Gregory Poland

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Vaccinomics and personalized vaccinology: is science leading us toward a new path of directed vaccine development and discovery?
    Gregory A Poland
    Mayo Vaccine Research Group, Department of Medicine, Mayo Clinic College of Medicine, Mayo Foundation, Rochester, Minnesota, United States of America
    PLoS Pathog 7:e1002344. 2011
  2. pmc Transcriptomic profiles of high and low antibody responders to smallpox vaccine
    R B Kennedy
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN, USA
    Genes Immun 14:277-85. 2013
  3. pmc Genome-wide characterization of transcriptional patterns in high and low antibody responders to rubella vaccination
    Iana H Haralambieva
    Vaccine Research Group, Mayo Clinic, Rochester, Minnesota, USA
    PLoS ONE 8:e62149. 2013
  4. pmc Ontology-based time information representation of vaccine adverse events in VAERS for temporal analysis
    Cui Tao
    Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA
    J Biomed Semantics 3:13. 2012
  5. pmc Technical and biological variance structure in mRNA-Seq data: life in the real world
    Ann L Oberg
    Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
    BMC Genomics 13:304. 2012
  6. pmc Vaccinomics, adversomics, and the immune response network theory: individualized vaccinology in the 21st century
    Gregory A Poland
    Mayo Clinic Vaccine Research Group, Rochester, MN 55905, USA
    Semin Immunol 25:89-103. 2013
  7. doi request reprint New Wisdom to Defy an Old Enemy: Summary from a scientific symposium at the 4th Influenza Vaccines for the World (IVW) 2012 Congress, 11 October, Valencia, Spain
    Gregory A Poland
    Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Vaccine 31:A1-20. 2013
  8. ncbi request reprint The clinician's guide to the anti-vaccinationists' galaxy
    Gregory A Poland
    Mayo Clinic Vaccine Research Group, Mayo Clinic, 611C Guggenheim Building, 200 First Street, SW Rochester, MN 55905, USA
    Hum Immunol 73:859-66. 2012
  9. pmc Associations between SNPs in candidate immune-relevant genes and rubella antibody levels: a multigenic assessment
    V Shane Pankratz
    Division of Biomedical Statistics and Informatics, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA
    BMC Immunol 11:48. 2010
  10. pmc 3' tag digital gene expression profiling of human brain and universal reference RNA using Illumina Genome Analyzer
    Yan W Asmann
    Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
    BMC Genomics 10:531. 2009

Research Grants

  1. The Immunogenetics of Measles Immunity
    Gregory A Poland; Fiscal Year: 2010
  2. IMMUNOGENETIC MECHANISMS OF VACCINE RESPONSE
    Gregory Poland; Fiscal Year: 2007
  3. IMMUNOGENETIC MECHANISMS OF VACCINE RESPONSE
    Gregory Poland; Fiscal Year: 2006
  4. NATURE OF MEASLES IMMUNITY IN TWO POPULATIONS
    Gregory Poland; Fiscal Year: 1999
  5. IMMUNOGENETIC MECHANISMS OF VACCINE RESPONSE
    Gregory A Poland; Fiscal Year: 2010
  6. The Immunogenetics of Measles Immunity
    Gregory Poland; Fiscal Year: 2009
  7. IMMUNOGENETIC MECHANISMS OF VACCINE RESPONSE
    Gregory Poland; Fiscal Year: 2009
  8. The Immunogenetics of Measles Immunity
    Gregory Poland; Fiscal Year: 2006
  9. IMMUNOGENETIC MECHANISMS OF VACCINE RESPONSE
    Gregory Poland; Fiscal Year: 2003
  10. The Immunogenetics of Measles Immunity
    Gregory Poland; Fiscal Year: 2004

Detail Information

Publications115 found, 100 shown here

  1. pmc Vaccinomics and personalized vaccinology: is science leading us toward a new path of directed vaccine development and discovery?
    Gregory A Poland
    Mayo Vaccine Research Group, Department of Medicine, Mayo Clinic College of Medicine, Mayo Foundation, Rochester, Minnesota, United States of America
    PLoS Pathog 7:e1002344. 2011
    ..While our laboratory's data and thinking (and hence also for this paper) has been directed toward viruses and viral vaccines, generalization to other pathogens and disease entities (i.e., anti-cancer vaccines) may be appropriate...
  2. pmc Transcriptomic profiles of high and low antibody responders to smallpox vaccine
    R B Kennedy
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN, USA
    Genes Immun 14:277-85. 2013
    ..Our results provide evidence that differential gene regulation patterns may be at work in individuals with robust humoral immunity compared with those with weaker humoral immune responses. ..
  3. pmc Genome-wide characterization of transcriptional patterns in high and low antibody responders to rubella vaccination
    Iana H Haralambieva
    Vaccine Research Group, Mayo Clinic, Rochester, Minnesota, USA
    PLoS ONE 8:e62149. 2013
    ..Such information may provide new scientific insights into vaccine-induced immunity useful in rational vaccine development and immune response monitoring...
  4. pmc Ontology-based time information representation of vaccine adverse events in VAERS for temporal analysis
    Cui Tao
    Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA
    J Biomed Semantics 3:13. 2012
    ..abstract:..
