Cao
    Department of Biochemistry and Molecular Biology, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Res 68:8667-72. 2008
    ..Inhibition of sonic hedgehog expression can be reversed by DeltaNp63alpha overexpression. Our study reveals that NRP-1 helps maintain an undifferentiated phenotype in cancer cells...
  23. pmc The 19-amino acid insertion in the tumor-associated splice isoform Rac1b confers specific binding to p120 catenin
    Lidiya Orlichenko
    Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida 32224, USA
    J Biol Chem 285:19153-61. 2010
    ....
  24. pmc Novel breast tissue feature strongly associated with risk of breast cancer
    Kevin P McKian
    Department of Oncology, Mayo Clinic Cancer Center, Mayo Graduate School of Medical Education, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Clin Oncol 27:5893-8. 2009
    ..Breast lobules are the anatomic sites of origin of breast cancer. As women age, these lobular structures should regress, which results in reduced breast cancer risk. However, this does not occur in all women...
  25. pmc Association between mammographic density and age-related lobular involution of the breast
    Karthik Ghosh
    Division of General Internal Medicine, Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Clin Oncol 28:2207-12. 2010
    ..We examined the involution and density association in a large benign breast disease (BBD) cohort...
  26. pmc Reactivation of suppressed RhoB is a critical step for the inhibition of anaplastic thyroid cancer growth
    Laura A Marlow
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Jacksonville, Florida 32224, USA
    Cancer Res 69:1536-44. 2009
    ..Our results implicate RhoB as a novel intermediate in critical signaling pathways and as an additional target for therapeutic intervention in ATC...
  27. pmc Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia
    Jordi Alcaraz
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    EMBO J 27:2829-38. 2008
    ..Our data indicate that tissue-specific gene expression is controlled by both the tissues' unique biochemical milieu and mechanical properties, processes involved in maintenance of tissue integrity and protection against tumorigenesis...
  28. pmc Delivering the message: epimorphin and mammary epithelial morphogenesis
    Derek C Radisky
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Trends Cell Biol 13:426-34. 2003
    ..We conclude with a review of recent studies that suggest similar morphogenic roles for epimorphin in other glandular organs...
  29. ncbi request reprint Cancer. Respect thy neighbor!
    Derek C Radisky
    Division of Life Sciences, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    Science 303:775-7. 2004
  30. ncbi request reprint Proliferation and polarity in breast cancer: untying the Gordian knot
    Hong Liu
    Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Cell Cycle 4:646-9. 2005
    ....
  31. pmc Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
    Derek C Radisky
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Nature 436:123-7. 2005
    ..These findings identify a previously undescribed pathway in which a component of the breast tumour microenvironment alters cellular structure in culture and tissue structure in vivo, leading to malignant transformation...
  32. ncbi request reprint NF-kappaB links oestrogen receptor signalling and EMT
    Derek C Radisky
    Nat Cell Biol 9:361-3. 2007
  33. ncbi request reprint Leading the charge
    Derek C Radisky
    Nat Cell Biol 9:1341-2. 2007
    ..To achieve this, leading cells trigger both proteolytic and structural modifications of the ECM to create channels that precede progressively widening chains of following cells...
  34. pmc Mechanisms of disease: epithelial-mesenchymal transition--does cellular plasticity fuel neoplastic progression?
    Eva A Turley
    London Health Sciences Centre, University of Western Ontario, London, ON, Canada
    Nat Clin Pract Oncol 5:280-90. 2008
    ..We also highlight the role of RAS-controlled signaling mediators, ERK1, ERK2 and phosphatidylinositol 3-kinase, as microenvironmental responsive regulators of EMT...
  35. pmc Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells
    Celeste M Nelson
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Cell Biochem 105:25-33. 2008
    ..Our data reveal a previously unanticipated cell shape-dependent mechanism that controls this key phenotypic alteration and provide insight into the distinct mechanisms activated by different EMT-inducing agents...
  36. pmc Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2
    Hong Liu
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 103:4134-9. 2006
    ....
  37. ncbi request reprint Non-classical export of epimorphin and its adhesion to alphav-integrin in regulation of epithelial morphogenesis
    Yohei Hirai
    Department of Morphoregulation, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Cell Sci 120:2032-43. 2007
    ..These findings provide key insight into how epimorphin functions as an epithelial morphogen...
  38. pmc Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells
    Hong Liu
    Life Science Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, CA 94720, USA
    J Cell Biol 164:603-12. 2004
    ..These findings reveal key events of the PI3K pathway that play distinct roles to maintain tissue polarity and that when disrupted are instrumental in the malignant phenotype...
  39. ncbi request reprint Malignant mammary cells acquire independence from extracellular context for regulation of estrogen receptor alpha
    Virginia Novaro
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, and Dipartimento di Patologia generale, Seconda Universita degli Studi di Napoli, Napoli, Italy
    Clin Cancer Res 10:402S-9S. 2004
    ..Evidence is presented to show the relevance of the cross-talk between different signaling pathways in the constitution of a functional tissue organization and how this integration may be disrupted in the malignant phenotype...
  40. pmc The organizing principle: microenvironmental influences in the normal and malignant breast
    Mina J Bissell
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Differentiation 70:537-46. 2002
    ..How this context determines functional integrity, and how its loss can lead to malignancy, appears to have much to do with tissue structure and polarity...

Research Grants4

  1. Mechanisms of MMP-Induced Malignancy in Breast Cells
    Derek Radisky; Fiscal Year: 2007
    ..We expect that by elucidating the chain of events in the induction of EMT and genomic instability by MMPs, we will be able to identify novel promising points for therapeutic intervention in breast cancer. ..
  2. Mechanisms of MMP-Induced Malignancy in Breast Cells
    Derek C Radisky; Fiscal Year: 2010
    ..We expect that by elucidating the chain of events in the induction of EMT and genomic instability by MMPs, we will be able to identify novel promising points for therapeutic intervention in breast cancer. ..