Jens U Ponikau

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi request reprint Detection of fungal organisms in eosinophilic mucin using a fluorescein-labeled chitin-specific binding protein
    Matthew J Taylor
    Division of Allergy and Infection Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Otolaryngol Head Neck Surg 127:377-83. 2002
  2. ncbi request reprint Striking deposition of toxic eosinophil major basic protein in mucus: implications for chronic rhinosinusitis
    Jens U Ponikau
    Department of Otorhinolaryngology Head and Neck Surgery, Mayo Clinic Rochester, Rochester, MN 55905, USA
    J Allergy Clin Immunol 116:362-9. 2005
  3. ncbi request reprint The role of ubiquitous airborne fungi in chronic rhinosinusitis
    Jens U Ponikau
    Department of Otorhinolaryngology, University at Buffalo, State University of New York, Buffalo, New York, USA
    Clin Allergy Immunol 20:177-84. 2007
  4. ncbi request reprint Treatment of chronic rhinosinusitis with intranasal amphotericin B: a randomized, placebo-controlled, double-blind pilot trial
    Jens U Ponikau
    Department of Otorhinolaryngology Head and Neck Surgery, Mayo Clinic, Rochester, MN 55905, USA
    J Allergy Clin Immunol 115:125-31. 2005
  5. ncbi request reprint The chemotactic behavior of eosinophils in patients with chronic rhinosinusitis
    Julie L Wei
    Department of Otorhinolaryngology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    Laryngoscope 113:303-6. 2003
  6. ncbi request reprint Intranasal antifungal treatment in 51 patients with chronic rhinosinusitis
    Jens U Ponikau
    Department of Otorhinolaryngology Head and Neck Surgery, Mayo Clinic Rochester, Rochester, MN 55905, USA
    J Allergy Clin Immunol 110:862-6. 2002
  7. ncbi request reprint New paradigm for the roles of fungi and eosinophils in chronic rhinosinusitis
    Jan Sasama
    Department of Otorhinolaryngology, Mayo Clinic Rochester, Rochester, Minnesota 55905, USA
    Curr Opin Otolaryngol Head Neck Surg 13:2-8. 2005
  8. pmc Recognition of fungal protease activities induces cellular activation and eosinophil-derived neurotoxin release in human eosinophils
    Yoshinori Matsuwaki
    Department of Medicine and Immunology, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 183:6708-16. 2009
  9. ncbi request reprint Features of airway remodeling and eosinophilic inflammation in chronic rhinosinusitis: is the histopathology similar to asthma?
    Jens U Ponikau
    Department of Otolaryngology Head and Neck Surgery, Mayo Clinic, Rochester, Minn 55905, USA
    J Allergy Clin Immunol 112:877-82. 2003
  10. ncbi request reprint Chronic rhinosinusitis: an enhanced immune response to ubiquitous airborne fungi
    Seung Heon Shin
    Department of Internal Medicine, Mayo Clinic Rochester, Rochester, MN 55905, USA
    J Allergy Clin Immunol 114:1369-75. 2004

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Detection of fungal organisms in eosinophilic mucin using a fluorescein-labeled chitin-specific binding protein
    Matthew J Taylor
    Division of Allergy and Infection Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Otolaryngol Head Neck Surg 127:377-83. 2002
    ..The ability to identify fungal hyphae in patients with chronic rhinosinusitis (CRS) has been inconsistent. A new fluorescein-labeled staining method targets chitin found in fungal cell walls...
  2. ncbi request reprint Striking deposition of toxic eosinophil major basic protein in mucus: implications for chronic rhinosinusitis
    Jens U Ponikau
    Department of Otorhinolaryngology Head and Neck Surgery, Mayo Clinic Rochester, Rochester, MN 55905, USA
    J Allergy Clin Immunol 116:362-9. 2005
    ..The mechanisms by which eosinophilic inflammation damages the epithelium and contributes to recurrent acute exacerbations in chronic rhinosinusitis (CRS) have not been fully elucidated...
  3. ncbi request reprint The role of ubiquitous airborne fungi in chronic rhinosinusitis
    Jens U Ponikau
    Department of Otorhinolaryngology, University at Buffalo, State University of New York, Buffalo, New York, USA
    Clin Allergy Immunol 20:177-84. 2007
  4. ncbi request reprint Treatment of chronic rhinosinusitis with intranasal amphotericin B: a randomized, placebo-controlled, double-blind pilot trial
    Jens U Ponikau
    Department of Otorhinolaryngology Head and Neck Surgery, Mayo Clinic, Rochester, MN 55905, USA
    J Allergy Clin Immunol 115:125-31. 2005
    ..Chronic rhinosinusitis (CRS) is one of the most common chronic diseases. Its etiology is unknown, and there is a paucity of effective medical treatments...
  5. ncbi request reprint The chemotactic behavior of eosinophils in patients with chronic rhinosinusitis
    Julie L Wei
    Department of Otorhinolaryngology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    Laryngoscope 113:303-6. 2003
    ..To characterize peripheral eosinophil migration in patients with chronic rhinosinusitis in the presence of nasal mucin and nasal tissue extracts...
  6. ncbi request reprint Intranasal antifungal treatment in 51 patients with chronic rhinosinusitis
    Jens U Ponikau
    Department of Otorhinolaryngology Head and Neck Surgery, Mayo Clinic Rochester, Rochester, MN 55905, USA
    J Allergy Clin Immunol 110:862-6. 2002
    ..Chronic rhinosinusitis (CRS) is the most common chronic disease that is frequently refractory to treatment...