  5. pmc Technical and biological variance structure in mRNA-Seq data: life in the real world
    Ann L Oberg
    Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
    BMC Genomics 13:304. 2012
    ..The Negative Binomial distribution which allows for over-dispersion, i.e., for the variance to be greater than the mean, is commonly used to model count data as well...
  6. pmc Vaccinomics, adversomics, and the immune response network theory: individualized vaccinology in the 21st century
    Gregory A Poland
    Mayo Clinic Vaccine Research Group, Rochester, MN 55905, USA
    Semin Immunol 25:89-103. 2013
    ..Herein, we discuss the above with a view toward the future of vaccinology. ..
  7. doi request reprint New Wisdom to Defy an Old Enemy: Summary from a scientific symposium at the 4th Influenza Vaccines for the World (IVW) 2012 Congress, 11 October, Valencia, Spain
    Gregory A Poland
    Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Vaccine 31:A1-20. 2013
    ....
  8. ncbi request reprint The clinician's guide to the anti-vaccinationists' galaxy
    Gregory A Poland
    Mayo Clinic Vaccine Research Group, Mayo Clinic, 611C Guggenheim Building, 200 First Street, SW Rochester, MN 55905, USA
    Hum Immunol 73:859-66. 2012
    ..It is hoped that clinicians will find this information useful in answering concerns and misconceptions about vaccines, and in educating their patients...
  9. pmc Associations between SNPs in candidate immune-relevant genes and rubella antibody levels: a multigenic assessment
    V Shane Pankratz
    Division of Biomedical Statistics and Informatics, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA
    BMC Immunol 11:48. 2010
    ..Associations between rubella-specific antibody levels and 726 candidate tagSNPs were assessed both one SNP at a time and in a variety of multigenic analyses...
  10. pmc 3' tag digital gene expression profiling of human brain and universal reference RNA using Illumina Genome Analyzer
    Yan W Asmann
    Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
    BMC Genomics 10:531. 2009
    ..In this preliminary effort, we evaluated the 3' DGE approach using two reference RNA samples from the MicroArray Quality Control Consortium (MAQC)...
  11. pmc SNPPicker: high quality tag SNP selection across multiple populations
    Hugues Sicotte
    Department of Biomedical STatistics and Informatics, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA
    BMC Bioinformatics 12:129. 2011
    ....
  12. ncbi request reprint Immunogenicity and reactogenicity of a novel vaccine for human papillomavirus 16: a 2-year randomized controlled clinical trial
    Gregory A Poland
    Division of General Internal Medicine, Mayo Vaccine Research Group, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 80:601-10. 2005
    ..To evaluate the immunogenicity, reactogenicity, and tolerability of a prototype human papillomavirus (HPV) 16 viruslike particle (VLP) vaccine directed against the L1 capsid protein...
  13. ncbi request reprint Vaccine availability in the US: problems and solutions
    Gregory A Poland
    Mayo Vaccine Research Group and Program in Translational Immunovirology and Biodefense, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Nat Immunol 5:1195-8. 2004
  14. ncbi request reprint Clinical practice: prevention of hepatitis B with the hepatitis B vaccine
    Gregory A Poland
    Mayo Vaccine Research Group, Program in Translational Immunovirology and Biodefense, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    N Engl J Med 351:2832-8. 2004
  15. ncbi request reprint Smallpox vaccines: from first to second to third generation
    Gregory A Poland
    Mayo Vaccine Research Group and Program in Translational Immunovirology and Biodefense, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Lancet 365:362-3. 2005
  16. ncbi request reprint The US smallpox vaccination program: a review of a large modern era smallpox vaccination implementation program
    Gregory A Poland
    Mayo Vaccine Research Group, and Department of Medicine, Program in Translational Immunovirology and Biodefense, 611 C Guggenheim Building, 200 First Street, SW, Mayo Clinic and Foundation, Rochester, Minnesota, MN, USA
    Vaccine 23:2078-81. 2005
    ..These results should inform current and future vaccinia vaccination programs and provide a historical rate of complications against which candidate vaccine side-effects can be compared in future clinical trials...
  17. ncbi request reprint Health care workers and influenza vaccine: first do no harm, then do the right thing
    Gregory A Poland
    Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Am Pharm Assoc (2003) 44:637-8. 2004
  18. ncbi request reprint Requiring influenza vaccination for health care workers: seven truths we must accept
    Gregory A Poland
    Mayo Vaccine Research Group, 611 C Guggenheim Building, 200 First Street, SW, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Vaccine 23:2251-5. 2005
    ..High rates of health care worker immunization will benefit patients, health care workers, their families and employers, and the communities within which they work and live...
  19. doi request reprint Increasing influenza vaccination rates: the need to vaccinate throughout the entire influenza season
    Gregory A Poland
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Med 121:S3-10. 2008
    ....
  20. doi request reprint Receptivity to mandatory influenza vaccination policies for healthcare workers among registered nurses working on inpatient units
    Gregory A Poland
    Mayo Vaccine Research Group, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Infect Control Hosp Epidemiol 29:170-3. 2008
    ..4%) of 512 RNs reported that they would support a policy requiring annual influenza vaccination for healthcare workers that allowed for informed declination...
