Research Topics
| Jens U PonikauSummaryAffiliation: Mayo Clinic Country: USA Publications
| Collaborators
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Detail Information
Publications
Detection of fungal organisms in eosinophilic mucin using a fluorescein-labeled chitin-specific binding proteinMatthew J Taylor
Division of Allergy and Infection Diseases, Mayo Clinic, Rochester, MN 55905, USA
Otolaryngol Head Neck Surg 127:377-83. 2002..CONCLUSION: The fluorescein-labeled chitinase-staining technique has greater sensitivity in detecting fungal organisms within eosinophilic mucin. Fungal organisms are present in the mucin of CRS patients...- Striking deposition of toxic eosinophil major basic protein in mucus: implications for chronic rhinosinusitisJens U Ponikau
Department of Otorhinolaryngology Head and Neck Surgery, Mayo Clinic Rochester, Rochester, MN 55905, USA
J Allergy Clin Immunol 116:362-9. 2005..The mechanisms by which eosinophilic inflammation damages the epithelium and contributes to recurrent acute exacerbations in chronic rhinosinusitis (CRS) have not been fully elucidated... - The role of ubiquitous airborne fungi in chronic rhinosinusitisJens U Ponikau
Department of Otorhinolaryngology, University at Buffalo, State University of New York, Buffalo, New York, USA
Clin Allergy Immunol 20:177-84. 2007 - Treatment of chronic rhinosinusitis with intranasal amphotericin B: a randomized, placebo-controlled, double-blind pilot trialJens U Ponikau
Department of Otorhinolaryngology Head and Neck Surgery, Mayo Clinic, Rochester, MN 55905, USA
J Allergy Clin Immunol 115:125-31. 2005..Chronic rhinosinusitis (CRS) is one of the most common chronic diseases. Its etiology is unknown, and there is a paucity of effective medical treatments... - The chemotactic behavior of eosinophils in patients with chronic rhinosinusitisJulie L Wei
Department of Otorhinolaryngology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
Laryngoscope 113:303-6. 2003..Because the eosinophils were obtained from the peripheral blood, this finding suggests activation of eosinophils in the systemic circulation in chronic rhinosinusitis... - Intranasal antifungal treatment in 51 patients with chronic rhinosinusitisJens U Ponikau
Department of Otorhinolaryngology-Head and Neck Surgery, Mayo Clinic Rochester, Rochester, MN 55905, USA
J Allergy Clin Immunol 110:862-6. 2002..Therefore controlled and blinded trials are indicated to clarify the novel role of intranasal antifungal drugs in the treatment of CRS... - New paradigm for the roles of fungi and eosinophils in chronic rhinosinusitisJan Sasama
Department of Otorhinolaryngology, Mayo Clinic Rochester, Rochester, Minnesota 55905, USA
Curr Opin Otolaryngol Head Neck Surg 13:2-8. 2005..Chronic rhinosinusitis represents a challenge with its poorly understood pathophysiology and limited treatment options. Potential roles of fungi and eosinophils in the etiology and pathophysiology of chronic rhinosinusitis are summarized... 
Recognition of fungal protease activities induces cellular activation and eosinophil-derived neurotoxin release in human eosinophilsYoshinori Matsuwaki
Department of Medicine and Immunology, Mayo Clinic, Rochester, MN 55905, USA
J Immunol 183:6708-16. 2009..Thus, fungal aspartate protease and eosinophil PAR-2 appear critical for the eosinophils' innate immune response to certain fungi, suggesting a novel mechanism for pathologic inflammation in asthma and for host-pathogen interaction...- Features of airway remodeling and eosinophilic inflammation in chronic rhinosinusitis: is the histopathology similar to asthma?Jens U Ponikau
Department of Otolaryngology Head and Neck Surgery, Mayo Clinic, Rochester, Minn 55905, USA
J Allergy Clin Immunol 112:877-82. 2003..Although epithelial damage and basement membrane thickening are well-known features of airway remodeling in asthma, they have not been described in CRS... - Chronic rhinosinusitis: an enhanced immune response to ubiquitous airborne fungiSeung-Heon Shin
Department of Internal Medicine, Mayo Clinic Rochester, Rochester, MN 55905, USA
J Allergy Clin Immunol 114:1369-75. 2004..The anomalous immune and inflammatory responses to ubiquitous fungi may explain the chronicity of airway inflammation in CRS... - Nonpathogenic, environmental fungi induce activation and degranulation of human eosinophilsYoshinari Inoue
Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA
J Immunol 175:5439-47. 2005..This innate response by eosinophils to certain environmental fungi may be important in host defense and in the exacerbation of inflammation in asthma and allergic diseases... - Eosinophilic fungal rhinosinusitis of the lacrimal sacMichelle L Facer
Department of Otorhinolaryngology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
Laryngoscope 113:210-4. 2003..CONCLUSIONS: Although never previously reported, eosinophilic fungal rhinosinusitis can occur in the lacrimal sac. It is important to recognize this so that the underlying disease process can be treated appropriately... - Innate antifungal immunity of human eosinophils mediated by a beta 2 integrin, CD11bJuhan Yoon
Department of Immunology, Division of Allergic Disease, Mayo Graduate School, Mayo Clinic, Rochester, MN 55905, USA
J Immunol 181:2907-15. 2008..This immune response by eosinophils may benefit the host, but, in turn, it may also play a role in the development and/or exacerbation of eosinophil-related allergic human diseases, such as asthma... - The role of airborne mold in chronic rhinosinusitisJens U Ponikau
J Allergy Clin Immunol 118:762-3; author reply 767-8. 2006 - The role of ubiquitous airborne fungi in chronic rhinosinusitisJens U Ponikau
Department of Otorhinolaryngology, University at Buffalo, The State University of New York, Buffalo, NY, USA
Clin Rev Allergy Immunol 30:187-94. 2006..Overall, these recent discoveries provide a logical mechanism for the pathophysiology of CRS, and they also suggest promising avenues for treatment of CRS with antifungal agents... - Rhinosinusitis: developing guidance for clinical trialsEli O Meltzer
Allergy and Asthma Medical Group and Research Center and Department of Pediatrics, University of California, San Diego, USA
J Allergy Clin Immunol 118:S17-61. 2006.... - The role of ubiquitous airborne fungi in chronic rhinosinusitisJens U Ponikau
Department of Otorhinolaryngology, University at Buffalo, The State University of New York, 3C41 Millard Fillmore Hospital, 3 Gates Circle, Buffalo, NY 14209, USA
Curr Allergy Asthma Rep 5:472-6. 2005..Overall, these recent discoveries provide a logical mechanism for the pathophysiology of CRS, and they also suggest promising avenues for treatment of CRS with antifungal agents... - Rhinosinusitis: Developing guidance for clinical trialsEli O Meltzer
Allergy and Asthma Medical Group and Research Center Department of Pediatrics, University of California, San Diego, San Diego, California
Otolaryngol Head Neck Surg 135:S31-80. 2006.... - Airway manifestations of pediatric eosinophilic esophagitis: a clinical and histopathologic report of an emerging associationEileen H Dauer
Department of Otorhinolaryngology-Head and Neck Surgery, Mayo Eugenio Litta Children's Hospital Rochester, Minnesota, USA
Ann Otol Rhinol Laryngol 115:507-17. 2006..Treatment with swallowed fluticasone is successful; however, relapses are common and require repeat treatment and close follow-up...