Douglas A Plager

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi request reprint A novel and highly divergent homolog of human eosinophil granule major basic protein
    D A Plager
    Departments of Immunology, Internal Medicine, and Biochemistry and Molecular Biology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Biol Chem 274:14464-73. 1999
  2. pmc Gene transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitis
    Douglas A Plager
    Allergic Diseases Research Laboratory, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 5:e11450. 2010
  3. pmc Eosinophil ribonucleases and their cutaneous lesion-forming activity
    Douglas A Plager
    Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 183:4013-20. 2009
  4. pmc Pimecrolimus reduces eosinophil activation associated with calcium mobilization
    Douglas A Plager
    Allergic Diseases Research Laboratory, Department of Dermatology, Mayo Clinic, Guggenheim 4 94, 200 First Street Southwest, Rochester, MN 55905, USA
    Int Arch Allergy Immunol 149:119-26. 2009
  5. ncbi request reprint Early cutaneous gene transcription changes in adult atopic dermatitis and potential clinical implications
    Douglas A Plager
    Department of Dermatology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Exp Dermatol 16:28-36. 2007
  6. ncbi request reprint Major basic protein homolog (MBP2): a specific human eosinophil marker
    Douglas A Plager
    Allergic Diseases Research Laboratory, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Immunol 177:7340-5. 2006
  7. ncbi request reprint A novel human homolog of eosinophil major basic protein
    D A Plager
    Department of Immunology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Immunol Rev 179:192-202. 2001
  8. ncbi request reprint Comparative structure, proximal promoter elements, and chromosome location of the human eosinophil major basic protein genes
    D A Plager
    Department of Immunology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Genomics 71:271-81. 2001
  9. ncbi request reprint Differential extraction of eosinophil granule proteins
    Lyo E Ohnuki
    Department of Dermatology, University of Utah, Salt Lake City, 84132, USA
    J Immunol Methods 307:54-61. 2005
  10. ncbi request reprint Interactions of eosinophil granule proteins with skin: limits of detection, persistence, and vasopermeabilization
    Mark D P Davis
    Department of Dermatology, Mayo Clinic and Foundation, Rochester, Minn, USA
    J Allergy Clin Immunol 112:988-94. 2003

Research Grants

  1. Global Gene Expression in Chronic Rhinosinusitis
    DOUGLAS PLAGER; Fiscal Year: 2005

Collaborators

Detail Information

Publications13

  1. ncbi request reprint A novel and highly divergent homolog of human eosinophil granule major basic protein
    D A Plager
    Departments of Immunology, Internal Medicine, and Biochemistry and Molecular Biology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Biol Chem 274:14464-73. 1999
    ..Overall, this novel homolog's unique physical properties indicated that the high net positive charge of hMBP is important but not essential for biological activity...
  2. pmc Gene transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitis
    Douglas A Plager
    Allergic Diseases Research Laboratory, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 5:e11450. 2010
    ....
  3. pmc Eosinophil ribonucleases and their cutaneous lesion-forming activity
    Douglas A Plager
    Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 183:4013-20. 2009
    ..In conclusion, ECP and EDN disrupt skin integrity and cause inflammation. Their presence in ulcerative skin lesions may explain certain findings in human eosinophil-associated diseases...
  4. pmc Pimecrolimus reduces eosinophil activation associated with calcium mobilization
    Douglas A Plager
    Allergic Diseases Research Laboratory, Department of Dermatology, Mayo Clinic, Guggenheim 4 94, 200 First Street Southwest, Rochester, MN 55905, USA
    Int Arch Allergy Immunol 149:119-26. 2009
    ..However, its effects on eosinophils, a cell type implicated in allergic disease pathology, are unknown. Therefore, we examined the effects of pimecrolimus on eosinophil superoxide anion production, degranulation and survival...
  5. ncbi request reprint Early cutaneous gene transcription changes in adult atopic dermatitis and potential clinical implications
    Douglas A Plager
    Department of Dermatology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Exp Dermatol 16:28-36. 2007
    ..Identification of these genes and pathways will direct future research towards controlling AD...
  6. ncbi request reprint Major basic protein homolog (MBP2): a specific human eosinophil marker
    Douglas A Plager
    Allergic Diseases Research Laboratory, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Immunol 177:7340-5. 2006
    ..These results indicate that MBP2 is present only in eosinophils and that it may be a useful biomarker for eosinophil-associated diseases...
  7. ncbi request reprint A novel human homolog of eosinophil major basic protein
    D A Plager
    Department of Immunology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Immunol Rev 179:192-202. 2001
    ....
  8. ncbi request reprint Comparative structure, proximal promoter elements, and chromosome location of the human eosinophil major basic protein genes
    D A Plager
    Department of Immunology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Genomics 71:271-81. 2001
    ..Furthermore, the identified conserved and distinct proximal promoter elements likely contribute to the eosinophil-restricted and relatively reduced transcription of the human MBPH gene...
  9. ncbi request reprint Differential extraction of eosinophil granule proteins
    Lyo E Ohnuki
    Department of Dermatology, University of Utah, Salt Lake City, 84132, USA
    J Immunol Methods 307:54-61. 2005
    ..These results indicate that repetitive extraction of eosinophil granules yields an increased amount of all granule proteins, and that MBP2 can now be recovered in good quantities and in a relatively pure form...
  10. ncbi request reprint Interactions of eosinophil granule proteins with skin: limits of detection, persistence, and vasopermeabilization
    Mark D P Davis
    Department of Dermatology, Mayo Clinic and Foundation, Rochester, Minn, USA
    J Allergy Clin Immunol 112:988-94. 2003
    ....
  11. ncbi request reprint Identification of basophils by a mAb directed against pro-major basic protein 1
    Douglas A Plager
    Department of Dermatology, Mayo Clinic Rochester, MN, and Department of Internal Medicine, Virginia Commonwealth University, USA
    J Allergy Clin Immunol 117:626-34. 2006
    ..A mAb (J175-7D4) generated against the recombinant pro-form of human eosinophil granule major basic protein 1 (rproMBP1) appeared to stain only basophils in tissue specimens...
  12. pmc Extensive fractionation and identification of proteins within nasal lavage fluids from allergic rhinitis and asthmatic chronic rhinosinusitis patients
    Linda M Benson
    Mayo Proteomics Research Center, Mayo Clinic, Rochester, MN, USA
    J Sep Sci 32:44-56. 2009
    ..This is the first extensive list of NLF proteins generated from CRS patients with coexisting asthma...
  13. doi request reprint Gene transcription abnormalities in canine atopic dermatitis and related human eosinophilic allergic diseases
    Douglas A Plager
    Allergic Diseases Research Laboratory, Mayo Clinic, Rochester, MN 55905, USA
    Vet Immunol Immunopathol 149:136-42. 2012
    ..Overall, numerous abnormally transcribed genes were observed only in canine AD; however, many others are common to related human eosinophilic allergic diseases and represent therapeutic targets testable in dogs with AD...

Research Grants1

  1. Global Gene Expression in Chronic Rhinosinusitis
    DOUGLAS PLAGER; Fiscal Year: 2005
    ..These new molecular approaches should shed light on the mechanisms of CRS and open novel avenues for diagnosis and treatment of this difficult disease. ..