  21. pmc Vaccine immunogenetics: bedside to bench to population
    Gregory A Poland
    Mayo Vaccine Research Group, The Program in Translational Immunovirology and Biodefense, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Vaccine 26:6183-8. 2008
    ..Such information may provide further understanding of genetic restrictions that influence the generation of protective immune responses to vaccines, and eventually the development of new vaccines...
  22. ncbi request reprint Heterogeneity in vaccine immune response: the role of immunogenetics and the emerging field of vaccinomics
    G A Poland
    Mayo Vaccine Research Group and the Program in Translational Immunovirology and Biodefense, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Clin Pharmacol Ther 82:653-64. 2007
    ..e., is the individual at risk for the outcome for which the vaccine is being administered?)...
  23. doi request reprint Health care worker pertussis immunization requirements and patient safety
    Gregory A Poland
    Mayo Clinic Vaccine Research Group, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Am J Infect Control 36:390-1. 2008
  24. pmc Personalized vaccines: the emerging field of vaccinomics
    Gregory A Poland
    Mayo Clinic College of Medicine, Mayo Vaccine Research Group, Program in TranslationalImmunovirology and Biodefense, Mayo Clinic, Rochester, Minnesota 55905, USA
    Expert Opin Biol Ther 8:1659-67. 2008
    ..This paper reviews the basis and logic of personalized vaccines, and describes recent advances in the field...
  25. pmc Trends affecting the future of vaccine development and delivery: the role of demographics, regulatory science, the anti-vaccine movement, and vaccinomics
    Gregory A Poland
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Vaccine 27:3240-4. 2009
    ..These issues have been under-valued, under-discussed, and in some cases, ignored. We hope that discussion of these issues will result in changes in how we develop, and how we communicate those developments, to the public...
  26. ncbi request reprint Avian and pandemic influenza: an overview
    Gregory A Poland
    Mayo Vaccine Research Group, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Vaccine 25:3057-61. 2007
    ..This brief overview will review basic virologic, immunologic and epidemiologic information relevant to understanding and preparing for this threat. In particular, the role of avian influenza vaccines will be reviewed...
  27. pmc Immunogenetics of seasonal influenza vaccine response
    Gregory A Poland
    Mayo Vaccine Research Group, The Program in Translational Immunovirology and Biodefense, Mayo Clinic, 611C Guggenheim Building, 200 First Street, SW, Rochester, MN 55905, USA
    Vaccine 26:D35-40. 2008
    ..Finally, we propose that a better understanding of vaccine immunogenetics offers insight towards the development of better influenza vaccines...
  28. pmc The social, political, ethical, and economic aspects of biodefense vaccines
    Gregory A Poland
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Vaccine 27:D23-7. 2009
    ..In this article we define bioterrorism as the deliberate use of naturally occurring or bioengineered microorganisms in order to cause harm to people, animals, or plants...
  29. ncbi request reprint Evaluating existing recommendations for hepatitis A and B vaccination
    Gregory A Poland
    Mayo Vaccine Research Group, Program in Translational Immunovirology and Biodefense, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Med 118:16S-20S. 2005
    ....
  30. doi request reprint Prevention of meningococcal disease: current use of polysaccharide and conjugate vaccines
    Gregory A Poland
    Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Clin Infect Dis 50:S45-53. 2010
    ..Obstacles to achieving optimal vaccine coverage among adolescents persist, and strategies are needed to address these shortcomings...
  31. doi request reprint The 2009-2010 influenza pandemic: effects on pandemic and seasonal vaccine uptake and lessons learned for seasonal vaccination campaigns
    Gregory A Poland
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Vaccine 28:D3-13. 2010
    ..This article explores what has been learned about cross-cultural responses to pandemic influenza, and seeks to apply those lessons to seasonal influenza immunization programs...
  32. ncbi request reprint Smallpox vaccine: problems and prospects
    Gregory A Poland
    Mayo Vaccine Research Group, Mayo Clinic and Foundation, 611C Guggenheim Building, 200 First Street SW, Rochester, MN 55905, USA
    Immunol Allergy Clin North Am 23:731-43. 2003
    ....
  33. ncbi request reprint The role of sodium bisulfite in the 1996-1997 USA influenza vaccine recall
    G A Poland
    Mayo Clinic and Foundation, Mayo Vaccine Research Group, Rochester, Minnesota 55905, USA
    Vaccine 16:1865-8. 1998
    ..This paper reviews these events and what we have learned...
  34. pmc Application of pharmacogenomics to vaccines
    Gregory A Poland
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Pharmacogenomics 10:837-52. 2009
    ..Additional benefits from vaccinomic studies include the development of personalized vaccines, the development of novel vaccines and the development of novel vaccine adjuvants...
  35. pmc New vaccine development
    Gregory A Poland
    Mayo Vaccine Research Group, 611C Guggenheim Building, Mayo Clinic and Foundation, 200 First Street, SW, Rochester, MN 55905, USA
    BMJ 324:1315-9. 2002
  36. ncbi request reprint The prevention of Lyme disease with vaccine
    G A Poland
    Department of Internal Medicine and Mayo Vaccine Research Group, 611C Guggenheim Building, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Vaccine 19:2303-8. 2001
    ..Only mild or moderate, transient vaccine-associated adverse events have been reported after immunization. The vaccine is a safe and effective method of preventing Lyme disease...