  7. ncbi request reprint New paradigm for the roles of fungi and eosinophils in chronic rhinosinusitis
    Jan Sasama
    Department of Otorhinolaryngology, Mayo Clinic Rochester, Rochester, Minnesota 55905, USA
    Curr Opin Otolaryngol Head Neck Surg 13:2-8. 2005
    ..Chronic rhinosinusitis represents a challenge with its poorly understood pathophysiology and limited treatment options. Potential roles of fungi and eosinophils in the etiology and pathophysiology of chronic rhinosinusitis are summarized...
  8. pmc Recognition of fungal protease activities induces cellular activation and eosinophil-derived neurotoxin release in human eosinophils
    Yoshinori Matsuwaki
    Department of Medicine and Immunology, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 183:6708-16. 2009
    ..Thus, fungal aspartate protease and eosinophil PAR-2 appear critical for the eosinophils' innate immune response to certain fungi, suggesting a novel mechanism for pathologic inflammation in asthma and for host-pathogen interaction...
  9. ncbi request reprint Features of airway remodeling and eosinophilic inflammation in chronic rhinosinusitis: is the histopathology similar to asthma?
    Jens U Ponikau
    Department of Otolaryngology Head and Neck Surgery, Mayo Clinic, Rochester, Minn 55905, USA
    J Allergy Clin Immunol 112:877-82. 2003
    ..Although epithelial damage and basement membrane thickening are well-known features of airway remodeling in asthma, they have not been described in CRS...
  10. ncbi request reprint Chronic rhinosinusitis: an enhanced immune response to ubiquitous airborne fungi
    Seung Heon Shin
    Department of Internal Medicine, Mayo Clinic Rochester, Rochester, MN 55905, USA
    J Allergy Clin Immunol 114:1369-75. 2004
    ..Chronic rhinosinusitis (CRS) is one of the most common long-term illnesses in the United States. The etiology of CRS is unknown, and no effective treatment has been established...
  11. ncbi request reprint Nonpathogenic, environmental fungi induce activation and degranulation of human eosinophils
    Yoshinari Inoue
    Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 175:5439-47. 2005
    ..This innate response by eosinophils to certain environmental fungi may be important in host defense and in the exacerbation of inflammation in asthma and allergic diseases...
  12. ncbi request reprint Eosinophilic fungal rhinosinusitis of the lacrimal sac
    Michelle L Facer
    Department of Otorhinolaryngology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    Laryngoscope 113:210-4. 2003
    ..We report a case of eosinophilic fungal rhinosinusitis of the lacrimal sac, an entity not previously reported...
  13. pmc Innate antifungal immunity of human eosinophils mediated by a beta 2 integrin, CD11b
    Juhan Yoon
    Department of Immunology, Division of Allergic Disease, Mayo Graduate School, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 181:2907-15. 2008
    ..This immune response by eosinophils may benefit the host, but, in turn, it may also play a role in the development and/or exacerbation of eosinophil-related allergic human diseases, such as asthma...
  14. ncbi request reprint The role of airborne mold in chronic rhinosinusitis
    Jens U Ponikau
    J Allergy Clin Immunol 118:762-3; author reply 767-8. 2006
  15. ncbi request reprint The role of ubiquitous airborne fungi in chronic rhinosinusitis
    Jens U Ponikau
    Department of Otorhinolaryngology, University at Buffalo, The State University of New York, Buffalo, NY, USA
    Clin Rev Allergy Immunol 30:187-94. 2006
    ..Overall, these recent discoveries provide a logical mechanism for the pathophysiology of CRS, and they also suggest promising avenues for treatment of CRS with antifungal agents...
  16. ncbi request reprint Rhinosinusitis: developing guidance for clinical trials
    Eli O Meltzer
    Allergy and Asthma Medical Group and Research Center and Department of Pediatrics, University of California, San Diego, USA
    J Allergy Clin Immunol 118:S17-61. 2006
    ....
  17. ncbi request reprint The role of ubiquitous airborne fungi in chronic rhinosinusitis
    Jens U Ponikau
    Department of Otorhinolaryngology, University at Buffalo, The State University of New York, 3C41 Millard Fillmore Hospital, 3 Gates Circle, Buffalo, NY 14209, USA
    Curr Allergy Asthma Rep 5:472-6. 2005
    ..Overall, these recent discoveries provide a logical mechanism for the pathophysiology of CRS, and they also suggest promising avenues for treatment of CRS with antifungal agents...
  18. ncbi request reprint Rhinosinusitis: Developing guidance for clinical trials
    Eli O Meltzer
    Allergy and Asthma Medical Group and Research Center Department of Pediatrics, University of California, San Diego, San Diego, California
    Otolaryngol Head Neck Surg 135:S31-80. 2006
    ....
  19. ncbi request reprint Airway manifestations of pediatric eosinophilic esophagitis: a clinical and histopathologic report of an emerging association
    Eileen H Dauer
    Department of Otorhinolaryngology Head and Neck Surgery, Mayo Eugenio Litta Children s Hospital Rochester, Minnesota, USA
    Ann Otol Rhinol Laryngol 115:507-17. 2006
    ....