  37. ncbi request reprint The role of mass spectrometry in vaccine development
    G A Poland
    Mayo Vaccine Research Group, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Vaccine 19:2692-700. 2001
    ..This paper will review the basics of mass spectrometry techniques as applied to the identification and characterization of vaccine peptide antigens, and discusses how these tools can be applied to vaccine development...
  38. ncbi request reprint Identification of an association between HLA class II alleles and low antibody levels after measles immunization
    G A Poland
    Department of Internal Medicine, Mayo Vaccine Research Group, Mayo Clinic and Foundation, 611C Guggenheim Building, 200 First Street, SW, Rochester, MN 55905, USA
    Vaccine 20:430-8. 2001
    ..These findings are crucial in designing both measles eradication by the use of vaccine, and future vaccines to be used in genetically heterozygous populations...
  39. ncbi request reprint Influenza vaccines: a review and rationale for use in developed and underdeveloped countries
    G A Poland
    Mayo Vaccine Research Group, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Vaccine 19:2216-20. 2001
    ..Recommendations for the use of the influenza vaccine in various countries and guidelines for influenza vaccine use worldwide will be proposed...
  40. ncbi request reprint High frequency of HLA-A*0103 allele in a Somali population
    G A Poland
    Mayo Vaccine Research Group, Rochester, MN 55905, USA
    Hum Immunol 62:197-200. 2001
    ..Lastly, this is the first identification of this allele in the homozygous state...
  41. ncbi request reprint Immunogenetic mechanisms of antibody response to measles vaccine: the role of the HLA genes
    G A Poland
    Mayo Vaccine Research Group, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Vaccine 17:1719-25. 1999
    ..In this paper, the results of studies are reviewed executed in my laboratory examining the role of the class I and II HLA genes on the antibody response to measles vaccine...
  42. pmc Vaccinomics and a new paradigm for the development of preventive vaccines against viral infections
    Gregory A Poland
    Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, Minnesota 55905, USA
    OMICS 15:625-36. 2011
    ....
  43. ncbi request reprint Measles antibody seroprevalence rates among immunized Inuit, Innu and Caucasian subjects
    G A Poland
    Mayo Vaccine Research Group, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN, USA
    Vaccine 17:1525-31. 1999
    ..The determination of these sources of variability may lead to the development of more efficacious vaccines or delivery strategies...
  44. doi request reprint Vaccines against Lyme disease: What happened and what lessons can we learn?
    Gregory A Poland
    Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Infect Dis 52:s253-8. 2011
    ....
  45. ncbi request reprint The burden of pneumococcal disease: the role of conjugate vaccines
    G A Poland
    Mayo Vaccine Research Group, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Vaccine 17:1674-9. 1999
    ..The solution to these dilemmas may lie in the development of protein conjugate-polysaccharide vaccines. This paper briefly reviews the role of conjugate pneumococcal vaccines...
  46. ncbi request reprint Effect of differing immunization policies on circulating measles antibody levels in US and Canadian children
    Gregory A Poland
    Mayo Vaccine Research Group, Division of General Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 77:446-52. 2002
    ..To examine the effect of differing age-at-immunization policies on measles antibody levels in US children immunized at the age of 15 months compared with Canadian children immunized at the age of 12 months...
  47. ncbi request reprint Current paradoxes and changing paradigms in vaccinology
    G A Poland
    Mayo Vaccine Research Group, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Vaccine 17:1605-11. 1999
    ..This paper will discuss a number of current paradoxes and changing paradigms related to the field of vaccinology...
  48. ncbi request reprint Understanding those who do not understand: a brief review of the anti-vaccine movement
    G A Poland
    Mayo Vaccine Research Group, Clinical Pharmacology Unit and Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Vaccine 19:2440-5. 2001
    ..This paper will examine the current anti-vaccine movement and provide current examples. Finally, a review of suggestions for dealing with the anti-vaccine movement will be presented...
  49. pmc HLA haplotype and supertype associations with cellular immune responses and cytokine production in healthy children after rubella vaccine
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Vaccine 27:3349-58. 2009
    ....
  50. pmc Effect of human leukocyte antigen homozygosity on rubella vaccine-induced humoral and cell-mediated immune responses
    Richard B Kennedy
    Mayo Clinic, Vaccine Research Group, Mayo Clinic, Rochester, Minnesota, USA
    Hum Immunol 71:128-35. 2010
    ..We also show that homozygosity within different HLA class I and class II loci is correlated with variations (but not necessarily decreases) in interleukin (IL)-2, IL-5, and IL-10 secretion after rubella virus stimulation...
  51. ncbi request reprint Associations between human leukocyte antigen (HLA) alleles and very high levels of measles antibody following vaccination
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Vaccine 22:1914-20. 2004
    ..These data increase our understanding of measles vaccine-induced immune response and will be useful for future mechanistic work on measles virus antigen processing and presentation in seronegative and hyperseropositive individuals...
  52. ncbi request reprint The contribution of HLA class I antigens in immune status following two doses of rubella vaccination
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Hum Immunol 65:1506-15. 2004
    ..These data may facilitate our understanding of immune response variation in a genetically outbred heterogeneous population...
  53. pmc Influence of host genetic variation on rubella-specific T cell cytokine responses following rubella vaccination
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Vaccine 27:3359-66. 2009
    ....
  54. pmc Relationship between HLA polymorphisms and gamma interferon and interleukin-10 cytokine production in healthy individuals after rubella vaccination
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Clin Vaccine Immunol 14:115-22. 2007
    ....
  55. pmc Human leukocyte antigen and cytokine receptor gene polymorphisms associated with heterogeneous immune responses to mumps viral vaccine
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Pediatrics 121:e1091-9. 2008
    ..We set out to assess whether HLA and cytokine gene polymorphisms are associated with variations in the immune response to mumps viral vaccine...
  56. pmc Importance of HLA-DQ and HLA-DP polymorphisms in cytokine responses to naturally processed HLA-DR-derived measles virus peptides
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Guggenheim 611C, 200 First Street SW, Rochester, MN 55905, USA
    Vaccine 24:5381-9. 2006
    ..This concept provides important information supporting the use of promiscuous peptides in a peptide-based vaccine approach...
  57. pmc SNP/haplotype associations in cytokine and cytokine receptor genes and immunity to rubella vaccine
    Neelam Dhiman
    Mayo Clinic Vaccine Research Group, Mayo Clinic, Guggenheim 611C, 200 First Street SW, Rochester, MN 55905, USA
    Immunogenetics 62:197-210. 2010
    ..Identification of such "genetic fingerprints" may predict the outcome of vaccine response and inform new vaccine strategies...
  58. ncbi request reprint Extinction of the human leukocyte antigen homozygosity effect after two doses of the measles-mumps-rubella vaccine
    Jennifer L St Sauver
    Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, MN 55905, USA
    Hum Immunol 66:788-98. 2005
    ..However, children who are HLA homozygous may be less protected against mumps compared with children who are heterozygous...
  59. pmc Replication of rubella vaccine population genetic studies: validation of HLA genotype and humoral response associations
    Inna G Ovsyannikova
    Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Vaccine 27:6926-31. 2009
    ....
  60. ncbi request reprint Differential HLA gene expression in measles vaccine seropositive and seronegative subjects: a pilot study
    Neelam Dhiman
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, Minnesota 55905, USA
    Scand J Infect Dis 35:332-6. 2003
    ..These results suggest an association between antibody response and differential HLA gene activation and may explain one potential mechanism underlying measles vaccine non-response...
  61. ncbi request reprint Immunologic significance of HLA class I genes in measles virus-specific IFN-gamma and IL-4 cytokine immune responses
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Immunogenetics 57:828-36. 2005
    ..Understanding the genetic factors that influence variations in cytokine secretion following measles vaccination will provide insight into the factors that influence both cell-mediated and humoral immunity to measles...
  62. ncbi request reprint Human leukocyte antigen class II alleles and rubella-specific humoral and cell-mediated immunity following measles-mumps-rubella-II vaccination
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Infect Dis 191:515-9. 2005
    ..This study of HLA class II-restricted humoral and cellular immune responses to rubella provides significant insight into mechanisms of vaccine response and new vaccine development...
  63. ncbi request reprint HLA class II alleles and measles virus-specific cytokine immune response following two doses of measles vaccine
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic and Foundation, Guggenheim 611C, 200 1st Street SW, Rochester, MN 55905, USA
    Immunogenetics 56:798-807. 2005
    ..These data suggest that IFN-gamma and IL-4 cytokine responses to measles may be genetically restricted in part by HLA class II genes, which in turn can restrict the cellular immune response to measles vaccine...
  64. pmc Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic, Guggenheim 611C, Rochester, MN 55905, USA
    Hum Genet 127:207-21. 2010
    ..This is the first paper to present evidence that polymorphisms in the TLR, vitamin A, vitamin D receptor, and innate immunity genes can influence adaptive cytokine responses to rubella vaccination...
  65. pmc Associations between SNPs in toll-like receptors and related intracellular signaling molecules and immune responses to measles vaccine: preliminary results
    Neelam Dhiman
    Mayo Vaccine Research Group, Mayo Clinic, Guggenheim 611C, 200 First Street SW, Rochester, MN 55905, USA
    Vaccine 26:1731-6. 2008
    ..These data contribute to understanding the immunogenetic mechanisms underlying variations in the immune response to measles vaccine...
  66. pmc Frequency of measles virus-specific CD4+ and CD8+ T cells in subjects seronegative or highly seropositive for measles vaccine
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, Minnesota 55905, USA
    Clin Diagn Lab Immunol 10:411-6. 2003
    ..These differences agree in directionality with the observed antibody response phenotype...
  67. ncbi request reprint Associations between measles vaccine immunity and single-nucleotide polymorphisms in cytokine and cytokine receptor genes
    Neelam Dhiman
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    J Infect Dis 195:21-9. 2007
    ..Cytokines are key regulators of measles vaccine humoral and cellular immunity. Single-nucleotide polymorphisms (SNPs) that are associated with differences in cytokine levels should also influence measles vaccine-induced immunity...
  68. pmc Identification and characterization of novel, naturally processed measles virus class II HLA-DRB1 peptides
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic and College of Medicine, Rochester, Minnesota 55905, USA
    J Virol 78:42-51. 2004
    ..This information is promising for new vaccine design strategies with peptide-based vaccines...
  69. ncbi request reprint Human leukocyte antigen haplotypes in the genetic control of immune response to measles-mumps-rubella vaccine
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Infect Dis 193:655-63. 2006
    ..002). Better characterization of such HLA profiles could inform and improve the design of novel epitope-rich vaccines and help to predict protective immune responses at the individual and population level...
  70. pmc 2'-5'-Oligoadenylate synthetase single-nucleotide polymorphisms and haplotypes are associated with variations in immune responses to rubella vaccine
    Iana H Haralambieva
    Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN, USA
    Hum Immunol 71:383-91. 2010
    ..Our results suggest that innate immunity and OAS genetic variations are likely involved in modulating the magnitude and quality of the adaptive immune responses to live attenuated rubella vaccine...
  71. ncbi request reprint Cytokine production patterns and antibody response to measles vaccine
    Inna G Ovsyannikova
    Department of Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Vaccine 21:3946-53. 2003
    ..There was no correlation between cytokine production by PBMC supernatants after PHA stimulation and circulating levels of plasma cytokines. No relationship was found between any specific cytokine level and measles antibody level...
  72. ncbi request reprint Association of parental vaccination reports with measles, mumps, and rubella protective antibody levels: comparison of Somali immigrant, Hispanic migrant, and US children in Rochester, Minn
    SauverJenniferL St
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minn 55905, USA
    Mayo Clin Proc 77:241-5. 2002
    ..To compare measles, mumps, and rubella antibody levels in Somali immigrant, Hispanic migrant, and US children in Rochester, Minn, and to determine whether parental vaccination reports predict seropositivity...
  73. ncbi request reprint Confronting bioterrorism: physicians on the front line
    Prathibha Varkey
    Division of Preventive Medicine and Occupational Medicine and Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 77:661-72. 2002
    ..Despite the unpredictable nature of bioterrorism, disaster preparedness and knowledge of essential diagnostic and epidemiological principles can contribute substantially toward combating this new threat...
  74. pmc Predominant inflammatory cytokine secretion pattern in response to two doses of live rubella vaccine in healthy vaccinees
    Neelam Dhiman
    Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Cytokine 50:24-9. 2010
    ..These results suggest an immune-deviation or "skewing" from Th1/Th2 cytokine patterns towards a predominant inflammatory response upon in vitro rubella virus stimulation...
  75. pmc Response surface methodology to determine optimal cytokine responses in human peripheral blood mononuclear cells after smallpox vaccination
    Jenna E Ryan
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, United States
    J Immunol Methods 341:97-105. 2009
    ..The use of the response surface methodology can be applied to the optimization of other laboratory assays; especially when the number of PBMC available limits the testing of all possible combinations of parameters...
  76. ncbi request reprint Hepatitis B vaccine nonresponse and celiac disease
    Kyung W Noh
    Department of Internal Medicine, Mayo Vaccine Research Group, and Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 98:2289-92. 2003
    ..We report a disproportionate number of patients with celiac disease who are nonresponders to the hepatitis B vaccine series...
  77. ncbi request reprint Identification of class II HLA-DRB1*03-bound measles virus peptides by 2D-liquid chromatography tandem mass spectrometry
    Kenneth L Johnson
    Mayo Proteomics Research Center, Mayo Vaccine Research Group, Program in Translational Immunovirology and Biodefense, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Proteome Res 4:2243-9. 2005
    ..These peptides provide an important first step toward understanding the mechanism of immune response to measles virus and development of a new generation of peptide-based vaccines...
  78. doi request reprint Influenza vaccination among registered nurses: information receipt, knowledge, and decision-making at an institution with a multifaceted educational program
    Cori L Ofstead
    Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Infect Control Hosp Epidemiol 29:99-106. 2008
    ..To evaluate the receipt of information and knowledge about influenza and vaccination, as well as influenza vaccination status and reasons for declining vaccination, among registered nurses...
  79. ncbi request reprint Variations in measles vaccine-specific humoral immunity by polymorphisms in SLAM and CD46 measles virus receptors
    Neelam Dhiman
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, Minn, USA
    J Allergy Clin Immunol 120:666-72. 2007
    ..Measles infection requires 2 cellular receptors, signaling lymphocyte activation molecule (SLAM) and CD46. Known and novel single nucleotide polymorphisms (SNPs) in SLAM and CD46 genes might influence the immune response to measles vaccine...
  80. ncbi request reprint Hepatitis B DNA vaccine induces protective antibody responses in human non-responders to conventional vaccination
    Scott T Rottinghaus
    Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Vaccine 21:4604-8. 2003
    ..This study provides evidence in humans for protective immunogenicity of a particle-mediated DNA vaccine in subjects who have responded suboptimally to conventional vaccination...
  81. pmc Influence of HLA-DRB1 alleles on lymphoproliferative responses to a naturally processed and presented measles virus phosphoprotein in measles immunized individuals
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Rochester, MN 55905, USA
    Hum Immunol 65:209-17. 2004
    ..We speculate that the glutamic acid at position 192 of the measles phosphoprotein is a critical immunogenicity factor and may influence the antigenicity of the naturally processed HLA class II MV-P1 epitope...
  82. ncbi request reprint T-Cell epitope discovery for variola and vaccinia viruses
    Richard Kennedy
    Mayo Vaccine Research Group, Mayo Clinic College of Medicine, Rochester, MN, USA
    Rev Med Virol 17:93-113. 2007
    ....
  83. ncbi request reprint HLA supertypes and immune responses to measles-mumps-rubella viral vaccine: findings and implications for vaccine design
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Vaccine 25:3090-100. 2007
    ..This information may be of significant value in the engineering of potential epitope-based vaccines that are recognized by T cells restricted by human HLA supertype alleles...
  84. ncbi request reprint Interleukin-4 induced by measles virus and measles-derived peptides as measured by IL-4 receptor-blocking ELISA
    Neelam Dhiman
    Mayo Vaccine Research Group, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Immunol Methods 287:217-25. 2004
    ..We propose that the IL-4 receptor-blocking assay is an easy-to-adapt technique for screening antigen-specific immune responses in large-scale population-based studies...
  85. ncbi request reprint Influenza vaccination and the elderly: pandemic preparedness
    Mary Jo Kasten
    Divisions of General Internal Medicine and Infectious Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota 59905, USA
    Drugs Aging 25:179-86. 2008
    ..Pandemic awareness and preparedness are essential to decrease the predicted chaos, death and illness arising from the next influenza pandemic...
  86. ncbi request reprint A taxonomy of reasoning flaws in the anti-vaccine movement
    Robert M Jacobson
    Vaccine Research Group, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905 0001, United States
    Vaccine 25:3146-52. 2007
    ..The claims illustrate the breadth of reasoning flaws while providing a basis for anticipating and correcting them...
  87. pmc Polymorphisms in the vitamin A receptor and innate immunity genes influence the antibody response to rubella vaccination
    Inna G Ovsyannikova
    Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Infect Dis 201:207-13. 2010
    ..Genetic polymorphisms play an important role in rubella vaccine-induced immunity...
  88. ncbi request reprint Studies of twins in vaccinology
    Robert M Jacobson
    Vaccine Research Group, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905 0001, United States
    Vaccine 25:3160-4. 2007
    ..We examine three of these studies in detail to illustrate important opportunities and limitations of twins studies in vaccinology...
  89. ncbi request reprint HLA homozygosity does not adversely affect measles vaccine-induced cytokine responses
    Inna G Ovsyannikova
    Mayo Clinic Vaccine Research Group, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Virology 364:87-94. 2007
    ..01). Our results suggest that HLA homozygosity showed no disadvantage for measles-specific cytokine responses and instead was associated with increased IFN-gamma levels...
  90. ncbi request reprint Severity of childhood asthma and human leukocyte antigens type
    Young J Juhn
    Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Asthma 44:163-8. 2007
    ..Because of limited statistical power, our study findings are subject to further investigation...
  91. pmc The identification of HLA class II-restricted T cell epitopes to vaccinia virus membrane proteins
    Richard B Kennedy
    Mayo Vaccine Research Group, Mayo Clinic, Rochester MN 55905, USA
    Virology 408:232-40. 2010
    ..This information may prove useful in peptide and protein-based subunit vaccine development as well as in the study of CD4 responses to poxviruses...
  92. ncbi request reprint Associations between human leukocyte antigen homozygosity and antibody levels to measles vaccine
    Jennifer L St Sauver
    Section of Clinical Epidemiology, Department of Health Sciences Research, Vaccine Research Group, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN 55905, USA
    J Infect Dis 185:1545-9. 2002
    ..These results suggest that lack of HLA diversity may limit the range of peptides that can be presented to antibody-producing cells, potentially resulting in a decreased immune response to viral infections...
  93. ncbi request reprint The overall safety profile of currently available vaccines directed against infectious diseases
    Robert M Jacobson
    Mayo Building E931, Mayo Clinic, 200 First Street Southwest, Rochester, Minnesota 55905 0001, USA
    Expert Opin Drug Saf 2:215-23. 2003
    ....
  94. ncbi request reprint Associations between measles antibody levels and the protein structure of class II human leukocyte antigens
    Jennifer L St Sauver
    Department of Health Sciences Research, Mayo Clinic and Foundation, Mayo Vaccine Research Group, Rochester, MN 55905, USA
    Hum Immunol 64:696-707. 2003
    ..Our data suggest that specific DQA and DQB amino acid variations are associated with measles seronegativity after vaccination...
  95. ncbi request reprint TAP1, TAP2, and HLA-DR2 alleles are predictors of cervical cancer risk
    Bobbie S Gostout
    Section of Gynecologic Surgery, Mayo Clinic, Rochester, MN 55905, USA
    Gynecol Oncol 88:326-32. 2003
    ..We evaluated immune response genes in the HLA region of chromosome 6 to see if individual or interactive associations with cervical cancer risk could be identified...
  96. ncbi request reprint The association of class I HLA alleles and antibody levels after a single dose of measles vaccine
    Robert M Jacobson
    Department of Pediatric and Adolescent MedicineMayo Clinic, Rochester, MN 55903, USA
    Hum Immunol 64:103-9. 2003
    ....
  97. ncbi request reprint The challenge of vaccine safety
    Robert M Jacobson
    Mayo Vaccine Research Group, The Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905 0001, USA
    Semin Pediatr Infect Dis 13:215-20. 2002
    ....
  98. pmc Score tests for association between traits and haplotypes when linkage phase is ambiguous
    Daniel J Schaid
    Department of Health Sciences Research, Mayo Clinic Foundation, Rochester, MN 55905, USA
    Am J Hum Genet 70:425-34. 2002
    ..Limited simulations are also presented to demonstrate the validity of our methods, as well as to provide guidelines on how our methods could be used...
  99. ncbi request reprint Why is evidence-based medicine so harsh on vaccines? An exploration of the method and its natural biases
    Robert M Jacobson
    Vaccine Research Group, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905 0001, United States
    Vaccine 25:3165-9. 2007
    ..In this review, we examine the criticisms and consider the shortcomings in the field of vaccinology as well as in the methodology of evidence-based medicine...
  100. doi request reprint Personal choice or evidence-based nursing intervention: nurses' decision-making about influenza vaccination
    Lori M Rhudy
    Department of Nursing, Mayo Clinic, Rochester, MN 55405, USA
    Worldviews Evid Based Nurs 7:111-20. 2010
    ..Yet, worldwide influenza vaccination rates among HCWs are low, with nurse vaccination rates among the lowest...
  101. pmc Extended LTA, TNF, LST1 and HLA gene haplotypes and their association with rubella vaccine-induced immunity
    Inna G Ovsyannikova
    Vaccine Research Group, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 5:e11806. 2010
    ..Apart from HLA, little is known about the effect of this extended genetic region on HLA haplotypic backgrounds as applied to immune responses...

Research Grants27

  1. The Immunogenetics of Measles Immunity
    Gregory A Poland; Fiscal Year: 2010
    ..Globally, measles kills over 500,000 children annually, and small outbreaks continue to occur in the U.S. ..
  2. IMMUNOGENETIC MECHANISMS OF VACCINE RESPONSE
    Gregory Poland; Fiscal Year: 2007
    ..The knowledge gained from these studies will enable us to design new strategies and new vaccines to protect human health against viral diseases. ..
  3. IMMUNOGENETIC MECHANISMS OF VACCINE RESPONSE
    Gregory Poland; Fiscal Year: 2006
    ..The knowledge gained from these studies will enable us to design new strategies and new vaccines to protect human health against viral diseases. ..
  4. NATURE OF MEASLES IMMUNITY IN TWO POPULATIONS
    Gregory Poland; Fiscal Year: 1999
    ....
  5. IMMUNOGENETIC MECHANISMS OF VACCINE RESPONSE
    Gregory A Poland; Fiscal Year: 2010
    ..The knowledge gained from these studies will enable us to design new strategies and new vaccines to protect human health against viral diseases. ..
  6. The Immunogenetics of Measles Immunity
    Gregory Poland; Fiscal Year: 2009
    ..Globally, measles kills over 500,000 children annually, and small outbreaks continue to occur in the U.S. ..
  7. IMMUNOGENETIC MECHANISMS OF VACCINE RESPONSE
    Gregory Poland; Fiscal Year: 2009
    ..The knowledge gained from these studies will enable us to design new strategies and new vaccines to protect human health against viral diseases. ..
  8. The Immunogenetics of Measles Immunity
    Gregory Poland; Fiscal Year: 2006
    ..abstract_text> ..
  9. IMMUNOGENETIC MECHANISMS OF VACCINE RESPONSE
    Gregory Poland; Fiscal Year: 2003
    ....
  10. The Immunogenetics of Measles Immunity
    Gregory Poland; Fiscal Year: 2004
    ..abstract_text> ..
  11. IMMUNOGENETIC MECHANISMS OF VACCINE RESPONSE
    Gregory Poland; Fiscal Year: 2004
    ....
  12. MEASLES IMMUNITY IN TWO POPULATIONS
    Gregory Poland; Fiscal Year: 1993
    ..These data are important in formulating national policy to eliminate measles...
  13. IMMUNOGENETIC MECHANISMS OF VACCINE RESPONSE
    Gregory Poland; Fiscal Year: 2002
    ....
  14. The Immunogenetics of Measles Immunity
    Gregory Poland; Fiscal Year: 2002
    ..abstract_text> ..
  15. IMMUNOGENETIC MECHANISMS OF VACCINE RESPONSE
    Gregory Poland; Fiscal Year: 2001
    ....
  16. The Immunogenetics of Measles Immunity
    Gregory Poland; Fiscal Year: 2005
    ..abstract_text> ..
  17. NATURE OF MEASLES IMMUNITY IN TWO POPULATIONS
    Gregory Poland; Fiscal Year: 2001
    ....
  18. NATURE OF MEASLES IMMUNITY IN TWO POPULATIONS
    Gregory Poland; Fiscal Year: 2000
    ....
  19. The Immunogenetics of Measles Immunity
    Gregory Poland; Fiscal Year: 2003
    ..abstract_text> ..
  20. IMMUNOGENETIC MECHANISMS OF VACCINE RESPONSE
    Gregory Poland; Fiscal Year: 2005
    ....